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Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge
Abstract
Cuproptosis shows good application prospects in tumor therapy. However, the copper efflux mechanism and highly expressed intracellular reducing substances can inhibit the cuproptosis effects. In this study, a platelet vesicle (PV) coated cuprous oxide nanoparticle (Cu 2 O)/TBP-2 cuproptosis sensitization system (PTC) was constructed for multiple induction of tumor cuproptosis. PTC was prepared by physical extrusion of AIE photosensitizer (TBP-2), Cu 2 O, and PV. After the biomimetic modification, PTC can enhance its long-term blood circulation and tumor targeting ability. Subsequently, PTC was rapidly degraded to release copper ions under acid conditions and hydrogen peroxides in tumor cells. Then, under light irradiation, TBP-2 quickly enters the cell membrane and generates hydroxyl radicals to consume glutathione and inhibit copper efflux. Accumulated copper can cause lipoylated protein aggregation and iron–sulfur protein loss, which result in proteotoxic stress and ultimately cuproptosis. PTC treatment can target and induce cuproptosis in tumor cells in vitro and in vivo, significantly inhibit lung metastasis of breast cancer, increase the number of central memory T cells in peripheral blood, and prevent tumor rechallenge. It provides an idea for the design of nanomedicine based on cuproptosis.
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PDT produces ROS that induce tumor cell death by stimulating photosensitizers with specific wavelengths of therapeutic light.
“PDT can produce ROS that induce tumor cell death by stimulating photosensitizers with specific wavelengths of therapeutic light [101–103].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [103]
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Cites
Copper induces cell death by targeting lipoylated TCA cycle proteins
Tsvetkov, P., Coy, S., Petrova, B., Dreishpoon, M., Verma, A., Abdusamad, M., Rossen, J., Joesch-Cohen, L., Humeidi, R., Spangler, R. D., et al. (2022) · Science · doi:10.1126/science.abf0529 · Cited by 4,932
Cell Membrane Coating Nanotechnology
Fang, R. H., Kroll, A. V., Gao, W., & Zhang, L. (2018) · Advanced Materials · doi:10.1002/adma.201706759 · Cited by 1,885
Recent Advances of Optical Imaging in the Second Near‐Infrared Window
Kenry, K., Duan, Y., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201802394 · Cited by 819
Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
Yong, T., Zhang, X., Bie, N., Zhang, H., Zhang, X., Li, F., Hakeem, A., Hu, J., Gan, L., Santos, H. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11718-4 · Cited by 806
Chang, M., Wang, M., Wang, M., Shu, M., Ding, B., Li, C., Pang, M., Cui, S., Hou, Z., & Lin, J. (2019) · Advanced Materials · doi:10.1002/adma.201905271 · Cited by 485
Zhang, W., Hu, X., Shen, Q., & Xing, D. (2019) · Nature Communications · doi:10.1038/s41467-019-09566-3 · Cited by 446
Wang, D., Su, H., Kwok, R. T. K., Hu, X., Zou, H., Luo, Q., Lee, M. M. S., Xu, W., Lam, J. W. Y., & Tang, B. Z. (2018) · Chemical Science · doi:10.1039/c7sc04963c · Cited by 443
Self-citationO'Day, S. J., Eggermont, A. M. M., Chiarion‐Sileni, V., Kefford, R. F., Grob, J., Mortier, L., Robert, C., Schachter, J., Testori, A., Mackiewicz, J., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.44.5585 · Cited by 385
Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine
Zhu, C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2018) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00600 · Cited by 348
Self-citationGathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284
Xu, W., Qian, J., Hou, G., Wang, T., Wang, J., Wang, Y., Yang, L., Cui, X., & Suo, A. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202205013 · Cited by 271
Guo, M., Wu, F., Hu, G., Chen, L., Xu, J., Xu, P., Wang, X., Li, Y., Liu, S., Zhang, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat5690 · Cited by 234
