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MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response
Open accessAbstract
Abiotic stresses, including drought and salinity, trigger a complex osmotic-stress and abscisic acid (ABA) signal transduction network. The core ABA signalling components are snf1-related protein kinase2s (SnRK2s), which are activated by ABA-triggered inhibition of type-2C protein-phosphatases (PP2Cs). SnRK2 kinases are also activated by a rapid, largely unknown, ABA-independent osmotic-stress signalling pathway. Here, through a combination of a redundancy-circumventing genetic screen and biochemical analyses, we have identified functionally-redundant MAPKK-kinases (M3Ks) that are necessary for activation of SnRK2 kinases. These M3Ks phosphorylate a specific SnRK2/OST1 site, which is indispensable for ABA-induced reactivation of PP2C-dephosphorylated SnRK2 kinases. ABA-triggered SnRK2 activation, transcription factor phosphorylation and SLAC1 activation require these M3Ks in vitro and in plants. M3K triple knock-out plants show reduced ABA sensitivity and strongly impaired rapid osmotic-stress-induced SnRK2 activation. These findings demonstrate that this M3K clade is required for ABA- and osmotic-stress-activation of SnRK2 kinases, enabling robust ABA and osmotic stress signal transduction.
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Liu, Q., Kasuga, M., Sakuma, Y., Abe, H., Miura, S., Yamaguchi-Shinozaki, K., & Shinozaki, K. (1998) · The Plant Cell · doi:10.1105/tpc.10.8.1391 · Cited by 3,044
Cited by
Signaling mechanisms in abscisic acid-mediated stomatal closure
Hsu, P., Dubeaux, G., Takahashi, Y., & Schroeder, J. I. (2021) · The Plant Journal · doi:10.1111/tpj.15067 · Cited by 546
Self-citationAbscisic acid (ABA) signaling: finding novel components off the beaten track
Wong, A., Bi, C., Pasqualini, S., & Gehring, C. (2022) · Plant Growth Regulation · doi:10.1007/s10725-022-00823-y · Cited by 12
Yang, S., & Ohtani, B. (2021) · Catalysis Today · doi:10.1016/j.cattod.2021.06.001 · Cited by 9
Metadata
- Authors
- Takahashi, Y., Zhang, J., Hsu, P.-K., Ceciliato, P. H. O., Zhang, L., Dubeaux, G., Munemasa, S., Ge, C., Zhao, Y., Hauser, F., & Schroeder, J. I.
- Venue
- Nature Communications
- Published
- 2020-01-02
- Volume
- 11
- Issue
- 1
- Pages
- 12-12
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2998064682
- Cited by
- 351
- References
- 1
- FWCI
- 30.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- The paper
- Takahashi, Y., Zhang, J., Hsu, P.-K., Ceciliato, P. H. O., Zhang, L., Dubeaux, G., Munemasa, S., Ge, C., Zhao, Y., Hauser, F., & Schroeder, J. I. (2020). MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response. Nature Communications. https://doi.org/10.1038/s41467-019-13875-y
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