The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation
Open accessAbstract
Osteoarthritis is one of the leading causes of pain and disability in the aged population due to articular cartilage damage. This warrants investigation of signaling mechanisms that could protect cartilage from degeneration and degradation. Here we show in a murine model of experimental osteoarthritis that YAP activation by transgenic overexpression or by deletion of its upstream inhibitory kinases Mst1/2 preserves articular cartilage integrity, whereas deletion of YAP in chondrocytes promotes cartilage disruption. Our work shows that YAP is both necessary and sufficient for the maintenance of cartilage homeostasis in osteoarthritis. Mechanistically, inflammatory cytokines, such as TNFα or IL-1β, trigger YAP/TAZ degradation through TAK1-mediated phosphorylation. Furthermore, YAP directly interacts with TAK1 and attenuates NF-κB signaling by inhibiting substrate accessibility of TAK1. Our study establishes a reciprocal antagonism between Hippo-YAP/TAZ and NF-κB signaling in regulating the induction of matrix-degrading enzyme expression and cartilage degradation during osteoarthritis pathogenesis.
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Cites
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
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Self-citationRole of proinflammatory cytokines in the pathophysiology of osteoarthritis
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TEAD mediates YAP-dependent gene induction and growth control
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Self-citationAuphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science · doi:10.1126/science.270.5234.286 · Cited by 2,390
Osteoarthritis cartilage histopathology: grading and staging
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Hippo pathway in organ size control, tissue homeostasis, and cancer
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Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
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Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
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Cited by
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
He, Y., Li, Z., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 380
YAP-mediated mechanotransduction tunes the macrophage inflammatory response
Meli, V. S., Atcha, H., Veerasubramanian, P. K., Nagalla, R. R., Luu, T. U., Chen, E. Y., Guerrero-Juarez, C. F., Yamaga, K., Pandori, W., Hsieh, J. Y., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb8471 · Cited by 329
Metadata
- Authors
- Deng, Y., Lu, J., Li, W., Wu, A., Zhang, X., Tong, W., Ho, K. K., Qin, L., Song, H., & Mak, K. K.
- Venue
- Nature Communications
- Published
- 2018-11-01
- Volume
- 9
- Issue
- 1
- Pages
- 4564-4564
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2898585678
- Cited by
- 328
- References
- 57
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- gold
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- Deng, Y., Lu, J., Li, W., Wu, A., Zhang, X., Tong, W., Ho, K. K., Qin, L., Song, H., & Mak, K. K. (2018). Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation. Nature Communications. https://doi.org/10.1038/s41467-018-07022-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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