Self-citationLuo, T., Ni, K., Culbert, A. A., Lan, G., Li, Z., Jiang, X., Kaufmann, M., & Lin, W. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c02129 · Cited by 211
Su, J., Sun, H., Meng, Q., Zhang, P., Yin, Q., & Li, Y. (2017) · Theranostics · doi:10.7150/thno.17259 · Cited by 210
Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy
Huang, J., Xiao, Z., An, Y., Han, S., Wu, W., Wang, Y., Guo, Y., & Shuai, X. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120636 · Cited by 210
Chen, D., Yu, Q. B., Huang, X., Dai, H., Luo, T., Shao, J., Chen, P., Chen, J., Huang, W., & Dong, X. (2020) · Small · doi:10.1002/smll.202001059 · Cited by 193
Type I AIE photosensitizers: Mechanism and application
Li, J., Zhuang, Z., Zhao, Z., & Tang, B. Z. (2021) · Open Research (University of Surrey) · doi:10.1002/viw.20200121 · Cited by 192
Self-citationKilling G(+) or G(−) Bacteria? The Important Role of Molecular Charge in AIE‐Active Photosensitizers
Shi, X., Sung, S. H. P., Chau, J. H. C., Li, Y., Liu, Z., Kwok, R. T. K., Liu, J., Xiao, P., Zhang, J., Liu, B., et al. (2020) · Small Methods · doi:10.1002/smtd.202000046 · Cited by 168
Self-citationTargeted pH-responsive polyion complex micelle for controlled intracellular drug delivery
Zheng, P., Liu, Y., Chen, J., Xu, W., Li, G., & Ding, J. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.12.001 · Cited by 166
Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer metastasis inhibition
Ye, H., Wang, K., Wang, M., Liu, R., Song, H., Li, N., Lu, Q., Zhang, W., Du, Y., Yang, W., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.03.024 · Cited by 166
Zhu, D., Duo, Y., Suo, M., Zhao, Y., Xia, L., Zheng, Z., Yang, L., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202003672 · Cited by 164
Self-citationZhang, K., Yu, Z., Meng, X., Zhao, W., Shi, Z., Yang, Z., Dong, H., & Zhang, X. (2019) · Advanced Science · doi:10.1002/advs.201900530 · Cited by 151
Wu, H., Chen, F., You, C., Zhang, Y., Sun, B., & Zhu, Q. X. (2020) · Small · doi:10.1002/smll.202001805 · Cited by 150
Liu, J., He, S., Luo, Y., Zhang, Y., Du, X., Xu, C., Pu, K., & Wang, J. (2021) · Advanced Materials · doi:10.1002/adma.202106654 · Cited by 148
Endoplasmic reticulum targeted AIE bioprobe as a highly efficient inducer of immunogenic cell death
Li, J., Gao, H., Liu, R., Chen, C., Zeng, S., Liu, Q., & Ding, D. (2020) · Science China Chemistry · doi:10.1007/s11426-020-9846-4 · Cited by 142
Nyasae, L. K., Bustos, R., Braiterman, L., Eipper, B. A., & Hubbard, A. L. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00472.2006 · Cited by 141
Enzyme-Driven Membrane-Targeted Chimeric Peptide for Enhanced Tumor Photodynamic Immunotherapy
Zhang, C., Gao, F., Wu, W., Qiu, W., Zhang, L., Li, R., Zhuang, Z., Yu, W., Cheng, H. L., & Zhang, X. (2019) · ACS Nano · doi:10.1021/acsnano.9b04315 · Cited by 136
Liu, Y., Zhai, S., Jiang, X., Liu, Y., Wang, K., Wang, C., Zhang, M., Liu, X., & Bu, W. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202010390 · Cited by 134
Zhu, D., Zhang, T., Yang, L., Huang, C., Suo, M., Xia, L., Xu, Y., Li, G., & Tang, B. Z. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121462 · Cited by 130
Self-citationErythrocyte membrane-coated gold nanocages for targeted photothermal and chemical cancer therapy
Zhu, D., Xie, W., Xiao, Y.-S., Suo, M., Zan, M., Liao, Q., Hu, X., Chen, L., Chen, B., Wu, W., et al. (2017) · Nanotechnology · doi:10.1088/1361-6528/aa9ca1 · Cited by 128
Self-citationBiomimetic copper single-atom nanozyme system for self-enhanced nanocatalytic tumor therapy
Zhu, D., Ling, R., Chen, H., Lyu, M., Qian, H., Wu, K., Li, G., & Wang, X. (2022) · Nano Research · doi:10.1007/s12274-022-4359-6 · Cited by 126
Self-citationChen, D., Wang, Z., Dai, H., Lv, X., Ma, Q., Yang, D., Shao, J., Xu, Z., & Dong, X. (2020) · Small Methods · doi:10.1002/smtd.202000013 · Cited by 121
Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells
Hu, Y., & Wang, Y. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s31133 · Cited by 120
Stellate Plasmonic Exosomes for Penetrative Targeting Tumor NIR-II Thermo-Radiotherapy
Zhu, D., Lyu, M., Huang, Q., Suo, M., Liu, Y., Jiang, W., Duo, Y., & Fan, K. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c09969 · Cited by 117
Self-citationChen, Y., Zhao, G., Wang, S., He, Y., Han, S., Du, C., Li, S., Fan, Z.-L., Wang, C., & Wang, J. (2019) · Biomaterials Science · doi:10.1039/c9bm00599d · Cited by 116
Bu, Y., Xu, T., Zhu, X., Zhang, J., Wang, L., Yu, Z., Yu, J., Wang, A., Tian, Y., Zhou, H., et al. (2020) · Chemical Science · doi:10.1039/d0sc03093g · Cited by 110
Zhu, D., Zhang, J., Luo, G., Duo, Y., & Tang, B. Z. (2021) · Advanced Science · doi:10.1002/advs.202004769 · Cited by 109
Self-citationRecent progress in tumor photodynamic immunotherapy
Shen, L., Zhou, T., Fan, Y., Chang, X. Y., Wang, Y., Sun, J., Xing, L., & Jiang, H. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.02.007 · Cited by 107
Xu, L., Gao, F., Fan, F., & Yang, L. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.12.028 · Cited by 107
Zhu, D., Liu, Z., Li, Y., Huang, Q., Xia, L., & Li, K. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120894 · Cited by 105
Self-citationJia, S., Gao, Z., Wu, Z., Gao, H., Wang, H., Ou, H., & Ding, D. (2021) · CCS Chemistry · doi:10.31635/ccschem.021.202101458 · Cited by 98
Wang, D., Yao, Y., He, J., Zhong, X., Li, B., Rao, S., Yu, H., He, S., Feng, X., Xu, T., et al. (2019) · Advanced Science · doi:10.1002/advs.201901293 · Cited by 96
Biosynthesis of fluopsin C, a copper-containing antibiotic from Pseudomonas aeruginosa
Patteson, J. B., Putz, A. T., Tao, L., Simke, W. C., Bryant, L. H., Britt, R. D., & Ли, Б. (2021) · Science · doi:10.1126/science.abj6749 · Cited by 95
Zhu, D., Zheng, Z., Luo, G., Suo, M., Li, X., Duo, Y., & Tang, B. Z. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101091 · Cited by 91
Self-citationNing, S., Zhang, T., Lyu, M., Lam, J. W. Y., Zhu, D., Huang, Q., & Tang, B. Z. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122034 · Cited by 79
Self-citationBerridge, M. V., Dong, L., & Neužil, J. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0859 · Cited by 70
Cao, R., Sun, W. C., Zhang, Z., Li, X., Du, J., Fan, J., & Peng, X. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.06.031 · Cited by 70
Hollow Cuprous Oxide@Nitrogen‐Doped Carbon Nanocapsules for Cascade Chemodynamic Therapy
Meng, X., Zhou, K., Qian, Y., Liu, H., Wang, X., Lin, Y., Shi, X., Tian, Y., Lu, Y., Chen, Q., et al. (2022) · Small · doi:10.1002/smll.202107422 · Cited by 65
Mot, A. I., Liddell, J. R., White, A. R., & Crouch, P. J. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.08.029 · Cited by 55
Advances in Prostate‐Specific Membrane Antigen (PSMA)‐Targeted Phototheranostics of Prostate Cancer
Wang, H., He, Z., Liu, X., Huang, Y., Hou, J., Zhang, W., & Ding, D. (2022) · Small Structures · doi:10.1002/sstr.202200036 · Cited by 55
Jin, R., Liu, Z., Liu, T., Yuan, P., Bai, Y., & Chen, X. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.03.084 · Cited by 54
A platelet-mimicking theranostic platform for cancer interstitial brachytherapy
Lyu, M., Chen, M., Liu, L., Zhu, D., Wu, X., Li, Y., Rao, L., & Bao, Z. (2021) · Theranostics · doi:10.7150/thno.61259 · Cited by 49
Self-citationAmorphous NiB@IrOx nanozymes trigger efficient apoptosis-ferroptosis hybrid therapy
Wang, Q., Shaik, F., Lu, X., Zhang, W., Wu, Y., Qian, H., & Zhang, W. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.10.048 · Cited by 49
Oxygen‐Independent Sulfate Radical for Stimuli‐Responsive Tumor Nanotherapy
Ding, D., Mei, Z., Huang, H., Feng, W., Chen, L., Chen, Y., & Zhou, J. (2022) · Advanced Science · doi:10.1002/advs.202200974 · Cited by 48
