The functional impact of nuclear reorganization in cellular senescence
Open accessAbstract
Cellular senescence is the irreversible cell cycle arrest in response to DNA damage. Because senescent cells accumulate with age and contribute to chronic inflammation, they are promising therapeutic targets for healthspan extension. The senescent phenotype can vary depending on cell type and on the specific insults that induce senescence. This variability is also reflected in the extensive remodeling of the genome organization within the nucleus of senescent cells. Here, we give an overview of the nuclear changes that occur in different forms of senescence, including changes to chromatin state and composition and to the three-dimensional organization of the genome, as well as alterations to the nuclear envelope and to the accessibility of repetitive genomic regions. Many of these changes are shared across all forms of senescence, implicating nuclear organization as a fundamental driver of the senescent state and of how senescent cells interact with the surrounding tissue.
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Senescent cells display substantial changes in the organization of chromatin and DNA within the nucleus.
“Senescent cells are known to display substantial changes in the organization of chromatin and DNA within the nucleus36.”
From Spatial mapping of cellular senescence: emerging challenges and opportunities (2023) · cites this paper as [36]
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Spatial mapping of cellular senescence: emerging challenges and opportunities
Gurkar, A. U., Gerencser, A. A., Mora, A. L., Nelson, A. C., Zhang, A. R., Lagnado, A. B., Enninful, A., Benz, C., Furman, D., Beaulieu, D., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00446-6 · Cited by 139 · see citing works
Self-citationDetection of senescence using machine learning algorithms based on nuclear features
Duran, I., Pombo, J., Sun, B., Gallage, S., Kudo, H., McHugh, D., Bousset, L., Barragan Avila, J. E., Forlano, R., Manousou, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45421-w · Cited by 85 · see citing works
- Authors
- Rocha, A., Dalgarno, A., & Neretti, N.
- Affiliations
- Brown University (US)
- Corresponding author
- Neretti, Nicola
- ORCID
- Neretti, Nicola
- Venue
- Briefings in Functional Genomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-03-23
- Volume
- 21
- Issue
- 1
- Pages
- 24-34
- ISSN
- 2041-2647 (ISSN-L)
- 2041-2649
- 2041-2657
- PMC
- PMC8789270
- OpenAlex
- W3137176315
- Cited by
- 38
- References
- 134
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 10 · 2023: 14 · 2022: 3 · 2021: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Briefings in Functional Genomics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (T32AG041688, T32GM128596, R01AG050582)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- cellular senescence, nuclear reorganization, chromatin state, 3D genome organization, nuclear envelope, repetitive DNA, DNA damage response, healthspan extension, chronic inflammation, senescent cells
- MeSH terms
- Cell Nucleus, Chromatin, Cellular Senescence, Genomics
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