The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
Open accessAbstract
Endogenous retroviruses (ERVs) can confer benefits to their host but present a threat to genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler SMARCAD1 as a key factor in the control of ERVs in embryonic stem cells. SMARCAD1 is enriched at ERV subfamilies class I and II, particularly at active intracisternal A-type particles (IAPs), where it preserves repressive histone methylation marks. Depletion of SMARCAD1 results in de-repression of IAPs and adjacent genes. Recruitment of SMARCAD1 to ERVs is dependent on KAP1, a central component of the silencing machinery. SMARCAD1 and KAP1 occupancy at ERVs is co-dependent and requires the ATPase function of SMARCAD1. Our findings uncover a role for the enzymatic activity of SMARCAD1 in cooperating with KAP1 to silence ERVs. This reveals ATP-dependent chromatin remodeling as an integral step in retrotransposon regulation in stem cells and advances our understanding of the mechanisms driving heterochromatin establishment.
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Cited by
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Metadata
- Authors
- Sachs, P., Ding, D., Bergmaier, P., Lamp, B., Schlagheck, C., Finkernagel, F., Nist, A., Stiewe, T., & Mermoud, J. E.
- Venue
- Nature Communications
- Published
- 2019-03-22
- Volume
- 10
- Issue
- 1
- Pages
- 1335-1335
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2924530200
- Cited by
- 2,384
- References
- 69
- FWCI
- 101.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sachs, P., Ding, D., Bergmaier, P., Lamp, B., Schlagheck, C., Finkernagel, F., Nist, A., Stiewe, T., & Mermoud, J. E. (2019). SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells. Nature Communications. https://doi.org/10.1038/s41467-019-09078-0
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