Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking
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Abstract
Immune response and new tissue formation are important aspects of tissue repair. However, only a single aspect is generally considered in previous biomedical interventions, and the synergistic effect is unclear. Here, a dual-effect coating with immobilized immunomodulatory metal ions (e.g., Zn 2+ ) and osteoinductive growth factors (e.g., BMP-2 peptide) is designed via mussel adhesion-mediated ion coordination and molecular clicking strategy. Compared to the bare TiO 2 group, Zn 2+ can increase M2 macrophage recruitment by up to 92.5% in vivo and upregulate the expression of M2 cytokine IL-10 by 84.5%; while the dual-effect of Zn 2+ and BMP-2 peptide can increase M2 macrophages recruitment by up to 124.7% in vivo and upregulate the expression of M2 cytokine IL-10 by 171%. These benefits eventually significantly enhance bone-implant mechanical fixation (203.3 N) and new bone ingrowth (82.1%) compared to the bare TiO 2 (98.6 N and 45.1%, respectively). Taken together, the dual-effect coating can be utilized to synergistically modulate the osteoimmune microenvironment at the bone-implant interface, enhancing bone regeneration for successful implantation.
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The reduction of CD68-positive cells in the ICMA@CZ group was notably greater than in the ICMA group, attributable to the capacity of zinc ions to regulate macrophage polarization.
“The reduction of CD68-positive cells in the group of ICMA@CZ was notably greater than that in the ICMA group (Fig. 4, G and H), attributable to the capacity of zinc ions to regulate the macrophage polarization (41).”
From Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation (2025) · cites this paper as [41]
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Cites
A reversible wet/dry adhesive inspired by mussels and geckos
Lee, H., Lee, B. P., & Messersmith, P. B. (2007) · Nature · doi:10.1038/nature05968 · Cited by 2,043 · see citing works
Polydopamine Surface Chemistry: A Decade of Discovery
Ryu, J. H., Messersmith, P. B., & Lee, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19865 · Cited by 1,843 · see citing works
Materials design for bone-tissue engineering
Koons, G. L., Diba, M., & Mikos, A. G. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-0204-2 · Cited by 1,733 · see citing works
Modulation of macrophage phenotype by cell shape
McWhorter, F. Y., Wang, T., Nguyen, P., Chung, T., & Liu, W. F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308887110 · Cited by 1,482 · see citing works
Self-citationBiomaterial based modulation of macrophage polarization: a review and suggested design principles
Sridharan, R., Cameron, A. R., Kelly, D. J., Kearney, C. J., & O’Brien, F. J. (2015) · Materials Today · doi:10.1016/j.mattod.2015.01.019 · Cited by 826 · see citing works
Design of biodegradable, implantable devices towards clinical translation
Li, C., Guo, C., Fitzpatrick, V., Ibrahim, A. G. A., Zwierstra, M. J., Hanna, P. C., Lechtig, A., Nazarian, A., Lin, S. J., & Kaplan, D. L. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0150-z · Cited by 819 · see citing works
Bayliss, L. E., Culliford, D. J., Monk, A. P., Glyn-Jones, S., Prieto‐Alhambra, D., Judge, A., Cooper, C. C., Carr, A. J., Arden, N., Beard, D. J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30059-4 · Cited by 817 · see citing works
Zinc and its role in immunity and inflammation
Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.008 · Cited by 798 · see citing works
Osteoimmunomodulation for the development of advanced bone biomaterials
Chen, Z., Klein, T. J., Murray, R. Z., Crawford, R., Chang, J., Wu, C., & Xiao, Y. (2015) · Materials Today · doi:10.1016/j.mattod.2015.11.004 · Cited by 742 · see citing works
Ferguson, R. J., Palmer, A. J. R., Taylor, A. H., Porter, M., Malchau, H., & Glyn‐Jones, S. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31777-x · Cited by 649 · see citing works
Macrophages in inflammation, repair and regeneration
Oishi, Y., & Manabe, I. (2018) · International Immunology · doi:10.1093/intimm/dxy054 · Cited by 645 · see citing works
Ellis, S., Lin, E. J., & Tartar, D. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0234-9 · Cited by 625 · cited 1× · see citing works
“Tissue regeneration involves three indispensable stages: (i) immune action, (ii) cell proliferation and new tissue formation, and (iii) remodeling and maturation 7,8 .”
