Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
Open accessAbstract
EGFR-mutant lung adenocarcinomas (LUAD) display diverse clinical trajectories and are characterized by rapid but short-lived responses to EGFR tyrosine kinase inhibitors (TKIs). Through sequencing of 79 spatially distinct regions from 16 early stage tumors, we show that despite low mutation burdens, EGFR-mutant Asian LUADs unexpectedly exhibit a complex genomic landscape with frequent and early whole-genome doubling, aneuploidy, and high clonal diversity. Multiple truncal alterations, including TP53 mutations and loss of CDKN2A and RB1, converge on cell cycle dysregulation, with late sector-specific high-amplitude amplifications and deletions that potentially beget drug resistant clones. We highlight the association between genomic architecture and clinical phenotypes, such as co-occurring truncal drivers and primary TKI resistance. Through comparative analysis with published smoking-related LUAD, we postulate that the high intra-tumor heterogeneity observed in Asian EGFR-mutant LUAD may be contributed by an early dominant driver, genomic instability, and low background mutation rates.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Data from GEMMs point towards a context-dependent, conditional haplo-insufficient role for Atm loss in KrasG12D-driven lung tumorigenesis.
“Thus, data from genetically engineered mouse models (GEMMs) point towards a context-dependent, conditional haplo-insufficient role for Atm loss in KrasG12D-driven lung tumorigenesis.”
From Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy (2019) · cites this paper as [104]
Complete Atm inactivation is incompatible with cellular viability in the context of KrasG12D expression and bi-allelic Trp53 inactivation, suggesting that excessive DNA damage removes incipient cancer cells from the proliferative pool.
“In contrast, complete Atm inactivation is incompatible with cellular viability in the context of KrasG12D expression and bi-allelic Trp53 inactivation, suggesting that excessive DNA damage in this context removes incipient cancer cells from the proliferative pool.”
From Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy (2019) · cites this paper as [104]
Kras-driven lung carcinogenesis is accelerated by incomplete Atm loss in a p53 deficient setting.
“Interestingly, Kras-driven lung carcinogenesis is accelerated by incomplete Atm loss in a p53 deficient setting”
From Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy (2019) · cites this paper as [104]
In murine models, the impact of Atm inactivation on Kras-driven lung carcinogenesis is context-dependent and varies according to the functional status of p53.
“In murine models the impact of Atm inactivation on Kras-driven lung carcinogenesis is context-dependent and varies according to the functional status of p53104.”
From Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy (2019) · cites this paper as [104]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
Wang, K., Li, M., & Hakonarson, H. H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq603 · Cited by 14,380 · see citing works
APE: Analyses of Phylogenetics and Evolution in R language
Paradis, E., Claude, J., & Strimmer, K. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg412 · Cited by 12,037 · see citing works
A framework for variation discovery and genotyping using next-generation DNA sequencing data
DePristo, M. A., Banks, E., Poplin, R. E., Garimella, K. V., Maguire, J., Hartl, C., Philippakis, A., del Angel, G., Rivas, M. A., Hanna, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.806 · Cited by 11,216 · see citing works
Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works
Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma
Mok, T. S., Wu, Y.-L., Thongprasert, S., Yang, C.-H., Chu, D.-T., Saijo, N., Sunpaweravong, P., Han, B., Margono, B., Ichinose, Y., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810699 · Cited by 8,261 · see citing works
Comprehensive molecular profiling of lung adenocarcinoma
The Cancer Genome Atlas Research Network (2014) · Nature · doi:10.1038/nature13385 · Cited by 5,732 · see citing works
Rosell, R., Carcereny, E., Gervais, R., Vergnenegre, A., Massuti, B., Felip, E., Palmero, R., Garcia-Gomez, R., Pallares, C., Sanchez, J. M., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70393-x · Cited by 5,489 · see citing works
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Lawrence, M. S., Stojanov, P., Polak, P., Kryukov, G. V., Cibulskis, K., Sivachenko, A., Carter, S. L., Stewart, C., Mermel, C. H., Roberts, S. A., et al. (2013) · Nature · doi:10.1038/nature12213 · Cited by 5,461 · see citing works
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Cibulskis, K., Lawrence, M. S., Carter, S. L., Sivachenko, A., Jaffe, D. B., Sougnez, C. L., Gabriel, S., Meyerson, M. M., Lander, E. S., & Getz, G. A. (2013) · Nature Biotechnology · doi:10.1038/nbt.2514 · Cited by 4,838 · see citing works
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencingPreprint
Koboldt, D. C., Zhang, Q., Larson, D. E., Shen, D., McLellan, M. D., Lin, L., Miller, C. A., Mardis, E. R., Ding, L., & Wilson, R. K. (2012) · Genome Research · doi:10.1101/gr.129684.111 · Cited by 4,822 · see citing works
Mutational landscape and significance across 12 major cancer types
Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., et al. (2013) · Nature · doi:10.1038/nature12634 · Cited by 4,419 · see citing works
The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017 · see citing works
Comprehensive molecular characterization of clear cell renal cell carcinoma
The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485 · see citing works
Self-citationFive-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid Leukemia
Druker, B. J., Guilhot, F., O’Brien, S. G., Gathmann, I., Kantarjian, H. M., Gattermann, N., Deininger, M. W., Silver, R. T., Goldman, J. M., Stone, R. M., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062867 · Cited by 3,473 · see citing works
A census of human cancer genes
Futreal, P. A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., Rahman, N., & Stratton, M. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1299 · Cited by 3,184 · see citing works
Discovery and saturation analysis of cancer genes across 21 tumour types
Lawrence, M. S., Stojanov, P., Mermel, C. H., Robinson, J. T., Garraway, L. A., Golub, T. R., Meyerson, M., Gabriel, S. B., Lander, E. S., & Getz, G. (2014) · Nature · doi:10.1038/nature12912 · Cited by 3,096 · see citing works
Somatic mutations affect key pathways in lung adenocarcinoma
Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., et al. (2008) · Nature · doi:10.1038/nature07423 · Cited by 2,681 · see citing works
Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, I. I., Fong, K. M., Lee, H., Toyooka, S., Shimizu, N., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji055 · Cited by 2,377 · see citing works
Tracking the Evolution of Non–Small-Cell Lung Cancer
Jamal-Hanjani, M., Wilson, G. A., McGranahan, N., Birkbak, N. J., Watkins, T. B. K., Veeriah, S., Shafi, S., Johnson, D. H., Mitter, R., Rosenthal, R., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1616288 · Cited by 2,349 · see citing works
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,066 · see citing works
Absolute quantification of somatic DNA alterations in human cancer
Carter, S. L., Cibulskis, K., Helman, E., McKenna, A., Shen, H., Zack, T. I., Laird, P. W., Onofrio, R. C., Winckler, W., Weir, B. A., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2203 · Cited by 2,003 · see citing works
Pan-cancer patterns of somatic copy number alteration
Zack, T. I., Schumacher, S. E., Carter, S. L., Cherniack, A. D., Saksena, G., Tabak, B., Lawrence, M. S., Zhang, C., Wala, J. A., Mermel, C. H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2760 · Cited by 1,843 · see citing works
Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
Imielinski, M., Berger, A. H., Hammerman, P. S., Hernandez, B., Pugh, T. J., Hodis, E., Cho, J., Suh, J., Capelletti, M., Sivachenko, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.029 · Cited by 1,789 · see citing works
Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs
Kris, M. G., Johnson, B. E., Berry, L. D., Kwiatkowski, D. J., Iafrate, A. J., Wistuba, I. I., Varella-Garcia, M., Franklin, W. A., Aronson, S. L., Su, P.-F., et al. (2014) · JAMA · doi:10.1001/jama.2014.3741 · Cited by 1,724 · see citing works
Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs
Saunders, C. T., Wong, W. S. W., Swamy, S., Becq, J., Murray, L. J., & Cheetham, R. K. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts271 · Cited by 1,589 · see citing works
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
Landau, D. A., Carter, S. L., Stojanov, P., McKenna, A., Stevenson, K., Lawrence, M. S., Sougnez, C., Stewart, C., Sivachenko, A., Wang, L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.019 · Cited by 1,379 · see citing works
Allele-specific copy number analysis of tumors
Loo, P. V., Nord, S., Lingjærde, O. C., Russnes, H. G., Rye, I. H., Sun, W., Weigman, V., Marynen, P., Zetterberg, A., Naume, B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009843107 · Cited by 1,231 · see citing works
Gerlinger, M., Horswell, S. D., Larkin, J., Rowan, A., Salm, M., Varela, I., Fisher, R. A., McGranahan, N., Matthews, N., Santos, C. R., et al. (2014) · Nature Genetics · doi:10.1038/ng.2891 · Cited by 1,211 · see citing works
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
Cancer Genome Atlas Research Network, Campbell, J. D., Alexandrov, A., Kim, J., Wala, J., Berger, A. H., Pedamallu, C. S., Shukla, S. A., Guo, G., Brooks, A. N., et al. (2016) · Nature Genetics · doi:10.1038/ng.3564 · Cited by 1,200 · see citing works
Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers
Govindan, R., Ding, L., Griffith, M., Subramanian, J., Dees, N. D., Kanchi, K., Maher, C. A., Fulton, R. S., Fulton, L., Wallis, J. W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.024 · Cited by 1,144 · see citing works
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
de Bruin, E. C., McGranahan, N., Mitter, R., Salm, M., Wedge, D. C., Yates, L., Jamal-Hanjani, M., Shafi, S., Murugaesu, N., Rowan, A. J., et al. (2014) · Science · doi:10.1126/science.1253462 · Cited by 1,117 · see citing works
Characterizing the cancer genome in lung adenocarcinoma
Weir, B. A., Woo, M. S., Getz, G., Perner, S., Ding, L., Beroukhim, R., Lin, W. M., Province, M. A., Kraja, A., Johnson, L. A., et al. (2007) · Nature · doi:10.1038/nature06358 · Cited by 1,105 · see citing works
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
