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Polydopamine Surface Chemistry: A Decade of Discovery

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Zinc and its role in immunity and inflammation

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

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Bone Repair Biomaterials: A Perspective from Immunomodulation

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Mechanically robust and personalized silk fibroin-magnesium composite scaffolds with water-responsive shape-memory for irregular bone regeneration

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Multiscale architecture design of 3D printed biodegradable Zn-based porous scaffolds for immunomodulatory osteogenesis

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Topography-mediated immunomodulation in osseointegration; Ally or Enemy

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Fit and forget: The future of dental implant therapy via nanotechnology

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Osteoimmune regulation underlies oral implant osseointegration and its perturbation

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Activating Macrophage Continual Efferocytosis via Microenvironment Biomimetic Short Fibers for Reversing Inflammation in Bone Repair

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Microenvironment-targeted strategy steers advanced bone regeneration

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Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration

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Macrophage-mediated immunomodulation in biomaterial-assisted bone repair: Molecular insights and therapeutic prospects

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Ultrasound-responsive smart composite biomaterials in tissue repair

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Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

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A multifunctional self-reinforced injectable hydrogel for enhancing repair of infected bone defects by simultaneously targeting macrophages, bacteria, and bone marrow stromal cells

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Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: Single-cell transcriptome analysis

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Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation

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Bio-inspired dual-adhesive particles from microfluidic electrospray for bone regeneration

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Mechanochemically Reprogrammed Interface Orchestrates Neutrophil Bactericidal Activity and Apoptosis for Preventing Implant‐Associated Infection

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Structure driven bio-responsive ability of injectable nanocomposite hydrogels for efficient bone regeneration

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Sericin/Nano-Hydroxyapatite Hydrogels Based on Graphene Oxide for Effective Bone Regeneration via Immunomodulation and Osteoinduction

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Surface Modification of Titanium Implants by Metal Ions and Nanoparticles for Biomedical Application

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Functionally Tailored Metal–Organic Framework Coatings for Mediating Ti Implant Osseointegration

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3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration

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Janus hydrogel microrobots with bioactive ions for the regeneration of tendon-bone interface

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Assessment of β stabilizers additions on microstructure and properties of as-cast β Ti–Nb based alloys

dos Santos, R. F. M., Rossi, M. C., Vidilli, A. L., Amigó, V., & Afonso, C. R. M. (2022) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2022.12.144 · Cited by 52

Ultrasonic-controlled “explosive” hydrogels to precisely regulate spatiotemporal osteoimmune disturbance

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Electrospun nanofibers for bone regeneration: from biomimetic composition, structure to function

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Biomechanics and Mechanobiology of Additively Manufactured Porous Load‐Bearing Bone Implants

Jin, Y. Q., Li, J., Fan, H., Du, J., & He, Y. (2025) · Small · doi:10.1002/smll.202409955 · Cited by 50

Photoelectrons Sequentially Regulate Antibacterial Activity and Osseointegration of Titanium Implants

Tang, Y., Wang, K., Wu, B., Yao, K., Feng, S., Zhou, X., & Xiang, L. (2023) · Advanced Materials · doi:10.1002/adma.202307756 · Cited by 49

A biodegradable magnesium alloy promotes subperiosteal osteogenesis via interleukin-10-dependent macrophage immunomodulation

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Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

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Calcium phosphate coating enhances osteointegration of melt electrowritten scaffold by regulating macrophage polarization

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ZnCe-LDO Nanozyme-Based Multifunctional Hydrogel Promotes Bone Regeneration by Inflammatory Macrophage Reprogramming and Piezo1 Activation

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In Situ-Activated Phospholipid-Mimic Artemisinin Prodrug via Injectable Hydrogel Nano/Microsphere for Rheumatoid Arthritis Therapy

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Programmed surface platform orchestrates anti-bacterial ability and time-sequential bone healing for implant-associated infection

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Bone Morphogenetic Protein-2–Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration

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3D printed strontium-doped calcium phosphate ceramic scaffold enhances early angiogenesis and promotes bone repair through the regulation of macrophage polarization

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A Zinc Oxide Nanowire‐Modified Mineralized Collagen Scaffold Promotes Infectious Bone Regeneration

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Biomimetic Implant Surfaces and Their Role in Biological Integration—A Concise Review

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BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization

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Peptide-based inflammation-responsive implant coating sequentially regulates bone regeneration to enhance interfacial osseointegration

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Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration

Li, J., Qu, Y., Chu, B., Wu, T., Pan, M., Mo, D., Li, L., Ming, Y., Yang, Y. S., Wang, M., et al. (2025) · Advanced Science · doi:10.1002/advs.202501209 · Cited by 50

Spatiotemporal Immunomodulation and Biphasic Osteo‐Vascular Aligned Electrospun Membrane for Diabetic Periosteum Regeneration

