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Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking
Open accessPublished version of a preprint
Abstract
Immune response and new tissue formation are important aspects of tissue repair. However, only a single aspect is generally considered in previous biomedical interventions, and the synergistic effect is unclear. Here, a dual-effect coating with immobilized immunomodulatory metal ions (e.g., Zn 2+ ) and osteoinductive growth factors (e.g., BMP-2 peptide) is designed via mussel adhesion-mediated ion coordination and molecular clicking strategy. Compared to the bare TiO 2 group, Zn 2+ can increase M2 macrophage recruitment by up to 92.5% in vivo and upregulate the expression of M2 cytokine IL-10 by 84.5%; while the dual-effect of Zn 2+ and BMP-2 peptide can increase M2 macrophages recruitment by up to 124.7% in vivo and upregulate the expression of M2 cytokine IL-10 by 171%. These benefits eventually significantly enhance bone-implant mechanical fixation (203.3 N) and new bone ingrowth (82.1%) compared to the bare TiO 2 (98.6 N and 45.1%, respectively). Taken together, the dual-effect coating can be utilized to synergistically modulate the osteoimmune microenvironment at the bone-implant interface, enhancing bone regeneration for successful implantation.
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“The reduction of CD68-positive cells in the group of ICMA@CZ was notably greater than that in the ICMA group (Fig. 4, G and H), attributable to the capacity of zinc ions to regulate the macrophage polarization (41).”
From Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation (2025) · cites this paper as [41]
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Metadata
- Authors
- Wang, T., Bai, J., Lu, M., Huang, C., Geng, D., Chen, G., Wang, L., Qi, J., Cui, W., & Deng, L.
- Affiliations
- Shanghai Jiao Tong University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Jiaxing University (CN)
- Corresponding author
- Cui, Wenguo
- Deng, Lianfu
- Venue
- Nature Communications
- Published
- 2022-01-10
- Volume
- 13
- Issue
- 1
- Pages
- 160-160
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8748715
- OpenAlex
- W4225729780
- Cited by
- 221
- References
- 69
- Citations by year
- 2026: 31 · 2025: 71 · 2024: 52 · 2023: 45 · 2022: 22
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Update notices
- correction (2026-09-09)
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82102535, 81972134)
- China Postdoctoral Science Foundation (2016M661560)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Keywords
- implant surface modification, mussel adhesion, zinc coordination, M2 macrophages, IL-10, osteoimmunomodulation, bone-implant interface, bone regeneration, titanium implants
- MeSH terms
- RAW 264.7 Cells, Bone-Implant Interface, Animals, Cell Differentiation, Femur, Lipopolysaccharides, Macrophage Activation, Macrophages, Male, Osteoblasts, Osteogenesis, Protein Precursors, Titanium, Zinc, Biomarkers, Antigens, CD, Interleukin-10, Rats, Sprague-Dawley, Prostheses and Implants, Bivalvia, Mice, Rats, Bone Morphogenetic Protein 2, Mesenchymal Stem Cells
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