Turke, A. B., Zejnullahu, K., Wu, Y.-L., Song, Y., Dias-Santagata, D., Lifshits, E., Toschi, L., Rogers, A., Mok, T., Sequist, L., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.022 · Cited by 1,059 · see citing works
Clock-like mutational processes in human somatic cells
Alexandrov, L. B., Jones, P. H., Wedge, D. C., Sale, J. E., Campbell, P. J., Nik‐Zainal, S., & Stratton, M. R. (2015) · Nature Genetics · doi:10.1038/ng.3441 · Cited by 1,038 · see citing works
PyClone: statistical inference of clonal population structure in cancer
Roth, A. J. L., Khattra, J. S., Yap, D., Wan, A. N. C., Laks, E., Biele, J., Ha, G., Aparicio, S. A. J. R., Bouchard‐Côté, A., & Shah, S. P. (2014) · Nature Methods · doi:10.1038/nmeth.2883 · Cited by 1,002 · see citing works
Hata, A. N., Niederst, M. J., Archibald, H. L., Gomez-Caraballo, M., Siddiqui, F. M., Mulvey, H. E., Maruvka, Y. E., Ji, F., Bhang, H.-E. C., Krishnamurthy Radhakrishna, V., et al. (2016) · Nature Medicine · doi:10.1038/nm.4040 · Cited by 985 · see citing works
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
Zhang, J., Fujimoto, J., Zhang, J., Wedge, D. C., Song, X., Zhang, J., Seth, S., Chow, C.-W., Cao, Y., Gumbs, C., et al. (2014) · Science · doi:10.1126/science.1256930 · Cited by 965 · see citing works
Takezawa, K., Pirazzoli, V., Arcila, M. E., Nebhan, C. A., Song, X., de Stanchina, E., Ohashi, K., Janjigian, Y. Y., Spitzler, P. J., Melnick, M. A., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0108 · Cited by 710 · see citing works
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
McGranahan, N., Favero, F., de Bruin, E. C., Birkbak, N. J., Szallasi, Z., & Swanton, C. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1408 · Cited by 685 · see citing works
Identification of neutral tumor evolution across cancer types
Williams, M. J., Werner, B., Barnes, C. P., Graham, T. A., & Sottoriva, A. (2016) · Nature Genetics · doi:10.1038/ng.3489 · Cited by 628 · see citing works
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity
Marusyk, A., Tabassum, D. P., Altrock, P. M., Almendro, V., Michor, F., & Polyák, K. (2014) · Nature · doi:10.1038/nature13556 · Cited by 588 · see citing works
Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells
Ramirez, M., Rajaram, S., Steininger, R. J., Osipchuk, D., Roth, M. A., Morinishi, L. S., Evans, L., Ji, W., Hsu, C.-H., Thurley, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms10690 · Cited by 581 · see citing works
A Genomics-Based Classification of Human Lung Tumors
Thomas, R. K., Buettner, R., & Wolf, J. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006802 · Cited by 508 · see citing works
Dewhurst, S. M., McGranahan, N., Burrell, R. A., Rowan, A., Gronroos, E. C., Endesfelder, D., Joshi, T., Mouradov, D., Gibbs, P., Ward, R. L., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0285 · Cited by 450 · see citing works
Jiménez-Sánchez, A., Memon, D., Pourpe, S., Veeraraghavan, H., Li, Y., Vargas, H. A., Gill, M. B., Park, K. J., Zivanovic, O., Konner, J. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.025 · Cited by 449 · see citing works
MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling
Huang, S., Hölzel, M., Knijnenburg, T., Schlicker, A., Roepman, P., McDermott, U., Garnett, M., Grernrum, W., Sun, C., Prahallad, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.035 · Cited by 430 · see citing works
Tumour heterogeneity and the evolution of polyclonal drug resistance
Burrell, R. A., & Swanton, C. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.06.005 · Cited by 417 · see citing works
Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes
Robertson‐Tessi, M., Gillies, R. J., Gatenby, R. A., & Anderson, A. R. A. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1428 · Cited by 274 · see citing works
Pilati, C., Letouzé, É., Nault, J., Imbeaud, S., Boulai, A., Caldéraro, J., Poussin, K., Franconi, A., Couchy, G., Morcrette, G., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.005 · Cited by 271 · see citing works
Mitsudomi, T., Oyama, T., Kusano, T., Osaki, T., Nakanishi, R., & Shirakusa, T. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.24.2018 · Cited by 211 · see citing works
High-throughput Phenotyping of Lung Cancer Somatic Mutations
Berger, A. H., Brooks, A. N., Wu, X., Shrestha, Y., Chouinard, C. R., Piccioni, F., Bagul, M., Kamburov, A., Imielinski, M. B., Hogstrom, L. J., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.06.022 · Cited by 207 · see citing works
Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers
Parikh, C., Janakiraman, V., Wu, W., Foo, C. K., Kljavin, N. M., Chaudhuri, S., Stawiski, E. W., Lee, B., Lin, J. M., Li, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204384109 · Cited by 146 · see citing works
Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution
Laughney, A. M., Elizalde, S., Genovese, G., & Bakhoum, S. F. W. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.065 · Cited by 122 · see citing works
EMu: probabilistic inference of mutational processes and their localization in the cancer genome
Fischer, A., Illingworth, C. J. R., Campbell, P., & Mustonen, V. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r39 · Cited by 108 · see citing works
β-Catenin Contributes to Lung Tumor Development Induced by EGFR Mutations
