The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
STING-dependent sensing of self-DNA drives silica-induced lung inflammation
Open accessAbstract
Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interferon genes (STING) is essential for silica-induced lung inflammation. In mice, silica induces lung cell death and self-dsDNA release in the bronchoalveolar space that activates STING pathway. Degradation of extracellular self-dsDNA by DNase I inhibits silica-induced STING activation and the downstream type I IFN response. Patients with silicosis have increased circulating dsDNA and CXCL10 in sputum, and patients with fibrotic interstitial lung disease display STING activation and CXCL10 in the lung. In vitro, while mitochondrial dsDNA is sensed by cGAS-STING in dendritic cells, in macrophages extracellular dsDNA activates STING independent of cGAS after silica exposure. These results reveal an essential function of STING-mediated self-dsDNA sensing after silica exposure, and identify DNase I as a potential therapy for silica-induced lung inflammation.
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Cited by
The cGAS–STING pathway as a therapeutic target in inflammatory diseases
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Mitochondrial control of inflammation
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Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy
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Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response
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Metadata
- Authors
- Benmerzoug, S., Rose, S., Bounab, B., Gosset, D., Duneau, L., Chenuet, P., Mollet, L., Le Bert, M., Lambers, C., Geleff, S., Roth, M., Fauconnier, L., Sedda, D., Carvalho, C., Perche, O., Laurenceau, D., Ryffel, B., Apetoh, L., Kiziltunc, A., Uslu, H., Albez, F. S., Akgun, M., Togbe, D., & Quesniaux, V. F. J.
- Venue
- Nature Communications
- Published
- 2018-12-06
- Volume
- 9
- Issue
- 1
- Pages
- 5226-5226
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2902485208
- Cited by
- 284
- References
- 71
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- gold
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- Benmerzoug, S., Rose, S., Bounab, B., Gosset, D., Duneau, L., Chenuet, P., Mollet, L., Le Bert, M., Lambers, C., Geleff, S., Roth, M., Fauconnier, L., Sedda, D., Carvalho, C., Perche, O., Laurenceau, D., Ryffel, B., Apetoh, L., Kiziltunc, A., . . . Quesniaux, V. F. J. (2018). STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nature Communications. https://doi.org/10.1038/s41467-018-07425-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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