A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone
Zhu, H., Guo, Z., Jiang, X., Li, H., Wang, X.-Y., Yao, H., Zhang, Y., & Mao, N. (2010) · Nature Protocols · doi:10.1038/nprot.2009.238 · Cited by 588 · see citing works
Ren, X., Feng, Y., Guo, J., Wang, H., Li, Q., Yang, J., Hao, X., Lv, J., Ma, N., & Li, W. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00483c · Cited by 573 · see citing works
Zhu, Y., Liang, H., Liu, X., Wu, J., Cao, Y., Wong, T. M., Kwan, K. Y.-H., Cheung, K., Wu, S., & Yeung, K. (2021) · Science Advances · doi:10.1126/sciadv.abf6654 · Cited by 415 · see citing works
Tailoring Materials for Modulation of Macrophage Fate
Li, J., Jiang, X., Li, H., Gelinsky, M., & Gu, Z. (2021) · Advanced Materials · doi:10.1002/adma.202004172 · Cited by 402 · see citing works
Mussel-inspired polydopamine for bio-surface functionalization
Ding, Y., Floren, M. L., & Tan, W. (2016) · Biosurface and Biotribology · doi:10.1016/j.bsbt.2016.11.001 · Cited by 396 · see citing works
Zinc and immunity: An essential interrelation
Maares, M., & Haase, H. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.03.022 · Cited by 359 · see citing works
Jin, S., He, D., Luo, D., Wang, Y., Yu, M.-G., Guan, B., Fu, Y., Li, Z.-X., Zhang, T., Zhou, Y.-H., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00489 · Cited by 304 · see citing works
Liu, W. X., Li, J., Cheng, M., Wang, Q., Yeung, K., Chu, P. K.-H., & Zhang, X. (2018) · Advanced Science · doi:10.1002/advs.201800749 · Cited by 301 · see citing works
Design, clinical translation and immunological response of biomaterials in regenerative medicine
Sadtler, K., Singh, A., Wolf, M. T., Wang, X.-K., Pardoll, D., & Elisseeff, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.40 · Cited by 294 · see citing works
Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology
Armiento, A. R., Hatt, L. P., Rosenberg, G. S., Thompson, K., & Stoddart, M. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909874 · Cited by 275 · see citing works
Biomaterial Surface Hydrophobicity-Mediated Serum Protein Adsorption and Immune Responses
Visalakshan, R. M., MacGregor, M., Sasidharan, S., Ghazaryan, A., Mierczynska-Vasilev, A. M., Morsbach, S., Mailänder, V., Landfester, K., Hayball, J. D., & Vasilev, K. A. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b09900 · Cited by 238 · see citing works
Unveiling the Mechanism of Surface Hydrophilicity‐Modulated Macrophage Polarization
Lv, L., Xie, Y., Li, K., Hu, T., Lǚ, X., Cao, Y., & Zheng, X. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800675 · Cited by 230 · see citing works
Zhou, X., Feng, W., Qiu, K., Chen, L., Wang, W., Nie, W., Mo, X., & He, C. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b02636 · Cited by 219 · see citing works
Niu, Y., Wang, Z., Shi, Y., Dong, L., & Wang, C. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.08.012 · Cited by 213 · see citing works
Xie, Y., Hu, C., Feng, Y., Li, D., Ai, T., Huang, Y., Chen, X., Huang, L., & Tan, J. (2020) · Regenerative Biomaterials · doi:10.1093/rb/rbaa006 · Cited by 212 · see citing works
Revision joint replacement, wear particles, and macrophage polarization
Rao, A. J., Gibon, E., Ma, T., Yao, Z., Smith, R. L., & Goodman, S. B. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.03.042 · Cited by 209 · see citing works
Cho, H.-J., Madhurakkat Perikamana, S. K., Lee, J.-H., Lee, J., Lee, K.-M., Shin, C. S., & Shin, H. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am501391z · Cited by 199 · see citing works
Zhu, Y., Ma, Z., Kong, L., He, Y., Chan, H. F., & Li, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120216 · Cited by 196 · see citing works
Immunomodulatory ECM-like Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus
Hu, Z., Ma, C., Rong, X., Zou, S., & Liu, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18458 · Cited by 188 · see citing works
Toward the biomimetic implant surface: Biopolymers on titanium-based implants for bone regeneration
Tejero, R., Anitua, E., & Orive, G. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.01.001 · Cited by 187 · see citing works
Molecular design principles of Lysine-DOPA wet adhesion
Li, Y., Cheng, J., Delparastan, P., Wang, H., Sigg, S. J., DeFrates, K. G., Cao, Y., & Messersmith, P. B. (2020) · Nature Communications · doi:10.1038/s41467-020-17597-4 · Cited by 168 · see citing works
Pan, G., Sun, S., Zhang, W., Zhao, R., Cui, W., He, F., Huang, L., Lee, S.-H., Shea, K. J., Shi, Q., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b09770 · Cited by 166 · see citing works
Self-citationVasconcelos, D. P., Costa, M. M., Amaral, I. F., Barbosa, M. A., Águas, A. P., & Barbosa, J. N. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.035 · Cited by 153 · see citing works