SDHB Suppresses the Tumorigenesis and Development of ccRCC by Inhibiting Glycolysis
Fang, Z., Sun, Q., Yang, H., & Zheng, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.639408 · Cited by 45
Ke, Y., Zhu, J., Chu, Y., Cen, L., Fu, Y. S., Fan, X., Shao, J., Li, R., Yu, L., Liu, B., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202201306 · Cited by 45
Erythrocyte-derived drug delivery systems in cancer therapy
Mao, Y., Zou, C., Jiang, Y., & Fu, D. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.08.048 · Cited by 40
FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression
Zhang, J., Kong, X., Zhang, Y., Sun, W., Wang, J., Chen, M., & Chen, X. (2020) · The Journal of Pathology · doi:10.1002/path.5451 · Cited by 36
Qian, W., Gao, Z., Zhao, K., Zhang, P., Zhong, Q., Yu, Q., Zhai, S., & Cui, J. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.11.040 · Cited by 34
Radiotherapy assisted with biomaterials to trigger antitumor immunity
Yu, X., Ma, H., Xu, G., & Liu, Z. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.02.049 · Cited by 31
Kano, A., Iwasaki, T., & Shindo, M. (2019) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2019.100683 · Cited by 29
Chen, N., Fu, W., Zhou, J., Mei, L., Yang, J., Tian, Y., Wang, Q., & Yin, W. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.02.030 · Cited by 29
Duo, Y., Liu, Q., Zhu, D., Zhang, B., Luo, G., Wang, F., Jinghua, C., & Cao, Y. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.132328 · Cited by 25
Self-citationSearching for a wrench to throw into the splicing machine
Jurica, M. S. (2007) · Nature Chemical Biology · doi:10.1038/nchembio0108-3 · Cited by 18
Zhang, H., Yan, X., Zhang, Y., Bao, C., & Li, C. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00309k · Cited by 17
Sun, H., Su, J., Meng, Q., Yin, Q., Chen, L., Gu, W., Zhang, Z., Yu, H., Zhang, P., Wang, S., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910230 · Cited by 16
Chen, T., Zeng, W., Liu, Y., Yu, M., Huang, C., Shi, Z., Lin, C., Tang, J., Mei, L., & Wu, M. (2022) · Small · doi:10.1002/smll.202270152 · Cited by 1
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Xiong, X., Zheng, L., Ding, Y., Chen, Y., Cai, Y., Wang, L., Huang, L., Liu, C., Shao, Z., & Yu, K. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02108-4 · Cited by 1,170
Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance
Wang, Y., Chen, Y., Zhang, J., Yang, Y., Fleishman, J. S., Wang, Y., Wang, J., Chen, J., Li, Y., & Wang, H. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.101018 · Cited by 275
Sabit, H., Pawlik, T. M., Radwan, F. F. Y., Abdel-Hakeem, M. A., Abdel-Ghany, S. E., Wadan, A.-H. S., El-Zawahri, M. M., El-Hashash, A. H. K., & Arneth, B. M. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02357-z · Cited by 250
Lü, S., Li, Y., & Yu, Y. (2024) · Advanced Materials · doi:10.1002/adma.202404971 · Cited by 244
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Guo, Z., Chen, D., Yao, L., Sun, Y., Li, D., Le, J., Dian, Y., Zeng, F., Chen, X., & Deng, G. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02192-0 · Cited by 209
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Li, M., Xiong, J., Zhang, Y., Yu, L., Yue, L., Yoon, C., Kim, Y., Zhou, Y., Chen, X., Xu, Y., et al. (2025) · Chemical Society Reviews · doi:10.1039/d1cs01079d · Cited by 209
Cuproptosis: Harnessing Transition Metal for Cancer Therapy
Wang, W., Mo, W., Hang, Z.-S., Huang, Y., Yi, H., Sun, Z., & Lei, A. (2023) · ACS Nano · doi:10.1021/acsnano.3c07775 · Cited by 201
Copper homeostasis and cuproptosis in cancer immunity and therapy
Liu, W., Lin, W., Li, Y., Xu, W., & Yang, J. H. (2023) · Immunological Reviews · doi:10.1111/imr.13276 · Cited by 186
A cuproptosis nanocapsule for cancer radiotherapy
Liao, Y., Wang, D., Gu, C., Wang, X., Zhu, S., Zheng, Z., Zhang, F., Yan, J., & Gu, Z. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01784-1 · Cited by 172
