T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model

Molecular and cellular insights into T cell exhaustion

Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652 · see citing works

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589 · see citing works

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · see citing works

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · see citing works

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., & Campbell, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1731 · Cited by 1,258 · see citing works

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,257 · see citing works

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

Yang, X., & Seto, E. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2346 · Cited by 1,239 · see citing works

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

Szabo, S. J., Sullivan, B. M., Stemmann, C., Satoskar, A. R., Sleckman, B. P., & Glimcher, L. H. (2002) · Science · doi:10.1126/science.1065543 · Cited by 1,172 · see citing works

Control of Effector CD8 ⁺ T Cell Function by the Transcription Factor <i>Eomesodermin</i>

Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., et al. (2003) · Science · doi:10.1126/science.1090148 · Cited by 1,014 · see citing works

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

Gao, L., Cueto, M. A., Asselbergs, F., & Atadja, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111871200 · Cited by 744 · see citing works

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

Schietinger, A., & Greenberg, P. D. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.001 · Cited by 677 · see citing works

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance

Villagra, A., Cheng, F., Wang, H.-W., Suarez, I., Glozak, M., Maurin, M., Nguyen, D., Wright, K. L., Atadja, P. W., Bhalla, K., et al. (2009) · Nature Immunology · doi:10.1038/ni.1673 · Cited by 455 · see citing works

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

Banerjee, A., Gordon, S. M., Intlekofer, A. M., Paley, M., Mooney, E. C., Lindsten, T., Wherry, E. J., & Reiner, S. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002042 · Cited by 429 · see citing works

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells

Intlekofer, A. M., Takemoto, N., Kao, C., Banerjee, A., Schambach, F., Northrop, J. K., Shen, H., Wherry, E. J., & Reiner, S. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070841 · Cited by 288 · see citing works

Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

Reddy, P. R., Maeda, Y., Hotary, K. B., Liu, C., Reznikov, L. L., Dinarello, C. A., & Ferrara, J. L. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400380101 · Cited by 266 · see citing works

Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3 + T-Regulatory Cells

de Zoeten, E. F., Wang, L., Butler, K. V., Beier, U. H., Akimova, T., Sai, H., Bradner, J. E., Mazitschek, R., Kozikowski, A. P., Matthias, P., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05155-11 · Cited by 257 · see citing works

Inhibition of HDAC9 Increases T Regulatory Cell Function and Prevents Colitis in Mice

de Zoeten, E. F., Wang, L., Sai, H., DILLMANN, W. H., & Hancock, W. W. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.10.037 · Cited by 236 · see citing works

Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

Agarwal, P., Raghavan, A., Nandiwada, S. L., Curtsinger, J., Bohjanen, P. R., Mueller, D. L., & Mescher, M. F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900592 · Cited by 203 · see citing works

Characterization of T-Bet and Eomes in Peripheral Human Immune Cells

Knox, J. J., Cosma, G. L., Betts, M. R., & McLane, L. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00217 · Cited by 189 · see citing works

Histone Acetylation Facilitates Rapid and Robust Memory CD8 T Cell Response through Differential Expression of Effector Molecules (Eomesodermin and Its Targets: Perforin and Granzyme B)

Araki, Y., Fann, M., Wersto, R. P., & Weng, N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8102 · Cited by 188 · see citing works

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice

Yu, Y., Wang, D., Liu, C., Kaosaard, K., Semple, K. M., Anasetti, C., & Yu, X. (2011) · Blood · doi:10.1182/blood-2011-03-340315 · Cited by 156 · see citing works

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells

Cheng, F., Lienlaf, M., Perez-Villarroel, P., Wang, H.-W., Lee, C., Woan, K., Woods, D., Knox, T., Bergman, J., Pinilla-Ibarz, J., et al. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.02.019 · Cited by 140 · see citing works

Differential Localization of T-bet and Eomes in CD8 T Cell Memory Populations

McLane, L. M., Banerjee, P. P., Cosma, G. L., Makedonas, G., Wherry, E. J., Orange, J. S., & Betts, M. R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201556 · Cited by 137 · see citing works

Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function

Sahakian, E., Powers, J. J., Chen, J., Deng, S., Cheng, F., Graeter, A. I., Woods, D. M., Rock-Klotz, J. A., Sodré, A. L., Youn, J., et al. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.08.002 · Cited by 120 · see citing works

Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans

Choi, S. W., Gatza, E., Hou, G., Sun, Y., Whitfield, J. R., Song, Y., Oravecz-Wilson, K. I., Tawara, I., Dinarello, C. A., & Reddy, P. R. (2014) · Blood · doi:10.1182/blood-2014-10-605238 · Cited by 106 · see citing works

The antimelanoma activity of the histone deacetylase inhibitor panobinostat (LBH589) is mediated by direct tumor cytotoxicity and increased tumor immunogenicity

Woods, D. M., Woan, K. V., Cheng, F., Wang, H., Perez-Villarroel, P., Lee, C., Lienlaf, M., Atadja, P. W., Seto, E., Weber, J. S., et al. (2013) · Melanoma Research · doi:10.1097/cmr.0b013e328364c0ed · Cited by 101 · see citing works

Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1

Leng, C., Gries, M., Ziegler, J. A., Lokshin, A. E., Mascagni, P., Lentzsch, S., & Mapara, M. Y. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.02.014 · Cited by 96 · see citing works

Developmental expression of histone deacetylase 11 in the murine brain

Liu, H., Hu, Q., Kaufman, A. R., D’Ercole, A. J., & Ye, P. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21521 · Cited by 88 · see citing works

Epigenetic regulation of established human type 1 versus type 2 cytokine responses

Su, R., Becker, A. B., Kozyrskyj, A. L., & HayGlass, K. T. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.004 · Cited by 85 · see citing works

Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in CD4/CD8 Double-Positive Thymocytes

Kasler, H. G., Young, B. D., Mottet, D., Lim, H. W., Collins, A., Olson, E. N., & Verdin, E. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001179 · Cited by 85 · see citing works

Discrete Roles for Histone Acetylation in Human T Helper 1 Cell-specific Gene Expression

Morinobu, A., Kanno, Y., & O’Shea, J. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407576200 · Cited by 77 · see citing works

HDAC5 controls the functions of Foxp3+ T‐regulatory and CD8+ T cells

Xiao, H., Jiao, J., Wang, L., O’Brien, S., Newick, K., Wang, L. S., Falkensammer, E., Liu, Y., Han, R., Kapoor, V., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29979 · Cited by 76 · see citing works

Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies

Imai, Y., Maru, Y., & Tanaka, J. (2016) · Cancer Science · doi:10.1111/cas.13062 · Cited by 63 · see citing works

Molecular Determinants of Regulatory T Cell Development: The Essential Roles of Epigenetic Changes

Kitagawa, Y., Ohkura, N., & Sakaguchi, S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00106 · Cited by 61 · see citing works

T-bet Is Critical for the Development of Acute Graft-versus-Host Disease through Controlling T Cell Differentiation and Function

Fu, J., Wang, D., Yu, Y., Heinrichs, J. L., Wu, Y., Schutt, S. D., Kaosaard, K., Liu, C., Haarberg, K. M. K., Bastian, D. A., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401618 · Cited by 44 · see citing works

Trichostatin Differentially Regulates Th1 and Th2 Responses and Alleviates Rheumatoid Arthritis in Mice

Zhou, X., Hua, X., Ding, X., Bian, Y., & Wang, X. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9508-8 · Cited by 33 · see citing works

LBH589 Enhances T Cell Activation In Vivo and Accelerates Graft-versus-Host Disease in Mice

Wang, D., Iclozan, C., Liu, C., Xia, C., Anasetti, C., & Yu, X. (2012) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2012.06.002 · Cited by 25 · see citing works

Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance

Jackson, S. R., Yuan, J., Berrien-Elliott, M. M., Chen, C. L., Meyer, J. M., Donlin, M. J., & Teague, R. M. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a0913-500rr · Cited by 10 · see citing works

Eomesodermin Regulates The Early Activation Of Alloreactive CD4 T Cells and Is Critical For Both Gvh and GVL Responses

Rocher, B. D., Smith, O. M., Intlekofer, A. M., Dudakov, J. A., Levy, E. R., Kreiners, F., Reiner, S. L., Abdelhay, E., van den Brink, M. R. M., & Hanash, A. M. (2013) · Blood · doi:10.1182/blood.v122.21.133.133 · Cited by 2 · see citing works

