The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
Open accessAbstract
A recently developed adenine base editor (ABE) efficiently converts A to G and is potentially useful for clinical applications. However, its precision and efficiency in vivo remains to be addressed. Here we achieve A-to-G conversion in vivo at frequencies up to 100% by microinjection of ABE mRNA together with sgRNAs. We then generate mouse models harboring clinically relevant mutations at Ar and Hoxd13, which recapitulates respective clinical defects. Furthermore, we achieve both C-to-T and A-to-G base editing by using a combination of ABE and SaBE3, thus creating mouse model harboring multiple mutations. We also demonstrate the specificity of ABE by deep sequencing and whole-genome sequencing (WGS). Taken together, ABE is highly efficient and precise in vivo, making it feasible to model and potentially cure relevant genetic diseases.
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Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A., & Liu, D. R. (2016) · Nature · doi:10.1038/nature17946 · Cited by 5,437
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
Gaudelli, N. M., Komor, A. C., Rees, H. A., Packer, M. S., Badran, A. H., Bryson, D. I., & Liu, D. R. (2017) · Nature · doi:10.1038/nature24644 · Cited by 4,184
ClinVar: public archive of interpretations of clinically relevant variants
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Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes
Yen, S.-T., Zhang, M., Deng, J. M., Usman, S. J., Smith, C. N., Parker-Thornburg, J., Swinton, P. G., Martin, J. F., & Behringer, R. R. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.06.017 · Cited by 300
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Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
Anzalone, A. V., Koblan, L. W., & Liu, D. R. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0561-9 · Cited by 2,237
Artificial intelligence: A powerful paradigm for scientific research
Xu, Y., Liu, X., Cao, X., Huang, C., Liu, E., Qian, S., Liu, X., Wu, Y., Dong, F., Qiu, C.-W., et al. (2021) · The Innovation · doi:10.1016/j.xinn.2021.100179 · Cited by 1,726
Self-citationBase editing: precision chemistry on the genome and transcriptome of living cells
Rees, H. A., & Liu, D. R. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0059-1 · Cited by 1,675
Plant- or microbial-derived? A review on the molecular composition of stabilized soil organic matter
Angst, G., Mueller, K. E., Nierop, K. G. J., & Simpson, M. J. (2021) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2021.108189 · Cited by 1,196
Richter, M. F., Zhao, K. T., Eton, E., Lapinaite, A., Newby, G. A., Thuronyi, B. W., Wilson, C., Koblan, L. W., Zeng, J., Bauer, D. E., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0453-z · Cited by 1,020
Metadata
- Authors
- Liu, Z., Lu, Z., Yang, G., Huang, S., Li, G., Feng, S., Liu, Y., Li, J., Yu, W., Zhang, Y., Chen, J., Sun, Q., & Huang, X.
- Venue
- Nature Communications
- Published
- 2018-06-14
- Volume
- 9
- Issue
- 1
- Pages
- 2338-2338
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2805837749
- Cited by
- 2,074
- References
- 5
- FWCI
- 158.36
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, Z., Lu, Z., Yang, G., Huang, S., Li, G., Feng, S., Liu, Y., Li, J., Yu, W., Zhang, Y., Chen, J., Sun, Q., & Huang, X. (2018). Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing. Nature Communications. https://doi.org/10.1038/s41467-018-04768-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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