The Revolution and Evolution of Shotgun Proteomics for Large-Scale Proteome Analysis
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Mass spectrometry has evolved at an exponential rate over the last 100 years. Innovations in the development of mass spectrometers have created powerful instruments capable of analyzing a wide range of targets, from rare atoms and molecules to very large molecules, such as a proteins, protein complexes, and DNA. These performance gains have been driven by sustaining innovations, punctuated by the occasional disruptive innovation. The use of mass spectrometry for proteome analysis was driven by disruptive innovations that created a capability for large-scale analysis of proteins and modifications.
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Mass spectrometry-based methods remain the most widely used approach for high-throughput proteomics research.
“Mass spectrometry (MS)–based methods continue to be the most widely used methods for high-throughput proteomics research1–4”
From Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research (2019) · cites this paper as [4]
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Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
Universal sample preparation method for proteome analysis
Wiśniewski, J. R., Zougman, A., Nagaraj, N., & Mann, M. (2009) · Nature Methods · doi:10.1038/nmeth.1322 · Cited by 8,352 · see citing works
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634 · see citing works
Eng, J. K., McCormack, A. L., & Yates, J. R. (1994) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(94)80016-2 · Cited by 6,484 · see citing works
Self-citationChen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
Ong, S.-E., Blagoev, B., Kratchmarova, I., Kristensen, D. B., Steen, H., Pandey, A., & Mann, M. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200025-mcp200 · Cited by 5,574 · see citing works
Large-scale analysis of the yeast proteome by multidimensional protein identification technology
Washburn, M. P., Wolters, D. A., & Yates, J. R. (2001) · Nature Biotechnology · doi:10.1038/85686 · Cited by 4,759 · see citing works
Self-citationFunctional organization of the yeast proteome by systematic analysis of protein complexes
Gavin, A., Böesche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A., Cruciat, C., et al. (2002) · Nature · doi:10.1038/415141a · Cited by 4,729 · see citing works
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
Gygi, S. P., Rist, B., Gerber, S. A., Turecek, F., Gelb, M. H., & Aebersold, R. (1999) · Nature Biotechnology · doi:10.1038/13690 · Cited by 4,683 · see citing works
Ross, P. L., Huang, Y. N., Marchese, J. N., Williamson, B., Parker, K., Hattan, S., Khainovski, N., Pillai, S., Dey, S., Daniels, S., et al. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400129-mcp200 · Cited by 4,401 · see citing works
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Ho, Y., Gruhler, A., Heilbut, A. M., Bader, G. D., Moore, L., Adams, S., Millar, A., Taylor, P. P., Bennett, K. L., Boutilier, K., et al. (2002) · Nature · doi:10.1038/415180a · Cited by 3,573 · see citing works
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
Krogan, N. J., Cagney, G., Yu, H., Zhong, G., Guo, X., Ignatchenko, A., Li, J., Pu, S., Datta, N., Tikuisis, A., et al. (2006) · Nature · doi:10.1038/nature04670 · Cited by 2,915 · see citing works
Proteome survey reveals modularity of the yeast cell machinery
Gavin, A., Aloy, P., Grandi, P., Krause, R., Böesche, M., Marzioch, M., Rau, C., Jensen, L. J., Bastuck, S., Dümpelfeld, B., et al. (2006) · Nature · doi:10.1038/nature04532 · Cited by 2,544 · see citing works
A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics
Liu, H., Sadygov, R. G., & Yates, J. R. (2004) · Analytical Chemistry · doi:10.1021/ac0498563 · Cited by 2,486 · see citing works
Self-citationThompson, A., Schäfer, J., Kuhn, K., Kienle, S., Schwarz, J., Schmidt, G., Neumann, T., & Hamon, C. (2003) · Analytical Chemistry · doi:10.1021/ac0262560 · Cited by 2,386 · see citing works
Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry
Syka, J. E. P., Coon, J. J., Schroeder, M. J., Shabanowitz, J., & Hunt, D. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402700101 · Cited by 2,370 · see citing works
Direct analysis of protein complexes using mass spectrometry
Link, A. J., Eng, J. K., Schieltz, D. M., Carmack, E., Mize, G. J., Morris, D. R., Garvik, B. M., & Yates, J. R. (1999) · Nature Biotechnology · doi:10.1038/10890 · Cited by 2,218 · see citing works
Self-citationA tissue-specific atlas of mouse protein phosphorylation and expression
Huttlin, E. L., Jedrychowski, M. P., Elias, J. E., Goswami, T., Rad, R., Beausoleil, S. A., Villén, J., Haas, W., Sowa, M. E., & Gygi, S. P. (2010) · Cell · doi:10.1016/j.cell.2010.12.001 · Cited by 1,778 · see citing works
Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae
Ficarro, S. B., McCleland, M. L., Stukenberg, P. T., Burke, D. J., Ross, M. M., Shabanowitz, J., Hunt, D. F., & White, F. M. (2002) · Nature Biotechnology · doi:10.1038/nbt0302-301 · Cited by 1,636 · see citing works
Beausoleil, S. A., Villén, J., Gerber, S. A., Rush, J., & Gygi, S. P. (2006) · Nature Biotechnology · doi:10.1038/nbt1240 · Cited by 1,577 · see citing works
Absolute Quantification of Proteins by LCMSE
Silva, J. C., Gorenstein, M. V., Li, G.-Z., Vissers, J. P. C., & Geromanos, S. J. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500230-mcp200 · Cited by 1,529 · see citing works
Larsen, M. R., Thingholm, T. E., Jensen, O. N., Roepstorff, P., & Jørgensen, T. J. D. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.t500007-mcp200 · Cited by 1,478 · see citing works
Practical implications of some recent studies in electrospray ionization fundamentals
Cech, N. B., & Enke, C. G. (2001) · Mass Spectrometry Reviews · doi:10.1002/mas.10008 · Cited by 1,436 · see citing works
Large-scale characterization of HeLa cell nuclear phosphoproteins
Beausoleil, S. A., Jedrychowski, M. P., Schwartz, D., Elias, J. E., Villén, J., Li, J., Cohn, M. A., Cantley, L. C., & Gygi, S. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404720101 · Cited by 1,376 · see citing works
A proteomic view of the Plasmodium falciparum life cycle
Florens, L., Washburn, M., Raine, J., Anthony, R. M., Grainger, M., Haynes, J., Moch, J. K., Muster, N., Sacci, J., Tabb, D. L., et al. (2002) · Nature · doi:10.1038/nature01107 · Cited by 1,330 · see citing works
Self-citationProteomic characterization of the human centrosome by protein correlation profiling
Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., & Mann, M. (2003) · Nature · doi:10.1038/nature02166 · Cited by 1,319 · see citing works
Yates, J. R., Eng, J. K., McCormack, A. L., & Schieltz, D. M. (1995) · Analytical Chemistry · doi:10.1021/ac00104a020 · Cited by 1,254 · see citing works
Self-citationQuantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins
Anderson, L., & Hunter, C. L. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500331-mcp200 · Cited by 1,230 · see citing works
Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226 · see citing works
Self-citationCharacterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass Spectrometry
Hunt, D. F., Henderson, R. A., Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., Cox, A. L., Appella, E., & Engelhard, V. H. (1992) · Science · doi:10.1126/science.1546328 · Cited by 1,198 · see citing works
Protein sequencing by tandem mass spectrometry.
