The DOI matches its Crossref record; 58 of the 60 references it cites were found in a registry or an index.
Analysis of SARS-CoV-2 vertical transmission during pregnancy
Open accessPublished version of a preprint
Abstract
The impact of SARS-CoV-2 infection during gestation remains unclear. Here, we analyse the viral genome on maternal and newborns nasopharyngeal swabs, vaginal swabs, maternal and umbilical cord plasma, placenta and umbilical cord biopsies, amniotic fluids and milk from 31 mothers with SARS-CoV-2 infection. In addition, we also test specific anti-SARS-CoV-2 antibodies and expression of genes involved in inflammatory responses in placentas, and in maternal and umbilical cord plasma. We detect SARS-CoV-2 genome in one umbilical cord blood and in two at-term placentas, in one vaginal mucosa and in one milk specimen. Furthermore, we report the presence of specific anti-SARS-CoV-2 IgM and IgG antibodies in one umbilical cord blood and in one milk specimen. Finally, in the three documented cases of vertical transmission, SARS-CoV-2 infection was accompanied by a strong inflammatory response. Together, these data support the hypothesis that in utero SARS-CoV-2 vertical transmission, while low, is possible. These results might help defining proper obstetric management of COVID-19 pregnant women, or putative indications for mode and timing of delivery.
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“Rare in utero transmission of SARS-CoV-2 has also been reported222,223; its implications on maternal, fetal and neonatal health are under active investigation.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [223]
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Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
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Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China
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The trinity of COVID-19: immunity, inflammation and intervention
Tay, M. Z., Poh, C. M., Rénia, L., MacAry, P. A., & Ng, L. F. P. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0311-8 · Cited by 4,360
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Antibody responses to SARS-CoV-2 in patients with COVID-19
Long, Q.-X., Liu, B.-Z., Deng, H.-J., Wu, G.-C., Deng, K., Chen, Y.-K., Liao, P., Qiu, J.-F., Lin, Y., Cai, X.-F., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0897-1 · Cited by 2,876
Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia
Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Gui-ping, C., Xia, S., & Zhou, W. (2020) · Translational Pediatrics · doi:10.21037/tp.2020.02.06 · Cited by 1,475
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Rasmussen, S. A., Smulian, J. C., Lednicky, J. A., Wen, T. S.-T., & Jamieson, D. J. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.02.017 · Cited by 1,306
Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients
Zhou, Y., Fu, B., Zheng, X., Wang, D., Zhao, C., Qi, Y., Sun, R., Tian, Z., Xu, X., & Wei, H. (2020) · National Science Review · doi:10.1093/nsr/nwaa041 · Cited by 1,295
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Raschetti, R., Vivanti, A. J., Vauloup‐Fellous, C., Loi, B., Benachi, A., & Luca, D. D. (2020) · Nature Communications · doi:10.1038/s41467-020-18982-9 · Cited by 327
Metadata
- Authors
- Fenizia, C., Biasin, M., Cetin, I., Vergani, P., Mileto, D., Spinillo, A., Gismondo, M. R., Perotti, F., Callegari, C., Mancon, A., Cammarata, S., Beretta, I., Nebuloni, M., Trabattoni, D., Clerici, M., & Savasi, V.
- Affiliations
- University of Milan (IT)
- ASST Fatebenefratelli Sacco (IT)
- University of Milano-Bicocca (IT)
- University of Pavia (IT)
- Policlinico San Matteo Fondazione (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Corresponding author
- Savasi, Valeria
- ORCID
- Venue
- Nature Communications
- Published
- 2020-10-12
- Volume
- 11
- Issue
- 1
- Pages
- 5128-5128
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC7552412
- OpenAlex
- W3092146863
- Cited by
- 361
- References
- 60
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 30 · 2023: 55 · 2022: 93 · 2021: 149 · 2020: 13
- FWCI
- 47.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
- BOA (University of Milano-Bicocca) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Università degli Studi di Milano
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, COVID-19 pandemic, vertical transmission, pregnancy, placenta, umbilical cord blood, SARS-CoV-2 antibodies, IgM and IgG antibodies, inflammation, placental gene expression, vaginal mucosa, breast milk, obstetric management
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adolescent, Adult, Antibodies, Viral, Female, Humans, Infant, Newborn, Inflammation, Middle Aged, Pneumonia, Viral, Pregnancy, Pregnancy Complications, Infectious, Genome, Viral, Coronavirus Infections, Infectious Disease Transmission, Vertical, Young Adult, Pandemics
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