Involvement of condensin in cellular senescence through gene regulation and compartmental reorganization
Open accessAbstract
Senescence is induced by various stimuli such as oncogene expression and telomere shortening, referred to as oncogene-induced senescence (OIS) and replicative senescence (RS), respectively, and accompanied by global transcriptional alterations and 3D genome reorganization. Here, we demonstrate that the human condensin II complex participates in senescence via gene regulation and reorganization of euchromatic A and heterochromatic B compartments. Both OIS and RS are accompanied by A-to-B and B-to-A compartmental transitions, the latter of which occur more frequently and are undergone by 14% (430 Mb) of the human genome. Mechanistically, condensin is enriched in A compartments and implicated in B-to-A transitions. The full activation of senescence genes (SASP genes and p53 targets) requires condensin; its depletion impairs senescence markers. This study describes that condensin reinforces euchromatic A compartments and promotes B-to-A transitions, both of which are coupled to optimal expression of senescence genes, thereby allowing condensin to contribute to senescent processes.
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Studies have shown senescence-associated 3D genome reorganization in dividing cell types.
“Additionally, studies have shown senescence-associated 3D genome reorganization in dividing cell types42,140–143.”
From Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (2023) · cites this paper as [142]
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- Authors
- Iwasaki, O., Tanizawa, H., Kim, K.-D., Kossenkov, A., Nacarelli, T., Tashiro, S., Majumdar, S., Showe, L. C., Zhang, R., & Noma, K.-I.
- Affiliations
- University of Oregon (US)
- Chung-Ang University (KR)
- The Wistar Institute (US)
- Corresponding author
- Noma, Ken-ichi
- ORCID
- Venue
- Nature Communications
- Published
- 2019-12-12
- Volume
- 10
- Issue
- 1
- Pages
- 5688-5688
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6908677
- OpenAlex
- W2995325699
- Cited by
- 58
- References
- 70
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 6 · 2022: 11 · 2021: 15 · 2020: 10
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R01GM124195)
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (P01AG031862)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- cellular senescence, oncogene-induced senescence, replicative senescence, 3D genome organization, euchromatin, heterochromatin, senescence-associated secretory phenotype, gene expression regulation, chromatin compartmentalization
- MeSH terms
- Adenosine Triphosphatases, Cell Line, Chromatin, DNA-Binding Proteins, Humans, Nuclear Proteins, Oncogenes, Promoter Regions, Genetic, Gene Expression Regulation, Neoplastic, Tumor Suppressor Protein p53, Cellular Senescence, Cell Cycle Proteins, Gene Expression Profiling, Genomics, Multiprotein Complexes, Gene Knockdown Techniques, Telomere Shortening
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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