The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
Open accessAbstract
Reactive oxygen species (ROS)-induced apoptosis is a promising treatment strategy for malignant neoplasms. However, current systems are highly dependent on oxygen status and/or external stimuli to generate ROS, which greatly limit their therapeutic efficacy particularly in hypoxic tumors. Herein, we develop a biomimetic nanoflower based on self-assembly of nanozymes that can catalyze a cascade of intracellular biochemical reactions to produce ROS in both normoxic and hypoxic conditions without any external stimuli. In our formulation, PtCo nanoparticles are firstly synthesized and used to direct the growth of MnO 2. By adjusting the ratio of reactants, highly-ordered MnO 2@PtCo nanoflowers with excellent catalytic efficiency are obtained, where PtCo behaves as oxidase mimic and MnO 2 functions as catalase mimic. In this way, the well-defined MnO 2@PtCo nanoflowers not only can relieve hypoxic condition but also induce cell apoptosis significantly through ROS-mediated mechanism, thereby resulting in remarkable and specific inhibition of tumor growth.
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Cites
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Reactive oxygen species in cancer cells: Live by the sword, die by the sword
Schumacker, P. T. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.015 · Cited by 1,242
Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941
Cited by
Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
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Li, S., Shang, L., Xu, B., Wang, S., Gu, K., Wu, Q., Sun, Y., Zhang, Q., Yang, H., Zhang, F., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904751 · Cited by 466
Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy
Xu, B., Cui, Y., Wang, W., Li, S., Lyu, C., Wang, S., Bao, W., Wang, H., Qin, M., Liu, Z., et al. (2020) · Advanced Materials · doi:10.1002/adma.202003563 · Cited by 404
Self-citationBioinspired Copper Single‐Atom Catalysts for Tumor Parallel Catalytic Therapy
Lu, X., Gao, S., Lin, H., Yu, L., Han, Y., Zhu, P., Bao, W., Yao, H., Chen, Y., & Shi, J. (2020) · Advanced Materials · doi:10.1002/adma.202002246 · Cited by 367
Wang, M., Chang, M., Chen, Q., Wang, D., Li, C., Hou, Z., Lin, J., Jin, D., & Xing, B. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120093 · Cited by 322
Metadata
- Authors
- Wang, Z., Zhang, Y., Ju, E., Liu, Z., Cao, F., Chen, Z., Ren, J., & Qu, X.
- Venue
- Nature Communications
- Published
- 2018-08-20
- Volume
- 9
- Issue
- 1
- Pages
- 3334-3334
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2887163385
- Cited by
- 643
- References
- 3
- FWCI
- 25.48
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, Z., Zhang, Y., Ju, E., Liu, Z., Cao, F., Chen, Z., Ren, J., & Qu, X. (2018). Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors. Nature Communications. https://doi.org/10.1038/s41467-018-05798-x
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