Deletion of a Class IIb Histone/protein Deacetylase (HDAC), HDAC10, Enhances FoxP3+ T-regulatory (Treg) Cell Suppressive Function, Gene Expression and Metabolism, and Promotes Allograft Survival

Dahiya, S., Wang, L., Beier, U. H., Angelin, A., Han, R., Wallace, D. C., & Hancock, W. W. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.196.supp.140.5 · Cited by 2 · see citing works

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Guo, L., Tian, Y., & Zhu, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.576946 · Cited by 358 · see citing works

Epigenetic modulation of antitumor immunity for improved cancer immunotherapy

Dai, E., Zhu, Z., Wahed, S., Qu, Z., Storkus, W. J., & Guo, Z. S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01464-x · Cited by 332 · see citing works

Advancing to the era of cancer immunotherapy

Wang, Y., Wang, M., Wu, H., & Xu, R. (2021) · 癌症：英文版 · doi:10.1002/cac2.12178 · Cited by 219 · see citing works

Histone deacetylase 11 is a fatty-acid deacylase

Kutil, Z., Novakova, Z., Meleshin, M., Mikesova, J., Schutkowski, M., & Barinka, C. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.7b00942 · Cited by 174 · see citing works

Histone deacetylase function in CD4+ T cells

Ellmeier, W., & Seiser, C. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0037-z · Cited by 144 · see citing works

Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy

Banik, D., Moufarrij, S., & Villagra, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092241 · Cited by 134 · see citing works

HDAC11: a rising star in epigenetics

Liu, S., Wu, F., Jin, Y., Weiqin, C., & Xu, T. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110607 · Cited by 116 · see citing works

HDAC11 is a regulator of diverse immune functions

Yanginlar, C., & Logie, C. (2017) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2017.12.002 · Cited by 106 · see citing works

HDAC11: a multifaceted histone deacetylase with proficient fatty deacylase activity and its roles in physiological processes

Núñez‐Álvarez, Y., & Suelves, M. (2021) · FEBS Journal · doi:10.1111/febs.15895 · Cited by 82 · see citing works

Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

Leslie, P. L., Chao, Y. L., Tsai, Y.-H., Ghosh, S. K., Porrello, A., Van Swearingen, A. E. D., Harrison, E. B., Cooley, B. C., Parker, J. S., Carey, L. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12222-5 · Cited by 80 · see citing works

Microtubule associated proteins as targets for anticancer drug development

Khwaja, S., Kumar, K., Das, R., & Negi, A. S. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105320 · Cited by 76 · see citing works

Lysine Deacetylases and Regulated Glycolysis in Macrophages

Shakespear, M. R., Iyer, A., Cheng, C. Y., Gupta, K. D., Singhal, A., Fairlie, D. P., & Sweet, M. J. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.02.009 · Cited by 70 · see citing works

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms

Yue, L., Sharma, V., Horvat, N. P., Akuffo, A. A., Beatty, M. S., Murdun, C., Colin, C., Billington, J. M. R., Goodheart, W. E., Sahakian, E., et al. (2020) · Blood · doi:10.1182/blood.2019895326 · Cited by 67 · see citing works

Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11

Martin, M. W., Lee, J. Y., Lancia, D. R., Ng, P. Y., Han, B., Thomason, J. R., Lynes, M. S., Marshall, C. G., Conti, C., Collis, A. J., et al. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.05.021 · Cited by 63 · see citing works

Histone deacetylase-mediated tumor microenvironment characteristics and synergistic immunotherapy in gastric cancer

Lin, Y., Jing, X., Chen, Z., Pan, X., Xu, D., Yu, X., Zhong, F., Zhao, L., Yang, C., Wang, B., et al. (2023) · Theranostics · doi:10.7150/thno.86928 · Cited by 60 · see citing works

HDACs and the epigenetic plasticity of cancer cells: target the complexity

Brancolini, C., Gagliano, T., & Minisini, M. (2022) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2022.108190 · Cited by 55 · see citing works

HDAC11, an emerging therapeutic target for metabolic disorders

Chen, H., Xie, C., Chen, Q., & Zhuang, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.989305 · Cited by 52 · see citing works

Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells

Chakraborty, P., Chatterjee, S., Kesarwani, P., Thyagarajan, K., Iamsawat, S., Dalheim, A. V., Nguyen, H. D., Selvam, S. P., Nasarre, P., Scurti, G. M., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006753 · Cited by 51 · see citing works

Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model

Sun, L., Telles, E., Karl, M. T., Cheng, F., Luetteke, N., Sotomayor, E. M., Miller, R. H., & Seto, E. (2018) · Life Science Alliance · doi:10.26508/lsa.201800039 · Cited by 47 · see citing works

Constructing and deconstructing GATA2-regulated cell fate programs to establish developmental trajectories

Johnson, K. D., Conn, D. J., Shishkova, E., Katsumura, K. R., Liu, P., Shen, S., Ranheim, E. A., Kraus, S. G., Wang, W., Calvo, K. R., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191526 · Cited by 40 · see citing works

How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications

Acker, H. H. V., Ma, S., Scolaro, T., Kaech, S. M., & Mazzone, M. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.03.006 · Cited by 38 · see citing works

Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)

Lu, G., Jin, S., Lin, S.-W., Gong, Y., Zhang, L., Yang, H. J., Mou, W., & Du, J. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01531-8 · Cited by 39 · see citing works

Regulation of T cell differentiation and function by epigenetic modification enzymes

Liu, H., Li, P., Wei, Z., Zhang, C., Xia, M., Du, Q., Chen, Y., Liu, N., Li, H., & Yang, X. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00731-w · Cited by 37 · see citing works

Restoring T Cell Tolerance, Exploring the Potential of Histone Deacetylase Inhibitors for the Treatment of Juvenile Idiopathic Arthritis

Nijhuis, L., Peeters, J. G. C., Vastert, S. J., & van Loosdregt, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00151 · Cited by 35 · see citing works

Loss of HDAC11 accelerates skeletal muscle regeneration in mice

Núñez‐Álvarez, Y., Hurtado, E., Muñoz, M., García‐Tuñón, I., Rech, G. E., Pluvinet, R., Sumoy, L., Pendás, A. M., Peinado, M. A., & Suelves, M. (2020) · FEBS Journal · doi:10.1111/febs.15468 · Cited by 34 · see citing works

Preclinical and clinical progress for HDAC as a putative target for epigenetic remodeling and functionality of immune cells

Zhang, S., Zhan, L., Li, X., Yang, Z., Luo, Y., & Zhao, H. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62001 · Cited by 31 · see citing works

Acetylation in Tumor Immune Evasion Regulation

Lu, J., He, X., Zhang, L., Zhang, R., & Li, W. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.771588 · Cited by 30 · see citing works

Cigarette smoke extract modulates Pseudomonas aeruginosa bacterial load via USP25/HDAC11 axis in lung epithelial cells

Chen, L., Lai, Y., Li, T., Nyunoya, T., & Zou, C. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00142.2019 · Cited by 28 · see citing works

Clinical and immune correlate results from a phase 1b study of the histone deacetylase inhibitor mocetinostat with ipilimumab and nivolumab in unresectable stage III/IV melanoma

Weber, J. S., Levinson, B. A., Laino, A. S., Pavlick, A. C., & Woods, D. M. (2022) · Melanoma Research · doi:10.1097/cmr.0000000000000818 · Cited by 27 · see citing works

HDAC11: A novel target for improved cancer therapy

Liu, Y., Tong, X., Hu, W., & Chen, D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115418 · Cited by 26 · see citing works

Epigenetic Modifiers: Anti-Neoplastic Drugs With Immunomodulating Potential

Maes, K., Mondino, A., Lasarte, J. J., Agirre, X., Vanderkerken, K., Prósper, F., & Breckpot, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.652160 · Cited by 25 · see citing works

Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma

Mostofa, A., Distler, A., Meads, M. B., Sahakian, E., Powers, J. J., Achille, A., Noyes, D., Wright, G., Fang, B., Izumi, V., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.151713 · Cited by 27 · see citing works

Role of Histone Deacetylases in T-Cell Development and Function

Pieniawska, M., & Iżykowska, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147828 · Cited by 22 · see citing works

The Effects of Interferons on Allogeneic T Cell Response in GVHD: The Multifaced Biology and Epigenetic Regulations

Zhao, C., Zhang, Y., & Zheng, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.717540 · Cited by 21 · see citing works

Enhancing Therapeutic Approaches for Melanoma Patients Targeting Epigenetic Modifiers