Hunt, D. F., Yates, J. R., Shabanowitz, J., Winston, S., & Hauer, C. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.17.6233 · Cited by 1,189 · see citing works
Self-citationActivity-based protein profiling: The serine hydrolases
Liu, Y., Patricelli, M. P., & Cravatt, B. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14694 · Cited by 1,133 · see citing works
Accurate quantitation of protein expression and site-specific phosphorylation.
Oda, Y., Huang, K., Cross, F., Cowburn, D., & Chait, B. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.12.6591 · Cited by 1,011 · see citing works
New developments in biochemical mass spectrometry: electrospray ionization.
Smith, R. D., Loo, J., Edmonds, C. G., Barinaga, C., & Udseth, H. (1990) · Analytical Chemistry · doi:10.1021/ac00208a002 · Cited by 975 · see citing works
Mootha, V. K., Bunkenborg, J., Olsen, J. V., Hjerrild, M., Wisniewski, J. R., Stahl, E., Bolouri, M. S., Ray, H. N., Sihag, S., Kamal, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00926-7 · Cited by 889 · see citing works
Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra
Venable, J. D., Dong, M., Wohlschlegel, J. A., Dillin, A. G., & Yates, J. R. (2004) · Nature Methods · doi:10.1038/nmeth705 · Cited by 798 · see citing works
Self-citationIsolation of phosphoproteins by immobilized metal (Fe3+) affinity chromatography
Andersson, L., & Porath, J. O. (1986) · Analytical Biochemistry · doi:10.1016/0003-2697(86)90523-3 · Cited by 774 · see citing works
Carlton, J. M., Angiuoli, S. V., Suh, B. B., Kooij, T. W. A., Pertea, M., da Silva, J. C. F., Ermolaeva, M. D., Allen, J., Selengut, J., Koo, H. L., et al. (2002) · Nature · doi:10.1038/nature01099 · Cited by 734 · see citing works
Self-citationMass spectrometry and the age of the proteome
Yates, J. R. (1998) · Journal of Mass Spectrometry · doi:10.1002/(sici)1096-9888(199801)33:1 · Cited by 730 · see citing works
Self-citationAnalysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry
Lasonder, E., Ishihama, Y., Andersen, J., Vermunt, A., Pain, A., Sauerwein, R., Eling, W., Hall, N., Waters, A., Stunnenberg, H., et al. (2002) · Nature · doi:10.1038/nature01111 · Cited by 694 · see citing works
Krüger, M., Moser, M., Ussar, S., Thievessen, I., Luber, C. A., Forner, F., Schmidt, S., Zanivan, S., Fässler, R., & Mann, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.033 · Cited by 680 · see citing works
Mapping intact protein isoforms in discovery mode using top-down proteomics
Tran, J. C., Zamdborg, L., Ahlf, D. R., Lee, J. E., Catherman, A. D., Durbin, K. R., Tipton, J. D., Vellaichamy, A., Kellie, J. F., Li, M., et al. (2011) · Nature · doi:10.1038/nature10575 · Cited by 665 · see citing works
A Protein Complex Network of Drosophila melanogaster
Guruharsha, K. G., Rual, J.-F. M., Zhai, B., Mintseris, J., Vaidya, P., Vaidya, N., Beekman, C. N., Wong, C. S. F., Rhee, D. Y., Cenaj, O., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.047 · Cited by 654 · see citing works
Nuclear Membrane Proteins with Potential Disease Links Found by Subtractive Proteomics
Schirmer, E. C., Florens, L. A., Guan, T., Yates, J. R., & Gerace, L. (2003) · Science · doi:10.1126/science.1088176 · Cited by 654 · see citing works
Self-citationA method for the comprehensive proteomic analysis of membrane proteins
Wu, C. C., MacCoss, M. J., Howell, K. E., & Yates, J. R. (2003) · Nature Biotechnology · doi:10.1038/nbt819 · Cited by 651 · see citing works
Self-citationShotgun identification of protein modifications from protein complexes and lens tissue
MacCoss, M. J., McDonald, W. H., Saraf, A., Sadygov, R. G., Clark, J., Tasto, J. J., Gould, K. L., Wolters, D. A., Washburn, M. P., Weiss, A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122231399 · Cited by 593 · see citing works
Self-citationUltrahigh-Pressure Reversed-Phase Liquid Chromatography in Packed Capillary Columns
MacNair, J. E., Lewis, K. C., & Jorgenson, J. W. (1997) · Analytical Chemistry · doi:10.1021/ac961094r · Cited by 584 · see citing works
Fast atom bombardment of solids as an ion source in mass spectrometry
Barber, M., Bordoli, R. S., Sedgwick, R. D., & Tyler, A. N. (1981) · Nature · doi:10.1038/293270a0 · Cited by 582 · see citing works
McCormack, A. L., Schieltz, D. M., Goode, B. L., Yang, S. T., Barnes, G., Drubin, D. G., & Yates, J. R. (1997) · Analytical Chemistry · doi:10.1021/ac960799q · Cited by 524 · see citing works
Self-citationKislinger, T., Cox, B., Kannan, A., Chung, C., Hu, P., Ignatchenko, A., Scott, M. S., Gramolini, A. O., Morris, Q., Hallett, M. T., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.044 · Cited by 482 · see citing works
Value of Using Multiple Proteases for Large-Scale Mass Spectrometry-Based Proteomics
Swaney, D. L., Wenger, C. D., & Coon, J. J. (2010) · Journal of Proteome Research · doi:10.1021/pr900863u · Cited by 469 · see citing works
Global analysis of transcript and protein levels across the Plasmodium falciparum life cyclePreprint
Roch, K. G. L., Johnson, J. R., Florens, L., Zhou, Y., Santrosyan, A., Grainger, M., Yan, S. F., Williamson, K. C., Holder, A. A., Carucci, D. J., et al. (2004) · Genome Research · doi:10.1101/gr.2523904 · Cited by 437 · see citing works
Self-citationAnalysis of the Human Endogenous Coregulator Complexome
Malovannaya, A., Lanz, R. B., Jung, S. Y., Bulynko, Y., Le, N. T., Chan, D. W., Ding, C., Shi, Y., Yucer, N., Krenciute, G., et al. (2011) · Cell · doi:10.1016/j.cell.2011.05.006 · Cited by 432 · see citing works
Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics
Krijgsveld, J., Ketting, R. F., Mahmoudi, T., Johansen, J., Artal‐Sanz, M., Verrijzer, C. P., Plasterk, R. H. A., & Heck, A. J. R. (2003) · Nature Biotechnology · doi:10.1038/nbt848 · Cited by 410 · see citing works
Washburn, M. P., Ulaszek, R. R., Deciu, C., Schieltz, D. M., & Yates, J. R. (2002) · Analytical Chemistry · doi:10.1021/ac015704l · Cited by 390 · see citing works
Self-citationMetabolic Labeling of Mammalian Organisms with Stable Isotopes for Quantitative Proteomic Analysis
Wu, C. C., MacCoss, M. J., Howell, K. E., Matthews, D. E., & Yates, J. R. (2004) · Analytical Chemistry · doi:10.1021/ac049208j · Cited by 386 · see citing works
Self-citationSample preparation and digestion for proteomic analyses using spin filters
Manza, L. L., Stamer, S. L., Ham, A. L., Codreanu, S. G., & Liebler, D. C. (2005) · PROTEOMICS · doi:10.1002/pmic.200401063 · Cited by 383 · see citing works
