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Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine
Open accessAbstract
Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug. There are currently no clinically available pharmacotherapies to treat cocaine addiction. Through a broad screen of innate immune mediators, we identify granulocyte-colony stimulating factor (G-CSF) as a potent mediator of cocaine-induced adaptations. Here we report that G-CSF potentiates cocaine-induced increases in neural activity in the nucleus accumbens (NAc) and prefrontal cortex. In addition, G-CSF injections potentiate cocaine place preference and enhance motivation to self-administer cocaine, while not affecting responses to natural rewards. Infusion of G-CSF neutralizing antibody into NAc blocks the ability of G-CSF to modulate cocaine’s behavioral effects, providing a direct link between central G-CSF action in NAc and cocaine reward. These results demonstrate that manipulating G-CSF is sufficient to alter the motivation for cocaine, but not natural rewards, providing a pharmacotherapeutic avenue to manipulate addictive behaviors without abuse potential.
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Metadata
- Authors
- Calipari, E. S., Godino, A., Peck, E. G., Salery, M., Mervosh, N. L., Landry, J. A., Russo, S. J., Hurd, Y. L., Nestler, E. J., & Kiraly, D. D.
- Venue
- Nature Communications
- Published
- 2018-01-16
- Volume
- 9
- Issue
- 1
- Pages
- 9-9
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2776955245
- Cited by
- 278
- References
- 10
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- gold
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- Calipari, E. S., Godino, A., Peck, E. G., Salery, M., Mervosh, N. L., Landry, J. A., Russo, S. J., Hurd, Y. L., Nestler, E. J., & Kiraly, D. D. (2018). Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine. Nature Communications. https://doi.org/10.1038/s41467-017-01881-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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