Bai, J., Wang, H., Chen, H., Ge, G., Wang, M., Gao, A., Tong, L., Xu, Y., Yang, H., Pan, G., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120197 · Cited by 153 · see citing works
Self-citationTitanium Fiber Plates for Bone Tissue Repair
Takizawa, T., Nakayama, N., Haniu, H., Aoki, K., Okamoto, M., Nomura, H., Tanaka, M., Sobajima, A., Yoshida, K., Kamanaka, T., et al. (2017) · Advanced Materials · doi:10.1002/adma.201703608 · Cited by 146 · see citing works
Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces
Yang, Z., Zhao, X., Hao, R., Tu, Q., Tian, X., Xiao, Y. M., Xiong, K., Wang, M., Feng, Y., Huang, N., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003732117 · Cited by 142 · see citing works
Modulating macrophage polarization with divalent cations in nanostructured titanium implant surfaces
Lee, C.-H., Kim, Y. J., Jang, J., & Park, J. (2016) · Nanotechnology · doi:10.1088/0957-4484/27/8/085101 · Cited by 141 · see citing works
Maitz, M. F., Martins, M. C. L., Grabow, N., Matschegewski, C., Huang, N., Chaikof, E. L., Barbosa, M. A., Werner, C., & Sperling, C. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.06.019 · Cited by 127 · see citing works
Yang, Y., Gao, P., Wang, J., Tu, Q., Bai, L., Xiong, K., Qiu, H., Zhao, X., Maitz, M. F., Wang, H., et al. (2020) · Research · doi:10.34133/2020/9203906 · Cited by 122 · see citing works
Shi, Z., Neoh, K. G., Kang, E. T., Poh, C., & Wang, W. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0415 · Cited by 106 · see citing works
Immunoregulation of macrophages by dynamic ligand presentation via ligand–cation coordination
Kang, H., Yang, B., Zhang, K., Pan, Q., Yuan, W., Li, G., & Bian, L. (2019) · Nature Communications · doi:10.1038/s41467-019-09733-6 · Cited by 106 · see citing works
Zhao, D., Liu, C., Zuo, K., Su, P., Li, L.-B., Xiao, G., & Cheng, L. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127362 · Cited by 106 · see citing works
Surface biofunctionalization by covalent co-immobilization of oligopeptides
Chen, X., Sevilla, P., & Aparicio, C. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.02.005 · Cited by 104 · see citing works
Rahman, C. V., Ben‐David, D., Dhillon, A. S., Kuhn, G. A., Gould, T. W. A., Müller, R., Rose, F. R. A. J., Shakesheff, K. M., & Livne, E. (2012) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1497 · Cited by 104 · see citing works
In Situ Deactivation of Catechol-Containing Adhesive Using Electrochemistry
Bhuiyan, M. S. A., Roland, J. D., Liu, B., Reaume, M., Zhang, Z., Kelley, J. D., & Lee, B. P. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b11266 · Cited by 103 · see citing works
Holloway, W. R., Collier, F., Herbst, R., Hodge, J. M., & Nicholson, G. C. (1996) · Bone · doi:10.1016/8756-3282(96)00141-x · Cited by 95 · see citing works
Li, Y., Xiong, W., Zhang, C., Gao, B., Guan, H., Cheng, H., Fu, J., & Li, F. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35060 · Cited by 82 · see citing works
Self-mineralizing Ca-enriched methacrylated gellan gum beads for bone tissue engineering
Vieira, S., Morais, A. D. S., Garet, E., Silva‐Correia, J., Reis, R. L., González‐Fernández, Á., & Oliveira, J. M. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.01.053 · Cited by 81 · see citing works
Chen, X., Gao, Y., Wang, Y., & Pan, G. (2020) · Smart Materials in Medicine · doi:10.1016/j.smaim.2020.10.005 · Cited by 81 · see citing works
Xiang, G., Liu, K., Wang, T., Hu, X., Wang, J., Gao, Z., Lei, W., Feng, Y., & Tao, T. H. (2020) · Advanced Science · doi:10.1002/advs.202002328 · Cited by 79 · see citing works
Self-citationShao, N., Guo, J., Guan, Y., Zhang, H., Li, X., Chen, X., Zhou, D., & Huang, Y. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00707 · Cited by 68 · see citing works
Chen, L., Wang, D., Peng, F., Qiu, J., Ouyang, L., Qiao, Y., & Liu, X. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00237 · Cited by 66 · see citing works
Qin, W., Li, Y., Ma, J., Liang, Q., Cui, X., Jia, H., & Tang, B. H. (2020) · Dental Materials · doi:10.1016/j.dental.2020.06.004 · Cited by 66 · see citing works
Silicon-Doped Titanium Dioxide Nanotubes Promoted Bone Formation on Titanium Implants
Zhao, X., Wang, T., Shi, Q., Liu, X., Sun, J., & Li, B. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030292 · Cited by 57 · see citing works
Self-citationTwo-faced immunology—from osteogenesis to bone resorption
Takayanagi, H. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.219 · Cited by 56 · see citing works
Gai, M., Simon, J., Lieberwirth, I., Mailänder, V., Morsbach, S., & Landfester, K. (2019) · Polymer Chemistry · doi:10.1039/c9py01136f · Cited by 55 · see citing works
Biomaterial surface modification for underwater adhesion
Hou, Y., Deng, X., & Xie, C. (2020) · Smart Materials in Medicine · doi:10.1016/j.smaim.2020.07.003 · Cited by 54 · see citing works