Nakayama, S., Sng, N., Carretero, J., Welner, R. S., Hayashi, Y., Yamamoto, M., Tan, A. J., Yamaguchi, N., Yasuda, H., Li, D., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0184 · Cited by 91 · see citing works
Thu, K. L., Vucic, E. A., Chari, R., Zhang, W., Lockwood, W. W., English, J. C., Fu, R., Wang, P., Feng, Z., MacAulay, C. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033003 · Cited by 77 · see citing works
Genomic Profiles Specific to Patient Ethnicity in Lung Adenocarcinoma
Broët, P., Dalmasso, C., Tan, E. H., Alifano, M., Zhang, S., Wu, J., Lee, M. H., Régnard, J., Lim, W., Koong, H. N., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2185 · Cited by 73 · see citing works
Self-citationWhy imatinib remains an exception of cancer research
Horne, S. D., Stevens, J. B., Abdallah, B. Y., Liu, G., Bremer, S. W., Ye, C. J., & Heng, H. H. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24233 · Cited by 53 · see citing works
Planck, M., Edlund, K., Botling, J., Micke, P., Isaksson, S., & Staaf, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078614 · Cited by 36 · see citing works
Jain, A., Lim, C., Gan, E. M., Ng, D. Z., Ng, Q. S., Ang, M. K., Takano, A., Chan, K. S., Tan, W. M., Kanesvaran, R., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0123587 · Cited by 32 · see citing works
Self-citationGenomic and Transcriptional Alterations in Lung Adenocarcinoma in Relation to Smoking History
Karlsson, A., Ringnér, M., Lauss, M., Botling, J., Micke, P., Planck, M., & Staaf, J. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0246 · Cited by 30 · see citing works
The Genomic Landscape of Cancers
Heng, H. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804310-3.00005-3 · Cited by 14 · see citing works
Yu, H. A., Jordan, E., Ni, A., Feldman, D., Rodríguez, C., Kim, H. R., Kris, M. G., Solit, D. B., Berger, M. F., Ladanyi, M., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.9053 · Cited by 13 · see citing works
The Genomic and Epigenomic Landscapes of Blast Crisis Transformation in Chronic Myeloid Leukemia
Ong, S. T., Pathiraja, T. N., Javed, A., Soh, X. X. S., Malik, S., Tan, J. H. J., Ko, T. K., Chuah, C. T. H., Takahashi, N., Bhatia, R., et al. (2015) · Blood · doi:10.1182/blood.v126.23.3737.3737 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Simoni, Y., Becht, E., Fehlings, M., Loh, C. Y., Koo, S.-L., Teng, K. W. W., Yeong, J. P. S., Nahar, R., Zhang, T., Kared, H., et al. (2018) · Nature · doi:10.1038/s41586-018-0130-2 · Cited by 1,370 · see citing works
Self-citationCo-occurring genomic alterations in non-small-cell lung cancer biology and therapy
Skoulidis, F., & Heymach, J. V. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0179-8 · Cited by 1,019 · see citing works
Lim, Z.-F., & Ma, P. C. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0818-2 · Cited by 639 · see citing works
Integrative Proteomic Characterization of Human Lung Adenocarcinoma
Xu, J., Zhang, C., Wang, X., Zhai, L., Ma, Y., Mao, Y., Qian, K., Sun, C., Liu, Z., Jiang, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.043 · Cited by 612 · see citing works
Genomic landscape of lung adenocarcinoma in East Asians
Chen, J., Yang, H., Teo, A. S. M., Amer, L. B., Sherbaf, F. G., Tan, C. Q., Alvarez, J. J. S., Lu, B., Lim, J. Q., Takano, A. M., et al. (2020) · Nature Genetics · doi:10.1038/s41588-019-0569-6 · Cited by 511 · see citing works
Self-citationDrug resistance to targeted therapeutic strategies in non-small cell lung cancer
Liu, W., Du, Y., Wen, R. M., Yang, M., & Xu, J. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107438 · Cited by 218 · see citing works
Zhang, C., Zhang, J. J., Xu, F.-P., Wang, Y.-G., Xie, Z., Su, J., Dong, S., Nie, Q., Shao, Y. W., Zhou, Q. H., et al. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2019.07.031 · Cited by 199 · see citing works
Revisiting neoadjuvant therapy in non-small-cell lung cancer
Saw, S. P. L., Ong, B., Chua, K. L. M., Takano, A. M., & Tan, D. S. W. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00383-1 · Cited by 204 · see citing works
Self-citationRoper, N., Brown, A., Wei, J. S., Pack, S., Trindade, C. J., Kim, C., Restifo, O., Gao, S., Sindiri, S., Mehrabadi, F. R., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100007 · Cited by 179 · see citing works
Kim, Y., Lee, B., Shim, J. H., Lee, S.-H., Park, W.-Y., Choi, Y.-L., Sun, J.-M., Ahn, J. S., Ahn, M.-J., & Park, K. (2019) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.10.150 · Cited by 174 · see citing works
Concurrent TP53 Mutations Facilitate Resistance Evolution in EGFR-Mutant Lung Adenocarcinoma
Vokes, N. I., Chambers, E. S., Nguyen, T. T., Coolidge, A., Lydon, C., Le, X., Sholl, L. M., Heymach, J. V., Nishino, M., Allen, E. M. V., et al. (2022) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2022.02.011 · Cited by 167 · see citing works
MET alterations in NSCLC—Current Perspectives and Future Challenges
Remón, J., Hendriks, L. E. L., Mountzios, G., García‐Campelo, R., Saw, S. P. L., Uprety, D., Recondo, G., Villacampa, G. J., & Reck, M. (2022) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2022.10.015 · Cited by 150 · see citing works
Su, S., Dong, Z., Xie, Z., Yan, L., Li, Y., Su, J., Liu, S. M., Yin, K., Chen, R., Huang, S., et al. (2018) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.07.016 · Cited by 144 · see citing works