Lu, J., Song, L., Feng, S., Wang, K., Mao, Y., Mao, Y., Zhao, Q., & Wang, S. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.148270 · Cited by 138
Crosstalk between ferroptosis and cuproptosis: From mechanism to potential clinical application
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Huang, Y., Liu, X., Zhu, J., Chen, Z., Lu, Y., Huang, X., Dong, C., Li, J., Zhou, H., Yang, Y. P., et al. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c14247 · Cited by 130
Innovative utilization of cell membrane‐coated nanoparticles in precision cancer therapy
He, Y., Zhang, S., She, Y., Liu, Z., Zhu, Y., Cheng, Q., & Ji, X. (2024) · Exploration · doi:10.1002/exp.20230164 · Cited by 126
Zhu, Y., Niu, X., Ding, C., Lin, Y., Fang, W., Yan, L., Cheng, J., Zou, J., Tian, Y., Huang, W., et al. (2024) · Advanced Science · doi:10.1002/advs.202402516 · Cited by 126
Wang, S., Liu, X., Wei, D., Zhou, H., Zhu, J., Yu, Q. L., Luo, L., Dai, X., Jiang, Y., Yu, L., et al. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c06338 · Cited by 124
Chen, K., Zhou, A., Zhou, X., He, J., Xu, Y., & Ning, X. (2024) · Science Advances · doi:10.1126/sciadv.adk3201 · Cited by 123
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Huang, L., Zhu, J., Wu, G., Xiong, W., Feng, J., Yan, C., Yang, J., Li, Z., Fan, Q., Ren, B., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122701 · Cited by 113
Copper homeostasis and cuproptosis in health and disease
Yang, Y., Wu, J., Wang, L., Ji, G., & Dang, Y. (2024) · MedComm · doi:10.1002/mco2.724 · Cited by 103
Li, Z., Tang, B. Z., & Wang, D. (2024) · Advanced Materials · doi:10.1002/adma.202406047 · Cited by 102
Self-citationCuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond
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Springer, C., Humayun, D., & Skouta, R. (2024) · Cancers · doi:10.3390/cancers16030647 · Cited by 96
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Du, C., Guo, X., Qiu, X., Jiang, W., Wang, X., An, H., Wang, J., Luo, Y., Du, Q., Wang, R., et al. (2024) · Advanced Science · doi:10.1002/advs.202306031 · Cited by 80
Zhang, N., Ping, W., Rao, K., Zhang, Z., Huang, R., Zhu, D., Li, G., & Ning, S. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.045 · Cited by 75
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He, G., Pan, Y., Zeng, F., Qin, S., Luan, X., Lu, Q., Xie, C., Hu, P., Gao, Y., Yang, J., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c12796 · Cited by 73
Guo, S., Tang, H., Zhang, Y., Wang, Z., & Tan, S. C. (2024) · BMEMat · doi:10.1002/bmm2.12076 · Cited by 73
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Li, K., Wu, L., Wang, H., Fu, Z., Gao, J., Liu, X., Fan, Y., Qin, X., Ni, D., Wang, J., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02828-3 · Cited by 70
Xu, Q., Zhang, M., Huang, Q., Gao, S., Chu, S., Li, Q., Chen, W., Zhang, X., Zhang, T., Tang, B. Z., et al. (2025) · Advanced Materials · doi:10.1002/adma.202502898 · Cited by 69
Self-citationZhu, G., Wang, M., Qiao, L., Xie, Y., Wang, J., Li, L., Sun, Q., Zheng, P., & Li, C. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202400496 · Cited by 62
Yan, L., Chang, L., Tian, Y., Hu, J., Cao, Z., Guo, X., & Geng, B. (2024) · Advanced Science · doi:10.1002/advs.202410606 · Cited by 61
Yan, C., Liu, Y., Zhao, G., Yang, H., Lv, H., Li, G., Li, Y., Fu, Y., Sun, F., Feng, Y., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.01.017 · Cited by 60
Cun, J., He, Z., Xi, F., Pan, Q., Luo, K., He, B., & Pu, Y. (2025) · Small · doi:10.1002/smll.202409875 · Cited by 60
Chiral CuxOS@Fe‐MOFs for Enhanced Cancer Therapy
Hao, C., Huang, L., Zhang, H., Xu, L., Sun, M., Kuang, H., Wang, Q., & Xu, C. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202312795 · Cited by 59
Zhu, Y., Xu, L., Kang, Y., Cheng, Q., He, Y., & Ji, X. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122478 · Cited by 59
