A Comprehensive Review of mRNA Vaccines

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2034577 · Cited by 14,592 · see citing works

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

Baden, L. R., El Sahly, H. M., Essink, B., Kotloff, K., Frey, S., Novak, R., Diemert, D., Spector, S. A., Rouphael, N., Creech, C. B., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2035389 · Cited by 10,119 · see citing works

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., RINGOLD, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,954 · see citing works

mRNA vaccines — a new era in vaccinology

Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667 · see citing works

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

Suk, J. S., Xu, Q., Kim, N., Hanes, J., & Ensign, L. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.012 · Cited by 4,523 · see citing works

Direct Gene Transfer into Mouse Muscle in Vivo

Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173 · cited 1× · see citing works

Lipid nanoparticles for mRNA delivery

Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076 · see citing works

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

Kawai, T., & Akira, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.006 · Cited by 3,658 · see citing works

A global survey of potential acceptance of a COVID-19 vaccine

Lazarus, J. V., Ratzan, S. C., Palayew, A., Gostin, L. O., Larson, H. J., Rabin, K., Kimball, S., & El-Mohandes, A. (2021) · Nature Medicine · doi:10.1038/s41591-020-1124-9 · Cited by 2,904 · see citing works

RNA-Based COVID-19 Vaccine BNT162b2 Selected for a Pivotal Efficacy Study

Walsh, E. E., Frenck, R., Falsey, A. R., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Neuzil, K., Mulligan, M. J., Bailey, R., et al. (2020) · doi:10.1101/2020.08.17.20176651 · Cited by 2,615 · see citing works

COVID-19 Vaccine Hesitancy Worldwide: A Concise Systematic Review of Vaccine Acceptance Rates

Sallam, M. (2021) · Vaccines · doi:10.3390/vaccines9020160 · Cited by 2,128 · see citing works

Rational design of cationic lipids for siRNA delivery

Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822 · cited 1× · see citing works

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akinc, A., Maier, M. A., Manoharan, M., Fitzgerald, K., Jayaraman, M., Barros, S., Ansell, S., Du, X., Hope, M. J., Madden, T. D., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0591-y · Cited by 1,636 · see citing works

Freeze-drying of nanoparticles: Formulation, process and storage considerations

ABDELWAHED, W., DEGOBERT, G., STAINMESSE, S., & FESSI, H. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.017 · Cited by 1,611 · see citing works

mRNA-lipid nanoparticle COVID-19 vaccines: structure and stability

Schoenmaker, L., Witzigmann, D., Kulkarni, J. A., Verbeke, R., Kersten, G., Jiskoot, W., & Crommelin, D. J. A. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120586 · Cited by 1,566 · see citing works

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555 · see citing works

RNAi-mediated gene silencing in non-human primates

Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., et al. (2006) · Nature · doi:10.1038/nature04688 · Cited by 1,357 · see citing works

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akinc, A., Zumbuehl, A., Goldberg, M. S., Leshchiner, E. S., Busini, V., Hossain, N., Bacallado, S., Nguyen, D. N., Fuller, J. E., Alvarez, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1402 · Cited by 1,228 · see citing works

The role of lipid components in lipid nanoparticles for vaccines and gene therapy

Gregersen, C. H., Kulkarni, J. A., Witzigmann, D., Lind, M. L., Petersson, K., & Simonsen, J. B. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114416 · Cited by 1,215 · see citing works

Lipid Nanoparticle Systems for Enabling Gene Therapies

Cullis, P. R., & Hope, M. J. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.013 · Cited by 1,208 · see citing works

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Corbett, K. S., Flynn, B., Foulds, K. E., Francica, J. R., Boyoglu-Barnum, S., Werner, A. P., Flach, B., O’Connell, S., Bock, K. W., Minai, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2024671 · Cited by 1,066 · see citing works

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Pardi, N., Tuyishime, S., Muramatsu, H., Kariko, K., Mui, B. L., Tam, Y. K., Madden, T. D., Hope, M. J., & Weissman, D. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.007 · Cited by 1,014 · see citing works

Lipid-like materials for low-dose, in vivo gene silencing

Love, K. T., Mahon, K. P., Levins, C. G., Whitehead, K. A., Querbes, W., Dorkin, J. R., Qin, J., Cantley, W., Qin, L. L., Racie, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910603106 · Cited by 969 · see citing works

Cationic liposome-mediated RNA transfection.

Malone, R. W., Felgner, P. L., & Verma, I. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6077 · Cited by 911 · see citing works

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

Daffis, S., Szretter, K. J., Schriewer, J. M., Li, J., Youn, S., Errett, J. S., Lin, T., Schneller, S. W., Züst, R., Dong, H., et al. (2010) · Nature · doi:10.1038/nature09489 · Cited by 910 · see citing works

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Karikó, K., Muramatsu, H., Ludwig, J., & Weissman, D. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr695 · Cited by 898 · see citing works

mRNA capping: biological functions and applications

Ramanathan, A., Robb, G. B., & Chan, S. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw551 · Cited by 892 · see citing works

The clinical progress of mRNA vaccines and immunotherapies

Barbier, A. J., Jiang, A. Y., Zhang, P., Wooster, R., & Anderson, D. G. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01294-2 · Cited by 823 · see citing works

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

Sabnis, S., Kumarasinghe, E. S., Salerno, T., Mihai, C., Ketova, T., Senn, J. J., Lynn, A., Bulychev, A., McFadyen, I., Chan, J., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.03.010 · Cited by 820 · see citing works

The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes

Tang, M., & Szoka, F. C. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300454 · Cited by 814 · see citing works

Tools for translation: non-viral materials for therapeutic mRNA delivery

Hajj, K. A., & Whitehead, K. A. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.56 · Cited by 799 · see citing works