Guo, S., Yu, D., Xiao, X., Liu, W., Wu, Z., Shi, L., Zhao, Q., Yang, D. S., Lu, Y., Wei, X., et al. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00282h · Cited by 47 · see citing works
Sasmal, R., Saha, N. D., Pahwa, M., Rao, S., Joshi, D., Inamdar, M. S., Sheeba, V., & Agasti, S. S. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01851 · Cited by 45 · see citing works
Yu, H., Yu, S., Qiu, H., Gao, P., Chen, Y., Zhao, X., Tu, Q., Zhou, M., Cai, L., Huang, N., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.11.011 · Cited by 45 · see citing works
The immunomodulatory role of sulfated chitosan in BMP-2-mediated bone regeneration
Shu, Y., Yu, Y., Zhang, S., Wang, J., Xiao, Y., & Liu, C. (2018) · Biomaterials Science · doi:10.1039/c8bm00701b · Cited by 44 · see citing works
The risk factors of early implant failure: A retrospective study of 6113 implants
Wu, X., Chen, S., Ji, W., & Shi, B. (2021) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.12992 · Cited by 43 · see citing works
Wang, Z., Niu, Y., Tian, X., Yu, N. H., Yin, X., Xing, Z., Li, Y., Dong, L., & Wang, C. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202007408 · Cited by 35 · see citing works
Ahmad, N., Colak, B., Gibbs, M. J., Zhang, D., Gautrot, J. E., Watkinson, M., Becer, C. R., & Krause, S. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00245 · Cited by 31 · see citing works
Synergistic effects of titania nanotubes and silicon to enhance the osteogenic activity
Wang, T., Shi, Q., Zha, G., Zhao, X., Ding, L., Sun, J., Li, B., & Liu, X. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.07.052 · Cited by 19 · see citing works
Self-citationCzuban, M., Kulka, M., Wang, L., Koliszak, A., Achazi, K., Schlaich, C., Donskyi, I., di Luca, M., Mejía-Oneto, J., Royzen, M., et al. (2020) · Materials Science and Engineering C: Materials for Biological Applications · doi:10.1016/j.msec.2020.111109 · Cited by 18 · see citing works
Self-citationCychy, S., Hiltrop, D., Andronescu, C., Muhler, M., & Schuhmann, W. W. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b02734 · Cited by 16 · see citing works
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- [41]Zhang, X., Chen, G., Yu, Y., Sun, L. & Zhao, Y. Bioinspired adhesive and antibacterial microneedles for versatile transdermal drug delivery. Res.-China 2020, 3672120 (2020). PMC7231261 32490376
Cited by
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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration
Yuan, X., Zhu, W., Yang, Z., He, N., Chen, F., Han, X., & Zhou, K. (2024) · Advanced Materials · doi:10.1002/adma.202403641 · Cited by 353 · see citing works
Bone Repair Biomaterials: A Perspective from Immunomodulation
Wang, Y., Zhang, H., Hu, Y., Jing, Y., Geng, Z., & Su, J. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202208639 · Cited by 209 · see citing works
Mao, Z., Bi, X., Yu, C., Chen, L., Shen, J., Huang, Y., Wu, Z., Qi, H. M., Guan, J., Shu, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48417-8 · Cited by 170 · see citing works
Li, S., Yang, H., Qu, X., Qin, Y., Liu, A., Guo, B. K., Huang, H., Sun, C., Dai, J., Tan, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47189-5 · Cited by 129 · see citing works
Topography-mediated immunomodulation in osseointegration; Ally or Enemy
Shirazi, S., Ravindran, S., & Cooper, L. F. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121903 · Cited by 104 · see citing works
Fit and forget: The future of dental implant therapy via nanotechnology
Gulati, K., Chopra, D., Kocak-Oztug, N. A., & Verron, E. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114900 · Cited by 89 · see citing works
Osteoimmune regulation underlies oral implant osseointegration and its perturbation
Albrektsson, T. O., Tengvall, P., Amengual‐Peñafiel, L., Coli, P., Kotsakis, G. A., & Cochran, D. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1056914 · Cited by 87 · see citing works
Wang, H., Zhang, Y., Zhang, Y., Li, C., Zhang, M., Wang, J., Zhang, Y., Du, Y., Cui, W., & Chen, W. (2024) · Advanced Materials · doi:10.1002/adma.202402968 · Cited by 79 · see citing works
Self-citationMicroenvironment-targeted strategy steers advanced bone regeneration
Hao, S., Wang, M., Yin, Z., Jing, Y., Bai, L., & Su, J. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100741 · Cited by 75 · see citing works
Yu, Y., Wu, J., Lin, C., Qin, X., Tay, F. R., Miao, L., Tao, B., & Jiao, Y. (2023) · Military Medical Research · doi:10.1186/s40779-023-00454-y · Cited by 74 · see citing works
Bi, Z., Cai, Y., Shi, X., Chen, J., Li, D., Zhang, P., & Liu, J. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.150631 · Cited by 72 · see citing works
Ultrasound-responsive smart composite biomaterials in tissue repair