Yates, J. R., Eng, J. K., & McCormack, A. L. (1995) · Analytical Chemistry · doi:10.1021/ac00114a016 · Cited by 377 · see citing works
Self-citationZybailov, B. L., Coleman, M. K., Florens, L. A., & Washburn, M. P. (2005) · Analytical Chemistry · doi:10.1021/ac050846r · Cited by 349 · see citing works
Extremely long-lived nuclear pore proteins in the rat brain
Savas, J. N., Toyama, B. H., Xu, T., Yates, J. R., & Hetzer, M. W. (2012) · Science · doi:10.1126/science.1217421 · Cited by 335 · see citing works
Self-citationA continuous-flow sample probe for fast atom bombardment mass spectrometry
Caprioli, R. M., Fan, T., & Cottrell, J. S. (1986) · Analytical Chemistry · doi:10.1021/ac00127a012 · Cited by 320 · see citing works
Sato, S., Tomomori‐Sato, C., Parmely, T. J., Florens, L. A., Zybailov, B. L., Swanson, S. K., Banks, C. A. S., Jin, J., Cai, Y., Washburn, M. P., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.006 · Cited by 313 · see citing works
Quantitative Mass Spectrometry Identifies Insulin Signaling Targets in C. elegans
Dong, M., Venable, J. D., Au, N., Xu, T., Park, S. K., Cociorva, D., Johnson, J. R., Dillin, A. G., & Yates, J. R. (2007) · Science · doi:10.1126/science.1139952 · Cited by 310 · see citing works
Self-citationKennedy, R. T., & Jorgenson, J. W. (1989) · Analytical Chemistry · doi:10.1021/ac00185a016 · Cited by 299 · see citing works
Variations in the Relative Abundance of the Carbon Isotopes
Nier, A. O. C., & Gulbransen, E. A. (1939) · Journal of the American Chemical Society · doi:10.1021/ja01872a047 · Cited by 299 · see citing works
Conrads, T. P., Alving, K., Veenstra, T. D., Belov, M. E., Anderson, G., Anderson, D. J., Lipton, M. S. W., Paša-Tolić, L., Udseth, H. R., Chrisler, W., et al. (2001) · Analytical Chemistry · doi:10.1021/ac001487x · Cited by 286 · see citing works
Shen, Y., Zhao, R., Berger, S. J., Anderson, G., Rodríguez, N., & Smith, R. D. (2002) · Analytical Chemistry · doi:10.1021/ac0202280 · Cited by 284 · see citing works
Time-of-Flight Mass Spectrometry and Gas-Liquid Partition Chromatography
Gohlke, R. S. (1959) · Analytical Chemistry · doi:10.1021/ac50164a024 · Cited by 284 · see citing works
Münchbach, M., Quadroni, M., Miotto, G., & James, P. (2000) · Analytical Chemistry · doi:10.1021/ac000265w · Cited by 280 · see citing works
A Correlation Algorithm for the Automated Quantitative Analysis of Shotgun Proteomics Data
MacCoss, M. J., Wu, C. C., Liu, H., Sadygov, R. G., & Yates, J. R. (2003) · Analytical Chemistry · doi:10.1021/ac034790h · Cited by 278 · see citing works
Self-citationSimultaneous Qualitative and Quantitative Analysis of theEscherichia coli Proteome
Silva, J. C., Denny, R., Dorschel, C. A., Gorenstein, M. V., Li, G., Richardson, K., Wall, D., & Geromanos, S. J. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500321-mcp200 · Cited by 266 · see citing works
Assigning Function to Yeast Proteins by Integration of Technologies
Hazbun, T. R., Malmström, L., Anderson, S., Graczyk, B., Fox, B., Riffle, M. E., Sundin, B. A., Aranda, J. D., McDonald, W. H., Chiu, C.-H., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00476-3 · Cited by 263 · see citing works
Self-citationFast atom bombardment: A new mass spectrometric method for peptide sequence analysis
Morris, H. R., Panico, M., Barber, M., Bordoli, R. S., Sedgwick, R. D., & Tyler, A. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)91304-8 · Cited by 261 · see citing works
Proteomic and phosphoproteomic comparison of human ES and iPS cells
Phanstiel, D. H., Brumbaugh, J., Wenger, C. D., Tian, S., Probasco, M. D., Bailey, D. J., Swaney, D. L., Tervo, M. A., Bolin, J. M., Ruotti, V., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1699 · Cited by 257 · see citing works
Michel, H., Hunt, D. F., Shabanowitz, J., & Bennett, J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57275-1 · Cited by 252 · see citing works
RNA-Dependent Cysteine Biosynthesis in Archaea
Sauerwald, A., Zhu, W., Major, T. A., Roy, H., Palioura, S., Jahn, D., Whitman, W. B., Yates, J. R., Ibba, M., & Söll, D. G. (2005) · Science · doi:10.1126/science.1108329 · Cited by 245 · see citing works
Self-citationIdentification of post-translational modifications by blind search of mass spectra
Tsur, D., Tanner, S. W., Zandi, E., Bafna, V., & Pevzner, P. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1168 · Cited by 240 · see citing works
Gatlin, C. L., Eng, J. K., Cross, S. T., DETTER, J. C., & Yates, J. R. (2000) · Analytical Chemistry · doi:10.1021/ac991025n · Cited by 233 · see citing works
Self-citationMultidimensional LC Separations in Shotgun Proteomics
Motoyama, A., & Yates, J. R. (2008) · Analytical Chemistry · doi:10.1021/ac8013669 · Cited by 225 · see citing works
Self-citationHigh Throughput Proteome-Wide Precision Measurements of Protein Expression Using Mass Spectrometry
Paša‐Tolić, L., Jensen, P. K., Anderson, G., Lipton, M. S. W., Hixson, K. K., Martinović, S., Tolić, N., Bruce, J. E., & Smith, R. D. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991063o · Cited by 214 · see citing works
Quantitative mouse brain proteomics using culture-derived isotope tags as internal standards
Ishihama, Y., Sato, T., Tabata, T., Miyamoto, N., Sagane, K., Nagasu, T., & Oda, Y. (2005) · Nature Biotechnology · doi:10.1038/nbt1086 · Cited by 212 · see citing works
Amino acid residue specific stable isotope labeling for quantitative proteomics
Zhu, H., Pan, S., Gu, S., Bradbury, E. M., & Chen, X. (2002) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.831 · Cited by 211 · see citing works
Davis, M. T., Stahl, D. C., Hefta, S. A., & Lee, T. D. (1995) · Analytical Chemistry · doi:10.1021/ac00120a019 · Cited by 201 · see citing works
Swaney, D. L., Wenger, C. D., Thomson, J. A., & Coon, J. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811964106 · Cited by 192 · see citing works
Shotgun collision‐induced dissociation of peptides using a time of flight mass analyzer
Purvine, S. O., Eppel, J., Yi, E. C., & Goodlett, D. R. (2003) · PROTEOMICS · doi:10.1002/pmic.200300362 · Cited by 192 · see citing works
Multidimensional Separations for Protein/Peptide Analysis in the Post-Genomic Era
Liu, H., Lin, D., & Yates, J. R. (2002) · BioTechniques · doi:10.2144/02324pt01 · Cited by 189 · see citing works
Self-citationFAB-MAPPING of recombinant-DNA protein products
Morris, H. R., Panico, M., & Taylor, G. W. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)91575-9 · Cited by 179 · see citing works
Partial primary structure of bacteriorhodopsin: sequencing methods for membrane proteins.