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Alameh, M.-G., Tombácz, I., Bettini, E., Lederer, K., Ndeupen, S., Sittplangkoon, C., Wilmore, J. R., Gaudette, B. T., Soliman, O. Y., Pine, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.001 · Cited by 775 · see citing works

Diversity and clonal selection in the human T-cell repertoire

Qi, Q., Liu, Y., Cheng, Y., Glanville, J., Zhang, D., Lee, J.-Y., Olshen, R. A., Weyand, C. M., Boyd, S. D., & Goronzy, J. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409155111 · Cited by 755 · see citing works

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

Miao, L., Li, L., Huang, Y., Delcassian, D., Chahal, J., Han, J., Shi, Y., Sadtler, K., Gao, W., Lin, J., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0247-3 · Cited by 723 · see citing works

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

Oberli, M. A., Reichmuth, A. M., Dorkin, J. R., Mitchell, M. J., Fenton, O. S., Jaklenec, A., Anderson, D. G., Langer, R., & Blankschtein, D. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b03329 · Cited by 719 · see citing works

N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

Andries, O., Mc Cafferty, S., De Smedt, S. C., Weiss, R., Sanders, N. N., & Kitada, T. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.051 · Cited by 701 · see citing works

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

Kozma, G. T., Shimizu, T., Ishida, T., & Szebeni, J. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.024 · Cited by 696 · see citing works

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Anderson, B. R., Muramatsu, H., Nallagatla, S. R., Bevilacqua, P. C., Sansing, L. H., Weissman, D., & Karikó, K. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq347 · Cited by 682 · see citing works

A thermostable mRNA vaccine against COVID-19

Zhang, N.-N., Li, X.-F., Deng, Y.-Q., Zhao, H., Huang, Y.-J., Yang, G., Huang, W.-J., Gao, P., Zhou, C., Zhang, R.-R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.07.024 · Cited by 671 · cited 1× · see citing works

History of vaccination

Plotkin, S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400472111 · Cited by 642 · see citing works

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

Maier, M. A., Jayaraman, M., Matsuda, S., Liu, J., Barros, S., Querbes, W., Tam, Y. K., Ansell, S. M., Kumar, V., Qin, J., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.124 · Cited by 625 · see citing works

COVID-19 mortality risk for older men and women

Yanez, N. D., Weiss, N. S., Romand, J.-A., & Treggiari, M. M. (2020) · BMC Public Health · doi:10.1186/s12889-020-09826-8 · Cited by 616 · see citing works

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

Patel, S., Ashwanikumar, N., Robinson, E., Xia, Y., Mihai, C., Griffith, J. P., Hou, S., Esposito, A. A., Ketova, T., Welsher, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14527-2 · Cited by 601 · see citing works

Nanomaterial Delivery Systems for mRNA Vaccines

Buschmann, M. D., Carrasco, M. J., Alishetty, S., Paige, M., Alameh, M. G., & Weissman, D. (2021) · Vaccines · doi:10.3390/vaccines9010065 · Cited by 582 · see citing works

The BCG World Atlas: A Database of Global BCG Vaccination Policies and Practices

Zwerling, A. A., Behr, M. A., Verma, A. D., Brewer, T. F., Menzies, D., & Pai, M. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001012 · Cited by 576 · see citing works

Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids

Heyes, J., Palmer, L., Bremner, K., & MacLachlan, I. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.06.014 · Cited by 572 · see citing works

An overview of liposome lyophilization and its future potential

Chen, C., Han, D., Cai, C., & Tang, X. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.10.024 · Cited by 547 · see citing works

mRNA vaccines manufacturing: challenges and bottlenecks

Rosa, S. S., Prazeres, D. M. F., Azevedo, A. M., & Marques, M. P. C. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.03.038 · Cited by 545 · see citing works

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

Yanez Arteta, M., Kjellman, T., Bartesaghi, S., Wallin, S., Wu, X., Kvist, A. J., Dabkowska, A., Székely, N., Radulescu, A., Bergenholtz, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720542115 · Cited by 534 · see citing works

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

Alberer, M., Gnad-Vogt, U., Hong, H. S., Mehr, K. T., Backert, L., Finak, G., Gottardo, R., Bica, M. A., Garofano, A., Koch, S. D., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31665-3 · Cited by 530 · see citing works

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

Pardi, N., Hogan, M. J., Naradikian, M. S., Parkhouse, K., Cain, D. W., Jones, L., Moody, M. A., Verkerke, H. P., Myles, A., Willis, E., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171450 · Cited by 530 · see citing works

Immunosenescence and human vaccine immune responses

Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0164-9 · Cited by 530 · see citing works

Self-assembled mRNA vaccines

Kim, J., Eygeris, Y., Gupta, M., & Sahay, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.014 · Cited by 514 · see citing works

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Mui, B. L., Tam, Y. K., Jayaraman, M., Ansell, S. M., Du, X., Tam, Y. Y. C., Lin, P. J. C., Chen, S., Narayanannair, J. K., Rajeev, K. G., et al. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.66 · Cited by 509 · see citing works

Self-amplifying RNA vaccines for infectious diseases

Bloom, K., van den Berg, F., & Arbuthnot, P. (2021) · Gene Therapy · doi:10.1038/s41434-020-00204-y · Cited by 487 · see citing works

Protein Stability During Freezing: Separation of Stresses and Mechanisms of Protein Stabilization

Bhatnagar, B. S., Bogner, R. H., & Pikal, M. J. (2007) · Pharmaceutical Development and Technology · doi:10.1080/10837450701481157 · Cited by 483 · see citing works

