Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double‐blind, Multicenter Study
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We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P < 0.0001) until week 8 (P = 0.041), a reduction of Enterobacteriaceae from day 3/5 (P = 0.002) till week 12 (P = 0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.
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Supplementation with probiotics and prebiotics can be used to decrease the impact of delivery mode on the microbiota.
“supplementation with probiotics and prebiotics can be used to decrease the impact of delivery mode on the microbiota (Chua et al., 2017;Moya-Perez et al., 2017a).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Chua et al., 2017
Cites
Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404 · see citing works
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life
Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315 · see citing works
Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
Dominguez-Bello, M. G., De Jesus-Laboy, K. M., Shen, N., Cox, L. M., Amir, A., Gonzalez, A., Bokulich, N. A., Song, S. J., Hoashi, M., Rivera-Vinas, J. I., et al. (2016) · Nature Medicine · doi:10.1038/nm.4039 · Cited by 1,014 · see citing works
Kuitunen, M., Kukkonen, A. K., Juntunen‐Backman, K., Korpela, R., Poussa, T. A., Tuure, T., Haahtela, T., & Savilahti, E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.11.019 · Cited by 408 · see citing works
A key genetic factor for fucosyllactose utilization affects infant gut microbiota development
Matsuki, T., Yahagi, K., Mori, H., Matsumoto, H., Hara, T., Tajima, S., Ogawa, E., Kodama, H., Yamamoto, K., Yamada, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms11939 · Cited by 376 · see citing works
Mode of Delivery – Effects on Gut Microbiota and Humoral Immunity
Huurre, A., Kalliomäki, M. A., Rautava, S., Rinne, M., Salminen, S., & Isolauri, E. (2007) · Neonatology · doi:10.1159/000111102 · Cited by 354 · see citing works
Dogra, S. K., Sakwińska, O., Soh, S., Ngom‐Bru, C., Brück, W. M., Berger, B. W., Brüssow, H., Lee, Y. S., Yap, F. K. P., Chong, Y. S., et al. (2015) · mBio · doi:10.1128/mbio.02419-14 · Cited by 348 · see citing works
Early life: gut microbiota and immune development in infancy
Martin, R., Nauta, A., Ben Amor, K., Knippels, L., Knol, J., & Garssen, J. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0027 · Cited by 338 · see citing works
Self-citationBeneficial effects of Bacteroides fragilis polysaccharides on the immune system
Erin, B. T. (2009) · Frontiers in bioscience · doi:10.2741/3603 · Cited by 322 · see citing works
Fukuda, S., Toh, H., Taylor, T. D., Ohno, H., & Hattori, M. (2012) · Gut Microbes · doi:10.4161/gmic.21214 · Cited by 248 · see citing works
Yuan, C., Gaskins, A. J., Blaine, A. I., Zhang, C., Gillman, M. W., Missmer, S. A., Field, A. E., & Chavarro, J. E. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.2385 · Cited by 200 · see citing works
Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis
van der Aa, L. B., van Aalderen, W. M. C., Heymans, H. S. A., Henk Sillevis Smitt, J., Nauta, A. J., Knippels, L. M. J., Ben Amor, K., Sprikkelman, A. B., & the Synbad Study Group (2011) · Allergy · doi:10.1111/j.1398-9995.2010.02416.x · Cited by 172 · see citing works
Effect of a new synbiotic mixture on atopic dermatitis in infants: a randomized‐controlled trial
van der Aa, L. B., Heymans, H. S. A., van Aalderen, W. M. C., Smitt, J. H. S., Knol, J., Amor, K. B., Goossens, D. A. M., Sprikkelman, A. B., & the Synbad Study Group (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03465.x · Cited by 160 · see citing works
Self-citationInfant B Cell Memory Differentiation and Early Gut Bacterial Colonization
Lundell, A., Björnsson, V., Ljung, A., Ceder, M., Johansen, S., Lindhagen, G., Törnhage, C., Adlerberth, I., Wold, A. E., & Rudin, A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103223 · Cited by 116 · see citing works
Comparative Analysis of Fecal Microbiota in Infants with and without Eczema
Hong, P., Lee, B. W., Aw, M., Shek, L. P., Yap, G. C., Chua, K. Y., & Liu, W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009964 · Cited by 112 · see citing works
Lee, S., Yu, J., Ahn, K.-M., Kim, K. W., Shin, Y. H., Lee, K., Hong, S. A., Jung, Y.-H., Lee, E. M., Yang, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096603 · Cited by 78 · see citing works
Colonization Resistance: Battle of the Bugs or Ménage à Trois with the Host?