Qiao, Y., Yu, L., Yang, P., Chen, M., Sun, H., Wang, L., Wu, B., Oh, C., Yang, H., Bai, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202302874 · Cited by 41

Biomaterials that passively and actively target macrophages promote the regeneration of injured tissues

Zhuang, P., Wu, Y., Chen, Y., Zhang, Y., Leboucher, C., Rosenholm, J. M., & Zhang, H. (2024) · Biomedical Technology · doi:10.1016/j.bmt.2024.09.005 · Cited by 46

Recent Advancements in Metallic Drug-Eluting Implants

Alshimaysawee, S., Obaid, R. F., Al-Gazally, M. E., Ramírez‐Coronel, A. A., & Bathaei, M. S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010223 · Cited by 40

Comprehensive Overview of Interface Strategies in Implant Osseointegration

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A 3D Bioprinted Nanoengineered Hydrogel with Photoactivated Drug Delivery for Tumor Apoptosis and Simultaneous Bone Regeneration via Macrophage Immunomodulation

Dutta, S. D., Ganguly, K., Hexiu, J., Randhawa, A., Moniruzzaman, M., & Lim, K. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300096 · Cited by 39

Immune regulation enhances osteogenesis and angiogenesis using an injectable thiolated hyaluronic acid hydrogel with lithium-doped nano-hydroxyapatite (Li-nHA) delivery for osteonecrosis

Luo, Y., Yang, Z., Zhao, X., Li, D., Li, Q., Wei, Y., Wan, L., Tian, M., & Kang, P. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100976 · Cited by 41

In situ fused granular hydrogels with ultrastretchability, strong adhesion, and mutli-bioactivities for efficient chronic wound care

Yuan, Z., Wan, Z., Tian, Z., Han, Y., Huang, X., Feng, Y., Xie, W., Duan, X., Huang, S., Liu, X., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138076 · Cited by 38

Biomimetically ordered ultralong hydroxyapatite nanowires-based hierarchical hydrogel scaffold with osteoimmunomodulatory and osteogenesis abilities for augmenting bone regeneration

Geng, X., Tang, Y., Yuan, B., Dai, Y., Yu, H., Xiong, Z., Zhu, Y., & Chen, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.151136 · Cited by 38

Mussel-inspired polydopamine decorated alginate dialdehyde-gelatin 3D printed scaffolds for bone tissue engineering application

Ghorbani, F., Kim, M., Monavari, M., Ghalandari, B., & Boccaccini, A. R. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.940070 · Cited by 36

Implantable Medical Devices, Biomaterials, and the Foreign Body Response: A Surgical Perspective

Kalashnikov, N., Barralet, J. E., & Vorstenbosch, J. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37983 · Cited by 39

Endogenous dual-responsive and self-adaptive silk fibroin-based scaffold with enhancement of immunomodulation for skull regeneration

Bi, X., Mao, Z., Zhang, Y., Ren, Z., Yang, K., Yu, C., Chen, L., Zheng, R., Guan, J., Liu, Z., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123261 · Cited by 34

The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review

Dong, C., Tan, G., Zhang, G., Lin, W., & Wang, G. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1133995 · Cited by 34

Immunomodulatory zinc-based materials for tissue regeneration

Pan, X., Ou, M., Lu, Y., Nie, Q., Dai, X., & Liu, O. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213503 · Cited by 33

Tailoring osteoimmunity and hemostasis using 3D-Printed nano-photocatalytic bactericidal scaffold for augmented bone regeneration

Dutta, S. D., Hexiu, J., Moniruzzaman, M., Patil, T. V., Acharya, R., Kim, J. S., & Lim, K. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122991 · Cited by 32

Canonical Wnt signaling enhances pro-inflammatory response to titanium by macrophages

Avery, D., Morandini, L., Sheakley, L. S., Shah, A. H., Bui, L., Abaricia, J. O., & Olivares‐Navarrete, R. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121797 · Cited by 35

Multifunctional modifications of polyetheretherketone implants for bone repair: A comprehensive review

Zheng, W., Wu, D., Zhang, Y., Luo, Y., Yang, L., Xu, X., & Luo, F. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213607 · Cited by 34

Mussel‐Derived and Bioclickable Peptide Mimic for Enhanced Interfacial Osseointegration via Synergistic Immunomodulation and Vascularized Bone Regeneration

Zhou, W., Liu, Y., Dong, J., Hu, X., Su, Z., Zhang, X., Zhu, C., Xiong, L., Huang, W. X., & Bai, J. (2024) · Advanced Science · doi:10.1002/advs.202401833 · Cited by 29

Concrete‐Inspired Bionic Bone Glue Repairs Osteoporotic Bone Defects by Gluing and Remodeling Aging Macrophages