Reports of Anaphylaxis After Receipt of mRNA COVID-19 Vaccines in the US—December 14, 2020-January 18, 2021

Shimabukuro, T. T., Cole, M., & Su, J. R. (2021) · JAMA · doi:10.1001/jama.2021.1967 · Cited by 475 · see citing works

Induction of virus‐specific cytotoxic T lymphocytes <i>in vivo</i> by liposome‐entrapped mRNA

Martinon, F., Krishnan, S., Lenzen, G., Magné, R., Gomard, E., Guillet, J., Lévy, J., & Meulien, P. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230749 · Cited by 473 · see citing works

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

Feldman, R. A., Fuhr, R., Smolenov, I., (Mick) Ribeiro, A., Panther, L., Watson, M., Senn, J. J., Smith, M., Almarsson, Ӧ., Pujar, H. S., et al. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.04.074 · Cited by 454 · see citing works

Microfluidic formulation of nanoparticles for biomedical applications

Shepherd, S. J., Issadore, D., & Mitchell, M. J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120826 · Cited by 448 · see citing works

Role of 5′‐ and 3′‐untranslated regions of mRNAs in human diseases

Chatterjee, S., & Pal, J. K. (2009) · Biology of the Cell · doi:10.1042/bc20080104 · Cited by 439 · see citing works

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and <i>Toxoplasma gondii</i> challenges with a single dose

Chahal, J. S., Khan, O. F., Cooper, C. L., McPartlan, J. S., Tsosie, J. K., Tilley, L. D., Sidik, S. M., Lourido, S., Langer, R., Bavari, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600299113 · Cited by 414 · see citing works

Freezing, Drying, and/or Vitrification of Membrane– Solute–Water Systems

Wolfe, J., & Bryant, G. (1999) · Cryobiology · doi:10.1006/cryo.1999.2195 · Cited by 389 · see citing works

Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery

Fang, Y., Xue, J., Gao, S., Lu, A., Yang, D., Jiang, H., He, Y., & Shi, K. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1388451 · Cited by 388 · see citing works

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation

Lederer, K., Castaño, D., Gómez Atria, D., Oguin, T. H., Wang, S., Manzoni, T. B., Muramatsu, H., Hogan, M. J., Amanat, F., Cherubin, P., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.11.009 · Cited by 383 · see citing works

Risk of anaphylaxis after vaccination in children and adults.

McNeil, M. M., Weintraub, E. S., Duffy, J., Sukumaran, L., Jacobsen, S. J., Klein, N. P., Hambidge, S. J., Lee, G. M., Jackson, L. A., Irving, S. A., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.07.048 · Cited by 381 · see citing works

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

Laczko, D. I., Hogan, M. J., Toulmin, S. A., Hicks, P. D., Lederer, K., Gaudette, B. T., Castaño, D., Amanat, F., Muramatsu, H., Oguin, T. H., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.019 · Cited by 366 · see citing works

Analysis of SARS-CoV-2 vertical transmission during pregnancy

Fenizia, C., Biasin, M., Cetin, I., Vergani, P., Mileto, D., Spinillo, A., Gismondo, M. R., Perotti, F., Callegari, C., Mancon, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18933-4 · Cited by 361 · see citing works

Control of mammalian translation by mRNA structure near caps

Babendure, J. R., Babendure, J. L., Ding, J.-H., & Tsien, R. Y. (2006) · RNA · doi:10.1261/rna.2309906 · Cited by 339 · see citing works

Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine

Muramatsu, H., Lam, K., Bajusz, C., Laczkó, D., Karikó, K., Schreiner, P., Martin, A., Lutwyche, P., Heyes, J., & Pardi, N. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.02.001 · Cited by 331 · see citing works

Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

Veiga, N., Goldsmith, M., Granot, Y., Rosenblum, D., Dammes, N., Kedmi, R., Ramishetti, S., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-06936-1 · Cited by 308 · see citing works

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice

Freyn, A. W., Ramos da Silva, J., Rosado, V. C., Bliss, C. M., Pine, M., Mui, B. L., Tam, Y. K., Madden, T. D., de Souza Ferreira, L. C., Weissman, D., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.04.018 · Cited by 299 · see citing works

A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo

Jiang, C., Mei, M., Li, B., Zhu, X., Zu, W., Tian, Y., Wang, Q., Guo, Y., Dong, Y., & Tan, X. (2017) · Cell Research · doi:10.1038/cr.2017.16 · Cited by 295 · see citing works

Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis

Hou, X., Zhang, X., Zhao, W., Zeng, C., Deng, B., McComb, D. W., Du, S., Zhang, C., Li, W., & Dong, Y. (2020) · Nature Nanotechnology · doi:10.1038/s41565-019-0600-1 · Cited by 290 · see citing works

Reversal of Diabetes Insipidus in Brattleboro Rats: Intrahypothalamic Injection of Vasopressin mRNA

Jirikowski, G. F., Sanna, P. P., Maciejewski-Lenoir, D., & Bloom, F. E. (1992) · Science · doi:10.1126/science.1546298 · Cited by 282 · see citing works

Control of poly(A) tail length

Eckmann, C. R., Rammelt, C., & Wahle, E. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.56 · Cited by 272 · see citing works

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

Robinson, E., MacDonald, K. D., Slaughter, K., McKinney, M., Patel, S., Sun, C., & Sahay, G. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.014 · Cited by 272 · see citing works

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease

Richner, J. M., Jagger, B. W., Shan, C., Fontes, C. R., Dowd, K. A., Cao, B., Himansu, S., Caine, E. A., Nunes, B. T. D., Medeiros, D. B. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.040 · Cited by 267 · see citing works

