Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
Open accessAbstract
Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. We have assessed the origin of new cells in the adult mouse spinal cord by genetic fate mapping. Oligodendrocyte progenitors self-renew, give rise to new mature oligodendrocytes, and constitute the dominating proliferating cell population in the intact adult spinal cord. In contrast, astrocytes and ependymal cells, which are restricted to limited self-duplication in the intact spinal cord, generate the largest number of cells after spinal cord injury. Only ependymal cells generate progeny of multiple fates, and neural stem cell activity in the intact and injured adult spinal cord is confined to this cell population. We provide an integrated view of how several distinct cell types contribute in complementary ways to cell maintenance and the reaction to injury.
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TAM has been exploited experimentally to induce permanent reporter expression in newly-born neurons in olfactory bulb and dentate gyrus, in physiologically-active neurons throughout the brain, and in progeny of ependymal cells of intact and injured murine spinal cord.
“TAM has been exploited experimentally to induce permanent reporter expression in, for example, newly-born neurons in the olfactory bulb and dentate gyrus [8], in physiologically-active neurons throughout the brain [9], and in progeny of ependymal cells of the intact and injured murine spinal cord [39].”
From Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis (2015) · cites this paper as [39]
In Barnabé-Heider et al., five daily treatments of TAM (80 mg/kg) were used to induce recombination in ependymal cells in FoxJ1-CreER mice to determine whether ependymal cells are multipotential in vitro, and in vivo following spinal cord injury.
“Here, five daily treatments of TAM (80 mg/kg) were used to induce recombination in ependymal cells in FoxJ1-CreER mice in order to determine whether ependymal cells are multipotential in vitro, and in vivo following a spinal cord injury.”
From Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis (2015) · cites this paper as [39]
In vivo, reporter-expressing ependyma self-renewed and produced astrocytes and oligodendrocyte-lineage cells 5 days following last TAM dose.
“In vivo, reporter-expressing ependyma self-renewed and produced astrocytes and oligodendrocyte-lineage cells 5 days following the last TAM dose.”
From Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis (2015) · cites this paper as [39]
The in vitro studies showed that 3 days after cessation of TAM treatment, recombined ependyma could give rise to neurospheres with cells expressing markers for neurons, astrocytes and oligodendrocyte-lineage cells.
“The in vitro studies showed that 3 days after cessation of TAM treatment, recombined ependyma could indeed give rise to neurospheres with cells expressing markers for neurons, astrocytes and oligodendrocyte-lineage cells.”
From Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis (2015) · cites this paper as [39]
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- Authors
- Barnabé-Heider, F., Göritz, C., Sabelström, H., Takebayashi, H., Pfrieger, F. W., Meletis, K., & Frisén, J.
- Affiliations
- Karolinska Institutet (SE)
- Kumamoto University (JP)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Frisén, Jonas
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 7
- Issue
- 4
- Pages
- 470-482
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2128475302
- Cited by
- 628
- References
- 58
- Citations by year
- 2026: 28 · 2025: 33 · 2024: 34 · 2023: 44 · 2022: 40 · 2021: 64 · 2020: 35 · 2019: 37 · 2018: 46 · 2017: 48 · 2016: 42 · 2015: 44 · 2014: 48 · 2013: 33 · 2012: 24
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- adult spinal cord, glial cell origin, spinal cord injury, oligodendrocyte progenitors, astrocytes, ependymal cells, neural stem cells, cell proliferation, self-renewal, genetic fate mapping
- MeSH terms
- Animals, Immunohistochemistry, Mice, Transgenic, Neuroglia, Spinal Cord Injuries, Stem Cells, Mice, Spinal Cord Regeneration
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