Gracia-Hernandez, M., Munoz, Z., & Villagra, A. (2021) · Cancers · doi:10.3390/cancers13246180 · Cited by 20 · see citing works

An Overview of Epigenetics in Clear Cell Renal Cell Carcinoma

GRAMMATIKAKI, S., Katifelis, H., Farooqı, A. A., STRAVODIMOS, K. G., Karamouzis, M. V., Souliotis, K. N., Varvaras, D., & Gazouli, M. (2023) · In Vivo · doi:10.21873/invivo.13049 · Cited by 20 · see citing works

Biological function and small molecule inhibitors of histone deacetylase 11

Jia, G., Liu, J., Hou, X., Jiang, Y., & Li, X. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116634 · Cited by 19 · see citing works

A pan‐cancer analysis identifies HDAC11 as an immunological and prognostic biomarker

Li, R., Wu, X., Zhao, P., Xue, K., & Li, J. (2022) · The FASEB Journal · doi:10.1096/fj.202101742rr · Cited by 19 · see citing works

HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3

Wu, H., Yin, X., Zhao, X., Wu, Z., Xiao, Y., Di, Q., Sun, P., Tang, H., Quan, J., & Chen, W. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102461 · Cited by 19 · see citing works

Abnormal Epigenetic Regulations in the Immunocytes of Sjögren’s Syndrome Patients and Therapeutic Potentials

Li, P., Han, M., Zhao, X., Ren, G., Mei, S., & Zhong, C. (2022) · Cells · doi:10.3390/cells11111767 · Cited by 17 · see citing works

shRNA-mediated gene silencing of HDAC11 empowers CAR-T cells against prostate cancer

Zhang, H., Yao, J., Ajmal, I., Farooq, M. A., & Jiang, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1369406 · Cited by 17 · see citing works

New insights into the basic biology of acute graft-versus-host-disease

Li, A. H., Abraham, C., Wang, Y., & Zhang, Y. (2020) · Haematologica · doi:10.3324/haematol.2019.240291 · Cited by 17 · see citing works

Chromatin-Modifying Enzymes in T Cell Development

Shapiro, M. J., & Shapiro, V. S. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-092719-082622 · Cited by 17 · see citing works

Combinatorial Epigenetic and Immunotherapy in Breast Cancer Management: A Literature Review

Lee, Y.-T., Chuang, Y., & Chan, M. W. Y. (2020) · Epigenomes · doi:10.3390/epigenomes4040027 · Cited by 16 · see citing works

Protein acetylation: a novel modus of obesity regulation

Liu, Y., Yang, H., Liu, X., Gu, H., Li, Y., & Sun, C. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02082-2 · Cited by 15 · see citing works

Unraveling HDAC11: Epigenetic orchestra in different diseases and structural insights for inhibitor design

Khatun, S., Bhagat, R. P., Dutta, R., Datta, A., Jaiswal, A., Halder, S., Jha, T., Amin, S. A., & Gayen, S. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116312 · Cited by 15 · see citing works

DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma

Kim, H. I., Park, J. B., Gallo, D. J., Shankar, S., Konečná, B., Han, Y., Banner‐Goodspeed, V., Capers, K., Ko, S., Otterbein, L. E., et al. (2023) · Annals of Surgery · doi:10.1097/sla.0000000000005898 · Cited by 12 · see citing works

HDAC11 regulates expression of C/EBPβ and immunosuppressive molecules in myeloid-derived suppressor cells

Chen, J., Cheng, F., Sahakian, E., Powers, J. J., Wang, Z., Tao, J., Seto, E., Pinilla-Ibarz, J. A., & Sotomayor, E. M. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.1a1119-606rrr · Cited by 11 · see citing works

Dissecting the regulatory network of transcription factors in T cell phenotype/functioning during GVHD and GVT

Harris, R., & Karimi, M. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1194984 · Cited by 9 · see citing works

Melanoma: Pathogenesis and Targeted Therapy

Fu, Y., Liu, J., Mo, Z., Wang, B., Deng, Y., & Jiang, Y. (2026) · MedComm · doi:10.1002/mco2.70566 · Cited by 10 · see citing works

Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses

Christensen, L. M., & Hancock, W. W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.909816 · Cited by 8 · see citing works

Development and validation of a microenvironment-related prognostic model for hepatocellular carcinoma patients based on histone deacetylase family