From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

Pilkington, E. H., Suys, E. J. A., Trevaskis, N. L., Wheatley, A. K., Zukancic, D., Algarni, A., Al-Wassiti, H. A., Davis, T. P., Pouton, C. W., Kent, S. J., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.023 · Cited by 265 · see citing works

Age‐related loss of naïve T cells and dysregulation of T‐cell/B‐cell interactions in human lymph nodes

Lazuardi, L., Jenewein, B., Wolf, A. M., Pfister, G., Tzankov, A., & Grubeck‐Loebenstein, B. (2005) · Immunology · doi:10.1111/j.1365-2567.2004.02006.x · Cited by 263 · see citing works

An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

Li, B., Luo, X., Deng, B., Wang, J., McComb, D. W., Shi, Y., Gaensler, K. M. L., Tan, X., Dunn, A. L., Kerlin, B. A., et al. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b03528 · Cited by 261 · see citing works

Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery

Ho, W., Gao, M., Li, F., Li, Z., Zhang, X., & Xu, X. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001812 · Cited by 261 · see citing works

Lipid nanoparticles for delivery of messenger RNA to the back of the eye

Patel, S., Ryals, R. C., Weller, K. K., Pennesi, M. E., & Sahay, G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.015 · Cited by 260 · see citing works

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

Lutz, J., Lazzaro, S., Habbeddine, M., Schmidt, K. E., Baumhof, P., Mui, B. L., Tam, Y. K., Madden, T. D., Hope, M. J., Heidenreich, R., et al. (2017) · npj Vaccines · doi:10.1038/s41541-017-0032-6 · Cited by 257 · see citing works

Controlling timing and location in vaccines

Irvine, D. J., Aung, A., & Silva, M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.019 · Cited by 251 · see citing works

Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling

Zhang, H., You, X., Wang, X., Cui, L., Wang, Z., Xu, F., Li, M., Yang, Z., Liu, J., Huang, P., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005191118 · Cited by 251 · see citing works

The osmotic rupture hypothesis of intracellular freezing injury

Muldrew, K. B., & McGann, L. E. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80806-9 · Cited by 247 · see citing works

Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response

Yu, X. M., Dai, Y., Zhao, Y., Qi, S., Liu, L., Lu, L., Luo, Q., & Zhang, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-14906-9 · Cited by 246 · see citing works

Regulation of mRNA cap methylation

Cowling, V. H. (2009) · Biochemical Journal · doi:10.1042/bj20091352 · Cited by 237 · see citing works

Freeze-drying of nanoparticles: How to overcome colloidal instability by formulation and process optimization

Trenkenschuh, E., & Frieß, W. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.05.024 · Cited by 234 · see citing works

Long-term storage of lipid-like nanoparticles for mRNA delivery

Zhao, P., Hou, X., Yan, J., Du, S., Xue, Y., Li, W., Xiang, G., & Dong, Y. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.03.001 · Cited by 233 · see citing works

Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging

Lindsay, K. E., Bhosle, S. M., Zurla, C., Beyersdorf, J., Rogers, K. A., Vanover, D., Xiao, P., Araínga, M., Shirreff, L. M., Pitard, B., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0378-3 · Cited by 218 · see citing works

Exosomes as Naturally Occurring Vehicles for Delivery of Biopharmaceuticals: Insights from Drug Delivery to Clinical Perspectives

Butreddy, A., Kommineni, N., & Dudhipala, N. R. (2021) · Nanomaterials · doi:10.3390/nano11061481 · Cited by 214 · see citing works

Techniques to measure lipase and esterase activity in vitro

Gilham, D., & Lehner, R. S. (2005) · Methods · doi:10.1016/j.ymeth.2004.11.003 · Cited by 212 · see citing works

Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine

Kwon, H., Kim, M., Seo, Y., Moon, Y. S., Lee, H. J., Lee, K., & Lee, H. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.034 · Cited by 208 · see citing works

Interactions between soluble sugars and POPC (1-palmitoyl-2-oleoylphosphatidylcholine) during dehydration: vitrification of sugars alters the phase behavior of the phospholipid

Koster, K. L., Webb, M. S., Bryant, G., et al. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90343-3 · Cited by 207 · see citing works

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

Paunovska, K., Da Silva Sanchez, A. J., Sago, C. D., Gan, Z., Lokugamage, M. P., Islam, F. Z., Kalathoor, S., Krupczak, B. R., & Dahlman, J. E. (2019) · Advanced Materials · doi:10.1002/adma.201807748 · Cited by 205 · see citing works

Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways

Li, M., Zhao, M., Fu, Y., Li, Y., Gong, T., Zhang, Z., & Sun, X. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.043 · Cited by 201 · see citing works

Is vitrification involved in depression of the phase transition temperature in dry phospholipids?

Crowe, J. H., Hoekstra, F. A., Nguyen, K. H. N., & Crowe, L. M. (1996) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(95)00287-1 · Cited by 198 · see citing works

Safety Evaluation of Lipid Nanoparticle–Formulated Modified mRNA in the Sprague-Dawley Rat and Cynomolgus Monkey

Sedic, M., Senn, J. J., Lynn, A., Laska, M., Smith, M., Platz, S. J., Bolen, J., Hoge, S., Bulychev, A., Jacquinet, E., et al. (2018) · Veterinary Pathology · doi:10.1177/0300985817738095 · Cited by 195 · see citing works

CD28 Expression in T Cell Aging and Human Longevity

Boucher, N., Dufeu-Duchesne, T., Vicaut, E., Farge, D., Effros, R. B., & Schächter, F. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(97)00132-0 · Cited by 194 · see citing works

Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications

Iqbal, S., Blenner, M., Alexander-Bryant, A. A., & Larsen, J. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.9b01754 · Cited by 192 · see citing works

How do cells cope with RNA damage and its consequences?

