Reactive oxygen species in cancer cells: Live by the sword, die by the sword
Open accessAbstract
Reactive oxygen species and tumor biology are intertwined in a complex web, making it difficult to understand which came first, whether oxidants are required for tumor cell growth, and whether oxidant stress can be exploited therapeutically. Evidence suggests that transformed cells use ROS signals to drive proliferation and other events required for tumor progression. This confers a state of increased basal oxidative stress, making them vulnerable to chemotherapeutic agents that further augment ROS generation or that weaken antioxidant defenses of the cell. In this respect, it appears that tumor cells may die by the same systems they require.
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Some chemotherapeutic drugs require oxygen to generate oxygen free radicals, which in turn induce cytotoxicity and promote the effect of antitumor drugs.
“It is generally believed that some chemotherapeutic drugs require oxygen to generate oxygen free radicals, which in turn induce cytotoxicity and promote the effect of antitumor drugs. 384”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [384]
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- Authors
- Schumacker, P. T.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Schumacker, Paul T.
- ORCID
- Schumacker, Paul T.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 10
- Issue
- 3
- Pages
- 175-176
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2011006339
- Cited by
- 1,242
- References
- 8
- Citations by year
- 2026: 23 · 2025: 55 · 2024: 56 · 2023: 57 · 2022: 76 · 2021: 88 · 2020: 82 · 2019: 86 · 2018: 71 · 2017: 81 · 2016: 91 · 2015: 89 · 2014: 90 · 2013: 67 · 2012: 65
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- reactive oxygen species, oxidative stress, cancer cells, tumor progression, cell proliferation, chemosensitization, antioxidant defense, ROS signaling, cancer therapy
- MeSH terms
- Antineoplastic Agents, Neoplasms, Thioredoxins, Apoptosis, Reactive Oxygen Species
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