Teng, L., Li, Z., Shi, Y., Gao, Z., Yang, Y., Wang, Y., & Bi, L. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101547 · Cited by 8 · see citing works

Editorial: Genetic and Epigenetic Control of Immune Responses

Noonepalle, S. K. R., Karabon, L., Chiappinelli, K. B., & Villagra, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.775101 · Cited by 8 · see citing works

Engineering novel scaffolds for specific HDAC11 inhibitors against metabolic diseases exploiting deep learning, virtual screening, and molecular dynamics simulations

Li, J., Chen, X., Liu, R., Liu, X., & Shu, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129810 · Cited by 7 · see citing works

The roles of epigenetic regulation in graft-versus-host disease

Wang, Y., Liu, Q., Deng, L., Ma, X., Gong, Y., Wang, Y., & Zhou, F. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116652 · Cited by 6 · see citing works

Seven chromatin regulators as immune cell infiltration characteristics, potential diagnostic biomarkers and drugs prediction in hepatocellular carcinoma

Chai, J.-W., Hu, X., Zhang, M., & Dong, Y.-N. (2023) · Scientific Reports · doi:10.1038/s41598-023-46107-x · Cited by 4 · see citing works

Emerging role of HDAC11 in skeletal muscle biology

Chen, J., & Li, Q. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1368171 · Cited by 4 · see citing works

Present and future perspectives for targeting histone modifications in therapy

Camilo, V., & Jerónimo, C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816422-8.00018-0 · Cited by 4 · see citing works

Epigenetic mechanisms and therapeutic advances in breast cancer: From molecular insights to clinical applications

Maqbool, M. S., Landry, J. W., Das, S. K., & Fisher, P. B. (2025) · Advances in cancer research · doi:10.1016/bs.acr.2025.08.002 · Cited by 3 · see citing works

Identification and function of a novel human memory-like NK cell population expressing CD160 in melioidosis

Preechanukul, A., Kronsteiner, B., Saiprom, N., Rochaikun, K., Moonmueangsan, B., Phunpang, R., Ottiwet, O., Kongphrai, Y., Wapee, S., Chotivanich, K., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107234 · Cited by 2 · see citing works

Firing up Cold Tumors—Targeting the Epigenetic Machinery to Enhance Cancer Immunotherapy

Lin, G., Tsai, L. H. J., Kuppen, P. J. K., & Chan, M. W. Y. (2021) · Epigenomes · doi:10.3390/epigenomes5020011 · Cited by 2 · see citing works

HDAC11 deficiency improves muscle phenotype in a Duchenne muscular dystrophy murine model by reducing inflammation and fibrosis

Odria, R., Mercado-Amarilla, A., Soler‐Botija, C., Borràs, D., Ohana, J., Maestre-Mora, P., Bigot, A., Suárez‐Calvet, X., Gallardo, E., Nogales‐Gadea, G., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124150 · Cited by 1 · see citing works

Therapeutic Potential of HDAC Inhibitors in Neurodegenerative Diseases

Singh, A. K., Sudhan, Y. G., Chandana, S. L., Iyaswamy, A., & Durairajan, S. S. K. (2026) · Springer eBooks · doi:10.1007/978-981-95-6099-8_14 · Cited by 2 · see citing works

Functional divergence and structural changes of Class IV histone deacetylases (HDACs) across the tree of life

Nováková, Z., Bartošová‐Sojková, P., Kudlacova, J., Baselious, F., Kutil, Z., Jaklová, P., Meleshin, M., Motlova, L., Schenkmayerová, A., Vrkoslav, V., et al. (2026) · Molecular Biology and Evolution · doi:10.1093/molbev/msag150 · Cited by 1 · see citing works

Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigens

Wilson, C. G., Acharya, M. P., Karsch, L., Duck, L. W., Twumasi-Ankrah, N., Wang, Y., Shen, H., Frey, B. F., McKee, A. R., Oza, V. H., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02656-7 · Cited by 3 · see citing works

The antiviral mechanism and viral antagonism of host histone deacetylase 4 in influenza A virus infection

Galvin, H. D. (2020) · Otago University Research Archive (University of Otago)

Pilar Jericó: "En el momento actual hay que recuperar valores como el heroísmo"

Muriel, J. A. C. (2010) · Capital humano: revista para la integración y desarrollo de los recursos humanos

