The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering
Open accessAbstract
Bone tissue engineering has emerged as a significant research area that provides promising novel tools for the preparation of biomimetic hydrogels applied in bone-related diseases (e.g., bone defects, cartilage damage, osteoarthritis, etc.). Herein, thermal sensitive polymers (e.g., PNIPAAm, Soluplus, etc.) were introduced into main chains to fabricate biomimetic hydrogels with injectability and compatibility for those bone defect need minimally invasive surgery. Mineral ions (e.g., calcium, copper, zinc, and magnesium), as an indispensable role in maintaining the balance of the organism, were linked with polymer chains to form functional hydrogels for accelerating bone regeneration. In the chemically triggered hydrogel section, advanced hydrogels crosslinked by different molecular agents (e.g., genipin, dopamine, caffeic acid, and tannic acid) possess many advantages, including extensive selectivity, rapid gel-forming capacity and tunable mechanical property. Additionally, photo crosslinking hydrogel with rapid response and mild condition can be triggered by different photoinitiators (e.g., I2959, LAP, eosin Y, riboflavin, etc.) under specific wavelength of light. Moreover, enzyme triggered hydrogels were also utilized in the tissue regeneration due to its rapid gel-forming capacity and excellent biocompatibility. Particularly, some key factors that can determine the therapy effect for bone tissue engineering were also mentioned. Finally, brief summaries and remaining issues on how to properly design clinical-oriented hydrogels were provided in this review.
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1 retracted
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Cited by
Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01852-x · Cited by 667
Articular cartilage repair biomaterials: strategies and applications
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Self-citationGuo, J., Wang, F., Hu, Y., Luo, Y., Wei, Y., Xu, K., Zhang, H., Liu, H., Bo, L., Lv, S., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100881 · Cited by 126
Self-citationSingle‐cell RNA sequencing in osteoarthritis
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Self-citationPolydopamine-Modified functional materials promote bone regeneration
Wang, J., Cui, Y., Zhang, B., Sun, S., Xu, H., Yao, M., Wu, D., & Wang, Y. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112655 · Cited by 56
Metadata
- Authors
- Xue, X., Hu, Y., Wang, S., Chen, X., Jiang, Y., & Su, J.
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 12
- Pages
- 327-339
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- OpenAlex
- W3209627144
- Cited by
- 423
- References
- 90
- FWCI
- 20.58
- Type
- journal article
- Language
- en
- Open access
- gold
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