The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
Open accessAbstract
Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it is thought to result from chronic ischemia, the underlying nature and mechanisms driving the involved cell death remain obscure. Here, we show that necrosis in glioblastoma (GBM) involves neutrophil-triggered ferroptosis. In a hyperactivated transcriptional coactivator with PDZ-binding motif-driven GBM mouse model, neutrophils coincide with necrosis temporally and spatially. Neutrophil depletion dampens necrosis. Neutrophils isolated from mouse brain tumors kill cocultured tumor cells. Mechanistically, neutrophils induce iron-dependent accumulation of lipid peroxides within tumor cells by transferring myeloperoxidase-containing granules into tumor cells. Inhibition or depletion of myeloperoxidase suppresses neutrophil-induced tumor cell cytotoxicity. Intratumoral glutathione peroxidase 4 overexpression or acyl-CoA synthetase long chain family member 4 depletion diminishes necrosis and aggressiveness of tumors. Furthermore, analyses of human GBMs support that neutrophils and ferroptosis are associated with necrosis and predict poor survival. Thus, our study identifies ferroptosis as the underlying nature of necrosis in GBMs and reveals a pro-tumorigenic role of ferroptosis. Together, we propose that certain tumor damage(s) occurring during early tumor progression (i.e. ischemia) recruits neutrophils to the site of tissue damage and thereby results in a positive feedback loop, amplifying GBM necrosis development to its fullest extent.
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Cites
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Neutrophil recruitment and function in health and inflammation
Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Patel, A. P., Tirosh, I., Trombetta, J. J., Shalek, A. K., Gillespie, S. M., Wakimoto, H., Cahill, D. P., Nahed, B. V., Curry, W. T., Martuza, R. L., et al. (2014) · Science · doi:10.1126/science.1254257 · Cited by 5,063
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Ferroptosis as a p53-mediated activity during tumour suppression
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Cited by
Tong, X., Tang, R., Xiao, M., Xu, J., Wang, W., Zhang, B., Liu, J., Yu, X., & Shi, S. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01392-3 · Cited by 883
Molecular mechanisms of cell death in neurological diseases
Moujalled, D., Strasser, A., & Liddell, J. R. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-021-00814-y · Cited by 749
Lei, G., Zhuang, L., & Gan, B. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.03.011 · Cited by 586
Glioma progression is shaped by genetic evolution and microenvironment interactions
Varn, F. S., Johnson, K. C., Martinek, J., Huse, J. T., Nasrallah, M. P., Wesseling, P., Cooper, L. A. D., Malta, T. M., Wade, T. E., Sabedot, T. S., et al. (2022) · Cell · doi:10.1016/j.cell.2022.04.038 · Cited by 494
Organelle-specific regulation of ferroptosis
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-021-00859-z · Cited by 398
Metadata
- Authors
- Yee, P. P., Wei, Y., Kim, S.-Y., Lu, T., Chih, S. Y., Lawson, C., Tang, M., Liu, Z., Anderson, B., Thamburaj, K., Young, M. M., Aregawi, D. G., Glantz, M. J., Zacharia, B. E., Specht, C. S., Wang, H.-G., & Li, W.
- Venue
- Nature Communications
- Published
- 2020-10-27
- Volume
- 11
- Issue
- 1
- Pages
- 5424-5424
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3094771195
- Cited by
- 412
- References
- 76
- FWCI
- 25.61
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yee, P. P., Wei, Y., Kim, S.-Y., Lu, T., Chih, S. Y., Lawson, C., Tang, M., Liu, Z., Anderson, B., Thamburaj, K., Young, M. M., Aregawi, D. G., Glantz, M. J., Zacharia, B. E., Specht, C. S., Wang, H.-G., & Li, W. (2020). Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression. Nature Communications. https://doi.org/10.1038/s41467-020-19193-y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