Yan, L. L., & Zaher, H. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.006513 · Cited by 185 · see citing works

Clinical and immunological effects of mRNA vaccines in malignant diseases

Heine, A., Juranek, S., & Brossart, P. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01339-1 · Cited by 185 · see citing works

HPLC purification of in vitro transcribed long RNA

Weissman, D., Pardi, N., Muramatsu, H., & Karikó, K. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-260-5_3 · Cited by 180 · see citing works

Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo

Sato, Y., Hashiba, K., Sasaki, K., Maeki, M., Tokeshi, M., & Harashima, H. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.001 · Cited by 180 · see citing works

Eliciting B cell immunity against infectious diseases using nanovaccines

Singh, A. (2021) · Nature Nanotechnology · doi:10.1038/s41565-020-00790-3 · Cited by 169 · see citing works

Lipid nanoparticles for short interfering RNA delivery

Leung, A. K. K., Tam, Y. Y. C., & Cullis, P. R. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800148-6.00004-3 · Cited by 158 · see citing works

Instability of therapeutic proteins — An overview of stresses, stabilization mechanisms and analytical techniques involved in lyophilized proteins

Butreddy, A., Janga, K. Y., Ajjarapu, S., Sarabu, S., & Dudhipala, N. R. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.11.188 · Cited by 158 · see citing works

Constrained Nanoparticles Deliver siRNA and sgRNA to T Cells In Vivo without Targeting Ligands

Lokugamage, M. P., Sago, C. D., Gan, Z., Krupczak, B. R., & Dahlman, J. E. (2019) · Advanced Materials · doi:10.1002/adma.201902251 · Cited by 155 · see citing works

Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint

Granot-Matok, Y., & Peer, D. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.08.015 · Cited by 154 · see citing works

Trehalose and dry dipalmitoylphosphatidylcholine revisited

Crowe, L. M., & Crowe, J. H. (1988) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(88)90392-6 · Cited by 152 · see citing works

Messenger RNA-based vaccines

Pascolo, S. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.8.1285 · Cited by 152 · see citing works

Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo

Zeng, C., Hou, X., Yan, J., Zhang, C., Li, W., Zhao, W., Du, S., & Dong, Y. (2020) · Advanced Materials · doi:10.1002/adma.202004452 · Cited by 152 · see citing works

Lipid-Based Nanoparticles for Delivery of Vaccine Adjuvants and Antigens: Toward Multicomponent Vaccines

Chatzikleanthous, D., O’Hagan, D. T., & Adamo, R. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00447 · Cited by 150 · see citing works

Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines

Carralot, J.-P., Probst, J., Hoerr, I., Scheel, B., Teufel, R., Jung, G., Rammensee, H.-G., & Pascolo, S. (2004) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/s00018-004-4255-0 · Cited by 149 · see citing works

Immunogenicity and protective efficacy induced by self-amplifying mRNA vaccines encoding bacterial antigens

Maruggi, G., Chiarot, E., Giovani, C., Buccato, S., Bonacci, S., Frigimelica, E., Margarit, I., Geall, A., Bensi, G., & Maione, D. (2017) · Vaccine · doi:10.1016/j.vaccine.2016.11.040 · Cited by 149 · see citing works

The broad socioeconomic benefits of vaccination

Bloom, D. E., Fan, V. Y., & Sevilla, J. P. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aaj2345 · Cited by 148 · see citing works

Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery

Lallana, E., Rosa, J. M. R. D. L., Tirella, A., Pelliccia, M., Gennari, A., Stratford, I. J., Puri, S., Ashford, M. B., & Tirelli, N. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00320 · Cited by 146 · see citing works

siRNA Delivery with Chitosan: Influence of Chitosan Molecular Weight, Degree of Deacetylation, and Amine to Phosphate Ratio on in Vitro Silencing Efficiency, Hemocompatibility, Biodistribution, and in Vivo Efficacy

Alameh, M., Lavertu, M., Tran‐Khanh, N., Chang, C., Lesage, F., Bail, M., Darras, V., Chevrier, A., & Buschmann, M. D. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01297 · Cited by 142 · see citing works

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5’ cap modulates protein expression in living cells

Sikorski, P. J., Warminski, M., Kubacka, D., Ratajczak, T., Nowis, D., Kowalska, J., & Jemielity, J. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa032 · Cited by 142 · see citing works

Large-scale preparation and purification of polyacrylamide-free RNA oligonucleotides

Lukavsky, P. J., & Puglisi, J. D. (2004) · RNA · doi:10.1261/rna.5264804 · Cited by 139 · see citing works

mRNA Vaccines Encoding the HA Protein of Influenza A H1N1 Virus Delivered by Cationic Lipid Nanoparticles Induce Protective Immune Responses in Mice

Zhuang, X., Qi, Y., Wang, M., Yu, N., Nan, F., Zhang, H., Tian, M., Li, C., Lu, H., & Jin, N. (2020) · Vaccines · doi:10.3390/vaccines8010123 · Cited by 132 · see citing works

Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development.