Spees, A. M., Lopez, C. A., Kingsbury, D. D., Winter, S., & Bäumler, A. J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003730 · Cited by 77 · see citing works
Ismail, I. H., Boyle, R. J., Licciardi, P. V., Oppedisano, F., Lahtinen, S. J., Robins-Browne, R. M., & Tang, M. L. K. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12646 · Cited by 58 · see citing works
Wegienka, G., Havstad, S. L., Zoratti, E. M., Kim, H., Ownby, D. R., & Johnson, C. C. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12467 · Cited by 31 · see citing works
Is society being reshaped on a microbiological and epigenetic level by the way women give birth?
Dahlen, H. G., Downe, S. M., Kennedy, H. P., & Foureur, M. J. (2014) · Midwifery · doi:10.1016/j.midw.2014.07.007 · Cited by 19 · see citing works
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Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond
Wegh, C. A. M., Geerlings, S. Y., Knol, J., Roeselers, G., & Belzer, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194673 · Cited by 662 · see citing works
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Ho, N. T., Li, F., Lee‐Sarwar, K. A., Tun, H. M., Brown, B. P., Pannaraj, P. S., Bender, J. M., Azad, M. B., Thompson, A. L., Weiss, S. T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06473-x · Cited by 473 · see citing works
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Shen, Y., Fan, N., Ma, S., Cheng, X., Yang, X., & Wang, G. (2025) · MedComm · doi:10.1002/mco2.70168 · Cited by 364 · see citing works
Factors affecting early-life intestinal microbiota development
Vandenplas, Y., Carnielli, V. P., Ksiazyk, J., Luna, M. S., Migacheva, N., Mosselmans, J. M., Picaud, J. C., Possner, M., Singhal, A., & Wabitsch, M. (2020) · Nutrition · doi:10.1016/j.nut.2020.110812 · Cited by 247 · see citing works
Cukrowská, B., Bierła, J. B., Zakrzewska, M., Klukowski, M., & Maciorkowska, E. (2020) · Nutrients · doi:10.3390/nu12040946 · Cited by 178 · see citing works
Chng, K. R., Ghosh, T. S., Tan, Y. H., Nandi, T., Lee, I. R., Ng, A. H. Q., Li, C., Ravikrishnan, A., Lim, K. M., Lye, D. C., et al. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-1236-0 · Cited by 162 · see citing works
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Munblit, D., Peroni, D. G., Boix-Amorós, A., Hsu, P. S., Land, B. V., Gay, M. C. L., Kolotilina, A., Skevaki, C. L., Boyle, R. J., Collado, M. C., et al. (2017) · Nutrients · doi:10.3390/nu9080894 · Cited by 159 · see citing works
Gut dysbacteriosis and intestinal disease: mechanism and treatment
Meng, X., ZHANG, G., Cao, H., Yu, D., Fang, X., de Vos, W. M., & Wu, H. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14661 · Cited by 127 · see citing works
Infant Formula Supplemented with Biotics: Current Knowledge and Future Perspectives
Salminen, S., Stahl, B., Vinderola, G., & Szajewska, H. (2020) · Nutrients · doi:10.3390/nu12071952 · Cited by 113 · see citing works
Lordan, C., Roche, A. K., Delsing, D. J. M., Nauta, A., Groeneveld, A., MacSharry, J. A., Cotter, P. D., & van Sinderen, D. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00094-23 · Cited by 113 · see citing works
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Morais, L. H., Golubeva, A. V., Moloney, G. M., Moya-Pérez, A., Ventura-Silva, A. P., Arboleya, S., Bastiaanssen, T. F. S., O’Sullivan, O., Rea, K., Borre, Y., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.07.044 · Cited by 104 · see citing works
Self-citationMills, S., Lane, J. A., Smith, G. J., Grimaldi, K. A., Ross, R. P., & Stanton, C. (2019) · Nutrients · doi:10.3390/nu11071468 · Cited by 88 · see citing works
Inchingolo, F., Inchingolo, A. D., Palumbo, I., Trilli, I., Guglielmo, M., Mancini, A., Palermo, A., Inchingolo, A. M., & Dipalma, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021055 · Cited by 82 · see citing works
Kumar, H., Collado, M. C., Wopereis, H., Salminen, S., Knol, J., & Roeselers, G. (2020) · Microorganisms · doi:10.3390/microorganisms8121855 · Cited by 80 · see citing works
Self-citationInteraction between dietary fiber and bifidobacteria in promoting intestinal health
Wang, H., Huang, X., Tan, H., Chen, X., Chen, C., & Nie, S. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.133407 · Cited by 73 · see citing works
Martín‐Peláez, S., Ibáñez, N. C., Pinto-Gallardo, M., & Amezcua‐Prieto, C. (2022) · Nutrients · doi:10.3390/nu14020341 · Cited by 68 · see citing works
Pre-, pro-, syn-, and Postbiotics in Infant Formulas: What Are the Immune Benefits for Infants?