Han, X., Yi, W., Chen, S., Cai, Z., Zhu, Y., Wang, H., Guo, X., Shen, J., Cui, W., & Bai, D. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101804 · Cited by 69 · see citing works
Self-citationLuo, Y., Liu, H., Zhang, Y., Liu, Y., Liu, X., Liu, X., & Luo, E. (2023) · Biomaterials Science · doi:10.1039/d3bm01146a · Cited by 66 · see citing works
Du, J., Chu, Y., Hu, Y., Liu, J., Liu, H., Wang, H., Yang, C., Wang, Z., Yu, A., & Ran, J. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.10.014 · Cited by 60 · see citing works
Li, J., Zhao, C., Xu, Y., Song, L., Chen, Y., Xu, Y., Ma, Y., Wang, S., Xu, A., & He, F. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.10.009 · Cited by 59 · see citing works
Dong, J., Zhou, W., Hu, X., Bai, J., Zhang, S., Zhang, X., Yu, L., Yang, P., Kong, L., Liu, M., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122515 · Cited by 59 · see citing works
Self-citationBio-inspired dual-adhesive particles from microfluidic electrospray for bone regeneration
Yang, L., Wang, X., Yu, Y., Shang, L., Xu, W., & Zhao, Y. (2022) · Nano Research · doi:10.1007/s12274-022-5202-9 · Cited by 58 · see citing works
Chu, G., Guan, M., Jin, J., Luo, Y., Luo, Z., Shi, T., Liu, T., Zhang, C., & Wang, Y. (2024) · Advanced Materials · doi:10.1002/adma.202311855 · Cited by 58 · see citing works
Song, T., Zhao, F., Yan, L., Liu, P., Yang, J., Ruan, C., Li, D., Xiao, Y., & Zhang, X. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122601 · Cited by 57 · see citing works
Fu, M., Li, J., Liu, M., Yang, C., Wang, Q., Wang, H., Chen, B., Fu, Q., & Sun, G. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s399487 · Cited by 56 · see citing works
Surface Modification of Titanium Implants by Metal Ions and Nanoparticles for Biomedical Application
Wu, N., Gao, H., Wang, X., & Pei, X. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00722 · Cited by 55 · see citing works
Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration
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Liu, X., Gaihre, B., Park, S., Li, L., Dashtdar, B., Potes, M. D. A., Terzic, A., Elder, B. D., & Lu, L. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.03.021 · Cited by 54 · see citing works
Janus hydrogel microrobots with bioactive ions for the regeneration of tendon-bone interface
Ding, Z., Cai, Y., Sun, H., Rong, X., Ye, S., Fan, J., Lai, Y., Liang, Z., Huang, C., Li, P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57499-x · Cited by 54 · see citing works
Self-citationdos Santos, R. F. M., Rossi, M. C., Vidilli, A. L., Amigó, V., & Afonso, C. R. M. (2022) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2022.12.144 · Cited by 52 · see citing works
Han, X., Shen, J., Chen, S., Cai, Z., Zhu, Y., Yi, W., Li, K., Cai, W., Tao, B., Cui, W., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122057 · Cited by 52 · see citing works
Self-citationElectrospun nanofibers for bone regeneration: from biomimetic composition, structure to function
Zhao, T., Zhang, J., Gao, X., Yuan, D., Gu, Z., & Xu, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01182d · Cited by 51 · see citing works
Biomechanics and Mechanobiology of Additively Manufactured Porous Load‐Bearing Bone Implants
Jin, Y. Q., Li, J., Fan, H., Du, J., & He, Y. (2025) · Small · doi:10.1002/smll.202409955 · Cited by 50 · see citing works
Tang, Y., Wang, K., Wu, B., Yao, K., Feng, S., Zhou, X., & Xiang, L. (2023) · Advanced Materials · doi:10.1002/adma.202307756 · Cited by 49 · see citing works
Chen, L., Zhu, J., Ge, N., Liu, Y., Yan, Z., Liu, G., Li, Y., Wang, Y., Wu, G., Qiu, T., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2024.122992 · Cited by 53 · see citing works
Dutta, S. D., Patil, T. V., Ganguly, K., Randhawa, A., & Lim, K. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.05.014 · Cited by 52 · see citing works
Shi, Y., Tao, W., Yang, W., Wang, L., Qiu, Z., Qu, X., Dang, J., He, J., & Fan, H. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02310-0 · Cited by 47 · see citing works
Self-citationXiao, Y., Xu, M., Shi, Y., Wang, J., Li, Z., Tong, X., Yu, H., Lv, N., Jiang, W., Sun, Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c10123 · Cited by 47 · see citing works
Du, Y., Li, C., Zhang, Y., Xiong, W., Wang, F., Wang, J., Zhang, Y., Deng, L., Li, X., Chen, W., et al. (2022) · Research · doi:10.34133/research.0003 · Cited by 46 · see citing works
Self-citationZhou, Y., Wang, Z., Chen, Y., Wang, Y., Tang, L., Xi, Y., Lai, K., Zhang, Q., Li, S., Xu, D., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122772 · Cited by 46 · see citing works
Chen, J., Zhao, Y., Ruan, R., Feng, X., Niu, Z., Pan, L., Xia, C., Gu, Q., Feng, W., Zhao, L., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c13690 · Cited by 45 · see citing works
Miao, Q., Yang, X., Diao, J., Ding, H., Wu, Y., Ren, X., Gao, J., Ma, M., & Yang, S. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100871 · Cited by 44 · see citing works