Li, C., Xu, W. L., Li, L., Zhou, Y., Yao, G., Chen, G., Xu, L., Yang, N., Yan, Z., Chen, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202408044 · Cited by 29

Mimicking Bone Extracellular Matrix: From BMP‐2‐Derived Sequences to Osteogenic‐Multifunctional Coatings

Oliver‐Cervelló, L., Martín-Gómez, H., Mandakhbayar, N., Jo, Y., Cavalcanti‐Adam, E. A., Kim, H., Ginebra, M., Lee, J., & Mas‐Moruno, C. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201339 · Cited by 33

Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells

Ge, J., Yu, Y., Li, J., Li, M., Xia, S., Xue, K., Wang, S., & Yang, C. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01066-x · Cited by 31

Injectable, Hierarchically Degraded Bioactive Scaffold for Bone Regeneration

Ye, J., Liu, N., Li, Z., Liu, L., Ming, Z., Wen, X., Wang, N., Xu, Y., Sun, B., & Zhou, Q. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c18824 · Cited by 28

Immunoregulatory silicon-deposited implant promotes osseointegration

Wang, T., Chen, X., Zhang, Y., Ye, T., Liu, Z., Wang, L., Cui, W., Pan, G., Zuo, G., & Deng, L. (2023) · Composites Part B Engineering · doi:10.1016/j.compositesb.2023.110618 · Cited by 28

Occlusive membranes for guided regeneration of inflamed tissue defects

Choi, W., Mangal, U., Park, J., Kim, J., Jun, T., Jung, J. W., Choi, M., Jung, S.-W., Lee, M., Na, J.-Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43428-3 · Cited by 30

Design principles and application research of mussel-inspired materials: A review

Xu, S., Kang, M., Xin, X., Liang, J., Xiao, H., Lu, Y., Yang, J., & Zhai, H. (2023) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2023.111655 · Cited by 27

Bioinspired Hybrid Nanostructured PEEK Implant with Enhanced Antibacterial and Anti-inflammatory Synergy

Ao, J., Zhang, X., You, Y., Chen, Y., Liu, Z., Gao, J., Qin, C., Hao, L., Zhao, J., & Jiang, R. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c06322 · Cited by 25

Biomimetic Surface Nanoengineering of Biodegradable Zn‐Based Orthopedic Implants for Enhanced Biocompatibility and Immunomodulation

Xiang, E., Vaquette, C., Liu, S., Raveendran, N. T., Schulz, B. L., Nowwarote, N., Dargusch, M. S., Abdal‐hay, A., Fournier, B., & Ivanovski, S. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202410033 · Cited by 27

Silver-quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming

Yang, N., Wu, T., Li, M., Hu, X., Ma, R., Jiang, W., Su, Z., Yang, R., & Zhu, C. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.012 · Cited by 25

A microenvironment responsive polyetheretherketone implant with antibacterial and osteoimmunomodulatory properties facilitates osseointegration

Chen, M., Qiao, Y., Yu, L., Wang, W., Wang, W., Sun, H., Xu, Y., Bai, J., Zhou, J., & Geng, D. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.017 · Cited by 26

Charge and receptor functional injectable hydrogels as cytokine-releasing reservoirs for wound healing

Mao, J., Cai, Z., Liu, Z., Qian, S., Zhao, B., Zhang, Y., Zhuang, Y., Zhang, L., Mao, X., Zhang, Y., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137880 · Cited by 25

Mussel-Inspired Caries Management Strategy: Constructing a Tribioactive Tooth Surface with Remineralization, Antibiofilm, and Anti-inflammation Activity

Xu, Y., Guan, J., Wang, Q., Xue, R., He, Z., Lu, X., Fan, J., Yu, H., Turghun, C., Wei, Y., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c21672 · Cited by 25

Recent advances in immunomodulatory hydrogels biomaterials for bone tissue regeneration

Fu, M., Yang, C., & Sun, G. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.09.010 · Cited by 26

3D‐Printed In Situ Growth of Bilayer MOF Hydrogels for Accelerated Osteochondral Defect Repair

Qin, K., Huang, X., Wang, S., Liang, J., & Fan, Z. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403840 · Cited by 24

Zinc Oxide-Copper Sulfide Nanozyme Hydrogels for Bone Defect Repair by Modulating the Bone Immune Microenvironment and Promoting Osteogenesis/Angiogenesis

Sun, Y., Yao, X., Zhang, Y., Zhang, W., Zhu, C., Shen, C., Wang, Y., & Wang, X. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c23069 · Cited by 24

An Injectable Hydrogel Composing Anti‐Inflammatory and Osteogenic Therapy toward Bone Erosions Microenvironment Remodeling in Rheumatoid Arthritis

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Modularity-based mathematical modeling of ligand inter-nanocluster connectivity for unraveling reversible stem cell regulation

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