The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
Open accessAbstract
Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18 hACE2) represent a susceptible rodent model. K18 hACE2 transgenic mice succumbed to SARS-CoV-2 infection by day 6, with virus detected in lung airway epithelium and brain. K18 ACE2 transgenic mice produced a modest TH1/2/17 cytokine storm in the lung and spleen that peaked by day 2, and an extended chemokine storm that was detected in both lungs and brain. This chemokine storm was also detected in the brain at day 6. K18 hACE2 transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS-CoV-2 infection and associated severe COVID-19 disease.
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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
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Structural basis of receptor recognition by SARS-CoV-2
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
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Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
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The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
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Into the Eye of the Cytokine Storm
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Lethal Infection of K18- hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus
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Suryadevara, N., Shrihari, S., Gilchuk, P., VanBlargan, L. A., Binshtein, E., Zost, S. J., Nargi, R. S., Sutton, R. E., Winkler, E. S., Chen, E. C., et al. (2021) · doi:10.1101/2021.01.19.427324 · Cited by 361
CVnCoV protects human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2
Hoffmann, D., Corleis, B., Rauch, S., Roth, N., Mühe, J., Halwe, N. J., Ulrich, L., Fricke, C., Schön, J., Kraft, A., et al. (2021) · doi:10.1101/2021.03.22.435960 · Cited by 48
Metadata
- Authors
- Oladunni, F. S., Park, J.-G., Pino, P. A., Gonzalez, O., Akhter, A., Allué-Guardia, A., Olmo-Fontánez, A., Gautam, S., Garcia-Vilanova, A., Ye, C., Chiem, K., Headley, C., Dwivedi, V., Parodi, L. M., Alfson, K. J., Staples, H. M., Schami, A., Garcia, J. I., Whigham, A., Platt, R. N., Gazi, M., Martinez, J., Chuba, C., Earley, S., Rodriguez, O. H., Mdaki, S. D., Kavelish, K. N., Escalona, R., Hallam, C. R. A., Christie, C., Patterson, J. L., Anderson, T. J. C., Carrion, R., Dick, E. J., Hall-Ursone, S., Schlesinger, L. S., Alvarez, X., Kaushal, D., Giavedoni, L. D., Turner, J., Martinez-Sobrido, L., & Torrelles, J. B.
- Venue
- Nature Communications
- Published
- 2020-11-30
- Volume
- 11
- Issue
- 1
- Pages
- 6122-6122
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3107191813
- Cited by
- 402
- References
- 18
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- gold
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- Oladunni, F. S., Park, J.-G., Pino, P. A., Gonzalez, O., Akhter, A., Allué-Guardia, A., Olmo-Fontánez, A., Gautam, S., Garcia-Vilanova, A., Ye, C., Chiem, K., Headley, C., Dwivedi, V., Parodi, L. M., Alfson, K. J., Staples, H. M., Schami, A., Garcia, J. I., Whigham, A., . . . Torrelles, J. B. (2020). Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice. Nature Communications. https://doi.org/10.1038/s41467-020-19891-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