A Zinc Oxide Nanowire‐Modified Mineralized Collagen Scaffold Promotes Infectious Bone Regeneration
Zhang, Y., Li, Z., Guo, B., Wang, Q., Chen, L., Zhu, L., Zhang, T., Wang, R., Li, W., Luo, D., et al. (2023) · Small · doi:10.1002/smll.202309230 · Cited by 44 · see citing works
Biomimetic Implant Surfaces and Their Role in Biological Integration—A Concise Review
Cruz, M., Silva, N., Marques, J. R. O. F., Mata, A., Silva, F. S., & Caramês, J. (2022) · Biomimetics · doi:10.3390/biomimetics7020074 · Cited by 44 · see citing works
Wang, J., Xue, Y., Wang, Y., Liu, C., Hu, S., Zhao, H., Gu, Q., Yang, H., Huang, L., Zhou, X., et al. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00279-2 · Cited by 43 · see citing works
Zhou, W., Liu, Y., Nie, X., Zhu, C., Xiong, L., Zhou, J., & Huang, W. H. (2025) · Nature Communications · doi:10.1038/s41467-025-58444-8 · Cited by 43 · see citing works
Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration
Li, J., Qu, Y., Chu, B., Wu, T., Pan, M., Mo, D., Li, L., Ming, Y., Yang, Y. S., Wang, M., et al. (2025) · Advanced Science · doi:10.1002/advs.202501209 · Cited by 43 · see citing works
Qiao, Y., Yu, L., Yang, P., Chen, M., Sun, H., Wang, L., Wu, B., Oh, C., Yang, H., Bai, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202302874 · Cited by 41 · see citing works
Self-citationZhuang, P., Wu, Y., Chen, Y., Zhang, Y., Leboucher, C., Rosenholm, J. M., & Zhang, H. (2024) · Biomedical Technology · doi:10.1016/j.bmt.2024.09.005 · Cited by 44 · see citing works
Recent Advancements in Metallic Drug-Eluting Implants
Alshimaysawee, S., Obaid, R. F., Al-Gazally, M. E., Ramírez‐Coronel, A. A., & Bathaei, M. S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010223 · Cited by 40 · see citing works
Comprehensive Overview of Interface Strategies in Implant Osseointegration
Lu, X., Zhao, Y., Peng, X., Lu, C., Wu, Z., Xu, H., Qin, Y., Xu, Y., Wang, Q., Hao, Y., et al. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202418849 · Cited by 41 · see citing works
Self-citationDutta, S. D., Ganguly, K., Hexiu, J., Randhawa, A., Moniruzzaman, M., & Lim, K. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300096 · Cited by 39 · see citing works
Luo, Y., Yang, Z., Zhao, X., Li, D., Li, Q., Wei, Y., Wan, L., Tian, M., & Kang, P. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100976 · Cited by 39 · see citing works
Yuan, Z., Wan, Z., Tian, Z., Han, Y., Huang, X., Feng, Y., Xie, W., Duan, X., Huang, S., Liu, X., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138076 · Cited by 38 · see citing works
Geng, X., Tang, Y., Yuan, B., Dai, Y., Yu, H., Xiong, Z., Zhu, Y., & Chen, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.151136 · Cited by 38 · see citing works
Ghorbani, F., Kim, M., Monavari, M., Ghalandari, B., & Boccaccini, A. R. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.940070 · Cited by 36 · see citing works
Implantable Medical Devices, Biomaterials, and the Foreign Body Response: A Surgical Perspective
Kalashnikov, N., Barralet, J. E., & Vorstenbosch, J. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37983 · Cited by 38 · see citing works
Bi, X., Mao, Z., Zhang, Y., Ren, Z., Yang, K., Yu, C., Chen, L., Zheng, R., Guan, J., Liu, Z., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123261 · Cited by 34 · see citing works
Dong, C., Tan, G., Zhang, G., Lin, W., & Wang, G. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1133995 · Cited by 32 · see citing works
Immunomodulatory zinc-based materials for tissue regeneration
Pan, X., Ou, M., Lu, Y., Nie, Q., Dai, X., & Liu, O. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213503 · Cited by 33 · see citing works
Dutta, S. D., Hexiu, J., Moniruzzaman, M., Patil, T. V., Acharya, R., Kim, J. S., & Lim, K. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122991 · Cited by 32 · see citing works
Canonical Wnt signaling enhances pro-inflammatory response to titanium by macrophages
Avery, D., Morandini, L., Sheakley, L. S., Shah, A. H., Bui, L., Abaricia, J. O., & Olivares‐Navarrete, R. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121797 · Cited by 32 · see citing works
Zheng, W., Wu, D., Zhang, Y., Luo, Y., Yang, L., Xu, X., & Luo, F. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213607 · Cited by 31 · see citing works
Zhou, W., Liu, Y., Dong, J., Hu, X., Su, Z., Zhang, X., Zhu, C., Xiong, L., Huang, W. X., & Bai, J. (2024) · Advanced Science · doi:10.1002/advs.202401833 · Cited by 29 · see citing works
Self-citationLi, C., Xu, W. L., Li, L., Zhou, Y., Yao, G., Chen, G., Xu, L., Yang, N., Yan, Z., Chen, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202408044 · Cited by 29 · see citing works