Lai, G. G. Y., Lim, T. H., Lim, J., Liew, P. J. R., Kwang, X. L., Nahar, R., Aung, Z. W., Takano, A., Lee, Y. Y., Lau, D. P. X., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.00177 · Cited by 118 · see citing works
Self-citationZhao, H., Yao, W., Min, X., Gu, K., Yu, G., Zhang, Z., Cui, J., Miao, L., Zhang, L., Yuan, X., et al. (2021) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2021.05.006 · Cited by 120 · see citing works
Tumor mutational burden in lung cancer: a systematic literature review
Willis, C., Fiander, M., Tran, D., Korytowsky, B., Thomas, J.-M., Calderon, F., Zyczynski, T. M., Brixner, D. I., & Stenehjem, D. D. (2019) · Oncotarget · doi:10.18632/oncotarget.27287 · Cited by 95 · see citing works
Tu, C., Zeng, Z., Qi, P., Li, X., Guo, C. J., Xiong, F., Xiang, B., Zhou, M., Liao, Q., Yu, J., et al. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy108 · Cited by 93 · see citing works
Corvaja, C., Passaro, A., Attili, I., Aliaga, P. T., Spitaleri, G., Signore, E. D., & de Marinis, F. (2024) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2024.102824 · Cited by 91 · see citing works
Guo, Y., Song, J., Wang, Y., Huang, L., Sun, L., Zhao, J., Zhang, S., Jing, W., Ma, J., & Han, C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.610923 · Cited by 85 · see citing works
Weeden, C. E., Gayevskiy, V., Marceaux, C., Batey, D., Tan, T., Yokote, K., Ribera, N. T., Clatch, A., Christo, S. N., Teh, C. E., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.03.019 · Cited by 81 · see citing works
Li, Y., Li, X., Li, H., Zhao, Y., Liu, Z., Sun, K., Zhu, X., Qi, Q., An, B., Shen, D., et al. (2019) · European Respiratory Journal · doi:10.1183/13993003.01409-2019 · Cited by 78 · see citing works
Liu, S., Bao, H., Wang, Q., Mao, W., Chen, Y., Tong, X., Xu, S.-T., Wu, L., Wei, Y., Liu, Y.-Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26806-7 · Cited by 77 · see citing works
Tan, D. S. W., Leighl, N. B., Riely, G. J., Yang, J. C., Sequist, L. V. D., Wolf, J., Seto, T., Felip, E., Ponce-Aix, S., Jonnaert, M., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30267-x · Cited by 75 · see citing works
Self-citationSmall cell transformation of ROS1 fusion-positive lung cancer resistant to ROS1 inhibition
Lin, J. J., Langenbucher, A., Gupta, P., Yoda, S., Fetter, I. J., Rooney, M. M., Do, A., Kem, M., Prutisto-Chang, K., Oh, A., et al. (2020) · npj Precision Oncology · doi:10.1038/s41698-020-0127-9 · Cited by 72 · see citing works
Xu, L., Xi, J., Zhong, W., Mao, W., Wu, L., Shen, Y., Liu, Y., Chen, C., Cheng, Y., Xu, L., et al. (2018) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2018.11.020 · Cited by 71 · see citing works
Ahn, E. R., Mangat, P. K., Garrett-Mayer, E. S., Halabi, S., Dib, E. G., Haggstrom, D. E., Alguire, K. B., Calfa, C. J., Cannon, T. L., Crilley, P. A., et al. (2020) · JCO Precision Oncology · doi:10.1200/po.20.00037 · Cited by 69 · see citing works
Advanced technological tools to study multidrug resistance in cancer
Andrei, L., Kasas, S., Ochoa, I., Stanković, T., Korsnes, M. S., Václavíková, R., Assaraf, Y. G., & Pešić, M. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100658 · Cited by 67 · see citing works
Stockhammer, P., Grant, M. J., Wurtz, A., Foggetti, G., Expósito, F., Gu, J., Zhao, H., Choi, J., Chung, S. T., Li, F., et al. (2023) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2023.10.001 · Cited by 67 · see citing works
Fang, Y. V., Wang, Y., Zeng, D., Zhi, S., Shu, T., Huang, N., Zheng, S., Wu, J., Liu, Y., Huang, G., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1951019 · Cited by 65 · see citing works
Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer
Nanjo, S., Wu, W., Karachaliou, N., Blakely, C. M., Suzuki, J., Chou, Y., Ali, S. M., Kerr, D. L., Olivas, V. R., Shue, J., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci145099 · Cited by 69 · see citing works
Self-citationLei, T., Xu, T., Zhang, N., Zou, X., Kong, Z., Wei, C., & Wang, Z. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106668 · Cited by 66 · see citing works
Addressing cellular heterogeneity in tumor and circulation for refined prognostication
Lim, S. B., Yeo, T., Lee, W. D., Bhagat, A. A. S., Tan, S. J., Tan, D. S. W., Lim, W., & Lim, C. T. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907904116 · Cited by 62 · see citing works
Self-citationLi, X.-M., Li, W., Lin, J., Yan, H., Tu, H., Chen, H., Wang, B.-C., Wang, Z., Zhou, Q. H., Zhang, X., et al. (2020) · Clinical Lung Cancer · doi:10.1016/j.cllc.2020.11.001 · Cited by 62 · see citing works
Middleton, G., Robbins, H. L., André, F., & Swanton, C. (2021) · Annals of Oncology · doi:10.1016/j.annonc.2021.11.004 · Cited by 58 · see citing works
Pros, E., Saigí, M., Alameda, D., Gómez‐Mariano, G., Martínez–Delgado, B., Alburquerque-Béjar, J. J., Carretero, J., Tonda, R., Esteve‐Codina, A., Català, I., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2019.09.001 · Cited by 55 · see citing works
Emerging nanotechnologies for targeting antimicrobial resistance
Weldrick, P. J., Wang, A., Halbus, A. F., & Paunov, V. N. (2022) · Nanoscale · doi:10.1039/d1nr08157h · Cited by 55 · see citing works
Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET
Pal, A. S., Agredo, A., Lanman, N. A., Son, J., Sohal, I. S., Bains, M., Li, C., Clingerman, J., Gates, K., & Kasinski, A. L. (2022) · Cancer Research · doi:10.1158/0008-5472.can-20-0821 · Cited by 57 · see citing works
