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Cited by 906

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Open access
Fajnzylber, Jesse, Regan, James, Coxen, Kendyll, Corry, Heather, Wong, Colline, Rosenthal, Alexandra, Worrall, Daniel, Giguel, Francoise, Piechocka-Trocha, Alicja, Atyeo, Caroline, Fischinger, Stephanie, Chan, Andrew, Flaherty, Keith T., Hall, Kathryn, Dougan, Michael, Ryan, Edward T., Gillespie, Elizabeth, Chishti, Rida, Li, Yijia, Jilg, Nikolaus, Hanidziar, Dusan, Baron, Rebecca M., Baden, Lindsey, Tsibris, Athe M., Armstrong, Katrina A., Kuritzkes, Daniel R., Alter, Galit, Walker, Bruce D., Yu, Xu, Li, Jonathan Z., The Massachusetts Consortium for Pathogen Readiness, Abayneh, Betelihem A., Allen, Patrick, Antille, Diane, Balazs, Alejandro, Bals, Julia, Barbash, Max, Bartsch, Yannic, Boucau, Julie, Boyce, Siobhan, Braley, Joan, Branch, Karen, Broderick, Katherine, Carney, Julia, Chevalier, Josh, Choudhary, Manish C., Chowdhury, Navin, Cordwell, Trevor, Daley, George, Davidson, Susan, Desjardins, Michael, Donahue, Lauren, Drew, David, Einkauf, Kevin, Elizabeth, Sampson, Elliman, Ashley, Etemad, Behzad, Fallon, Jon, Fedirko, Liz, Finn, Kelsey, Flannery, Jeanne, Forde, Pamela, Garcia-Broncano, Pilar, Gettings, Elise, Golan, David, Goodman, Kirsten, Griffin, Amanda, Grimmel, Sheila, Grinke, Kathleen, Hartana, Ciputra Adijaya, Healy, Meg, Heller, Howard, Henault, Deborah, Holland, Grace, Jiang, Chenyang, Jordan, Hannah, Kaplonek, Paulina, Karlson, Elizabeth W., Karpell, Marshall, Kayitesi, Chantal, Lam, Evan C., LaValle, Vlasta, Lefteri, Kristina, Lian, Xiaodong, Lichterfeld, Mathias, Lingwood, Daniel, Liu, Hang, Liu, Jinqing, Lopez, Kell, Lu, Yuting, Luthern, Sarah, Ly, Ngoc L., MacGowan, Maureen, Magispoc, Karen, Marchewka, Jordan, Martino, Brittani, McNamara, Roseann, Michell, Ashlin, Millstrom, Ilan, Miranda, Noah, Nambu, Christian, Nelson, Susan, Noone, Marjorie, Novack, Lewis, O’Callaghan, Claire, Ommerborn, Christine, Osborn, Matthew, Pacheco, Lois Chris, Phan, Nicole, Pillai, Shiv, Porto, Falisha A., Rassadkina, Yelizaveta, Reissis, Alexandra, Ruzicka, Francis, Seiger, Kyra, Selleck, Kathleen, Sessa, Libera, Sharpe, Arlene, Sharr, Christianne, Shin, Sally, Singh, Nishant, Slaughenhaupt, Sue, Sheppard, Kimberly Smith, Sun, Weiwei, Sun, Xiaoming, Suschana, Elizabeth, Talabi, Opeyemi, Ticheli, Hannah, Weiss, Scott T., Wilson, Vivine, Zhu, Alex·2020·Nature Communications
DOI 10.1038/s41467-020-19057-5
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Abstract

The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 viral load from participants with a diverse range of COVID-19 disease severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. We detected SARS-CoV-2 plasma RNA in 27% of hospitalized participants, and 13% of outpatients diagnosed with COVID-19. Amongst the participants hospitalized with COVID-19, we report that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. SARS-CoV-2 viral loads, especially plasma viremia, are associated with increased risk of mortality. Our data show that SARS-CoV-2 viral loads may aid in the risk stratification of patients with COVID-19, and therefore its role in disease pathogenesis should be further explored.

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Authors
Fajnzylber, J., Regan, J., Coxen, K., Corry, H., Wong, C., Rosenthal, A., Worrall, D., Giguel, F., Piechocka-Trocha, A., Atyeo, C., Fischinger, S., Chan, A., Flaherty, K. T., Hall, K., Dougan, M., Ryan, E. T., Gillespie, E., Chishti, R., Li, Y., Jilg, N., Hanidziar, D., Baron, R. M., Baden, L., Tsibris, A. M., Armstrong, K. A., Kuritzkes, D. R., Alter, G., Walker, B. D., Yu, X., Li, J. Z., The Massachusetts Consortium for Pathogen Readiness, Abayneh, B. A., Allen, P., Antille, D., Balazs, A., Bals, J., Barbash, M., Bartsch, Y., Boucau, J., Boyce, S., Braley, J., Branch, K., Broderick, K., Carney, J., Chevalier, J., Choudhary, M. C., Chowdhury, N., Cordwell, T., Daley, G., Davidson, S., Desjardins, M., Donahue, L., Drew, D., Einkauf, K., Elizabeth, S., Elliman, A., Etemad, B., Fallon, J., Fedirko, L., Finn, K., Flannery, J., Forde, P., Garcia-Broncano, P., Gettings, E., Golan, D., Goodman, K., Griffin, A., Grimmel, S., Grinke, K., Hartana, C. A., Healy, M., Heller, H., Henault, D., Holland, G., Jiang, C., Jordan, H., Kaplonek, P., Karlson, E. W., Karpell, M., Kayitesi, C., Lam, E. C., LaValle, V., Lefteri, K., Lian, X., Lichterfeld, M., Lingwood, D., Liu, H., Liu, J., Lopez, K., Lu, Y., Luthern, S., Ly, N. L., MacGowan, M., Magispoc, K., Marchewka, J., Martino, B., McNamara, R., Michell, A., Millstrom, I., Miranda, N., Nambu, C., Nelson, S., Noone, M., Novack, L., O’Callaghan, C., Ommerborn, C., Osborn, M., Pacheco, L. C., Phan, N., Pillai, S., Porto, F. A., Rassadkina, Y., Reissis, A., Ruzicka, F., Seiger, K., Selleck, K., Sessa, L., Sharpe, A., Sharr, C., Shin, S., Singh, N., Slaughenhaupt, S., Sheppard, K. S., Sun, W., Sun, X., Suschana, E., Talabi, O., Ticheli, H., Weiss, S. T., Wilson, V., & Zhu, A.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2020-10-30
Volume
11
Issue
1
Pages
5493-5493
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-020-19057-5
OpenAlex
W3095153958
Cited by
906
References
37
FWCI
21.88
Type
journal article
Language
en
Open access
gold

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Fajnzylber, J., Regan, J., Coxen, K., Corry, H., Wong, C., Rosenthal, A., Worrall, D., Giguel, F., Piechocka-Trocha, A., Atyeo, C., Fischinger, S., Chan, A., Flaherty, K. T., Hall, K., Dougan, M., Ryan, E. T., Gillespie, E., Chishti, R., Li, Y., . . . Zhu, A. (2020). SARS-CoV-2 viral load is associated with increased disease severity and mortality. Nature Communications. https://doi.org/10.1038/s41467-020-19057-5

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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