The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy
Open accessAbstract
Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In situ mitochondrial ROS amplification is a promising strategy to enhance cancer therapy. Here we report cancer cell and mitochondria dual-targeting polyprodrug nanoreactors (DT-PNs) covalently tethered with a high content of repeating camptothecin (CPT) units, which release initial free CPT in the presence of endogenous mitochondrial ROS (mtROS). The in situ released CPT acts as a cellular respiration inhibitor, inducing mtROS upregulation, thus achieving subsequent self-circulation of CPT release and mtROS burst. This mtROS amplification endows long-term high oxidative stress to induce cancer cell apoptosis. This current strategy of endogenously activated mtROS amplification for enhanced chemodynamic therapy overcomes the short lifespan and action range of ROS, avoids the penetration limitation of exogenous light in photodynamic therapy, and is promising for theranostics.
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Cites
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Cited by
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Zheng, Z., Liu, H., Zhai, S., Zhang, H., Shan, G., Kwok, R. T. K., Ma, C., Sung, H. H. Y., Williams, I. D., Lam, J. W. Y., et al. (2020) · Chemical Science · doi:10.1039/c9sc06441a · Cited by 172
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Nanoscale Mixed-Ligand Metal–Organic Framework for X-ray Stimulated Cancer Therapy
Zhen, W., Xu, Z., Mao, Y., McCleary, C., Jiang, X., Weichselbaum, R. R., & Lin, W. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c12140 · Cited by 37
Metadata
- Authors
- Zhang, W., Hu, X., Shen, Q., & Xing, D.
- Venue
- Nature Communications
- Published
- 2019-04-12
- Volume
- 10
- Issue
- 1
- Pages
- 1704-1704
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2938196301
- Cited by
- 438
- References
- 6
- FWCI
- 20.65
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhang, W., Hu, X., Shen, Q., & Xing, D. (2019). Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy. Nature Communications. https://doi.org/10.1038/s41467-019-09566-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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