Lemoine, A., Tounian, P., Adel‐Patient, K., & Thomas, M. (2023) · Nutrients · doi:10.3390/nu15051231 · Cited by 68 · see citing works
Specific synbiotics in early life protect against diet‐induced obesity in adult mice
Mischke, M., Arora, T., Tims, S., Engels, E., Sommer, N., van Limpt, K., Baars, A., Oozeer, R., Oosting, A., Bäckhed, F., et al. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13240 · Cited by 59 · see citing works
Self-citationBilal, M., Ashraf, S., & Zhao, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931458 · Cited by 58 · see citing works
Impact of synbiotics on gut microbiota during early life: a randomized, double-blind study
Phavichitr, N., Wang, S., Chomtho, S., Tantibhaedhyangkul, R., Kakourou, A., Intarakhao, S., Jongpiputvanich, S., COLOR Study Group, Wongteerasut, A., Amor, K. B., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83009-2 · Cited by 59 · see citing works
Self-citationFrom Short- to Long-Term Effects of C-Section Delivery on Microbiome Establishment and Host Health
Ríos-Covián, D., Langella, P., & Martín, R. (2021) · Microorganisms · doi:10.3390/microorganisms9102122 · Cited by 56 · see citing works
C-section and the Neonatal Gut Microbiome Acquisition: Consequences for Future Health
Arboleya, S., Suárez, M., Fernández, N., Mantecón, L., Solís, G., Gueimonde, M., & Reyes‐Gavilán, C. G. D. L. (2018) · Annals of Nutrition and Metabolism · doi:10.1159/000490843 · Cited by 52 · see citing works
Implications of Gut Microbiota in Complex Human Diseases
Yu, D., Meng, X., de Vos, W. M., Wu, H., Fang, X., & Maiti, A. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312661 · Cited by 50 · see citing works
Nutraceuticals as modulators of gut microbiota: Role in therapy
Quigley, E. M. M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14902 · Cited by 47 · see citing works
Early life antibiotics and childhood gastrointestinal disorders: a systematic review
Kamphorst, K., Daele, E. V., Vlieger, A. M., Daams, J. G., Knol, J., & van Elburg, R. M. (2021) · BMJ Paediatrics Open · doi:10.1136/bmjpo-2021-001028 · Cited by 46 · see citing works
Self-citationSims, I. M., & Tannock, G. W. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.00214-20 · Cited by 43 · see citing works
Cukrowská, B. (2018) · Nutrients · doi:10.3390/nu10101541 · Cited by 42 · see citing works
Cerdó, T., García-Santos, J. A., Rodríguez-Pöhnlein, A., García-Ricobaraza, M., Nieto-Ruíz, A., García-Bermúdez, M., & Campoy, C. (2022) · Nutrients · doi:10.3390/nu14214691 · Cited by 39 · see citing works
Kosuwon, P., Lao‐Araya, M., Uthaisangsook, S., Lay, C., BINDELS, J. G., Knol, J., & Chatchatee, P. (2018) · Beneficial Microbes · doi:10.3920/bm2017.0110 · Cited by 38 · see citing works
Self-citationLay, C., Chu, C. W., Purbojati, R. W., Acerbi, E., Drautz‐Moses, D. I., de Sessions, P. F., Jie, S., Ho, E. X. P., Kok, Y. J., Bi, X., et al. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02230-1 · Cited by 36 · see citing works
Self-citationGut microbiota of homologous Chinese soft-shell turtles (Pelodiscus sinensis) in different habitats
Wu, B., Huang, L., Chen, J., Zhang, Y., Wang, J., & He, J. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02209-y · Cited by 32 · see citing works
Halemani, K., Shetty, A. P., Latha, T., Issac, A., Dhiraaj, S., Radha, K., Mishra, P., & Mathias, E. G. (2023) · Journal of Global Health · doi:10.7189/jogh.13.04038 · Cited by 31 · see citing works
Ke, A., Parreira, V. R., Goodridge, L. D., & Farber, J. M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.755083 · Cited by 31 · see citing works
