Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis

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The Effects of Parathyroid Hormone and Alendronate Alone or in Combination in Postmenopausal Osteoporosis

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PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

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Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate

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Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

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Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

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Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit

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Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

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Osteoclast-derived activity in the coupling of bone formation to resorption

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Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

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Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

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MicroRNA control of bone formation and homeostasis

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Coupling of bone resorption and formation by RANKL reverse signalling

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v-ATPase V0 subunit d2–deficient mice exhibit impaired osteoclast fusion and increased bone formation

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Suppression of bone formation by osteoclastic expression of semaphorin 4D

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The skeleton: a multi-functional complex organ. The growth plate chondrocyte and endochondral ossification

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Mechanical Signaling for Bone Modeling and Remodeling

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The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation

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Cancellous Bone Remodeling Occurs in Specialized Compartments Lined by Cells Expressing Osteoblastic Markers

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The coupling of bone formation to bone resorption: A critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis

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BMP‐2, BMP‐4, and PDGF‐bb stimulate chemotactic migration of primary human mesenchymal progenitor cells

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Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL

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Targeting skeletal endothelium to ameliorate bone loss

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Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2

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Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

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Suggested Sequential Mode of Control of Changes in Cell Behaviour in Adult Bone Remodelling

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Localization of RANKL (receptor activator of NFκB ligand) mRNA and protein in skeletal and extraskeletal tissues

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Sphingosine 1‐phosphate as a regulator of osteoclast differentiation and osteoclast–osteoblast coupling

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Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

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Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

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Quantifying the osteocyte network in the human skeleton

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Autocrine and paracrine roles of sphingosine-1-phosphate

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Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation

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Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation

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Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts

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Sema4D induces angiogenesis through Met recruitment by Plexin B1

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Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

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Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation

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miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway

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Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein‐6

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Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice

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Monocyte Exosomes Stimulate the Osteogenic Gene Expression of Mesenchymal Stem Cells

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Osteoclast-Derived Complement Component 3a Stimulates Osteoblast Differentiation

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EphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts

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Role of IGF-I Signaling in Regulating Osteoclastogenesis

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Characterization of Regulatory Extracellular Vesicles from Osteoclasts

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T Lymphocytes Amplify the Anabolic Activity of Parathyroid Hormone through Wnt10b Signaling

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Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

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Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

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Transforming Growth Factor-β Stimulates Bone Matrix Apposition and Bone Cell Replication in Cultured Fetal Rat Calvariae*

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Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: implications for diagnosis and treatment

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Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts.

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Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

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Osteoclast-secreted SLIT3 coordinates bone resorption and formation

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Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

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The anabolic effect of human PTH (1–34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate—is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system?

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The Bone Remodeling Compartment: A Circulatory Function for Bone Lining Cells

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The reversal phase of the bone-remodeling cycle: cellular prerequisites for coupling resorption and formation

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Identification of cell cycle–arrested quiescent osteoclast precursors in vivo

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Acidification of the Osteoclastic Resorption Compartment Provides Insight into the Coupling of Bone Formation to Bone Resorption

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Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

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Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs

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Bone density, strength, and formation in adult cathepsin K (−/−) mice

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The effect of systemically administered PDGF-BB on the rodent skeleton

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Characterization of circulating osteoblast lineage cells in humans

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Osteoclast-derived activity in the coupling of bone formation to resorption

Martin, T. J., & Sims, N. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.004 · Cited by 659 · see citing works

Molecular Mechanisms in Coupling of Bone Formation to Resorption

Martin, T. J., Gooi, J. H., & Sims, N. A. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i1.40 · Cited by 167 · see citing works

Coupling of bone formation and resorption

Sims, N. A., & Martin, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00010-5 · Cited by 9 · see citing works

Beyond resorption-driven coupling: a multi-layered framework for osteoclast–osteoblast communication and its therapeutic consequences

Qiu, H., Liu, S., Jiang, Y., Lai, Y., Lin, Q., & Huang, A. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1821292 · Cited by 2 · see citing works