The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
Open accessAbstract
Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue loses the ability to facilitate gas exchange and provide cells with needed oxygen. Currently, IPF has few treatment options and no effective therapies, aside from lung transplant. Here we present a series of studies utilizing lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation to treat different models of lung injury and fibrosis. Analysis reveals that LSC-Sec and LSC-Exo treatments could attenuate and resolve bleomycin- and silica-induced fibrosis by reestablishing normal alveolar structure and decreasing both collagen accumulation and myofibroblast proliferation. Additionally, LSC-Sec and LSC-Exo exhibit superior therapeutic benefits than their counterparts derived from mesenchymal stem cells in some measures. We showed that an inhalation treatment of secretome and exosome exhibited therapeutic potential for lung regeneration in two experimental models of pulmonary fibrosis.
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Cites
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Self-citationInhalable dry powder mRNA vaccines based on extracellular vesicles
Popowski, K. D., Moatti, A., Scull, G., Silkstone, D., Lutz, H., López de Juan Abad, B., George, A., Belcher, E., Zhu, D., Mei, X., et al. (2022) · Matter · doi:10.1016/j.matt.2022.06.012 · Cited by 218
Self-citationInhalable exosomes outperform liposomes as mRNA and protein drug carriers to the lung
Popowski, K. D., López de Juan Abad, B., George, A., Silkstone, D., Belcher, E., Chung, J., Ghodsi, A., Lutz, H., Davenport, J., Flanagan, M., et al. (2022) · Extracellular Vesicle · doi:10.1016/j.vesic.2022.100002 · Cited by 158
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Metadata
- Authors
- Dinh, P.-U. C., Paudel, D., Brochu, H., Popowski, K. D., Gracieux, M. C., Cores, J., Huang, K., Hensley, M. T., Harrell, E., Vandergriff, A. C., George, A. K., Barrio, R. T., Hu, S., Allen, T. A., Blackburn, K., Caranasos, T. G., Peng, X., Schnabel, L. V., Adler, K. B., Lobo, L. J., Goshe, M. B., & Cheng, K.
- Venue
- Nature Communications
- Published
- 2020-02-28
- Volume
- 11
- Issue
- 1
- Pages
- 1064-1064
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3009979587
- Cited by
- 435
- References
- 5
- FWCI
- 26.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Dinh, P.-U. C., Paudel, D., Brochu, H., Popowski, K. D., Gracieux, M. C., Cores, J., Huang, K., Hensley, M. T., Harrell, E., Vandergriff, A. C., George, A. K., Barrio, R. T., Hu, S., Allen, T. A., Blackburn, K., Caranasos, T. G., Peng, X., Schnabel, L. V., Adler, K. B., . . . Cheng, K. (2020). Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. Nature Communications. https://doi.org/10.1038/s41467-020-14344-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