Zhang, W., Zhang, Y. L., Zhao, Y., Liang, L., Zhang, Z., Hettinga, K. A., Yang, H., & Deng, J. (2024) · Nutrients · doi:10.3390/nu16234122 · Cited by 29 · see citing works
Human pharyngeal microbiota in age-related macular degeneration
Ho, E. X. P., Cheung, C. M. G., Sim, S., Chu, C. W., Wilm, A., Lin, C. B., Mathur, R., Wong, D., Chan, C. M., Bhagarva, M., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201768 · Cited by 29 · see citing works
Synbiotics Combined with Glutamine Stimulate Brain Development and the Immune System in Preterm Pigs
Andersen, A. D., Nguyen, D. N., Langhorn, L., Renes, I. B., van Elburg, R. M., Hartog, A., Tims, S., van de Looij, Y., Sangild, P. T., & Thymann, T. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy243 · Cited by 27 · see citing works
Vandenplas, Y., Meyer, R. W., Chouraqui, J.-P., Dupont, C. M., Fiocchi, A. G., Salvatore, S., Shamir, R., Szajewska, H., Thapar, N., Venter, C., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.10.025 · Cited by 24 · see citing works
Building Robust Assemblages of Bacteria in the Human Gut in Early Life
Tannock, G. W. (2021) · Applied and Environmental Microbiology · doi:10.1128/aem.01449-21 · Cited by 23 · see citing works
Tang, G., Carr, A. V., Perez, C., Sarmiento, K. R., Levy, L., Lampe, J. W., Diener, C., & Gibbons, S. M. (2025) · mSystems · doi:10.1128/msystems.00984-25 · Cited by 23 · see citing works
Targeting the gut-lung axis by synbiotic feeding to infants in a randomized controlled trial
Sjödin, K. S., Sjödin, A., Ruszczyński, M., Kristensen, M. B., Hernell, O., Szajewska, H., & West, C. E. (2023) · BMC Biology · doi:10.1186/s12915-023-01531-3 · Cited by 27 · see citing works
Longitudinal microbiome profiling reveals impermanence of probiotic bacteria in domestic pigeons
Grond, K., Perreau, J. M., Loo, W. T., Spring, A. J., Cavanaugh, C. M., & Hird, S. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217804 · Cited by 23 · see citing works
An overview of postbiotics: unveiling their distinct role in gut health
Ikram, A., Safdar, S. Z., Arshad, M. T., Rasheed, A., & Gnedeka, K. T. (2024) · Food and Agricultural Immunology · doi:10.1080/09540105.2024.2434463 · Cited by 20 · see citing works
Rodríguez-Sorrento, A., Castillejos, L., López-Colom, P., Cifuentes-Orjuela, G., Rodrı́guez-Palmero, M., Moreno-Muñoz, J. A., Luise, D., Trevisi, P., & Martín-Orúe, S. M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.642549 · Cited by 20 · see citing works
Kebbe, M., Leung, K., Perrett, B., Reimer, R. A., Adamo, K. B., & Redman, L. M. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuae184 · Cited by 16 · see citing works
Andreou, E. P., & Papaneophytou, C. P. (2025) · Nutrients · doi:10.3390/nu17101685 · Cited by 17 · see citing works
Heuven, L. A. J., Pyle, S., Greyling, A., Melse‐Boonstra, A., & Eilander, A. (2021) · Current Developments in Nutrition · doi:10.1093/cdn/nzab124 · Cited by 16 · see citing works
Cerdó, T., Nieto-Ruíz, A., García-Santos, J. A., Rodríguez-Pöhnlein, A., García-Ricobaraza, M., Suárez, A., García-Bermúdez, M., & Campoy, C. (2023) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061021-025355 · Cited by 15 · see citing works
Heston, S. M., Lim, C. S. E., Ong, C., Chua, M. C., Kelly, M. S., & Yeo, K. T. (2023) · Gut Pathogens · doi:10.1186/s13099-023-00583-8 · Cited by 15 · see citing works
Self-citationvan Oudenhoven, F. M., Willemsen‐Swinkels, S. H. N., Ibrahim, J. G., & Rizopoulos, D. (2020) · Statistics in Medicine · doi:10.1002/sim.8713 · Cited by 14 · see citing works
