Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Vrahnas, Christina; Blank, Martha; Dite, Toby A.; Tatarczuch, Liliana; Ansari, Niloufar; Crimeen-Irwin, Blessing; Nguyen, Huynh; Forwood, Mark R.; Hu, Yifang; Ikegame, Mika; Bambery, Keith R.; Petibois, Cyril; Mackie, Eleanor J.; Tobin, Mark J.; Smyth, Gordon K.; Oakhill, Jonathan S.; Martin, T. John; Sims, Natalie A.

doi:10.1038/s41467-019-11373-9

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly (secondary mineralization) until bone is remodeled. The interconnected osteocyte network within the bone matrix differentiates from bone-formi…