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The Human Skin Microbiome in Selected Cutaneous Diseases

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Carmona-Cruz, Silvia, Orozco-Covarrubias, Luz, Sáez-de-Ocariz, Marimar·2022·Frontiers in Cellular and Infection Microbiology
DOI 10.3389/fcimb.2022.834135PMC PMC8936186
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Abstract

The human skin harbors a wide variety of microbes that, together with their genetic information and host interactions, form the human skin microbiome. The role of the human microbiome in the development of various diseases has lately gained interest. According to several studies, changes in the cutaneous microbiota are involved in the pathophysiology of several dermatoses. A better delineation of the human microbiome and its interactions with the innate and adaptive immune systems could lead to a better understanding of these diseases, as well as the opportunity to achieve new therapeutic modalities. The present review centers on the most recent knowledge on skin microbiome and its participation in the pathogenesis of several skin disorders: atopic and seborrheic dermatitis, alopecia areata, psoriasis and acne.

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  • AD is associated with increased abundance of S. aureus in lesions, which interferes with host immunity and damages the skin barrier; psoriasis is associated with abnormal colonization of S. aureus and decreased S. epidermidis abundance in psoriatic lesions; seborrheic dermatitis involves Malassezia in its pathogenesis.

    “Further examples of disease-microbiota association in human skin are AD (where the increased abundance of S. aureus in the lesions interferes with the host immunity, directly damaging the skin barrier), psoriasis (with abnormal colonization of S. aureus and decrease of S. epidermidis abundance in psoriatic lesions), and seborrheic dermatitis (where the most abundant fungal skin commensal, Malassez”

    From Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account? (2024) · cites this paper as [129]

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Cited by

Sorted by citations

Authors
Carmona-Cruz, S., Orozco-Covarrubias, L., & Sáez-de-Ocariz, M.
Venue
Frontiers in Cellular and Infection Microbiology
Publisher
Frontiers Media SA
Published
2022-03-07
Volume
12
Pages
834135-834135
ISSN
2235-2988 (ISSN-L)
DOI
10.3389/fcimb.2022.834135
PMC
PMC8936186
OpenAlex
W4220866664
Cited by
170
References
6
Citations by year
2026: 29 · 2025: 55 · 2024: 49 · 2023: 29 · 2022: 8
FWCI
6.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords
skin microbiome, skin diseases, atopic dermatitis, seborrheic dermatitis, alopecia areata, psoriasis, acne, host-microbe interactions, innate and adaptive immunity, skin disease pathogenesis, microbiota-based therapy
MeSH terms
Alopecia Areata, Dermatitis, Atopic, Humans, Psoriasis, Skin, Microbiota

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