Fontaine, F., Turjeman, S., Haib, M., Collado, M. C., Callens, K., & Koren, O. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70385 · Cited by 18 · see citing works
Carpay, N. C., Kamphorst, K., de Meij, T. G. J., Daams, J. G., Vlieger, A. M., & van Elburg, R. M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277405 · Cited by 13 · see citing works
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Giordani, B., Parolin, C., Abruzzo, A., Foschi, C., Marangoni, A., Luppi, B., & Vitali, B. (2023) · Nutrients · doi:10.3390/nu15204433 · Cited by 12 · see citing works
Hoedt, E. C., Hueston, C. M., Cash, N., Bongers, R. S., Keane, J. M., van Limpt, K., Amor, K. B., Knol, J., MacSharry, J. A., & van Sinderen, D. (2023) · Microbiome · doi:10.1186/s40168-023-01595-x · Cited by 12 · see citing works
Self-citationWang, Y., Wopereis, H., Kakourou, A., Liu, M., Wu, J., Li, Z., Zhang, L., Tan, M., Low, J., Liu, M., et al. (2025) · European Journal of Clinical Nutrition · doi:10.1038/s41430-025-01571-8 · Cited by 12 · see citing works
Self-citationWang, Y., Li, Z., Wu, J., Zhang, L., Liu, M., Tan, M., Botma, A., Liu, M., Mulder, K., Berkeveld, M. A., et al. (2021) · Nutrition · doi:10.1016/j.nut.2021.111472 · Cited by 10 · see citing works
Wang, S., Xun, Y., Ahern, G. J., Feng, L., Zhang, D., Xue, Y., Ross, R. P., Doolan, A., Stanton, C., & Zhu, H. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2533 · Cited by 10 · see citing works
Qian, J., Fang, Z., Chang, S., Zeng, Z., & Zhang, J. (2024) · European Journal of Clinical Nutrition · doi:10.1038/s41430-024-01506-9 · Cited by 9 · see citing works
Dinleyici, E. Ç., Indrio, F., Szajewska, H., Hojsak, I., Salvatore, S., Mihatsch, W., Canani, R. B., Campoy, C., Domellöf, M., Francavilla, R., et al. (2025) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.70195 · Cited by 9 · see citing works
Imdad, A., Rehman, F., Davis, E. W., Ranjit, D., Surin, G. S., Attia, S. L., Lawler, S., Smith, A. A., & Bhutta, Z. A. (2021) · Campbell Systematic Reviews · doi:10.1002/cl2.1141 · Cited by 9 · see citing works
Chew, C. W. Y., Matsuyama, M., Davies, P. S. W., Hill, R. J., Morrison, M., Martı́n, R., Codoñer, F. M., Knol, J., & Roeselers, G. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2024.1193027 · Cited by 9 · see citing works
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Kamphorst, K., Carpay, N. C., de Meij, T. G. J., Daams, J. G., van Elburg, R. M., & Vlieger, A. M. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.974608 · Cited by 7 · see citing works
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Zhou, B., Wang, C., Putzel, G., Hu, J., Liu, M., Wu, F., Chen, Y., Pironti, A., & Li, H. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01431-24 · Cited by 6 · see citing works
Ma, G., Chen, Z., Li, Z. Y., & Xiao, X. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-024-07843-1 · Cited by 6 · see citing works
Gut microbiome recovery after antibiotic usage is mediated by specific bacterial speciesPreprint
Nandi, T., Lee, I. R., Ghosh, T. S., Ng, A. H. Q., Chng, K. R., Li, C., Tan, Y. H., Lye, D. C., Barkham, T., Chen, S. L., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/350470 · Cited by 6 · see citing works
Infant gut microbiota and functional foods: Opportunities for early health intervention
Shirazi, P. G., & Gholamipour‐Shirazi, A. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.10.032 · Cited by 5 · see citing works
Wang, J. P., Liu, N., Chen, Y., You, J., Yang, Y., Jin, Y. C., Sun, G., & Zhou, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1396087 · Cited by 5 · see citing works