Gerber, G. E., Anderegg, R. J., Herlihy, W. C., Gray, C. P., BIEMANN, K., & Khorana, H. G. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.227 · Cited by 170 · see citing works
Yue, G. E., Luo, Q., Zhang, J., Wu, S., & Karger, B. L. (2006) · Analytical Chemistry · doi:10.1021/ac061411m · Cited by 156 · see citing works
Dephoure, N., & Gygi, S. P. (2012) · Science Signaling · doi:10.1126/scisignal.2002548 · Cited by 153 · see citing works
15N Metabolic Labeling of Mammalian Tissue with Slow Protein Turnover
McClatchy, D. B., Dong, M., Wu, C. C., Venable, J. D., & Yates, J. R. (2007) · Journal of Proteome Research · doi:10.1021/pr060599n · Cited by 151 · see citing works
Self-citationTrends in ultrasensitive proteomics
Altelaar, M. A. F., & Heck, A. J. R. (2012) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2011.12.011 · Cited by 139 · see citing works
Hunt, D. F., Bone, W. M., Shabanowitz, J., Rhodes, J. L., & Ballard, J. M. (1981) · Analytical Chemistry · doi:10.1021/ac00234a035 · Cited by 138 · see citing works
Blonder, J., Conrads, T. P., Yu, L., Terunuma, A., Janini, G. M., Issaq, H. J., Vogel, J. C., & Veenstra, T. D. (2004) · PROTEOMICS · doi:10.1002/pmic.200300543 · Cited by 137 · see citing works
Motoyama, A., Venable, J. D., Ruse, C. I., & Yates, J. R. (2006) · Analytical Chemistry · doi:10.1021/ac060354u · Cited by 136 · see citing works
Self-citationA protease for 'middle-down' proteomics
Wu, C., Tran, J. C., Zamdborg, L., Durbin, K. R., Li, M., Ahlf, D. R., Early, B. P., Thomas, P. M., Sweedler, J. V., & Kelleher, N. L. (2012) · Nature Methods · doi:10.1038/nmeth.2074 · Cited by 128 · see citing works
Luo, Q., Yue, G. E., Valaskovic, G. A., Gu, Y., Wu, S., & Karger, B. L. (2007) · Analytical Chemistry · doi:10.1021/ac070583w · Cited by 123 · see citing works
Masselon, C., Anderson, G., Harkewicz, R., Bruce, J. E., Paša‐Tolić, L., & Smith, R. D. (2000) · Analytical Chemistry · doi:10.1021/ac991133+ · Cited by 116 · see citing works
Kennedy, R. T., & Jorgenson, J. W. (1989) · Analytical Chemistry · doi:10.1021/ac00180a012 · Cited by 110 · see citing works
APPLICATION OF MASS SPECTROMETRY TO STRUCTURE PROBLEMS. I. AMINO ACID SEQUENCE IN PEPTIDES
BIEMANN, K., Gapp, G., & SEIBL, J. (1959) · Journal of the American Chemical Society · doi:10.1021/ja01518a069 · Cited by 109 · see citing works
Zhang, X., Jin, Q. K., Carr, S. A., & Annan, R. S. (2002) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.864 · Cited by 104 · see citing works
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification
Kubota, K., Anjum, R., Yu, Y., Kunz, R. C., Andersen, J. N., Kraus, M., Keilhack, H., Nagashima, K., Krauss, S., Paweletz, C. P., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1566 · Cited by 102 · see citing works
Poulter, L., Ang, S.-G., Gibson, B. W., Williams, D. H., Holmes, C. F. B., Caudwell, F. B., Pitcher, J. A., & COHEN, P. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14222.x · Cited by 102 · see citing works
Fonslow, B. R., Carvalho, P. C., Academia, K., Freeby, S., Xu, T., Nakorchevsky, A., Paulus, A., & Yates, J. R. (2011) · Journal of Proteome Research · doi:10.1021/pr200304u · Cited by 101 · see citing works
Self-citationQuantification of the synaptosomal proteome of the rat cerebellum during post-natal developmentPreprint
McClatchy, D. B., Liao, L., Park, S. K., Venable, J. D., & Yates, J. R. (2007) · Genome Research · doi:10.1101/gr.6375007 · Cited by 99 · see citing works
Self-citationBIEMANN, K., Cone, C. W., Webster, B. R., & Arsenault, G. P. (1966) · Journal of the American Chemical Society · doi:10.1021/ja00975a045 · Cited by 98 · see citing works
Chemo-affinity of Titania for the Column-switching HPLC Analysis of Phosphopeptides
Sano, A., & Nakamura, H. (2004) · Analytical Sciences · doi:10.2116/analsci.20.565 · Cited by 97 · see citing works
Glass capillary columns and their significance in biochemical research
Novotný, M. V., & Zlatkis, A. (1971) · Chromatographic Reviews · doi:10.1016/0009-5907(71)80010-8 · Cited by 95 · see citing works
Evaluation of the Compact High-Field Orbitrap for Top-Down Proteomics of Human Cells
Ahlf, D. R., Compton, P. D., Tran, J. C., Early, B. P., Thomas, P. M., & Kelleher, N. L. (2012) · Journal of Proteome Research · doi:10.1021/pr3004216 · Cited by 89 · see citing works
Yates, J. R., McCormack, A. L., Link, A. J., Schieltz, D. M., Eng, J. K., & Hays, L. G. (1996) · The Analyst · doi:10.1039/an996210065r · Cited by 78 · see citing works
Self-citationIto, Y., Takeuchi, T., Ishii, D., Goto, M., & Mizuno, T. (1986) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)90330-9 · Cited by 74 · see citing works
Advancing formaldehyde cross-linking towards quantitative proteomic applications
Klockenbusch, C., O’Hara, J. E., & Kast, J. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6065-9 · Cited by 66 · see citing works
Venable, J. D., Wohlschlegel, J. A., McClatchy, D. B., Park, S. K., & Yates, J. R. (2007) · Analytical Chemistry · doi:10.1021/ac062054i · Cited by 63 · see citing works
Self-citationKellie, J. F., Catherman, A. D., Durbin, K. R., Tran, J. C., Tipton, J., Norris, J. L., Witkowski, C. E., Thomas, P. M., & Kelleher, N. (2011) · Analytical Chemistry · doi:10.1021/ac202384v · Cited by 62 · see citing works
