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Cited by 41Tactile and Sensory InteractionsNeural dynamics and brain functionMultisensory perception and integration

Cortical modulation of sensory flow during active touch in the rat whisker system

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Chakrabarti, Shubhodeep, Schwarz, Cornelius·2018·Nature Communications
DOI 10.1038/s41467-018-06200-6PMC PMC6156333
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Abstract

Sensory gating, where responses to stimuli during sensor motion are reduced in amplitude, is a hallmark of active sensing systems. In the rodent whisker system, sensory gating has been described only at the thalamic and cortical stages of sensory processing. However, does sensory gating originate at an even earlier synaptic level? Most importantly, is sensory gating under top-down or bottom-up control? To address these questions, we used an active touch task in behaving rodents while recording from the trigeminal sensory nuclei. First, we show that sensory gating occurs in the brainstem at the first synaptic level. Second, we demonstrate that sensory gating is pathway-specific, present in the lemniscal but not in the extralemniscal stream. Third, using cortical lesions resulting in the complete abolition of sensory gating, we demonstrate its cortical dependence. Fourth, we show accompanying decreases in whisking-related activity, which could be the putative gating signal.

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  • Cortico-fugal and cortico-thalamo-cortical organization is also mainly ipsilateral and known to form feedback control loops.

    “Similarly, cortico-fugal (61, 62) and cortico-thalamo-cortical (57, 58) organization is also mainly ipsilateral and known to form feedback control loops.”

    From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [61]

    The Introduction (page unavailable) says descending projections from somatosensory and parietal cortex to the trigeminal sensory nuclei close a sensory loop, supporting the corticofugal feedback-loop portion. The paper does not establish that this organization is mainly ipsilateral or describe cortico-thalamo-cortical organization as a feedback control loop; its uses of “ipsilateral” concern experimental anatomy, not that general claim. (LLM, conf=0.84)

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References 79 · Cited by 41

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Authors
Chakrabarti, S., & Schwarz, C.
Affiliations
Hertie Institute for Clinical Brain Research (DE)
Corresponding author
Chakrabarti, Shubhodeep
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2018-09-25
Volume
9
Issue
1
Pages
3907-3907
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-018-06200-6
PMC
PMC6156333
OpenAlex
W2892265359
Cited by
41
References
79
Citations by year
2026: 9 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 4 · 2020: 5 · 2019: 3
FWCI
1.77
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft (CH 1232/1-1, SCHW 577-16-1)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
Keywords
sensory gating, active touch, whisker system, trigeminal sensory nucleus, brainstem, lemniscal pathway, top-down control, bottom-up control, cortical lesions, whisking, active sensing
MeSH terms
Animals, Brain Stem, Cerebral Cortex, Female, Sensory Thresholds, Synapses, Thalamic Nuclei, Touch, Vibrissae, Rats, Sprague-Dawley

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