Zhou, H., Hu, Y., Luo, R., Zhao, Y., Pan, H., Ji, L., Zhou, T., Zhang, L., Long, H., Fu, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25787-x · Cited by 54 · see citing works
Kawachi, H., Tamiya, M., Tamiya, A., Ishii, S., Hirano, K., Matsumoto, H., Fukuda, Y., Yokoyama, T., Kominami, R., Fujimoto, D., et al. (2019) · Investigational New Drugs · doi:10.1007/s10637-019-00882-5 · Cited by 52 · see citing works
Karagiannakos, A., Adamaki, M., Tsintarakis, A., Vojtěšek, B., Fåhræus, R., Zoumpourlis, V. C., & Karakostis, K. (2022) · Cancers · doi:10.3390/cancers14030664 · Cited by 55 · see citing works
Song, K. J., Choi, S., Kim, K., Hwang, H. S., Chang, E., Park, J. S., Shim, S. B., Choi, S., Heo, Y. J., Yang, D. Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54434-4 · Cited by 44 · see citing works
Why loss of Y? A pan-cancer genome analysis of tumors with loss of Y chromosome
Müller, P., Camacho, O. V., Yazbeck, A. M., Wölwer, C. B., Zhai, W., Schumacher, J., Heider, D., Buettner, R., Quaas, A., & Hillmer, A. M. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.02.024 · Cited by 43 · see citing works
Self-citationCo-occurring genomic alterations and immunotherapy efficacy in NSCLC
Zhang, F., Wang, J., Xu, Y., Cai, S., Li, T., Wang, G., Li, C., Zhao, L., & Hu, Y. (2022) · npj Precision Oncology · doi:10.1038/s41698-021-00243-7 · Cited by 41 · see citing works
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
Bakir, M. A., Reading, J. L., Gamble, S., Rosenthal, R., Uddin, I., Rowan, A., Przewrocka, J., Rogers, A., Wong, Y. N. S., Bentzen, A. K., et al. (2025) · Nature · doi:10.1038/s41586-025-08586-y · Cited by 40 · see citing works
Chua, K. P., Teng, Y. H. F., Tan, A. C., Takano, A. M., Alvarez, J. J. S., Nahar, R. R., Rohatgi, N., Lai, G. G. Y., Aung, Z. W., Yeong, J. P.-S., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4607 · Cited by 37 · see citing works
Self-citationAlthubiti, M. (2018) · Saudi Journal of Medicine and Medical Sciences · doi:10.4103/sjmms.sjmms_154_18 · Cited by 38 · see citing works
Vendrell, J. A., Mazières, J., Senal, R., Rouquette, I., Quantin, X., Pujol, J.-L., Roch, B., Bouidioua, A., Godreuil, S., Coyaud, É., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2683 · Cited by 38 · see citing works
Leong, T. L., Gayevskiy, V., Steinfort, D., de Massy, M. R., González-Rajal, Á., Marini, K. D., Stone, E. C. A., Chin, V. T., Havryk, A. P., Plit, M., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0536-1 · Cited by 37 · see citing works
The comparison of cancer gene mutation frequencies in Chinese and U.S. patient populations
Ma, F., Laster, K. V., & Dong, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-33351-4 · Cited by 36 · see citing works
Adjuvant Treatments for Surgically Resected Non–Small Cell Lung Cancer Harboring EGFR Mutations
Passaro, A., Mok, T. S. K., Attili, I., Wu, Y.-L. L. C., Tsuboi, M., de Marinis, F., & Peters, S. (2023) · JAMA Oncology · doi:10.1001/jamaoncol.2023.0459 · Cited by 36 · see citing works
Cai, L., Chen, Y., Tong, X., Wu, X., Bao, H., Shao, Y. W., Luo, Z., Wang, X., & Cao, Y. (2021) · International Journal of Cancer · doi:10.1002/ijc.33583 · Cited by 35 · see citing works
Gini, B., Thomas, N. J., & Blakely, C. M. (2020) · Journal of Thoracic Disease · doi:10.21037/jtd.2020.03.78 · Cited by 38 · see citing works
Perioperative targeted therapy for oncogene-driven NSCLC
Liu, S. M., Zhang, J.-T., Zeng, K.-H., & Wu, Y.-L. L. C. (2022) · Lung Cancer · doi:10.1016/j.lungcan.2022.05.007 · Cited by 34 · see citing works
Phasing analysis of lung cancer genomes using a long read sequencer
Sakamoto, Y., Miyake, S., Oka, M., Kanai, A., Kawai, Y., Nagasawa, S., Shiraishi, Y., Tokunaga, K., Kohno, T., Seki, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31133-6 · Cited by 31 · see citing works
Gorman, B. R., Ji, S., Francis, M., Sendamarai, A. K., Shi, Y., Devineni, P., Saxena, U., Partan, E. S., DeVito, A. K., Byun, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52129-4 · Cited by 35 · see citing works
Comprehensive molecular profiling of pulmonary pleomorphic carcinoma
Nagano, M., Kohsaka, S., Hayashi, T., Ueno, T., Kojima, S., Shinozaki‐Ushiku, A., Morita, S., Tsuda, M., Tanaka, S., Shinohara, T., et al. (2021) · npj Precision Oncology · doi:10.1038/s41698-021-00201-3 · Cited by 32 · see citing works
Which Is Better EGFR-TKI Followed by Osimertinib: Afatinib or Gefitinib/Erlotinib?
Tamiya, M., Tamiya, A., Suzuki, H., Moriizumi, K., Nakahama, K., Taniguchi, Y., Kunimasa, K., Kimura, M., Inoue, T., Kuhara, H., et al. (2019) · Anticancer Research · doi:10.21873/anticanres.13544 · Cited by 31 · see citing works
Chang, S.-C., Lai, Y.-C., Chang, C.-Y., Huang, L.-K., Chen, S.-J., Tan, K. T., Yu, P., & Lai, J. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.07.008 · Cited by 31 · see citing works
New Frontiers for Molecular Pathology
Domagala-Kulawik, J. J. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00284 · Cited by 31 · see citing works
Restricting Glutamine Uptake Enhances NSCLC Sensitivity to Third-Generation EGFR-TKI Almonertinib
Liu, Y., Ge, X., Pang, J., Zhang, Y., Zhang, H., Wu, H., Fan, F., & Liu, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.671328 · Cited by 31 · see citing works
