The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Microbe-host interplay in atopic dermatitis and psoriasis
Open accessAbstract
Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we perform a comparative analysis of skin microbial communities coupled to global patterns of cutaneous gene expression in patients with atopic dermatitis or psoriasis. The skin microbiota is analysed by 16S amplicon or whole genome sequencing and the skin transcriptome by microarrays, followed by integration of the data layers. We find that atopic dermatitis and psoriasis can be classified by distinct microbes, which differ from healthy volunteers microbiome composition. Atopic dermatitis is dominated by a single microbe (Staphylococcus aureus), and associated with a disease relevant host transcriptomic signature enriched for skin barrier function, tryptophan metabolism and immune activation. In contrast, psoriasis is characterized by co-occurring communities of microbes with weak associations with disease related gene expression. Our work provides a basis for biomarker discovery and targeted therapies in skin dysbiosis.
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Cites
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Search and clustering orders of magnitude faster than BLAST
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The Immunology of Psoriasis-Current Concepts in Pathogenesis
Sieminska, I., Pieniawska, M., & Grzywa, T. M. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08991-7 · Cited by 346
Keratinocytes: innate immune cells in atopic dermatitis
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The Human Skin Microbiome in Selected Cutaneous Diseases
Carmona-Cruz, S., Orozco-Covarrubias, L., & Sáez-de-Ocariz, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.834135 · Cited by 170
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Self-citationAltered Skin and Gut Microbiome in Hidradenitis Suppurativa
McCarthy, S., Barrett, M., Kirthi, S., Pellanda, P., Vlckova, K., Tobin, A.-M., Murphy, M., Shanahan, F., & O’Toole, P. W. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.05.036 · Cited by 98
Metadata
- Authors
- Fyhrquist, N., Muirhead, G., Prast-Nielsen, S., Jeanmougin, M., Olah, P., Skoog, T., Jules-Clement, G., Feld, M., Barrientos-Somarribas, M., Sinkko, H., van den Bogaard, E. H., Zeeuwen, P. L. J. M., Rikken, G., Schalkwijk, J., Niehues, H., Däubener, W., Eller, S. K., Alexander, H., Pennino, D., Suomela, S., Tessas, I., Lybeck, E., Baran, A. M., Darban, H., Gangwar, R. S., Gerstel, U., Jahn, K., Karisola, P., Yan, L., Hansmann, B., Katayama, S., Meller, S., Bylesjö, M., Hupé, P., Levi-Schaffer, F., Greco, D., Ranki, A., Schröder, J. M., Barker, J., Kere, J., Tsoka, S., Lauerma, A., Soumelis, V., Nestle, F. O., Homey, B., Andersson, B., & Alenius, H.
- Venue
- Nature Communications
- Published
- 2019-10-16
- Volume
- 10
- Issue
- 1
- Pages
- 4703-4703
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2980691057
- Cited by
- 409
- References
- 70
- FWCI
- 33.76
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fyhrquist, N., Muirhead, G., Prast-Nielsen, S., Jeanmougin, M., Olah, P., Skoog, T., Jules-Clement, G., Feld, M., Barrientos-Somarribas, M., Sinkko, H., van den Bogaard, E. H., Zeeuwen, P. L. J. M., Rikken, G., Schalkwijk, J., Niehues, H., Däubener, W., Eller, S. K., Alexander, H., Pennino, D., . . . Alenius, H. (2019). Microbe-host interplay in atopic dermatitis and psoriasis. Nature Communications. https://doi.org/10.1038/s41467-019-12253-y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
