The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Immunological and inflammatory profiles in mild and severe cases of COVID-19
Open accessAbstract
COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell activation and high expression of T-cell inhibitory molecules are more prominent in severe cases than in those with mild disease. CD8+ T cells in patients with severe disease express high levels of cytotoxic molecules. Histochemical studies of lung tissue from one fatality show sub-anatomical distributions of SARS-CoV-2 RNA and massive infiltration of T cells and macrophages. Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients.
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Metadata
- Authors
- Song, J.-W., Zhang, C., Fan, X., Meng, F.-P., Xu, Z., Xia, P., Cao, W.-J., Yang, T., Dai, X.-P., Wang, S.-Y., Xu, R.-N., Jiang, T.-J., Li, W.-G., Zhang, D.-W., Zhao, P., Shi, M., Agrati, C., Ippolito, G., Maeurer, M., Zumla, A., Wang, F.-S., & Zhang, J.-Y.
- Venue
- Nature Communications
- Published
- 2020-07-08
- Volume
- 11
- Issue
- 1
- Pages
- 3410-3410
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3040928076
- Cited by
- 394
- References
- 27
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- gold
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- Song, J.-W., Zhang, C., Fan, X., Meng, F.-P., Xu, Z., Xia, P., Cao, W.-J., Yang, T., Dai, X.-P., Wang, S.-Y., Xu, R.-N., Jiang, T.-J., Li, W.-G., Zhang, D.-W., Zhao, P., Shi, M., Agrati, C., Ippolito, G., Maeurer, M., . . . Zhang, J.-Y. (2020). Immunological and inflammatory profiles in mild and severe cases of COVID-19. Nature Communications. https://doi.org/10.1038/s41467-020-17240-2
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