Self-citationOliver‐Cervelló, L., Martín-Gómez, H., Mandakhbayar, N., Jo, Y., Cavalcanti‐Adam, E. A., Kim, H., Ginebra, M., Lee, J., & Mas‐Moruno, C. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201339 · Cited by 29 · see citing works
Ge, J., Yu, Y., Li, J., Li, M., Xia, S., Xue, K., Wang, S., & Yang, C. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01066-x · Cited by 31 · see citing works
Injectable, Hierarchically Degraded Bioactive Scaffold for Bone Regeneration
Ye, J., Liu, N., Li, Z., Liu, L., Ming, Z., Wen, X., Wang, N., Xu, Y., Sun, B., & Zhou, Q. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c18824 · Cited by 28 · see citing works
Immunoregulatory silicon-deposited implant promotes osseointegration
Wang, T., Chen, X., Zhang, Y., Ye, T., Liu, Z., Wang, L., Cui, W., Pan, G., Zuo, G., & Deng, L. (2023) · Composites Part B Engineering · doi:10.1016/j.compositesb.2023.110618 · Cited by 28 · see citing works
Self-citationOcclusive membranes for guided regeneration of inflamed tissue defects
Choi, W., Mangal, U., Park, J., Kim, J., Jun, T., Jung, J. W., Choi, M., Jung, S.-W., Lee, M., Na, J.-Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43428-3 · Cited by 28 · see citing works
Design principles and application research of mussel-inspired materials: A review
Xu, S., Kang, M., Xin, X., Liang, J., Xiao, H., Lu, Y., Yang, J., & Zhai, H. (2023) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2023.111655 · Cited by 26 · see citing works
Ao, J., Zhang, X., You, Y., Chen, Y., Liu, Z., Gao, J., Qin, C., Hao, L., Zhao, J., & Jiang, R. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c06322 · Cited by 25 · see citing works
Xiang, E., Vaquette, C., Liu, S., Raveendran, N. T., Schulz, B. L., Nowwarote, N., Dargusch, M. S., Abdal‐hay, A., Fournier, B., & Ivanovski, S. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202410033 · Cited by 27 · see citing works
Yang, N., Wu, T., Li, M., Hu, X., Ma, R., Jiang, W., Su, Z., Yang, R., & Zhu, C. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.012 · Cited by 25 · see citing works
Chen, M., Qiao, Y., Yu, L., Wang, W., Wang, W., Sun, H., Xu, Y., Bai, J., Zhou, J., & Geng, D. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.017 · Cited by 25 · see citing works
Self-citationMao, J., Cai, Z., Liu, Z., Qian, S., Zhao, B., Zhang, Y., Zhuang, Y., Zhang, L., Mao, X., Zhang, Y., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137880 · Cited by 25 · see citing works
Self-citationXu, Y., Guan, J., Wang, Q., Xue, R., He, Z., Lu, X., Fan, J., Yu, H., Turghun, C., Wei, Y., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c21672 · Cited by 25 · see citing works
Recent advances in immunomodulatory hydrogels biomaterials for bone tissue regeneration
Fu, M., Yang, C., & Sun, G. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.09.010 · Cited by 24 · see citing works
3D‐Printed In Situ Growth of Bilayer MOF Hydrogels for Accelerated Osteochondral Defect Repair
Qin, K., Huang, X., Wang, S., Liang, J., & Fan, Z. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403840 · Cited by 24 · see citing works
Sun, Y., Yao, X., Zhang, Y., Zhang, W., Zhu, C., Shen, C., Wang, Y., & Wang, X. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c23069 · Cited by 24 · see citing works
Liu, X., Zhang, Q., Cao, Y., Hussain, Z., Xu, M., Liu, Y., Ullah, I., Lu, Z., Osaka, A., Lin, J., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304668 · Cited by 23 · see citing works
Kim, C., Kang, N., Min, S., Thangam, R., Lee, S., Hong, H., Kim, K., Kim, S. Y., Kim, D., Rha, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54557-8 · Cited by 23 · see citing works
Cai, W., Xu, X., Jiang, Y., Cheng, K., Liu, F., Song, C., Guo, D., Hu, Z., Liu, Z., & Liu, Z. (2023) · Materials Today Advances · doi:10.1016/j.mtadv.2023.100381 · Cited by 23 · see citing works
Ji, Z., Wan, Y., Wang, H., Yu, M., Zhao, Z., Wang, T., Ma, G., Fan, S., & Liu, Z. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acd976 · Cited by 23 · see citing works
Self-citationLiu, X., Zhou, Z., Zeng, W., Zeng, Q., & Zhang, X. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1277686 · Cited by 23 · see citing works
Lai, P., Ma, Y., Sang, W., Zhou, Q., Chen, H., Wang, C., Yin, J., Wang, T., Zhu, L., Zhou, X., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c19160 · Cited by 22 · see citing works
Self-citationZhou, X., Wang, Z., Li, T., Liu, Z., Sun, X., Wang, W., Chen, L., & He, C. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100681 · Cited by 22 · see citing works
Zhang, X., Guan, S. W., Qiu, J., Qiao, Y., Shi, Q., Tan, J., Yeung, K., & Liu, X. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00217 · Cited by 22 · see citing works
Xu, Y., Zhu, S., Xia, C., Yu, H., Shi, S., Chen, K., He, Y., Deng, C., Jin, H., Liu, J., et al. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.06.030 · Cited by 27 · see citing works