Li, Y., Wang, Y., Li, Z., Stenzel, M. H., & Jiang, Y. (2024) · Materials Horizons · doi:10.1039/d4mh00470a · Cited by 59
Liu, Y., Niu, R., Zhang, X., Zhang, B., Chen, X., Guo, J., Song, S., Wang, Y., Zhang, H., & Zhao, Y. (2024) · ACS Nano · doi:10.1021/acsnano.4c01518 · Cited by 58
Tian, X., Xu, H. X., Zhou, F., Gong, X., Tan, S., & He, Y. (2024) · Chemistry of Materials · doi:10.1021/acs.chemmater.3c02323 · Cited by 56
Copper-Based biomaterials for anti-tumor therapy: Recent advances and perspectives
Zhang, S., & Peng, S. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.01.014 · Cited by 56
Hu, H., Hua, S., Lu, F., Zhang, W., Zhang, Z., Cui, J., Lei, X., Xia, J., Xu, F., & Zhou, M. (2025) · Advanced Science · doi:10.1002/advs.202408580 · Cited by 56
Chen, H., Luo, X. Q., Huang, Q., Liu, Z., Lyu, M., Chen, D., Mo, J., & Zhu, D. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.146276 · Cited by 54
Self-citationBai, J., Zhang, X., Zhao, Z., Sun, S., Cheng, W., Yu, H., Chang, X., & Wang, B. (2024) · Small · doi:10.1002/smll.202400326 · Cited by 54
You, P., Suo, M., Huang, Q., Lyu, M., Jiang, Y. H., Wang, S., Tang, W., Ning, S., & Zhang, T. (2023) · Aggregate · doi:10.1002/agt2.432 · Cited by 53
Self-citationActivated aggregation‐induced emission therapeutics agents for triggering regulated cell death
Zhao, Y., Yu, L., Zhang, L., Liu, H., Zhou, Y. M., & Kim, J. S. (2024) · Aggregate · doi:10.1002/agt2.503 · Cited by 52
Zu, H., Wu, Y., Meng, H., Cheng, X., Wang, Y., Zhang, L. W., & Wang, Y. (2024) · ACS Nano · doi:10.1021/acsnano.3c10588 · Cited by 51
Wang, W., Wang, J., Hu, Z., Yan, X., Gao, Q., Li, X., Zheng, J., Li, B., Wu, Y., & Liao, Y. (2024) · Aggregate · doi:10.1002/agt2.715 · Cited by 50
The physiological role of copper: Dietary sources, metabolic regulation, and safety concerns
Fu, Y., Hou, L., Han, K., Zhao, C., Hu, H., & Yin, S. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.03.023 · Cited by 50
Feng, J. Y., He, D., Chen, J., Li, M., Luo, J., Han, Y., Wei, X., Ren, S., Wang, Z., Wu, Y., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102343 · Cited by 49
Nanomedicine-mediated regulated cell death in cancer immunotherapy
Sun, Y. L., Lian, T., Huang, Q., Chang, Y., Li, Y., Guo, X., Kong, W., Yang, Y., Zhang, K., Wang, P., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.10.032 · Cited by 47
Self-citationXiao, W., Qu, K., Zhang, W., Lai, L., He, L., Cheng, F., & Wang, L. (2024) · Small Science · doi:10.1002/smsc.202300164 · Cited by 47
Wang, Y., Yan, T., Cai, J., Dou, H., Zhu, Y., Geng, B., Pan, D., & Shen, L. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123319 · Cited by 47
Zhang, W. Y., Chen, Z., Chen, X., Yuan, L., Hu, J., Dai, J. Y., Xia, F., & Lou, X. (2024) · ACS Nano · doi:10.1021/acsnano.4c12123 · Cited by 46
Nanomedicine strategies for cuproptosis: Metabolic reprogramming and tumor immunotherapy
Zhang, R., Li, Y., Fu, H., Zhao, C., Li, X., Wang, Y., Sun, Y., & Li, Y. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.007 · Cited by 46
Yang, H., Chen, X., Huang, S., Dai, H., Xiao, Z., Fan, J., Zhang, H., Du, K., & Qin, Y. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117488 · Cited by 45
Nanosensitizer-assisted sonodynamic therapy for breast cancer
Yu, J., Hu, J.-R., Tian, Y., Lei, Y.-M., Hu, H.-M., Lei, B.-S., Zhang, G., Sun, Y., & Ye, H.-R. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03311-3 · Cited by 43
Ning, S., Zhang, X., Suo, M., Lyu, M., You, P., Jiang, Y. H., Yang, H., Lam, J. W. Y., Zhang, T., Pan, L., et al. (2023) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2023.101505 · Cited by 42
Self-citationLi, B., Tian, J., Xie, X., Zhang, F., Wu, C., Shan, Y., Qi, G., Song, W., Yuan, P., & Liu, B. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202309524 · Cited by 42
Suo, M., Shen, H., Lyu, M., Jiang, Y. H., Liao, X., Tang, W., You, P., Zhang, T., Ning, S., & Tang, B. Z. (2024) · Small · doi:10.1002/smll.202400666 · Cited by 42