Identification and functional analysis of the HDAC11 gene in Helicoverpa armigera

Teng, Z., Liao, Z., Li, Y., Xia, S., Fei, M., Cai, D., Jianjun, G., Cai, G., & Li, H. (2026) · Journal of Asia-Pacific Entomology · doi:10.1016/j.aspen.2026.102539

Barrier Immune Memory is Promoted by Intestinal Epithelial Cell Presentation of Injected Bacterial AntigensPreprint

Wilson, C. G., Acharya, P., Karsch, L., Duck, L. W., Twumasi-Ankrah, N., Wang, Y., Shen, H., Xing, C., Frey, B. F., Oza, V. H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.27.714828

A histone deacetylase CgHDAC11 regulates CgIL17 expression in the immune response of Pacific oyster (Crassostrea gigas)

Lun, L., Lian, X., Wang, W., Yuan, P., Zuo, J., Wang, J., Wang, L., & Song, L. (2026) · Comparative Immunology Reports · doi:10.1016/j.cirep.2026.200280

HDAC11 as a potential therapeutic target for Alzheimer’s disease

Zhang, W., Wang, Y., Tocci, D. R., Wang, C., & Zhang, C. M. (2026) · Drug Discovery Today · doi:10.1016/j.drudis.2026.104730

Epigenetic regulation in transplant rejection and tolerance: mechanisms and therapeutic prospects

Li, Y., Ran, S., Zou, Y., & Cui, J. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1878170

Elevenostat Is an HDAC6/Class I-Biased Multi-HDAC Inhibitor Rather than an HDAC11-Selective Chemical Probe

Vošahlíková, M., Kutil, Z., Kudlacova, J., Havlínová, B., Meleshin, M., Nováková, Z., Šnajdr, I., Schutkowski, M., & Bařinka, C. (2026) · ACS Chemical Biology · doi:10.1021/acschembio.6c00703

BindingDB Entry 50003811: Biological function and small molecule inhibitors of histone deacetylase 11.

BindingDB (2026) · UC San Diego · doi:10.7270/q2b85dzw

BindingDB Entry 50001250: Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.

BindingDB (2020) · UC San Diego · doi:10.7270/q2pr7zgx

HDAC11 Inhibits T-Cell Response to Alloantigens and Reduces Gvhd In Mice.

Wang, D., Cheng, F., Yu, Y., Semple, K. M., Peng, L., Telles, E., Luetteke, N., Seto, E., Anasetti, C., Sotomayor, E. M., et al. (2010) · Blood · doi:10.1182/blood.v116.21.1466.1466 · Cited by 2 · see citing works

Histone Deacetylase 11 (HDAC11) Regulates Cytotoxic T-Cell Function and Memory Phenotype

Woods, D. M., Woan, K. V., Sahakian, E., Powers, J. J., Cheng, F., Wang, H., Rock-Klotz, J. A., Weber, J. S., Villagra, A., Pinilla-Ibarz, J. A., et al. (2012) · Blood · doi:10.1182/blood.v120.21.840.840

Histone deacetylase 11 is an epigenetic regulator of cytotoxic T-lymphocyte effector function and memory formation (P1404)

Woods, D. M., Woan, K. V., Wang, D., Yu, Y., Powers, J. J., Sahakian, E., Cheng, F., Wang, H., Rock-Klotz, J. A., Villagra, A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.190.supp.117.2 · Cited by 1 · see citing works

Abstract A066: Histone deacetylase 11 is an epigenetic regulator of T-cell pro-inflammatory function and novel target for enhancing T-cell anti-tumor activity

Woods, D. M., Sodré, A. L., Woan, K. V., Villagra, A., Sarnaik, A. A., Weber, J. S., & Sotomayor, E. M. (2016) · Cancer Immunology Research · doi:10.1158/2326-6074.cricimteatiaacr15-a066 · Cited by 1 · see citing works

Histone Deacetylase 11 (HDAC11) Is a Regulatory Checkpoint of T-Cell Function: Implications for T-Cell Adoptive Immunotherapy

Woan, K. V., Wang, D., Wang, Z., Cheng, F., Vazquez, L., Woods, D. M., Yu, Y., Sahakian, E., Wang, H., Telles, E., et al. (2011) · Blood · doi:10.1182/blood.v118.21.359.359 · Cited by 1 · see citing works