The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona
Open accessAbstract
Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma proteome. Here we report a highly parallel protein quantitation platform integrating nanoparticle (NP) protein coronas with liquid chromatography-mass spectrometry for efficient proteomic profiling. A protein corona is a protein layer adsorbed onto NPs upon contact with biofluids. Varying the physicochemical properties of engineered NPs translates to distinct protein corona patterns enabling differential and reproducible interrogation of biological samples, including deep sampling of the plasma proteome. Spike experiments confirm a linear signal response. The median coefficient of variation was 22%. We screened 43 NPs and selected a panel of 5, which detect more than 2,000 proteins from 141 plasma samples using a 96-well automated workflow in a pilot non-small cell lung cancer classification study. Our streamlined workflow combines depth of coverage and throughput with precise quantification based on unique interactions between proteins and NPs engineered for deep and scalable quantitative proteomic studies.
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Metadata
- Authors
- Blume, J. E., Manning, W. C., Troiano, G., Hornburg, D., Figa, M., Hesterberg, L., Platt, T. L., Zhao, X., Cuaresma, R. A., Everley, P. A., Ko, M., Liou, H., Mahoney, M., Ferdosi, S., Elgierari, E. M., Stolarczyk, C., Tangeysh, B., Xia, H., Benz, R., Siddiqui, A., Carr, S. A., Ma, P., Langer, R., Farias, V., & Farokhzad, O. C.
- Venue
- Nature Communications
- Published
- 2020-07-22
- Volume
- 11
- Issue
- 1
- Pages
- 3662-3662
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3043870236
- Cited by
- 452
- References
- 72
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- creativecommons.org/licenses/by/4.0 (tdm)
- creativecommons.org/licenses/by/4.0 (vor)
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- Blume, J. E., Manning, W. C., Troiano, G., Hornburg, D., Figa, M., Hesterberg, L., Platt, T. L., Zhao, X., Cuaresma, R. A., Everley, P. A., Ko, M., Liou, H., Mahoney, M., Ferdosi, S., Elgierari, E. M., Stolarczyk, C., Tangeysh, B., Xia, H., Benz, R., . . . Farokhzad, O. C. (2020). Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona. Nature Communications. https://doi.org/10.1038/s41467-020-17033-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