Self-citationCuproptosis: Advances in Stimulus‐Responsive Nanomaterials for Cancer Therapy
Lu, J., Miao, Y., & Li, Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400652 · Cited by 42
Copper-Based Nanomedicines for Cuproptosis-Mediated Effective Cancer Treatment
Noh, D., Lee, H., Lee, S., Sun, I., & Yoon, H. Y. (2024) · Biomaterials Research · doi:10.34133/bmr.0094 · Cited by 41
Niu, M., Li, Q., Huang, Q., Qin, Y., Meng, D., Liang, J., & Zhang, X. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202413255 · Cited by 40
Self-citationLiu, Y., Zhao, H. Q., Niu, R., Zhang, B., Lim, B. T. G., Song, S., Wang, Y., Zhang, H., & Zhao, Y. (2024) · Chem · doi:10.1016/j.chempr.2024.08.020 · Cited by 38
AIEgen-functionalized nanoprobes and nanomedicines for cancer diagnosis and therapy
Wang, C., Li, S., Qian, B., Sun, J., He, Z., Wang, Y., Zhang, S., & Luo, C. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216148 · Cited by 37
Regulated cell death mechanisms in mitochondria-targeted phototherapy
Ding, Q., Rha, H., Yoon, C., Kim, Y., Hong, S. J., Kim, H. J., Li, Y., Lee, M. H., & Kim, J. S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113720 · Cited by 37
Wang, Y., Li, S., Zhang, X., Jiang, F., Guo, Q., Jiang, P., & Liu, Y. (2024) · Small · doi:10.1002/smll.202400254 · Cited by 36
Chong, W., Ren, H., Chen, H., Xu, K., Zhu, X., Liu, Y., Sang, Y., Han, L., Liu, J., Ye, C., et al. (2024) · iMeta · doi:10.1002/imt2.190 · Cited by 35
Immunogenic cell death-based cancer vaccines: promising prospect in cancer therapy
Wang, J., Ma, J., Xie, F., Miao, F., lv, L., Huang, Y., Zhang, X., Yu, J., Tai, Z., Zhu, Q., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1389173 · Cited by 35
CRISPR-Cas9 gene editing strengthens cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy
Wu, X., Bai, Z., Wang, H., Wang, H., Hou, D., Xu, Y., Wo, G., Cheng, H., Sun, D., & Tao, W. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.029 · Cited by 35
Advancements in Cell Membrane-Derived Biomimetic Nanotherapeutics for Breast Cancer
Zeng, M., Hu, C., Chen, T., Zhao, T., & Dai, X. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s502144 · Cited by 35
Pei, Z., Li, L., Yang, N., Sun, S., Jiang, N., & Cheng, L. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215969 · Cited by 34
Hu, J., Yan, L., Cao, Z. M., Geng, B., Cao, X. P., Liu, B., Guo, J., & Zhu, J. (2024) · Advanced Science · doi:10.1002/advs.202407196 · Cited by 34
Cuproptosis: A Copper‐Mediated Programmed Cell Death
Meena, R., Sahoo, S. S., Sunil, A., & Manna, D. (2024) · Chemistry - An Asian Journal · doi:10.1002/asia.202400934 · Cited by 32
Metalloptosis: metal ions-induced programmed cell death based on nanomaterials for cancer therapy
Wang, S., Ma, R., Mei, Z., & Hou, Y. (2024) · MedMat. · doi:10.1097/mm9.0000000000000004 · Cited by 30
Chen, M., Xu, C., Wang, C., Huang, N., Bian, Z., Xiao, Y., Ruan, J., Sun, F., & Shi, S. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401567 · Cited by 30
Chen, L., Yan, S., Guo, W.-J., Qiao, L., Zhan, X., Liu, B., & Peng, H. (2024) · Chemical Science · doi:10.1039/d4sc05345a · Cited by 30
Emerging Nanozyme Strategies for Precision Breast Cancer Treatment
Zang, J., Ren, Z., Wang, H., Yang, X., Yang, S. T., Liao, J., & Li, X. (2025) · Advanced Science · doi:10.1002/advs.202514085 · Cited by 30
Boaru, D. L., León-Oliva, D. D., Castro-Martinez, P. D., Montero, C. G., Fraile‐Μartinez, O., García-González, B., Pérez-González, I., Alhaddadin, M. N. M., Barrena-Blázquez, S., López-González, L., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118422 · Cited by 29
Cuproptosis Nanomedicine: Clinical challenges and opportunities for anti-tumor therapy
Liu, Y., Chen, G., You, X., & Wang, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.153373 · Cited by 28
Nanomaterial‐Triggered Ferroptosis and Cuproptosis in Cancer Therapy