[26] Liquid secondary ion mass spectrometry of phosphorylated and sulfated peptides and proteins
Gibson, B. W., & Cohen, P. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)93434-m · Cited by 61 · see citing works
Capillary zone electrophoresis-MS
Smith, R., & Udseth, H. R. (1988) · Nature · doi:10.1038/331639a0 · Cited by 60 · see citing works
Carr, S. A., Hauschka, P. V., & BIEMANN, K. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68721-1 · Cited by 58 · see citing works
Chan, J. N. Y., Vuckovic, D., Sleno, L., Olsen, J. B., Pogoutse, O., Havugimana, P. C., Hewel, J. A., Bajaj, N., Wang, Y., Musteata, F. M., et al. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.016642 · Cited by 57 · see citing works
XLIV. The constitution of atmospheric neon
Aston, F. W. (1920) · The London Edinburgh and Dublin Philosophical Magazine and Journal of Science · doi:10.1080/14786440408636058 · Cited by 57 · see citing works
Cristobal, A., Hennrich, M. L., Giansanti, P., Goerdayal, S. S., Heck, A. J. R., & Mohammed, S. (2012) · The Analyst · doi:10.1039/c2an35445d · Cited by 51 · see citing works
Fonslow, B. R., Niessen, S., Singh, M., Wong, C. C. L., Xu, T., Carvalho, P. C., Choi, J. H., Park, S. K., & Yates, J. R. (2012) · Journal of Proteome Research · doi:10.1021/pr300200x · Cited by 50 · see citing works
Self-citationThe mammalian Mediator complex
Conaway, J. W., Florens, L. A., Sato, S., Tomomori‐Sato, C., Parmely, T. J., Yao, T., Swanson, S. K., Banks, C. A. S., Washburn, M. P., & Conaway, R. C. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.11.031 · Cited by 49 · see citing works
On the structure of lysopine, a new amino acid isolated from crown gall tissue
BIEMANN, K., Lioret, C., Asselineau, J., LEDERER, E., & Polonsky, J. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)91370-6 · Cited by 47 · see citing works
Hunt, D. F., Giordani, A. B., Rhodes, G. R., & Herold, D. A. (1982) · Clinical Chemistry · doi:10.1093/clinchem/28.12.2387 · Cited by 45 · see citing works
A Shotgun Proteomic Method for the Identification of Membrane-Embedded Proteins and Peptides
Blackler, A. R., Speers, A. E., Ladinsky, M. S., & Wu, C. C. (2008) · Journal of Proteome Research · doi:10.1021/pr700795f · Cited by 41 · see citing works
Dynamics of Subcellular Proteomes During Brain Development
McClatchy, D. B., Liao, L., Lee, J. H., Park, S. K., & Yates, J. R. (2012) · Journal of Proteome Research · doi:10.1021/pr201176v · Cited by 40 · see citing works
Self-citationStable isotopes in biosciences, their measurement and models for amino acid metabolism
Bier, D. M. (1997) · European Journal of Pediatrics · doi:10.1007/pl00014265 · Cited by 39 · see citing works
Geddes, A. J., Graham, G. N., Morris, H. R., Lucas, F., Barber, M., & Wolstenholme, W. A. (1969) · Biochemical Journal · doi:10.1042/bj1140695 · Cited by 39 · see citing works
Analysis of Rates of Multiple Enzymes in Cell Lysates by Electrospray Ionization Mass Spectrometry
Gerber, S. A., Scott, C. R., Tureček, F., & Gelb, M. H. (1999) · Journal of the American Chemical Society · doi:10.1021/ja982878k · Cited by 38 · see citing works
Link, A. J., Carmack, E., & Yates, J. R. (1997) · International Journal of Mass Spectrometry and Ion Processes · doi:10.1016/s0168-1176(96)04489-8 · Cited by 37 · see citing works
Self-citationMeasuring mass: from positive rays to proteins
(2003) · Choice Reviews Online · doi:10.5860/choice.40-2806 · Cited by 37 · see citing works
Herlihy, W. C., Royal, N., BIEMANN, K., Putney, S. D., & SCHIMMEL, P. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.11.6531 · Cited by 33 · see citing works
The Promise of a Cure: 20 Years and Counting
Couzin-Frankel, J. (2009) · Science · doi:10.1126/science.324_1504 · Cited by 32 · see citing works
Nau, H., Kelley, J. A., & BIEMANN, K. (1973) · Journal of the American Chemical Society · doi:10.1021/ja00802a048 · Cited by 32 · see citing works
Differential Proteomic Analysis of Mammalian Tissues Using SILAM
McClatchy, D. B., Liao, L., Park, S. K., Xu, T., Lu, B., & Yates, J. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016039 · Cited by 31 · see citing works
Self-citationMapping and Sequencing the Human Genome
Campbell, P. N. (1989) · Biotechnology and Applied Biochemistry · doi:10.1111/j.1470-8744.1989.tb00056.x · Cited by 24 · see citing works
Kunz, R. C., McAllister, F. E., Rush, A. J., & Gygi, S. P. (2012) · Analytical Chemistry · doi:10.1021/ac301116z · Cited by 23 · see citing works
Krisp, C., McKay, M. J., Wolters, D. A., & Molloy, M. P. (2012) · Analytical Chemistry · doi:10.1021/ac2028485 · Cited by 20 · see citing works
The decline and fall of protein chemistry?
MALCOLM, A. D. B. (1978) · Nature · doi:10.1038/275090a0 · Cited by 19 · see citing works
15N-Labeled Brain Enables Quantification of Proteome and Phosphoproteome in Cultured Primary Neurons
Liao, L., Sando, R. C., Farnum, J. B., Vanderklish, P. W., Maximov, A., & Yates, J. R. (2011) · Journal of Proteome Research · doi:10.1021/pr200987h · Cited by 16 · see citing works
Self-citationGibson, B. W., Poulter, L., & Williams, D. H. (1986) · Journal of Natural Products · doi:10.1021/np50043a002 · Cited by 14 · see citing works
Is the number of genes we possess limited by the presence of an adaptive immune system?
