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Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks
Open accessAbstract
Metal–organic frameworks (MOFs) have recently garnered consideration as an attractive solid substrate because the highly tunable MOF framework can not only serve as an inert host but also enhance the selectivity, stability, and/or activity of the enzymes. Herein, we demonstrate the advantages of using a mechanochemical strategy to encapsulate enzymes into robust MOFs. A range of enzymes, namely β-glucosidase, invertase, β-galactosidase, and catalase, are encapsulated in ZIF-8, UiO-66-NH 2, or Zn-MOF-74 via a ball milling process. The solid-state mechanochemical strategy is rapid and minimizes the use of organic solvents and strong acids during synthesis, allowing the encapsulation of enzymes into three prototypical robust MOFs while maintaining enzymatic biological activity. The activity of encapsulated enzyme is demonstrated and shows increased resistance to proteases, even under acidic conditions. This work represents a step toward the creation of a suite of biomolecule-in-MOF composites for application in a variety of industrial processes.
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Alsaiari, S. K., Patil, S., Alyami, M., Alamoudi, K. O., Aleisa, F. A., Merzaban, J. S., Li, M., & Khashab, N. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11754 · Cited by 517
Cited by
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Liang, W., Wied, P., Carraro, F., Sumby, C. J., Nidetzky, B., Tsung, C.-K., Falcaro, P., & Doonan, C. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01029 · Cited by 784
Self-citationBioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis
Wang, K.-Y., Zhang, J., Hsu, Y.-C., Lin, H., Han, Z., Pang, J., Yang, Z., Liang, R.-R., Shi, W., & Zhou, H.-C. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00879 · Cited by 490
Self-citationMechanochemistry: Toward green synthesis of metal–organic frameworks
Głowniak, S., Szczęśniak, B., Choma, J., & Jaroniec, M. (2021) · Materials Today · doi:10.1016/j.mattod.2021.01.008 · Cited by 435
Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions
Cuccu, F., De Luca, L., Delogu, F., Colacino, E., Solin, N., Mocci, R., & Porcheddu, A. (2022) · ChemSusChem · doi:10.1002/cssc.202200362 · Cited by 339
Metadata
- Authors
- Wei, T.-H., Wu, S.-H., Huang, Y.-D., Lo, W.-S., Williams, B. P., Chen, S.-Y., Yang, H.-C., Hsu, Y.-S., Lin, Z.-Y., Chen, X.-H., Kuo, P.-E., Chou, L.-Y., Tsung, C.-K., & Shieh, F.-K.
- Venue
- Nature Communications
- Published
- 2019-11-01
- Volume
- 10
- Issue
- 1
- Pages
- 5002-5002
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2984423045
- Cited by
- 230
- References
- 1
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wei, T.-H., Wu, S.-H., Huang, Y.-D., Lo, W.-S., Williams, B. P., Chen, S.-Y., Yang, H.-C., Hsu, Y.-S., Lin, Z.-Y., Chen, X.-H., Kuo, P.-E., Chou, L.-Y., Tsung, C.-K., & Shieh, F.-K. (2019). Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks. Nature Communications. https://doi.org/10.1038/s41467-019-12966-0
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