Kong, S. L., Liu, X., Tan, S. J., Tai, J. A., Phua, L. Y., Poh, H. M., Yeo, T., Chua, Y. W., Haw, Y. X., Ling, W. H., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.698551 · Cited by 31 · see citing works
Self-citationKim, M., Hwang, J., Kim, K., Hwang, S., Lee, H., Jung, J. Y., Lee, J. G., Cha, Y. J., & Shim, H. S. (2021) · Modern Pathology · doi:10.1038/s41379-021-00872-0 · Cited by 30 · see citing works
Racial and Ethnic Disparities in Survival Among People With Second Primary Cancer in the US
Sung, H., Nisotel, L. E., Sedeta, E. T., Islami, F., & Jemal, A. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.27429 · Cited by 28 · see citing works
Iwama, E., Sakai, K., Hidaka, N., Inoue, K., Fujii, A., Nakagaki, N., Ota, K., Toyozawa, R., Azuma, K., Nakatomi, K., et al. (2019) · Cancer · doi:10.1002/cncr.32481 · Cited by 28 · see citing works
Testa, U., Pelosi, E., & Castelli, G. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2022.2017774 · Cited by 28 · see citing works
Structural Racism and Lung Cancer Risk
Bonner, S. N., Curley, R. J., Love, K., Akande, T., Akhtar, A., & Erhunmwunsee, L. (2023) · JAMA Oncology · doi:10.1001/jamaoncol.2023.4897 · Cited by 26 · see citing works
Remón, J., Saw, S. P. L., Cortiula, F., Singh, P. K., Menis, J., Mountzios, G., & Hendriks, L. E. L. (2023) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2023.09.1451 · Cited by 26 · see citing works
Saw, S. P. L., Ng, W. P., Zhou, S., Lai, G. G. Y., Tan, A. C., Ang, M., Lim, W., Kanesvaran, R., Ng, Q. S., Jain, A., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.10.012 · Cited by 25 · see citing works
Self-citationYang, Z. Q., Wei, B., Anbang, Q., Yang, P., Chen, W., Zhen, D., & Qiu, X. (2021) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbab217 · Cited by 24 · see citing works
Prognostic significance of CDC25C in lung adenocarcinoma: An analysis of TCGA data
Xia, Z., Ou-yang, W., Hu, T., & Du, K. (2019) · Cancer Genetics · doi:10.1016/j.cancergen.2019.04.001 · Cited by 24 · see citing works
Liang, H., Li, C., Zhao, Y., Zhao, S., Huang, J., Cai, X., Cheng, B., Xiong, S., Li, J., Wang, W., et al. (2020) · Cancer Management and Research · doi:10.2147/cmar.s255967 · Cited by 23 · see citing works
Tan, J., Hu, C., Deng, P., Wan, R., Cao, L., Li, M., Yang, H., Gu, Q., An, J., & Jiang, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.646577 · Cited by 22 · see citing works
Gristina, V., Mantia, M. L., Galvano, A., Cutaia, S., Barraco, N., Castiglia, M., Perez, A., Bono, M., Iacono, F., Greco, M., et al. (2021) · Journal of Molecular Pathology · doi:10.3390/jmp2020016 · Cited by 23 · see citing works
Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung
Sivakumar, S., Lucas, F. A. S., Jakubek, Y. A., McDowell, T. L., Lang, W., Kallsen, N. A., Peyton, S., Davies, G. E., Fukuoka, J., Yatabe, Y., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.020 · Cited by 21 · see citing works
Kobayashi, K., & Tan, A. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044126 · Cited by 22 · see citing works
Presentation of EGFR mutations in 162 family probands with multiple primary lung cancer
Li, C., Wang, Y., Su, K., Liu, Y., Wang, L., Zheng, B. J., Yan, N., Yuan, D., Zhang, Y., Xue, L., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-1001 · Cited by 17 · see citing works
Blons, H., Oudart, J.-B., Merlio, J., Debieuvre, D., de Fraipont, F., Audigier-Valette, C., Escande, F., Hominal, S., Bringuier, P., Fraboulet, S. M., et al. (2020) · Lung Cancer · doi:10.1016/j.lungcan.2020.11.008 · Cited by 19 · see citing works
Hara, N., Ichihara, E., Kano, H., Ando, C., Morita, A., Nishi, T., Okawa, S., Nakasuka, T., Hirabae, A., Abe, M., et al. (2023) · Translational Lung Cancer Research · doi:10.21037/tlcr-23-99 · Cited by 20 · see citing works
Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer
Nokin, M., Ambrogio, C., Nadal, E., & Santamarı́a, D. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.11.005 · Cited by 19 · see citing works
Keflee, R. D., Leong, K. H., Ogawa, S., Bignon, J. S., Chan, M. C., & Kong, K. W. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115262 · Cited by 17 · see citing works
Wu, N., Liu, S., Li, J., Hu, Z., Yan, S., Duan, H., Wu, D., Ma, Y., Li, S., Wang, X., et al. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-1086 · Cited by 16 · see citing works
Suda, K., Murakami, I., Obata, K., Sakai, K., Fujino, T., Koga, T., Ohara, S., Hamada, A., Soh, J., Nishio, K., et al. (2020) · Lung Cancer · doi:10.1016/j.lungcan.2020.08.010 · Cited by 15 · see citing works
Wu, X., Song, P., Guo, L., Ying, J., & Li, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.888951 · Cited by 15 · see citing works
WMDS.net: a network control framework for identifying key players in transcriptome programs
Cheng, X., Amanullah, M., Liu, W., Liu, Y., Pan, X., Zhang, H., Xu, H., Liu, P., & Lü, Y. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad071 · Cited by 15 · see citing works
Duan, J., Ge, M., Peng, J., Zhang, Y., Yang, L., Wang, T., Tian, Q., Rui, Y., Zhang, Y., & Cheng, W. (2020) · Scientific Reports · doi:10.1038/s41598-020-75935-4 · Cited by 15 · see citing works
Chen, T. W., Pang, A. S. L., Puhaindran, M. E., Maw, M. M., Loong, H. H.-F., Sriuranpong, V., Chang, C., Mingmalairak, S., Hirose, T., Endo, M., et al. (2021) · Cancer Science · doi:10.1111/cas.14793 · Cited by 15 · see citing works
