Cited by 117Infant Nutrition and HealthGut microbiota and healthProbiotics and Fermented Foods

Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double‐blind, Multicenter Study

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Chua, Mei Chien, Ben‐Amor, Kaouther, Lay, Christophe, Goh, Anne E.N., Chiang, Wen Chin, Rao, Rajeshwar, Chew, Charmaine, Chaithongwongwatthana, Surasith +3 more·2017·Journal of Pediatric Gastroenterology and Nutrition

Abstract

We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P < 0.0001) until week 8 (P = 0.041), a reduction of Enterobacteriaceae from day 3/5 (P = 0.002) till week 12 (P = 0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.

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Crossref · 10.1097/mpg.0000000000001623

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  • Supplementation with probiotics and prebiotics can be used to decrease the impact of delivery mode on the microbiota.

    “supplementation with probiotics and prebiotics can be used to decrease the impact of delivery mode on the microbiota (Chua et al., 2017;Moya-Perez et al., 2017a).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Chua et al., 2017

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Authors
Chua, M. C., Ben‐Amor, K., Lay, C., Goh, A. E. N., Chiang, W. C., Rao, R., Chew, C., Chaithongwongwatthana, S., Khemapech, N., Knol, J., & Chongsrisawat, V.
Affiliations
  • KK Women's and Children's Hospital (SG)
  • Danone Nutricia Research Utrecht The Netherlands
  • Danone Nutricia Research Singapore
  • Chulalongkorn University (TH)
  • Nutricia Research (Netherlands) (NL)
Corresponding author
  • Chua, Mei Chien
  • Goh, Anne E.N.
  • Chiang, Wen Chin
  • Rao, Rajeshwar
Venue
Journal of Pediatric Gastroenterology and Nutrition
Publisher
Wiley
Published
2017-07
Volume
65
Issue
1
Pages
102-106
ISSN
  • 0277-2116 (ISSN-L)
  • 1536-4801
OpenAlex
W2611643124
Cited by
117
References
20
Citations by year
2026: 12 · 2025: 11 · 2024: 20 · 2023: 12 · 2022: 11 · 2021: 20 · 2020: 13 · 2019: 7 · 2018: 10 · 2017: 1
FWCI
7.05
Type
journal article
Language
en
Open access
Locations
  • Journal of Pediatric Gastroenterology and Nutrition (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
Funders
American Friends of Laniado Hospital
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
synbiotics, gut microbiota, cesarean section, infants, Bifidobacterium breve M-16V, prebiotics, Bifidobacterium, Enterobacteriaceae, fecal pH, acetate, infant formula supplementation
MeSH terms
Gastrointestinal Microbiome, Bifidobacterium breve, Cesarean Section, Double-Blind Method, Female, Humans, Infant, Infant, Newborn, Male, Oligosaccharides, Pregnancy, Outcome Assessment, Health Care, Infant Formula, Synbiotics

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