The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering
Open accessAbstract
Injectable hydrogels can fill irregular defects and promote in situ tissue regrowth and regeneration. The ability of directing stem cell differentiation in a three-dimensional microenvironment for bone regeneration remains a challenge. In this study, we successfully nanoengineer an interconnected microporous networked photocrosslinkable chitosan in situ-forming hydrogel by introducing two-dimensional nanoclay particles with intercalation chemistry. The presence of the nanosilicates increases the Young’s modulus and stalls the degradation rate of the resulting hydrogels. We demonstrate that the reinforced hydrogels promote the proliferation as well as the attachment and induced the differentiation of encapsulated mesenchymal stem cells in vitro. Furthermore, we explore the effects of nanoengineered hydrogels in vivo with the critical-sized mouse calvarial defect model. Our results confirm that chitosan-montmorillonite hydrogels are able to recruit native cells and promote calvarial healing without delivery of additional therapeutic agents or stem cells, indicating their tissue engineering potential.
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Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Morice, M.-C., Serruys, P. W., Sousa, J. E., Fajadet, J., Ban Hayashi, E., Perin, M., Colombo, A., Schuler, G., Barragan, P., Guagliumi, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012843 · Cited by 4,033
Designing materials for biology and medicine
Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198
Tissue Engineering--Current Challenges and Expanding Opportunities
Griffith, L. G., & Naughton, G. (2002) · Science · doi:10.1126/science.1069210 · Cited by 2,343
Nanotechnological strategies for engineering complex tissues
Dvir, T., Timko, B. P., Kohane, D. S., & Langer, R. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.246 · Cited by 1,367
Mechanical properties of hydrogels and their experimental determination
Anseth, K. S., Bowman, C. N., & Brannon-Peppas, L. (1996) · Biomaterials · doi:10.1016/0142-9612(96)87644-7 · Cited by 1,156
Synthesis of nylon 6–clay hybrid by montmorillonite intercalated with ϵ‐caprolactam
Kojima, Y., Usuki, A., Kawasumi, M., Okada, A., Kurauchi, T., & Kamigaito, O. (1993) · Journal of Polymer Science Part A: Polymer Chemistry · doi:10.1002/pola.1993.080310418 · Cited by 893
Biofabrication strategies for 3D in vitro models and regenerative medicine
Moroni, L., Burdick, J. A., Highley, C., Lee, S. J., Morimoto, Y., Takeuchi, S., & Yoo, J. J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0006-y · Cited by 753
Langer, R. (2001) · Science · doi:10.1126/science.1063273 · Cited by 579
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Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications
Feng, P., Luo, Y., Ke, C., Qiu, H., Wang, W., Zhu, Y., Hou, R., Xu, L., & Wu, S. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.650598 · Cited by 491
Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management
Jacob, S., Nair, A. B., Shah, J., Sreeharsha, N., Gupta, S., & Shinu, P. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030357 · Cited by 485
Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering
Xue, X., Hu, Y., Wang, S., Chen, X., Jiang, Y., & Su, J. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.10.029 · Cited by 423
Biodegradable materials for bone defect repair
Wei, S., Ma, J.-X., Xu, L., Gu, X.-S., & Ma, X.-L. (2020) · Military Medical Research · doi:10.1186/s40779-020-00280-6 · Cited by 406
Metadata
- Authors
- Cui, Z.-K., Kim, S., Baljon, J. J., Wu, B. M., Aghaloo, T., & Lee, M.
- Venue
- Nature Communications
- Published
- 2019-08-06
- Volume
- 10
- Issue
- 1
- Pages
- 3523-3523
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2966113523
- Cited by
- 432
- References
- 37
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cui, Z.-K., Kim, S., Baljon, J. J., Wu, B. M., Aghaloo, T., & Lee, M. (2019). Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering. Nature Communications. https://doi.org/10.1038/s41467-019-11511-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