George, A. J. T. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02241-x · Cited by 12 · see citing works
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Palaniappan, K. K., & Bertozzi, C. R. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00023 · Cited by 276 · see citing works
Ion Activation Methods for Peptides and Proteins
Brodbelt, J. S. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b04563 · Cited by 245 · see citing works
Comprehensive Overview of Bottom-Up Proteomics Using Mass Spectrometry
Jiang, Y., Balaya, R. D. A., Schuster, D., Neely, B. A., Rosano, G. L., Volkmar, N., Momenzadeh, A., Peters-Clarke, T. M., Egbert, S., Kreimer, S. D., et al. (2024) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.3c00068 · Cited by 200 · see citing works
Biological Nanopore Approach for Single‐Molecule Protein Sequencing
Hu, Z., Huo, M., Ying, Y., & Long, Y. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202013462 · Cited by 193 · see citing works
Creating reference gene annotation for the mouse C57BL6/J genome assembly
Mudge, J. M., & Harrow, J. (2015) · Mammalian Genome · doi:10.1007/s00335-015-9583-x · Cited by 169 · see citing works
Transformative Impact of Proteomics on Cardiovascular Health and Disease
Lindsey, M. L., Mayr, M., Gomes, A. V., Delles, C., Arrell, D. K., Murphy, A. M., Lange, R. A., Costello, C. E., Jin, Y.-F., Laskowitz, D. T., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000226 · Cited by 174 · see citing works
Cristobal, A., van den Toorn, H., van de Wetering, M., Clevers, H. C., Heck, A. J. R., & Mohammed, S. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.016 · Cited by 152 · see citing works
Post-translational Modifications and Mass Spectrometry Detection
Silva, A. M. N., Vitorino, R. M. P., Domingues, M. R., Spickett, C. M., & Domingues, P. M. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.184 · Cited by 140 · see citing works
Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research
Gomes, F. P., & Yates, J. R. (2019) · Mass Spectrometry Reviews · doi:10.1002/mas.21599 · Cited by 112 · see citing works
Self-citationSheynkman, G., Shortreed, M. R., Cesnik, A. J., & Smith, L. M. (2016) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-071015-041722 · Cited by 99 · see citing works
Gunkel‐Grabole, G., & Huck, W. T. S. (2013) · Journal of the American Chemical Society · doi:10.1021/ja402126t · Cited by 96 · see citing works
Biological Nanopore Approach for Single‐Molecule Protein Sequencing
Hu, Z., Huo, M., Ying, Y., & Long, Y. (2020) · Angewandte Chemie · doi:10.1002/ange.202013462 · Cited by 74 · see citing works
Yasueda, Y., Tamura, T., Fujisawa, A., Kuwata, K., Tsukiji, S., Kiyonaka, S., & Hamachi, I. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b02254 · Cited by 67 · see citing works
Mass spectrometry based proteomics and metabolomics in personalized oncology
Kowalczyk, T., Ciborowski, M., Kiśluk, J., Kretowski, A. J., & Barbas, C. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165690 · Cited by 67 · see citing works
Cantafio, M. E. G., Grillone, K., Caracciolo, D., Scionti, F., Arbitrio, M., Barbieri, V., Pensabene, L., Guzzi, P. H., & Martino, M. T. D. (2018) · Microarrays · doi:10.3390/ht7040033 · Cited by 66 · see citing works
Less is More: Membrane Protein Digestion Beyond Urea–Trypsin Solution for Next-level Proteomics*
Zhang, X. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r114.042572 · Cited by 49 · see citing works
Functional transcriptomics in the post-ENCODE eraPreprint
Mudge, J. M., Frankish, A., & Harrow, J. (2013) · Genome Research · doi:10.1101/gr.161315.113 · Cited by 64 · see citing works
Chen, W., Smeekens, J. M., & Wu, R. (2015) · Chemical Science · doi:10.1039/c5sc01124h · Cited by 62 · see citing works
Capillary zone electrophoresis-mass spectrometry for bottom-up proteomics
Zhang, Z., Qu, Y., & Dovichi, N. J. (2018) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.08.008 · Cited by 61 · see citing works
Deciphering combinatorial post-translational modifications by top-down mass spectrometry
Brodbelt, J. (2022) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2022.102180 · Cited by 50 · see citing works
Lipid Metabolic Versatility in Malassezia spp. Yeasts Studied through Metabolic Modeling
Triana, S., de Cock, H., Ohm, R. A., Danies, G., Wösten, H. A. B., Restrepo, S., Barrios, A. F. G., & Ramírez, A. M. C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01772 · Cited by 55 · see citing works
Miniaturized LC in Molecular Omics
Aydoğan, C., Rigano, F., Krčmová, L. K., Chung, D. S., Macka, M., & Mondello, L. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c01436 · Cited by 55 · see citing works
Smeekens, J. M., Chen, W., & Wu, R. (2014) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-014-1016-7 · Cited by 50 · see citing works
Multi-Enzymatic Limited Digestion: The Next-Generation Sequencing for Proteomics?
Morsa, D., Baiwir, D., Rocca, R. L., Zimmerman, T. A., Hanozin, E., Grifnée, E., Longuespée, R., Meuwis, M., Smargiasso, N., Pauw, E. D., et al. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00044 · Cited by 44 · see citing works
Nuclear LC3 Associates with Slowly Diffusing Complexes that Survey the Nucleolus
Kraft, L. J., Manral, P., Dowler, J., & Kenworthy, A. K. (2016) · Traffic · doi:10.1111/tra.12372 · Cited by 43 · see citing works
Data storage using peptide sequences
Ng, C. C. A., Tam, W. M., Yin, H., Wu, Q., So, P.-K., Wong, M. Y.-M., Lau, F. C. M., & Yao, Z.-P. (2021) · Nature Communications · doi:10.1038/s41467-021-24496-9 · Cited by 41 · see citing works
Unraveling the exercise-related proteome signature in heart
Ferreira, R. M., Moreira‐Gonçalves, D., Azevedo, A. L., Duarte, J. A., Amado, F. M. L., & Vitorino, R. M. P. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0454-5 · Cited by 40 · see citing works
Feng, X., Deng, C., Gao, M., Yan, G., & Zhang, X. (2017) · Talanta · doi:10.1016/j.talanta.2017.11.040 · Cited by 40 · see citing works
Fan, C., Shi, Z., Pan, Y., Song, Z., Zhang, W., Zhao, X., Tian, F., Peng, B., Qin, W., Cai, Y., et al. (2014) · Analytical Chemistry · doi:10.1021/ac402696b · Cited by 39 · see citing works
Proteomic Analysis and NIR-II Imaging of MCM2 Protein in Hepatocellular Carcinoma
Yang, J. H., Xie, Q., Zhou, H., Chang, L., Wei, W., Wang, Y., Li, H., Deng, Z., Xiao, Y., Wu, J., et al. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00181 · Cited by 39 · see citing works
Yuan, Y., Yu, L.-L., Bi, C., Huang, L., Su, B., Nie, J., Dou, Z., Yang, S., & Li, Y. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01075-4 · Cited by 40 · see citing works
Proteomic approaches to uncover MMP function
Schlage, P., & Keller, U. A. D. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.01.003 · Cited by 37 · see citing works
Cancer metabolism and mass spectrometry-based proteomics
Zhou, W., Liotta, L. A., & Petricoin, E. F. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.11.003 · Cited by 37 · see citing works