Karikó, K., & Weissman, D. (2007) · PubMed · Cited by 130 · see citing works

Synthesis and characterization of novel poly(ethylene glycol)-lipid conjugates suitable for use in drug delivery

Heyes, J. A., Hall, K., Tailor, V., Lenz, R., & MacLachlan, I. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.02.012 · Cited by 123 · see citing works

Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study

van den Biggelaar, A. H. J., Huizinga, T. W. J., de Craen, A. J. M., Gussekloo, J., Heijmans, B. T., Frölich, M., & Westendorp, R. G. J. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.009 · Cited by 122 · see citing works

COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory Analysis

Bilotta, C., Perrone, G., Adelfio, V., Spatola, G. F., Uzzo, M. L., Argo, A., & Zerbo, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729251 · Cited by 119 · see citing works

Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy

Shobaki, N., Sato, Y., Suzuki, Y., Okabe, N., & Harashima, H. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.001 · Cited by 118 · see citing works

Long-term storage of DNA-free RNA for use in vaccine studies

Jones, K. L., Drane, D., & Gowans, E. J. (2007) · BioTechniques · doi:10.2144/000112593 · Cited by 115 · see citing works

Development of mRNA Vaccines: Scientific and Regulatory Issues

Knezevic, I., Liu, M. A., Peden, K., Zhou, T., & Kang, H.-N. (2021) · Vaccines · doi:10.3390/vaccines9020081 · Cited by 114 · see citing works

Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines

Goswami, R., Chatzikleanthous, D., Lou, G., Giusti, F., Bonci, A., Taccone, M., Brazzoli, M., Gallorini, S., Ferlenghi, I., Berti, F., et al. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00084 · Cited by 113 · see citing works

Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression

Turnbull, I. C., Eltoukhy, A. A., Fish, K. M., Nonnenmacher, M. E., Ishikawa, K., Chen, J., Hajjar, R. J., Anderson, D. G., & Costa, K. D. (2015) · Molecular Therapy · doi:10.1038/mt.2015.193 · Cited by 112 · see citing works

From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine Landscape

Chakraborty, C., Sharma, A. R., Bhattacharya, M., & Lee, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.679344 · Cited by 111 · see citing works

Accelerated Blood Clearance of Lipid Nanoparticles Entails a Biphasic Humoral Response of B-1 Followed by B-2 Lymphocytes to Distinct Antigenic Moieties

Besin, G., Milton, J., Sabnis, S., Howell, R. D., Mihai, C., Burke, K. E., Benenato, K. E., Stanton, M., Smith, P., Senn, J. J., et al. (2019) · ImmunoHorizons · doi:10.4049/immunohorizons.1900029 · Cited by 108 · see citing works

Fluad®-MF59®-Adjuvanted Influenza Vaccine in Older Adults

Tsai, T. F. (2013) · Infection &amp; Chemotherapy · doi:10.3947/ic.2013.45.2.159 · Cited by 107 · see citing works

Linear plasmid vector for cloning of repetitive or unstable sequences in Escherichia coli

Godiska, R., Mead, D. A., Dhodda, V. K., Wu, C., Hochstein, R. A., Karsi, A., Usdin, K., Entezam, A., & Ravin, N. V. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1181 · Cited by 106 · see citing works

Rapid development and deployment of high‐volume vaccines for pandemic response

Kis, Z., Kontoravdi, C., Dey, A. K., Shattock, R., & Shah, N. (2020) · Journal of Advanced Manufacturing and Processing · doi:10.1002/amp2.10060 · Cited by 105 · see citing works

Development of Novel Biodegradable Polymeric Nanoparticles-in-Microsphere Formulation for Local Plasmid DNA Delivery in the Gastrointestinal Tract

Bhavsar, M. D., & Amiji, M. M. (2008) · AAPS PharmSciTech · doi:10.1208/s12249-007-9021-9 · Cited by 104 · see citing works

Influence of cationic lipid composition on uptake and intracellular processing of lipid nanoparticle formulations of siRNA

Lin, P. J. C., Tam, Y. Y. C., Hafez, I. M., Sandhu, A. P., Chen, S., Ciufolini, M. A., Nabi, I. R., & Cullis, P. R. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.05.019 · Cited by 101 · see citing works

Purification and characterization of transcribed RNAs using gel filtration chromatography

McKenna, S. A., Kim, I., Puglisi, E. V., Lindhout, D. A., Aitken, C. E., Marshall, R. A., & Puglisi, J. D. (2007) · Nature Protocols · doi:10.1038/nprot.2007.480 · Cited by 98 · see citing works

COVID-19: neonatal–perinatal perspectives

On behalf of the Harvard Neonatal-Perinatal Fellowship COVID-19 Working Group, Barrero-Castillero, A., Beam, K. S., Bernardini, L. B., Ramos, E. G. C., Davenport, P. E., Duncan, A. R., Fraiman, Y. S., Frazer, L. C., Healy, H., et al. (2021) · Journal of Perinatology · doi:10.1038/s41372-020-00874-x · Cited by 92 · see citing works

Modified mRNA-LNP Vaccines Confer Protection against Experimental DENV-2 Infection in Mice

Zhang, M., Sun, J., Li, M., & Jin, X. (2020) · Molecular Therapy - Methods &amp; Clinical Development · doi:10.1016/j.omtm.2020.07.013 · Cited by 90 · see citing works

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

Saunders, K. O., Pardi, N., Parks, R., Santra, S., Mu, Z., Sutherland, L. L., Scearce, R. M., Barr, M., Eaton, A., Hernandez, G. E., et al. (2021) · npj Vaccines · doi:10.1038/s41541-021-00307-6 · Cited by 90 · see citing works

CD 8 T‐cell priming upon mRNA vaccination is restricted to bone‐marrow‐derived antigen‐presenting cells and may involve antigen transfer from myocytes

Lazzaro, S., Giovani, C., Mangiavacchi, S., Magini, D., Maione, D., Baudner, B. C., Geall, A. J., Gregorio, E. D., D’Oro, U., & Buonsanti, C. (2015) · Immunology · doi:10.1111/imm.12505 · Cited by 88 · see citing works

Role of Ionizable Lipids in SARS-CoV-2 Vaccines As Revealed by Molecular Dynamics Simulations: From Membrane Structure to Interaction with mRNA Fragments

