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Molecular design principles of Lysine-DOPA wet adhesion
Open accessAbstract
The mussel byssus has long been a source of inspiration for the adhesion community. Recently, adhesive synergy between flanking lysine (Lys, K) and 3,4-Dihydroxyphenylalanine (DOPA, Y) residues in the mussel foot proteins (Mfps) has been highlighted. However, the complex topological relationship of DOPA and Lys as well as the interfacial adhesive roles of other amino acids have been understudied. Herein, we study adhesion of Lys and DOPA-containing peptides to organic and inorganic substrates using single-molecule force spectroscopy (SMFS). We show that a modest increase in peptide length, from K Y to (K Y)3, increases adhesion strength to TiO 2. Surprisingly, further increase in peptide length offers no additional benefit. Additionally, comparison of adhesion of dipeptides containing Lys and either DOPA (K Y) or phenylalanine (KF) shows that DOPA is stronger and more versatile. We furthermore demonstrate that incorporating a nonadhesive spacer between (K Y) repeats can mimic the hidden length in the Mfp and act as an effective strategy to dissipate energy.
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Fantner, G. E., Hassenkam, T., Kindt, J. H., Weaver, J. C., Birkedal, H., Pechenik, L., Cutroni, J. A., Cidade, G. A. G., Stucky, G. D., Morse, D. E., et al. (2005) · Nature Materials · doi:10.1038/nmat1428 · Cited by 933
Adaptive synergy between catechol and lysine promotes wet adhesion by surface salt displacement
Maier, G. P., Rapp, M. V., Waite, J. H., Israelachvili, J. N., & Butler, A. (2015) · Science · doi:10.1126/science.aab0556 · Cited by 722
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Fu, M., Zhao, Y., Wang, Y., Li, Y., Wu, M., Liu, Q., Hou, Z., Lu, Z., Wu, K., & Guo, J. (2023) · Small · doi:10.1002/smll.202205489 · Cited by 107
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Metadata
- Authors
- Li, Y., Cheng, J., Delparastan, P., Wang, H., Sigg, S. J., DeFrates, K. G., Cao, Y., & Messersmith, P. B.
- Venue
- Nature Communications
- Published
- 2020-08-04
- Volume
- 11
- Issue
- 1
- Pages
- 3895-3895
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3047371915
- Cited by
- 167
- References
- 2
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, Y., Cheng, J., Delparastan, P., Wang, H., Sigg, S. J., DeFrates, K. G., Cao, Y., & Messersmith, P. B. (2020). Molecular design principles of Lysine-DOPA wet adhesion. Nature Communications. https://doi.org/10.1038/s41467-020-17597-4
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