Bioinformatics applied to biotechnology: A review towards bioenergy research
de Carvalho, L. M., Borelli, G., Camargo, A. P., de Assis, M. A., de Ferraz, S. M. F., Fiamenghi, M. B., José, J., Mofatto, L. S., Nagamatsu, S. T., Persinoti, G. F., et al. (2019) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2019.02.016 · Cited by 37 · see citing works
Direct and indirect approaches to identify drug modes of action
Tulloch, L. B., Menzies, S. K., Coron, R. P., Roberts, M. D., Florence, G. J., & Smith, T. (2017) · IUBMB Life · doi:10.1002/iub.1697 · Cited by 35 · see citing works
Mass Spectrometry-Based Biomarker Discovery
Zhou, W., Petricoin, E. F., & Longo, C. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6990-6_19 · Cited by 34 · see citing works
Zhang, Z., Hebert, A. S., Westphall, M. S., Qu, Y., Coon, J. J., & Dovichi, N. J. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b02991 · Cited by 30 · see citing works
Post-Genomics Nanotechnology Is Gaining Momentum: Nanoproteomics and Applications in Life Sciences
Kobeissy, F. H., Gülbakan, B., Alawieh, A. M., Karam, P., Zhang, Z., Guingab-Cagmat, J. D., Mondello, S., Tan, W., Anagli, J. Y., & Wang, K. (2014) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2013.0074 · Cited by 28 · see citing works
New‐generation mass spectrometry expands the toolbox of cell and developmental biology
Lombard‐Banek, C., Portero, E. P., Onjiko, R. M., & Nemes, P. (2017) · genesis · doi:10.1002/dvg.23012 · Cited by 28 · see citing works
Park, H., & Park, S. B. (2019) · Chemical Science · doi:10.1039/c8sc05465g · Cited by 27 · see citing works
Aydoğan, C. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117759 · Cited by 27 · see citing works
Köcher, T., Pichler, P., Pra, M. D., Rieux, L., Swart, R., & Mechtler, K. (2014) · PROTEOMICS · doi:10.1002/pmic.201300418 · Cited by 26 · see citing works
Navas-Carrillo, D., Marín, F. R., Valdés, M., & Orenes‐Piñero, E. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2016.1241214 · Cited by 26 · see citing works
Impact of Protease on Ultraviolet Photodissociation Mass Spectrometry for Bottom-up Proteomics
Greer, S. M., Parker, W. R., & Brodbelt, J. S. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00165 · Cited by 24 · see citing works
Xiao, Z., Wang, L., Liu, Y., Wang, Q., & Zhang, B. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.12.002 · Cited by 23 · see citing works
Polasky, D. A., Lermyte, F., Nshanian, M., Sobott, F., Andrews, P., Loo, J. A., & Ruotolo, B. T. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04806 · Cited by 22 · see citing works
Nogueira, F. C. S., & Domont, G. B. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0685-7_1 · Cited by 21 · see citing works
Prediction of Peptide Fragment Ion Mass Spectra by Data Mining Techniques
Dong, N., Liang, Y., Xu, Q., Mok, D. K., Yi, L., Lü, H., He, M., & Fan, W. (2014) · Analytical Chemistry · doi:10.1021/ac501094m · Cited by 21 · see citing works
Mass Spectrometry-Based Biomarker Discovery
Zhou, W., Petricoin, E. F., & Longo, C. (2011) · Methods in molecular biology · doi:10.1007/978-1-60327-216-2_16 · Cited by 21 · see citing works
Seeing the forest through the trees: characterizing the glycoproteome
Critcher, M., Hassan, A. A., & Huang, M. L. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.02.007 · Cited by 21 · see citing works
Engineered ChymotrypsiN for Mass Spectrometry-Based Detection of Protein Glycosylation
Ramesh, B., Abnouf, S., Mali, S., Moree, W. J., Patil, U., Bark, S. J., & Varadarajan, N. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00506 · Cited by 20 · see citing works
Current status of clinical proteogenomics in lung cancer
Nishimura, T., Nakamura, H., Végvári, Á., Marko‐Varga, G., Furuya, N., & Saji, H. (2019) · Expert Review of Proteomics · doi:10.1080/14789450.2019.1654861 · Cited by 19 · see citing works
Nano‐liquid chromatography with a new nano‐structured monolithic nanocolumn for proteomics analysis
Günyel, Z., Aslan, H., Demir, N., & Aydoğan, C. (2021) · Journal of Separation Science · doi:10.1002/jssc.202100454 · Cited by 19 · see citing works
Foodomics: LC and LC-MS-based omics strategies in food science and nutrition
Gilbert‐López, B., Valdés, A., Acunha, T., García‐Cañas, V., Simó, C., & Cifuentes, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805392-8.00010-4 · Cited by 18 · see citing works
Zhang, X., & Miller, K. W. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.042556 · Cited by 17 · see citing works
Protein Analysis by Shotgun Proteomics
Gao, Y., & Yates, J. R. (2019) · Wiley eBooks · doi:10.1002/9781118970195.ch1 · Cited by 17 · see citing works
Self-citationBustamante‐Filho, I. C., Pasini, M., & Moura, A. A. (2022) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2022.107075 · Cited by 17 · see citing works
Lombard‐Banek, C., & Schiel, J. E. (2020) · Molecules · doi:10.3390/molecules25061396 · Cited by 16 · see citing works
Proteomics in the World of Induced Pluripotent Stem Cells
Lindoso, R. S., Kasai-Brunswick, T. H., Monnerat, G., Collino, F., Carvalho, A. B., de Carvalho, A. C. C., & Vieyra, A. R. (2019) · Cells · doi:10.3390/cells8070703 · Cited by 15 · see citing works
Yao, Y., Huang, J., Cheng, K., Pan, Y., Qin, H., Ye, M., & Zou, H. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02711 · Cited by 14 · see citing works
Huang, J., Wang, J., Li, Q., Zhang, Y., & Zhang, X. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00521 · Cited by 13 · see citing works
IMTBX and Grppr: Software for Top-Down Proteomics Utilizing Ion Mobility-Mass Spectrometry
Avtonomov, D. M., Polasky, D. A., Ruotolo, B. T., & Nesvizhskii, A. I. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04999 · Cited by 14 · see citing works
Yuan, Z., Chen, M., Wang, J., Li, Z., Geng, X., & Sun, J. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.05.003 · Cited by 13 · see citing works
Aydoğan, C., Aslan, H., Günyel, Z., Demir, N., Erdoğan, İ. Y., Alharthi, S., & Rassi, Z. E. (2021) · Electrophoresis · doi:10.1002/elps.202100050 · Cited by 13 · see citing works
Proteomics strategies to analyze HPV-transformed cells: relevance to cervical cancer
Domenico, F. D., Marco, F. D., & Marzia Perluigi, A. (2013) · Expert Review of Proteomics · doi:10.1586/14789450.2013.842469 · Cited by 13 · see citing works
Detergents: Friends not foes for high‐performance membrane proteomics toward precision medicine
Zhang, X. (2016) · PROTEOMICS · doi:10.1002/pmic.201600209 · Cited by 12 · see citing works
Sanders, J. D., Greer, S. M., & Brodbelt, J. S. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03396 · Cited by 13 · see citing works
Greer, S. M., Bern, M. W., Becker, C. H., & Brodbelt, J. S. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00673 · Cited by 12 · see citing works
Advances in proteomics for production strain analysis
Landels, A. R., Evans, C. A., Noirel, J., & Wright, P. C. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.05.001 · Cited by 12 · see citing works