Paloncýová, M., Čechová, P., Šrejber, M., Kührová, P., & Otyepka, M. (2021) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.1c03109 · Cited by 82 · see citing works

Nanocarrier vaccines for SARS-CoV-2

Machhi, J., Shahjin, F., Das, S., Patel, M., Abdelmoaty, M. M., Cohen, J. D., Singh, P., Baldi, A., Bajwa, N., Kumar, R., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.002 · Cited by 80 · see citing works

Systems vaccinology and big data in the vaccine development chain

Raeven, R. H. M., van Riet, E., Meiring, H. D., Metz, B., & Kersten, G. F. A. (2018) · Immunology · doi:10.1111/imm.13012 · Cited by 78 · see citing works

Recent advances in polymeric materials for the delivery of RNA therapeutics

Ulkoski, D., Bak, A., Wilson, J. T., & Krishnamurthy, V. R. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1663822 · Cited by 74 · see citing works

Combinatorial Approach to Determine Functional Group Effects on Lipidoid-Mediated siRNA Delivery

Mahon, K. P., Love, K. T., Whitehead, K. A., Qin, J., Akinc, A., Leshchiner, E. S., Leshchiner, I., Langer, R., & Anderson, D. G. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100041r · Cited by 73 · see citing works

Optimization of an mRNA vaccine assisted with cyclodextrin-polyethyleneimine conjugates

Tan, L., Zheng, T., Li, M., Zhong, X., Tang, Y., Qin, M., & Sun, X. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00725-4 · Cited by 72 · see citing works

Update on the clinical utility of an RNA interference-based treatment: focus on Patisiran

Rizk, M., & Tüzmen, Ş. (2017) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s87945 · Cited by 68 · see citing works

Injectable Biodegradable Chitosan‐Alginate 3D Porous Gel Scaffold for mRNA Vaccine Delivery

Yan, J., Chen, R., Zhang, H., & Bryers, J. D. (2018) · Macromolecular Bioscience · doi:10.1002/mabi.201800242 · Cited by 68 · see citing works

Contributions of maternal and fetal antiviral immunity in congenital disease

Yockey, L. J., Lucas, C., & Iwasaki, A. (2020) · Science · doi:10.1126/science.aaz1960 · Cited by 68 · see citing works

Adjuvant incorporated lipid nanoparticles for enhanced mRNA-mediated cancer immunotherapy

Lee, K., Kim, S. Y., Seo, Y., Kim, M. H., Chang, J., & Lee, H. (2019) · Biomaterials Science · doi:10.1039/c9bm01564g · Cited by 65 · see citing works

Lyophilization of Small-Molecule Injectables: an Industry Perspective on Formulation Development, Process Optimization, Scale-Up Challenges, and Drug Product Quality Attributes

Butreddy, A., Dudhipala, N. R., Janga, K. Y., et al. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01787-w · Cited by 64 · see citing works

Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery

Kim, J., Jozic, A., & Sahay, G. (2020) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-020-00619-y · Cited by 61 · see citing works

Covid-19: Pfizer and BioNTech submit vaccine for US authorisation

Mahase, E. (2020) · BMJ · doi:10.1136/bmj.m4552 · Cited by 58 · see citing works

Development of lipid-like materials for RNA delivery based on intracellular environment-responsive membrane destabilization and spontaneous collapse

Tanaka, H., Sakurai, Y., Anindita, J., & Akita, H. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.07.001 · Cited by 56 · see citing works

Design of in vitro Transcribed mRNA Vectors for Research and Therapy

Tusup, M., French, L. E., Matos, M. D., Gatfield, D., Kündig, T. M., & Pascolo, S. (2019) · CHIMIA International Journal for Chemistry · doi:10.2533/chimia.2019.391 · Cited by 54 · see citing works

Protective Efficacy of Nucleic Acid Vaccines Against Transmission of Zika Virus During Pregnancy in Mice

Jagger, B. W., Dowd, K. A., Chen, R. E., Desai, P., Foreman, B., Burgomaster, K. E., Himansu, S., Kong, W.-P., Graham, B. S., Pierson, T. C., et al. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz338 · Cited by 53 · see citing works

Nanoparticles versus Dendritic Cells as Vehicles to Deliver mRNA Encoding Multiple Epitopes for Immunotherapy

Firdessa-Fite, R., & Creusot, R. J. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.10.015 · Cited by 53 · see citing works

Investigation of Drying Stresses on Proteins during Lyophilization: Differentiation between Primary and Secondary-Drying Stresses on Lactate Dehydrogenase Using a Humidity Controlled Mini Freeze-Dryer

Luthra, S., Obert, J., Kalonia, D. S., et al. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20758 · Cited by 49 · see citing works

Fabrication of Niclosamide loaded solid lipid nanoparticles:in vitrocharacterization and comparativein vivoevaluation

Rehman, M. U., Khan, M. A., Khan, W. S., Shafique, M. S., & Khan, M. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1396996 · Cited by 47 · see citing works

The Effects of Solutes on the Freezing Properties of and Hydration Forces in Lipid Lamellar Phases

Yoon, Y.-H., POPE, J. M., & Wolfe, J. (1998) · Biophysical Journal · doi:10.1016/s0006-3495(98)77903-2 · Cited by 45 · see citing works

mRNA delivery using non-viral PCL nanoparticles

Palamà, I. E., Cortese, B., D’Amone, S., & Gigli, G. (2014) · Biomaterials Science · doi:10.1039/c4bm00242c · Cited by 44 · see citing works