Sahoo, S. S., & Manna, D. (2025) · Small · doi:10.1002/smll.202412462 · Cited by 28
Liu, Z., Ling, J., Wang, N., & Ouyang, X. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.08.234 · Cited by 26
SRF/SLC31A1 signaling promotes cuproptosis induced by celastrol in NSCLC
Xue, R., Qin, C., Li, L., Huang, L., Tang, K., Chen, J., Liang, H., Xu, H., Qin, X., Yang, C., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114165 · Cited by 26
Liang, X., Fang, S., Xin, Y., Lei, J., Wang, W., Wei, Y., Li, W., Li, C., Tang, H., Wei, X., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03722-2 · Cited by 26
Zhang, M., Xu, H. X., Wu, X., Chen, B., Gong, X., & He, Y. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c22546 · Cited by 25
Cuproptosis and its potential role in musculoskeletal disease
Xiang, Z., Mei, H., Wang, H., Yao, X., Rao, J., Zhang, W., Xu, A., & Lü, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1570131 · Cited by 25
Dai, Y., Leng, D., Guo, Z., Wang, J., Gu, Y., Peng, Y., Zhu, L., & Zhao, Q. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.147704 · Cited by 25
Zhang, N., Ping, W., Suo, M., Zhang, Z., Zhang, W., Zhang, T., Ning, S., & Tang, B. Z. (2024) · Advanced Science · doi:10.1002/advs.202405575 · Cited by 25
Self-citationWang, S., Liu, Y., Su, M., Wang, Y., Wang, W., Wang, W., Yang, Q., Zhang, Z., Hong, X., Sun, Z., et al. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202411609 · Cited by 25
Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy
Yang, Y., Dong, C., Ma, X., Wang, Y., Li, Z.-K., Xu, Y., Chen, T., Gao, C., Ye, X., Wu, A., et al. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb02746a · Cited by 24
Hao, D., Luo, W., Yan, Y., & Zhou, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117182 · Cited by 24
Luo, X., Zhou, Y., Rao, K., Xiang, J., Ning, S., Zhu, D., Li, G., & Chen, H. (2025) · Small · doi:10.1002/smll.202411576 · Cited by 23
Self-citationSuo, M., Yang, D., Yang, M., Wang, J., Zhang, D., Zhu, D., Xu, Q., & Song, Y. (2025) · Advanced Science · doi:10.1002/advs.202518037 · Cited by 23
Self-citationLi, A., Huang, K., Pan, W., Wu, Y., Liang, Y., Zhang, Z., Wu, D., Ma, L., & Gou, Y. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00257 · Cited by 23
Biomolecule-based engineered nanoparticles for Cancer Theranostics
Parthasarathy, N., Thangam, R., Rithisa, B., Sudhakar, S., Shanthi, K., Hong, H., Sathuvan, M., Fabiola, M., Kang, H., & Vivek, R. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216489 · Cited by 23
Metadata
- Authors
- Ning, S., Lyu, M., Zhu, D., Lam, J. W. Y., Huang, Q., Zhang, T., & Tang, B. Z.
- Affiliations
- Guangxi Medical University (CN)
- Jinan University (CN)
- Nanfang Hospital (CN)
- Hong Kong University of Science and Technology (HK)
- Zhengzhou University (CN)
- Corresponding author
- Huang, Qinqin
- Zhang, Tianfu
- Tang, Ben Zhong
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2023-05-15
- Volume
- 17
- Issue
- 11
- Pages
- 10206-10217
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W4376612072
- Cited by
- 293
- References
- 68
- Citations by year
- 2026: 64 · 2025: 104 · 2024: 107 · 2023: 18
- FWCI
- 23.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- Guangxi Clinical Research Center for Anesthesiology (AD22035214)
- Distinguished Talent Cultivation Program of Science and Technology Innovative (2020BJRCA02)
- Cultivation of High-level Internationalized Talents Project (22180007)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- cuproptosis, breast cancer metastasis, tumor rechallenge, cuprous oxide nanoparticles, biomimetic nanoparticles, glutathione depletion, hydroxyl radicals, proteotoxic stress, lung metastasis, central memory T cells, photodynamic therapy, nanomedicine
- MeSH terms
- Melanoma, Cutaneous Malignant, Cutaneous Malignant Melanoma, Copper, Humans, Skin Neoplasms, Apoptosis, Photosensitizing Agents, Biomimetics
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