Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes
Open accessAbstract
Lymph node (LN) metastases correspond with a worse prognosis in nearly all cancers, yet the occurrence of cancer spreading from LNs remains controversial. Additionally, the mechanisms explaining how cancers survive and exit LNs are largely unknown. Here, we show that breast cancer patients frequently have LN metastases that closely resemble distant metastases. In addition, using a microsurgical model, we show how LN metastasis development and dissemination is regulated by the expression of a chromatin modifier, histone deacetylase 11 (HDAC11). Genetic and pharmacologic blockade of HDAC11 decreases LN tumor growth, yet substantially increases migration and distant metastasis formation. Collectively, we reveal a mechanism explaining how HDAC11 plasticity promotes breast cancer growth as well as dissemination from LNs and suggest caution with the use of HDAC inhibitors.
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HDAC11 is important for tumorigenesis and growth in lymph nodes.
“HDAC11 is important for tumorigenesis and growth in lymph nodes, but its downregulation in the lymph nodes leads to increased migration and colonization of distal sites, resulting in distal metastasis.”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Leslie et al., 2019
HDACs exhibit ambivalent behavior in cancer.
“This study is another example of the ambivalent behavior of HDACs in cancer and another indication of adverse effects of their selective targeting in a therapeutic perspective.”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Leslie et al., 2019
The effect of HDAC11 on cell proliferation depends on the repression of cell cycle inhibitors E2F7 and E2F8.
“The effect of HDAC11 on cell proliferation depends on the repression of cell cycle inhibitors E2F7 and E2F8 (Leslie et al., 2019).”
From HDACs and the epigenetic plasticity of cancer cells: target the complexity (2022) · cites this paper as Leslie et al., 2019
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- Authors
- Leslie, P. L., Chao, Y. L., Tsai, Y.-H., Ghosh, S. K., Porrello, A., Van Swearingen, A. E. D., Harrison, E. B., Cooley, B. C., Parker, J. S., Carey, L. A., & Pecot, C. V.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Pecot, Chad V.
- Venue
- Nature Communications
- Published
- 2019-09-13
- Volume
- 10
- Issue
- 1
- Pages
- 4192-4192
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6744422
- OpenAlex
- W2972598242
- Cited by
- 80
- References
- 50
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 13 · 2023: 9 · 2022: 19 · 2021: 12 · 2020: 12
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Funders
- American Cancer Society (MRSG-14-222-01-RMC)
- North Carolina Biotechnology Center (2012-IDG-1006)
- Lung Cancer Research Foundation
- George Washington University
- Free To Breathe
- National Institutes of Health (2012-IDG-1006, CA016086, CA58223)
- National Cancer Institute (T32CA196589, CA-58223, CA016086, 2012-IDG-1006, R01CA215075, P50 CA 58223, P50CA058223, P30CA016086)
- National Institute of Environmental Health Sciences (P30ES010126)
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill (CA016086)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- HDAC11, breast cancer, lymph node metastasis, distant metastasis, chromatin modification, tumor cell migration, histone deacetylase inhibitors, metastasis
- MeSH terms
- Animals, Breast Neoplasms, Cell Movement, Flow Cytometry, Histone Deacetylases, Humans, Lymph Nodes, Lymphatic Metastasis, Mice, Inbred BALB C, Mice, Inbred C57BL, Blotting, Western, DNA Methylation, Cell Line, Tumor, Chromatin Immunoprecipitation, Mice, HEK293 Cells, Real-Time Polymerase Chain Reaction
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