Salvatore, S., Dinleyici, E. Ç., Szajewska, H., Canani, R. B., Gutiérrez‐Castrellón, P., Hojsak, I., Indrio, F., Mihatsch, W., Orel, R., van Goudoever, J. B., et al. (2025) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.70031 · Cited by 5 · see citing works
Urine Metabolomic Profile of Breast- versus Formula-Fed Neonates Using a Synbiotic-Enriched Formula
Falaina, V., Fotakis, C., Boutsikou, Τ., Tsiaka, T., Moros, G., Ouzounis, S., Andreou, V., Iliodromiti, Z., Xanthos, T. T., Vandenplas, Y., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810476 · Cited by 4 · see citing works
The Influence of Protein Secretomes of Enterococcus durans on ex vivo Human Gut Microbiome
Comerlato, C. B., Zhang, X., Walker, K., Mayne, J., Figeys, D., & Brandelli, A. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10136-9 · Cited by 4 · see citing works
Basrowi, R. W., Sundjaya, T., Sitorus, N. L., & Masita, B. M. (2020) · World Nutrition Journal · doi:10.25220/wnj.v04.s2.0008 · Cited by 4 · see citing works
Imdad, A., Ranjit, D., Surin, G. S., Lawler, S., Smith, A. A., & Bhutta, Z. A. (2019) · Campbell Systematic Reviews · doi:10.1002/cl2.1021 · Cited by 3 · see citing works
Silva, A. P. V., Moloney, G. M., Sequeira, A. M., Liber, M., Bastiaanssen, T. F. S., Rea, K., Fitzgerald, P., Golubeva, A. V., Rodriguez‐Aburto, M., Renes, I. B., et al. (2025) · Neurogastroenterology & Motility · doi:10.1111/nmo.70107 · Cited by 3 · see citing works
Self-citationWang, X., Xie, Q., Li, J., & Jiang, S. (2026) · Food & Function · doi:10.1039/d6fo00335d · Cited by 3 · see citing works
Fiber and the gut microbiome and its impact on inflammation
Duman, H., & Karav, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18979-1.00004-6 · Cited by 3 · see citing works
Mihatsch, W., Dinleyici, E. Ç., Canani, R. B., Hojsak, I., Mosca, A., Orel, R., Salvatore, S., Savino, F., Szajewska, H., van den Akker, C. H. P., et al. (2025) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.70064 · Cited by 3 · see citing works
Anafi, P., & Mprah, W. K. (2022) · Women · doi:10.3390/women2040035 · Cited by 2 · see citing works
Evolution of a Pathogenic Microbiome
Wong, P. Y., Yip, C., Lemberg, D. A., Day, A. S., & Leach, S. T. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12227184 · Cited by 2 · see citing works
Dewi, D. K., Adi, N. P., Prayogo, A., Sundjaya, T., Wasito, E., Kekalih, A., Basrowi, R. W., & Jo, J. (2024) · The Open Public Health Journal · doi:10.2174/0118749445290351240520104252 · Cited by 6 · see citing works
Horwell, E., Bearn, P. E., & Cutting, S. M. (2024) · Microbiome Research Reports · doi:10.20517/mrr.2024.32 · Cited by 3 · see citing works
Breast Milk: Possible Mechanisms to Shape the Behaviour and Cognitive Functions of a Child
Евгеньевич, У. С., Paramonova, N. S., & Malyovannaya, I. A. (2018) · Вопросы современной педиатрии · doi:10.15690/vsp.v17i5.1956 · Cited by 2 · see citing works
Ali, F., Lui, K., Wang, A. Y., Day, A. S., & Leach, S. T. (2020) · Journal of the Royal Society of New Zealand · doi:10.1080/03036758.2019.1706586 · Cited by 2 · see citing works
Fernando, D., Darus, F., Kinesya, E., Kartjito, M. S., Wasito, E., Dilantika, C., & Basrowi, R. W. (2024) · The Open Public Health Journal · doi:10.2174/0118749445342381241206052407 · Cited by 1 · see citing works
Chatchatee, P., Breedveld, A. C., Eussen, S. R. B. M., Nowak-Wegrzyn, A. H., Lange, L., Benjaponpitak, S., Chong, K. W., Sangsupawanich, P., Wopereis, H., Nijhuis, M. M. O., et al. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2025.1667162 · Cited by 1 · see citing works