Tsuchida, S., Satoh, M., Sogawa, K., Kawashima, Y., Kado, S., Ishige, T., Beppu, M., Sawai, S., Nishimura, M., Kodera, Y., et al. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300122 · Cited by 10 · see citing works
Topology-driven discovery of transmembrane protein S-palmitoylation
Forrester, M. T., Egol, J. R., Ozbay, S., Waddell, F. D., Singh, R., & Tata, P. R. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108259 · Cited by 9 · see citing works
Pan, Y., Ye, M., Zheng, H., Cheng, K., Sun, Z., Liu, F., Liu, J., Wang, K., Qin, H., & Zou, H. (2013) · Analytical Chemistry · doi:10.1021/ac403060d · Cited by 9 · see citing works
Mutant Proteomics of Lung Adenocarcinomas Harboring Different EGFR Mutations
Nishimura, T., Végvári, Á., Nakamura, H., Kato, H., & Saji, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01494 · Cited by 9 · see citing works
Pomilio, A. B., Vitale, A. A., & Lazarowski, A. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220413094918 · Cited by 8 · see citing works
Yu, H.-Y., Tai, Q., Yang, C.-J., Gao, M.-X., & Zhang, X.-M. (2023) · Journal of Chromatography A · doi:10.1016/j.chroma.2023.464048 · Cited by 7 · see citing works
Identification of Single Amino Acid Substitutions in Proteogenomics
Moshkovskii, S., Ivanov, M., Kuznetsova, K. G., & Gorshkov, M. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918030057 · Cited by 7 · see citing works
Gaspari, M., Chiesa, L. M., Nicastri, A., Gabriele, C., Harper, V., Britti, D., Cuda, G., & Procopio, A. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02848 · Cited by 7 · see citing works
Mauser, A., Gensberger‐Reigl, S., Dalabasmaz, S., Schichtl, T. M., Dittrich, D., & Pischetsrieder, M. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00207 · Cited by 7 · see citing works
Solovyeva, E. M., Kopysov, V. N., Pereverzev, A. Y., Lobas, A. A., Moshkovskii, S. A., Gorshkov, M. V., & Boyarkin, O. V. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00770 · Cited by 7 · see citing works
Proteomic approaches for cancer epigenetics research
Marchione, D. M., Garcia, B. A., & Wojcik, J. B. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2019.1550363 · Cited by 7 · see citing works
Kumar, M., Possemato, A. P., Zee, B. M., Subramanian, S., Ren, J. M., Nelson, A. J., Zhang, B., Landry, S. D., Silva, J. C., Larsen, B. G., et al. (2026) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2026.101562 · Cited by 6 · see citing works
Shotgun Approaches for Venom Analysis
Melani, R. D., Goto‐Silva, L., Nogueira, F. C. S., Junqueira, M., & Domont, G. B. (2016) · Springer eBooks · doi:10.1007/978-94-007-6416-3_26 · Cited by 6 · see citing works
Guo, C., Zhao, X., Zhang, W., Bai, H., Qin, W., Song, H., & Qian, X. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-017-0417-4 · Cited by 6 · see citing works
Prediction of Protein-Protein Interactions: Looking Through the Kaleidoscope
Laddach, A., Chung, S. S., & Fraternali, F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.20470-6 · Cited by 6 · see citing works
Forbes, M., Kempa, R., Mastrobuoni, G., Rayman, L., Pietzke, M., Bayram, Ş., Arlt, B., Spruessel, A., Deubzer, H. E., & Kempa, S. (2024) · Cancers · doi:10.3390/cancers16091664 · Cited by 5 · see citing works
Low-Abundance Protein Access by Combinatorial Peptide Libraries
Righetti, P. G., & Boschetti, E. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-401734-4.00004-x · Cited by 5 · see citing works
Vinh, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814013-0.00017-x · Cited by 5 · see citing works
Zhang, X. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.047514 · Cited by 5 · see citing works
Aini, A. N., Aırın, C. M., & Raharjo, T. J. (2022) · Indonesian Journal of Chemistry · doi:10.22146/ijc.73656 · Cited by 4 · see citing works
Shahin‐Shamsabadi, A., & Cappuccitti, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40772 · Cited by 4 · see citing works
Aydoğan, C., & Alharthi, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413646 · Cited by 4 · see citing works
Unfolding of protein using MoS2/SnS2 heterostructure for nanopore-based sequencing
Yuan, R., Zhang, Z., Wu, G., Zhang, Y., Sha, J., Chen, Y., & Si, W. (2023) · Nanotechnology · doi:10.1088/1361-6528/ad177f · Cited by 4 · see citing works
ARID3C Acts as a Regulator of Monocyte-to-Macrophage Differentiation Interacting with NPM1
Kim, H.-S., Kim, Y., & Cho, J. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00509 · Cited by 4 · see citing works
Zhang, T., Niu, X., Yuan, T., Tessari, M., de Vries, M. P., Permentier, H. P., & Bischoff, R. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b01154 · Cited by 4 · see citing works
Cantero, P., Ehret‐Sabatier, L., Lenormand, C., Hansmann, Y., Sauleau, E., Zilliox, L., Westermann, B., Jaulhac, B., Mutter, D., Barthel, C., et al. (2024) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2024.10.014 · Cited by 3 · see citing works
KYSS: Mass spectrometry data quality assessment for protein analysis and large-scale proteomics
Such-Sanmartín, G., Sidoli, S., Ventura-Espejo, E., & Jensen, O. N. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.066 · Cited by 3 · see citing works
Emerging insights and challenges for understanding T cell function through the proteome
Solt, L. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1028366 · Cited by 3 · see citing works
Equipping Physiologists with an Informatics Tool Chest: Toward an Integerated Mitochondrial Phenome
Garlid, A. O., Polson, J., Garlid, K., Hermjakob, H., & Ping, P. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_93 · Cited by 3 · see citing works
Si, W., Chen, H., & Wu, G. (2025) · Physical Chemistry Chemical Physics · doi:10.1039/d5cp01017a · Cited by 2 · see citing works
- Authors
- Yates, J. R.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Yates, John R.
- ORCID
- Yates, John R.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-01-16
- Volume
- 135
- Issue
- 5
- Pages
- 1629-1640
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- PMC
- PMC3751590
- OpenAlex
- W35392279
- Cited by
- 131
- References
- 145
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 12 · 2015: 13 · 2014: 14 · 2013: 9
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of the American Chemical Society (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (HHSN2682010000035C)
- National Institute on Aging (P01AG031097)
- National Heart, Lung, and Blood Institute (R01HL079442)
- National Institute of Mental Health (R01MH067880)
- National Institute of General Medical Sciences (P41GM103533, P41 RR011823/GM103533)
- National Center for Research Resources (P41RR011823)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- shotgun proteomics, mass spectrometry instrumentation, disruptive innovation, sustained innovation, protein modification, protein complexes, history of mass spectrometry
- MeSH terms
- Animals, Humans, Models, Molecular, Mass Spectrometry, Proteome, Proteomics, Mice, Rats
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