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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations

Open access
Ho, Nhan T., Li, Fan, Lee-Sarwar, Kathleen A., Tun, Hein M., Brown, Bryan P., Pannaraj, Pia S., Bender, Jeffrey M., Azad, Meghan B., Thompson, Amanda L., Weiss, Scott T., Azcarate-Peril, M. Andrea, Litonjua, Augusto A., Kozyrskyj, Anita L., Jaspan, Heather B., Aldrovandi, Grace M., Kuhn, Louise·2018·Nature Communications

Abstract

Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to compare the gut microbiota of non-EBF and EBF infants across populations. In the first 6 months of life, gut bacterial diversity, microbiota age, relative abundances of Bacteroidetes and Firmicutes, and predicted microbial pathways related to carbohydrate metabolism are consistently higher in non-EBF than in EBF infants, whereas relative abundances of pathways related to lipid metabolism, vitamin metabolism, and detoxification are lower. Variation in predicted microbial pathways associated with non-EBF infants is larger among infants born by Caesarian section than among those vaginally delivered. Longer duration of exclusive breastfeeding is associated with reduced diarrhea-related gut microbiota dysbiosis. Furthermore, differences in gut microbiota between EBF and non-EBF infants persist after 6 months of age. Our findings elucidate some mechanisms of short and long-term benefits of exclusive breastfeeding across different populations.

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Metadata

Authors
Ho, N. T., Li, F., Lee-Sarwar, K. A., Tun, H. M., Brown, B. P., Pannaraj, P. S., Bender, J. M., Azad, M. B., Thompson, A. L., Weiss, S. T., Azcarate-Peril, M. A., Litonjua, A. A., Kozyrskyj, A. L., Jaspan, H. B., Aldrovandi, G. M., & Kuhn, L.
Venue
Nature Communications
Published
2018-10-09
Volume
9
Issue
1
Pages
4169-4169
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2895153150
Cited by
466
References
7
FWCI
3.37
Type
journal article
Language
en
Open access
gold

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