Al‐Beltagi, M., Alzayani, S., Saeed, N. K., Bediwy, A. S., Kumar, A. P., Bediwy, H. A., & Elbeltagi, R. M. (2026) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v15.i1.111501 · Cited by 1 · see citing works
Aldekhail, W., Al‐Beltagi, M., Indrio, F., Alnemri, A. M., Tomerak, A., Sawai, A. A., AlRefaee, F., Al-Ghanem, G., Rozi, I. H., Alallah, J., et al. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1809889 · Cited by 1 · see citing works
Temneanu, O. R., Mihai, A., Olariu, R., Oroș, M., Ioniuc, I. K., Lupu, V. V., Ignat, A., Grudnicki, A., Roșu, M. F., Șerban, R., et al. (2026) · Nutrients · doi:10.3390/nu18152496 · Cited by 1 · see citing works
Future Prospects and Advancement in Synbiotics Containing Nutraceuticals
Loshali, A., Kukreti, G., & Sundriyal, A. (2024) · Springer eBooks · doi:10.1007/978-981-99-5575-6_35 · Cited by 1 · see citing works
Probiotics in Allergy Prevention
Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65459-6_4 · Cited by 1 · see citing works
Prebiotics, probiotics, synbiotics and their role in allergy prevention
El‐Lababidi, N. (2019) · Pediatrie pro praxi · doi:10.36290/ped.2019.049
Clinical data from postnatal interventions
Szajewska, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818097-6.00013-4
Krejsek, J. (2022) · Pediatrie pro praxi · doi:10.36290/ped.2022.007
Nikolinyová, J. (2022) · Pediatrie pro praxi · doi:10.36290/ped.2022.036
(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811351-6.00026-7
Biotics in neonatal period: what's the evidence?
Indrio, F., Marchese, F., Beghetti, I., Pettoello‐Mantovani, M., Grillo, A., & Aceti, A. (2022) · Minerva Pediatrics · doi:10.23736/s2724-5276.22.06968-3
Şahin, S., Büyüktiryaki, M., Okur, N., Akcan, A. B., Deveci, M. F., Yurttutan, S., Gunes, S., Anık, A., Оздемир, Р., Uygur, Ö., et al. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1270442
Fang, P., Lei, Q., Lv, M., Xu, L., Dong, K., Zhao, W., Yue, D., Cao, Z., & Lin, Q. (2023) · Letters in Applied Microbiology · doi:10.1093/lambio/ovad134
LiMei, D. A. I., Deng, Y., YunLong, M. E. N. G., Tan, B., Yin, Y., Ming, Q. I., & Jing, W. A. N. G. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0076
- Authors
- Chua, M. C., Ben‐Amor, K., Lay, C., Goh, A. E. N., Chiang, W. C., Rao, R., Chew, C., Chaithongwongwatthana, S., Khemapech, N., Knol, J., & Chongsrisawat, V.
- Affiliations
- KK Women's and Children's Hospital (SG)
- Danone Nutricia Research Utrecht The Netherlands
- Danone Nutricia Research Singapore
- Chulalongkorn University (TH)
- Nutricia Research (Netherlands) (NL)
- Corresponding author
- Chua, Mei Chien
- Goh, Anne E.N.
- Chiang, Wen Chin
- Rao, Rajeshwar
- ORCID
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2017-07
- Volume
- 65
- Issue
- 1
- Pages
- 102-106
- ISSN
- 0277-2116 (ISSN-L)
- 1536-4801
- OpenAlex
- W2611643124
- Cited by
- 117
- References
- 20
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 20 · 2023: 12 · 2022: 11 · 2021: 20 · 2020: 13 · 2019: 7 · 2018: 10 · 2017: 1
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Funders
- American Friends of Laniado Hospital
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- synbiotics, gut microbiota, cesarean section, infants, Bifidobacterium breve M-16V, prebiotics, Bifidobacterium, Enterobacteriaceae, fecal pH, acetate, infant formula supplementation
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium breve, Cesarean Section, Double-Blind Method, Female, Humans, Infant, Infant, Newborn, Male, Oligosaccharides, Pregnancy, Outcome Assessment, Health Care, Infant Formula, Synbiotics
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