The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
Open accessAbstract
Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate anti-pathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats.
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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
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Cited by
The biology , function , and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770
“In vitro, after T cell contact, the priming of dendritic cells (immune instruction that changes the activity of dendritic cells to enhance their response to future stimulation) is also associated with the uptake of exosomal genomic andmitochondrial DNA (mtDNA) fromT cells, inducing type I IFN production by cGAS-STING…”
BackgroundExosome biogenesis: machinery, regulation, and therapeutic implications in cancer
Han, Q.-F., Li, W.-J., Hu, K.-S., Gao, J., Zhai, W.-L., Yang, J.-H., & Zhang, S.-J. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01671-0 · Cited by 678
The ins-and-outs of exosome biogenesis, secretion, and internalization
Arya, S. B., Collie, S. P., & Parent, C. A. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.06.006 · Cited by 427
Todkar, K., Chikhi, L., Desjardins, V., El-Mortada, F., Pépin, G., & Germain, M. (2021) · Nature Communications · doi:10.1038/s41467-021-21984-w · Cited by 382
Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy
Garland, K. M., Sheehy, T. L., & Wilson, J. T. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00750 · Cited by 357
Metadata
- Authors
- Torralba, D., Baixauli, F., Villarroya-Beltri, C., Fernández-Delgado, I., Latorre-Pellicer, A., Acín-Pérez, R., Martín-Cófreces, N. B., Jaso-Tamame, Á. L., Iborra, S., Jorge, I., González-Aseguinolaza, G., Garaude, J., Vicente-Manzanares, M., Enríquez, J. A., Mittelbrunn, M., & Sánchez-Madrid, F.
- Venue
- Nature Communications
- Published
- 2018-07-09
- Volume
- 9
- Issue
- 1
- Pages
- 2658-2658
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2809795782
- Cited by
- 375
- References
- 70
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- gold
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- Torralba, D., Baixauli, F., Villarroya-Beltri, C., Fernández-Delgado, I., Latorre-Pellicer, A., Acín-Pérez, R., Martín-Cófreces, N. B., Jaso-Tamame, Á. L., Iborra, S., Jorge, I., González-Aseguinolaza, G., Garaude, J., Vicente-Manzanares, M., Enríquez, J. A., Mittelbrunn, M., & Sánchez-Madrid, F. (2018). Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nature Communications. https://doi.org/10.1038/s41467-018-05077-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
