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Cited by 1,027Inflammasome and immune disordersImmune Response and InflammationMitochondrial Function and Pathology

Mitochondrial control of inflammation

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Marchi, Saverio, Guilbaud, Emma, Tait, Stephen W. G., Yamazaki, Takahiro, Galluzzi, Lorenzo·2023·Nature Reviews Immunology
DOI 10.1038/s41577-022-00760-xPMC PMC9310369
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Abstract

Numerous mitochondrial constituents and metabolic products can function as damage-associated molecular patterns (DAMPs) and promote inflammation when released into the cytosol or extracellular milieu. Several safeguards are normally in place to prevent mitochondria from eliciting detrimental inflammatory reactions, including the autophagic disposal of permeabilized mitochondria. However, when the homeostatic capacity of such systems is exceeded or when such systems are defective, inflammatory reactions elicited by mitochondria can become pathogenic and contribute to the aetiology of human disorders linked to autoreactivity. In addition, inefficient inflammatory pathways induced by mitochondrial DAMPs can be pathogenic as they enable the establishment or progression of infectious and neoplastic disorders. Here we discuss the molecular mechanisms through which mitochondria control inflammatory responses, the cellular pathways that are in place to control mitochondria-driven inflammation and the pathological consequences of dysregulated inflammatory reactions elicited by mitochondrial DAMPs.

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Authors
Marchi, S., Guilbaud, E., Tait, S. W. G., Yamazaki, T., & Galluzzi, L.
Affiliations
  • Marche Polytechnic University (IT)
  • Weill Cornell Medicine (US)
  • Cancer Research UK Scotland Institute (GB)
Corresponding author
  • Yamazaki, Takahiro
  • Galluzzi, Lorenzo
ORCID
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2022-07-25
Volume
23
Issue
3
Pages
159-173
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
DOI
10.1038/s41577-022-00760-x
PMC
PMC9310369
OpenAlex
W4287447395
Cited by
1,027
References
218
Citations by year
2026: 250 · 2025: 322 · 2024: 264 · 2023: 171 · 2022: 19
FWCI
20.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
Funders
  • National Science Foundation
  • U.S. Department of Defense (#BC180476P1, #BC210945)
  • Cancer Research UK
  • Tenovus
  • Prostate Cancer UK
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • Ministero della Salute (GR‐2016‐02364602)
  • National Institutes of Health
  • Weill Cornell Medical College
  • Stand Up To Cancer (ZP-6177)
  • National Cancer Institute (CA274291, U54CA274291)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
mitochondrial dysfunction, inflammation, damage-associated molecular patterns, mitochondrial membrane permeabilization, mitophagy, autophagy, autoreactivity, autoimmunity, infectious diseases, cancer
MeSH terms
Alarmins, Humans, Inflammation, Mitochondria, Neoplasms

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