The Development of mRNA Vaccines for Infectious Diseases: Recent Updates

Nitika, Wei, J., & Hui, A. (2021) · Infection and Drug Resistance · doi:10.2147/idr.s341694 · Cited by 42 · see citing works

Vaccination with Liposomal Leishmanial Antigens Adjuvanted with Monophosphoryl Lipid–Trehalose Dicorynomycolate (MPL-TDM) Confers Long-Term Protection against Visceral Leishmaniasis through a Human Administrable Route

Ravindran, R., Maji, M., & Ali, N. (2011) · Molecular Pharmaceutics · doi:10.1021/mp2002494 · Cited by 39 · see citing works

Isolation of Poly(A) + Messenger RNA Using Magnetic Oligo(dT) BeadsPreprint

Green, M. R., & Sambrook, J. (2019) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot101733 · Cited by 39 · see citing works

Protection against herpes simplex virus type 2 infection in a neonatal murine model using a trivalent nucleoside-modified mRNA in lipid nanoparticle vaccine

LaTourette, P. C., Awasthi, S., Desmond, A., Pardi, N., Cohen, G. H., Weissman, D., & Friedman, H. M. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.09.079 · Cited by 39 · see citing works

Effectiveness, immunogenicity, and safety of influenza vaccines with MF59 adjuvant in healthy people of different age groups: A systematic review and meta-analysis

Yang, J., Zhang, J., Han, T., Liu, C., Li, X., Yan, L., Yang, B., & Yang, X. (2020) · Medicine · doi:10.1097/md.0000000000019095 · Cited by 37 · see citing works

Delivery of mRNA Vaccine against SARS-CoV-2 Using a Polyglucin:Spermidine Conjugate

Karpenko, L., Rudometov, A. P., Sharabrin, S. V., Shcherbakov, D., Borgoyakova, M. B., Bazhan, S., Volosnikova, E., Rudometova, N., Orlova, L. A., Pyshnaya, I., et al. (2021) · Vaccines · doi:10.3390/vaccines9020076 · Cited by 37 · see citing works

Preparation of eukaryotic mRNA having differently methylated adenosine at the 5'-terminus and the effect of the methyl group in translation

Ishikawa, M., Murai, R., Hagiwara, H., Hoshino, T., & Suyama, K. (2009) · Nucleic Acids Symposium Series · doi:10.1093/nass/nrp065 · Cited by 35 · see citing works

How will emerging SARS-CoV-2 variants impact herd immunity?

Lippi, G., & Henry, B. M. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-893 · Cited by 33 · see citing works

Purification and Quantitative Analysis of Nucleic Acids by Anion-Exchange High-Performance Liquid Chromatography

Henninger, H., HOFFMANN, R., Grewe, M., et al. (1993) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1993.374.7-12.625 · Cited by 32 · see citing works

Development of an alcohol dilution-lyophilization method for preparing lipid nanoparticles containing encapsulated siRNA

Shirane, D., Tanaka, H., Nakai, Y., Yoshioka, H., & Akita, H. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00208 · Cited by 30 · see citing works

Development of thermostable vaccine adjuvants

Qi, Y., & Fox, C. B. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1902314 · Cited by 25 · see citing works

Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles

Chikh, G., de Jong, S. D., Sekirov, L., et al. (2009) · International Immunology · doi:10.1093/intimm/dxp044 · Cited by 23 · see citing works

An mRNA vaccine against SARS-CoV-2: Lyophilized, liposome-based vaccine candidate EG-COVID induces high levels of virus neutralizing antibodiesPreprint

Hong, H., Kim, K. S., Park, S. A., Chun, M. J., Hong, E. Y., Chung, S. W., Kim, H. J., Shin, B. G., Braka, A., Thanappan, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.22.436375 · Cited by 20 · see citing works

Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics

O'Sullivan, J., Muñoz-Muñoz, J., Turnbull, G., Sim, N., Penny, S., & Moschos, S. A. (2022) · RSC Advances · doi:10.1039/d2ra01999j · Cited by 18 · see citing works

Poly(2-Propylacrylic Acid) Increases In Vitro Bioactivity of Chitosan/mRNA Nanoparticles

Jeandupeux, E., Alameh, M., Ghattas, M., Crescenzo, G. D., & Lavertu, M. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.06.003 · Cited by 13 · see citing works

Evaluation of Packaging Materials in Freeze-Drying: Use of Polymer Caps and Nested Vials and Their Impact on Process and Product Attributes

Wenzel, T., & Gieseler, H. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-01953-8 · Cited by 4 · see citing works

An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial

Saraf, A., Gurjar, R., Kaviraj, S., Kulkarni, A., Kumar, D., Kulkarni, R., Virkar, R., Krishnan, J., Yadav, A., Baranwal, E., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02955-2 · Cited by 66 · see citing works

Identification of novel 5’ UTR variants for enhanced mRNA translation and vaccine immunogenicity

Mazunina, E. P., Dzharullaeva, A. S., Kleymenov, D. A., Bykonia, E. N., Kozlova, S. R., Usachev, E. V., Panova, E. A., Konopleva, M. V., Telegina, D. V., Kukushkina-Zvezdova, A. A., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-59586-5

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works

EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS

Grimm, B. (2002) · Journal of Molluscan Studies · doi:10.1093/mollus/68.1.25 · Cited by 41 · see citing works

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Preprint

Sasaki, T., Gan, E. C., Wakeham, A. C., Kornbluth, S. A., Mak, T. W., & Okada, H. (2007) · Genes & Development · doi:10.1101/gad.1534107 · Cited by 127 · see citing works

Anthoxanthum Mosaic Virus

Catherall, P. L. (1970) · Plant Pathology · doi:10.1111/j.1365-3059.1970.tb00999.x · Cited by 6 · see citing works