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Cited by 578

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

Open access
Li, Baisheng, Deng, Aiping, Li, Kuibiao, Hu, Yao, Li, Zhencui, Shi, Yaling, Xiong, Qianling, Liu, Zhe, Guo, Qianfang, Zou, Lirong, Zhang, Huan, Zhang, Meng, Ouyang, Fangzhu, Su, Juan, Su, Wenzhe, Xu, Jing, Lin, Huifang, Sun, Jing, Peng, Jinju, Jiang, Huiming, Zhou, Pingping, Hu, Ting, Luo, Min, Zhang, Yingtao, Zheng, Huanying, Xiao, Jianpeng, Liu, Tao, Tan, Mingkai, Che, Rongfei, Zeng, Hanri, Zheng, Zhonghua, Huang, Yushi, Yu, Jianxiang, Yi, Lina, Wu, Jie, Chen, Jingdiao, Zhong, Haojie, Deng, Xiaoling, Kang, Min, Pybus, Oliver G., Hall, Matthew, Lythgoe, Katrina A., Li, Yan, Yuan, Jun, He, Jianfeng, Lu, Jing·2022·Nature Communications
DOI 10.1038/s41467-022-28089-y
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Abstract

The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on its virological profile, we here report the first local transmission of Delta in mainland China. All 167 infections could be traced back to the first index case. Daily sequential PCR testing of quarantined individuals indicated that the viral loads of Delta infections, when they first become PCR-positive, were on average ~1000 times greater compared to lineage A/B infections during the first epidemic wave in China in early 2020, suggesting potentially faster viral replication and greater infectiousness of Delta during early infection. The estimated transmission bottleneck size of the Delta variant was generally narrow, with 1-3 virions in 29 donor-recipient transmission pairs. However, the transmission of minor iSNVs resulted in at least 3 of the 34 substitutions that were identified in the outbreak, highlighting the contribution of intra-host variants to population-level viral diversity during rapid spread.

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Metadata

Authors
Li, B., Deng, A., Li, K., Hu, Y., Li, Z., Shi, Y., Xiong, Q., Liu, Z., Guo, Q., Zou, L., Zhang, H., Zhang, M., Ouyang, F., Su, J., Su, W., Xu, J., Lin, H., Sun, J., Peng, J., Jiang, H., Zhou, P., Hu, T., Luo, M., Zhang, Y., Zheng, H., Xiao, J., Liu, T., Tan, M., Che, R., Zeng, H., Zheng, Z., Huang, Y., Yu, J., Yi, L., Wu, J., Chen, J., Zhong, H., Deng, X., Kang, M., Pybus, O. G., Hall, M., Lythgoe, K. A., Li, Y., Yuan, J., He, J., & Lu, J.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2022-01-24
Volume
13
Issue
1
Pages
460-460
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-022-28089-y
OpenAlex
W4226076101
Cited by
578
References
34
FWCI
47.07
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant. https://app.cochat.ai/papers/10.1038/s41467-022-28089-y
The paper
Li, B., Deng, A., Li, K., Hu, Y., Li, Z., Shi, Y., Xiong, Q., Liu, Z., Guo, Q., Zou, L., Zhang, H., Zhang, M., Ouyang, F., Su, J., Su, W., Xu, J., Lin, H., Sun, J., Peng, J., . . . Lu, J. (2022). Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant. Nature Communications. https://doi.org/10.1038/s41467-022-28089-y

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.