Types of Bone Substitutes and Their Application in Regenerative Medicine: A Systematic Review
Ivanova, N., Ivanov, S., Peev, S., & Dikova, T. D. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16090341 · Cited by 21 · see citing works
Geometric Angles and Gene Expression in Cells for Structural Bone Regeneration
Wang, J., Yang, Q., Saiding, Q., Chen, L., Liu, M., Wang, Z., Xiang, L., Deng, L., Chen, Y., & Cui, W. (2023) · Advanced Science · doi:10.1002/advs.202304111 · Cited by 21 · see citing works
Self-citationLi, S., Man, Z., Zuo, K., Zhang, L., Zhang, T., Xiao, G., Lu, Y., Li, W., & Li, N. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.05.004 · Cited by 21 · see citing works
Frumento, D., & Ţălu, Ş. (2025) · Coatings · doi:10.3390/coatings15091026 · Cited by 20 · see citing works
Recent progress of 3D printed responsive scaffolds for bone repair: A review
Bai, Y., Wu, N., Li, X., Liu, Z., Li, K., Jiao, T., & Liu, F. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102351 · Cited by 22 · see citing works
Yang, X., Wang, Q., Yan, C., Huang, D., Zhang, Y., He, H., Xiong, S., Li, C., Chen, P., Ye, T., et al. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113643 · Cited by 20 · see citing works
Self-citationEngineering tunable dual peptide hybrid coatings promote osseointegration of implants
Shou, Z., Bai, Z., Zhou, H., Shen, Y., Huang, X., Meng, H., Xu, C., Wu, S., Li, N., & Chen, C. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100921 · Cited by 20 · see citing works
Engineered Metallic Ion-Based Hydrogel for Tendon-Bone Reconstruction
Zhang, X., Ma, J., Hu, H., Xu, Z., Liu, J., Chen, J., Chen, B., Shi, L., Luo, H., Chen, G., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c16494 · Cited by 20 · see citing works
Self-citationYang, N., Ma, T., Wang, W., Sun, J., Zhang, X., Hu, J., & Chen, Z. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102389 · Cited by 20 · see citing works
Li, J., Fan, M., Jiao, Z., Chan, Y. K., Cheng, L., Li, J., Deng, Y., & Liang, K. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102541 · Cited by 20 · see citing works
Zhang, L., Li, Z., Fu, Y., Tian, H., Wang, T., Liu, H., Li, J., Liu, H., Ge, S., & Ma, B. (2024) · Small Structures · doi:10.1002/sstr.202400408 · Cited by 19 · see citing works
Self-citationEngineering immunomodulatory hydrogels and cell-laden systems towards bone regeneration
Nadine, S., Correia, C. R., & Mano, J. F. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213058 · Cited by 20 · see citing works
Shah, S. A., Sohail, M. F., Nakielski, P., Rinoldi, C., Zargarian, S. S., Kosik‐Kozioł, A., Ziai, Y., Bayan, M. A. H., Zakrzewska, A., Rybak, D., et al. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c01133 · Cited by 18 · see citing works
Luo, Y., Liu, B., Qiu, Y., Li, L., Yang, F., Zhang, C., & Wang, J. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.01.034 · Cited by 19 · see citing works
The changes and potential effects of zinc homeostasis in periodontitis microenvironment
Liu, Y., Li, X., Liu, S., Du, J., Xu, J., Liu, Y. F., & Guo, L. (2022) · Oral Diseases · doi:10.1111/odi.14354 · Cited by 18 · see citing works
Zhang, Y., Wei, J., Xing-bang, Y., Chen, L., Ren, R., Dong, Y., Wang, S., Zhu, M., Ming, N., zhu, Z., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100816 · Cited by 18 · see citing works
- Authors
- Wang, T., Bai, J., Lu, M., Huang, C., Geng, D., Chen, G., Wang, L., Qi, J., Cui, W., & Deng, L.
- Affiliations
- Shanghai Jiao Tong University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Jiaxing University (CN)
- Corresponding author
- Cui, Wenguo
- Deng, Lianfu
- Venue
- Nature Communications
- Published
- 2022-01-10
- Volume
- 13
- Issue
- 1
- Pages
- 160-160
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8748715
- OpenAlex
- W4225729780
- Cited by
- 221
- References
- 69
- Citations by year
- 2026: 31 · 2025: 71 · 2024: 52 · 2023: 45 · 2022: 22
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Update notices
- correction (2026-09-09)
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82102535, 81972134)
- China Postdoctoral Science Foundation (2016M661560)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Keywords
- implant surface modification, mussel adhesion, zinc coordination, M2 macrophages, IL-10, osteoimmunomodulation, bone-implant interface, bone regeneration, titanium implants
- MeSH terms
- RAW 264.7 Cells, Bone-Implant Interface, Animals, Cell Differentiation, Femur, Lipopolysaccharides, Macrophage Activation, Macrophages, Male, Osteoblasts, Osteogenesis, Protein Precursors, Titanium, Zinc, Biomarkers, Antigens, CD, Interleukin-10, Rats, Sprague-Dawley, Prostheses and Implants, Bivalvia, Mice, Rats, Bone Morphogenetic Protein 2, Mesenchymal Stem Cells
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