Kumar, S. U., Balasundaram, A., Hephzibah Cathryn, R., Varghese, R. P., Ramamoorthy, S., Ramanathan, G., Younes, S. N., Zayed, H., & Doss, C. G. P. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105701 · Cited by 15 · see citing works
Third generation EGFR TKI landscape for metastatic EGFR mutant non-small cell lung cancer (NSCLC)
Tan, A. C., Teh, Y. L., Lai, G. G. Y., & Tan, D. S.-W. (2019) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2019.1604228 · Cited by 15 · see citing works
Self-citationPredicting EGFR gene mutation status in lung adenocarcinoma based on multifeature fusion
Jiang, Y., Ma, S., Xiao, W. L., Wang, J., Ding, Y., Zheng, Y., & Sui, X. (2023) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2023.104786 · Cited by 14 · see citing works
Schatz, S., Falk, M., Jóri, B., Ramdani, H., Schmidt, S., Willing, E., Menon, R., Groen, H. J. M., Diehl, L., Kröger, M., et al. (2020) · Cancers · doi:10.3390/cancers12061685 · Cited by 14 · see citing works
Gu, W., Wang, N., Gu, W., Qiu, Y., Zhang, H., Liang, J., Zhou, T., Ma, L., Cai, W., Feng, W., et al. (2020) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-457 · Cited by 13 · see citing works
Characterising acquired resistance to erlotinib in non-small cell lung cancer patients
Karachaliou, N., Codony‐Servat, J., Bracht, J. W. P., Ito, M., Filipska, M., Pedraz‐Valdunciel, C., CHAIB-OUKADOUR, I., Bertrán-Alamillo, J., Cardona, A. F., Molina‐Vila, M. Á., et al. (2019) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1656068 · Cited by 12 · see citing works
Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma
Hoppe, S., Jonas, C., Wenzel, M. C., Camacho, O. V., Arolt, C., Zhao, Y., Büttner, R., Quaas, A., Plum, P. S., & Hillmer, A. M. (2021) · Cancers · doi:10.3390/cancers13174300 · Cited by 15 · see citing works
Self-citationLi, J., Liu, B., Ye, Q., Xiao, X., Yan, S., Guan, W., He, L., Wang, C., Yu, Z., Tai, Z., et al. (2022) · Modern Pathology · doi:10.1038/s41379-022-01116-5 · Cited by 12 · see citing works
A phylogenetic approach to study the evolution of somatic mutational processes in cancer
Miura, S., Vu, T., Choi, J., Townsend, J. P., Karim, S., & Kumar, S. (2022) · Communications Biology · doi:10.1038/s42003-022-03560-0 · Cited by 12 · see citing works
Sueoka‐Aragane, N., Nakashima, C., Yoshida, H., Matsumoto, N., Iwanaga, K., Ebi, N., Nishiyama, A., Yatera, K., Kuyama, S., Fukuda, M., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.3929 · Cited by 13 · see citing works
Chen, Y., Su, P., Huang, W., Chang, C., Yen, Y., Lin, C., & Tseng, Y. (2022) · Scientific Reports · doi:10.1038/s41598-022-22957-9 · Cited by 11 · see citing works
The clinicopathological and molecular characteristics of resected EGFR‐mutant lung adenocarcinoma
Zhou, W., Liu, Z., Wang, Y., Zhang, Y., Qian, F., Lü, J., Wang, H., Gu, P., Hu, M., Chen, Y., et al. (2022) · Cancer Medicine · doi:10.1002/cam4.4543 · Cited by 11 · see citing works
Targeted Therapy in Early Stage Non-small Cell Lung Cancer
Liu, S., Liu, S. M., Zhong, W., & Wu, Y.-L. L. C. (2022) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-00994-w · Cited by 12 · see citing works
Pradhan, D., Kumar, A., Singh, H., & Agrawal, U. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816548-5.00004-6 · Cited by 10 · see citing works
- Authors
- Nahar, R., Zhai, W., Zhang, T., Takano, A., Khng, A. J., Lee, Y. Y., Liu, X., Lim, C. H., Koh, T. P. T., Aung, Z. W., Lim, T. K. H., Veeravalli, L., Yuan, J., Teo, A. S. M., Chan, C. X., Poh, H. M., Chua, I. M. L., Liew, A. A., Lau, D. P. X., Kwang, X. L., Toh, C. K., Lim, W.-T., Lim, B., Tam, W. L., Tan, E.-H., Hillmer, A. M., & Tan, D. S. W.
- Affiliations
- Genome Institute of Singapore (SG)
- Nanyang Technological University (SG)
- Singapore General Hospital (SG)
- National Heart Centre Singapore (SG)
- National Cancer Centre Singapore (SG)
- University Hospital Cologne (DE)
- Corresponding author
- Hillmer, Axel M.
- Tan, Daniel S. W.
- ORCID
- Venue
- Nature Communications
- Published
- 2018-01-15
- Volume
- 9
- Issue
- 1
- Pages
- 216-216
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5768770
- OpenAlex
- W2783397995
- Cited by
- 173
- References
- 65
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 12 · 2023: 26 · 2022: 26 · 2021: 34 · 2020: 25 · 2019: 23 · 2018: 10
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- National University of Singapore (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion, cc-by)
- Funders
- Francis Crick Institute (10112)
- National Cancer Centre of Singapore
- Nanomaterials Microdevices Research Center, Osaka Institute of Technology
- Singapore General Hospital
- Genome Institute of Singapore
- Medical Research Council
- National Medical Research Council (NMRC/TCR/007-NCC/2013)
- Biomedical Research Council
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- EGFR-mutant lung adenocarcinoma, Asian patients, whole-genome duplication, aneuploidy, clonal diversity, TP53 mutation, CDKN2A loss, RB1 loss, cell cycle dysregulation, gene amplification, gene deletion, EGFR tyrosine kinase inhibitor resistance, intratumoral heterogeneity, genomic instability, smoking-related lung cancer
- MeSH terms
- Exome Sequencing, Adenocarcinoma, Humans, Lung Neoplasms, Mutation, Drug Resistance, Neoplasm, Genetic Predisposition to Disease, Genomics, Asian People, Cell Line, Tumor, Protein Kinase Inhibitors, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review