The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy
Open accessAbstract
Golgi apparatus (GA) oxidative stress induced by in situ reactive oxygen species (ROS) could severely damage the morphology and function of GA, which may open up an avenue for effective photodynamic therapy (PDT). However, due to the lack of effective design strategy, photosensitizers (PSs) with specific GA targeting ability are in high demand and yet quite challenging. Herein, we report an aggregation-induced emission luminogen (AIEgen) based PS (TPE-PyT-CPS) that can effectively target the GA via caveolin/raft mediated endocytosis with a Pearson correlation coefficient up to 0.98. Additionally, the introduction of pyrene into TPE-PyT-CPS can reduce the energy gap between the lowest singlet state (S 1 ) and the lowest triplet state (T 1 ) (Δ E ST ) and exhibits enhanced singlet oxygen generation capability. GA fragmentation and cleavage of GA proteins (p115/GM130) are observed upon light irradiation. Meanwhile, the apoptotic pathway is activated through a crosstalk between GA oxidative stress and mitochondria in HeLa cells. More importantly, GA targeting TPE-T-CPS show better PDT effect than its non-GA-targeting counterpart TPE-PyT-PS, even though they possess very close ROS generation rate. This work provides a strategy for the development of PSs with specific GA targeting ability, which is of great importance for precise and effective PDT.
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Cites
Activation of apoptosis signalling pathways by reactive oxygen species
Redza-Dutordoir, M., & Averill-Bates, D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.09.012 · Cited by 3,731
BODIPY dyes in photodynamic therapy
Kamkaew, A., Lim, S. H., Lee, H. B., Kiew, L. V., Chung, L. Y., & Burgess, K. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35216h · Cited by 2,104
Photosensitizers with Aggregation‐Induced Emission: Materials and Biomedical Applications
Hu, F., Xu, S., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201801350 · Cited by 859
Nguyen, V.-N., Yan, Y., Zhao, J., & Yoon, J. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00606 · Cited by 650
Aggregation‐enhanced theranostics: AIE sparkles in biomedical field
Kang, M., Zhang, Z., Song, N., Li, M., Sun, P., Chen, X., Wang, D., & Tang, B. Z. (2020) · Aggregate · doi:10.1002/agt2.7 · Cited by 485
Gathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284
Cited by
Feng, X., Wang, X., Redshaw, C., & Tang, B. Z. (2023) · Chemical Society Reviews · doi:10.1039/d3cs00251a · Cited by 382
A Forward Vision for Chemodynamic Therapy: Issues and Opportunities
Zhao, P., Li, H., & Bu, W. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202210415 · Cited by 308
Liang, M., Liu, L., Sun, Y., Li, J., Zhang, L., Jiang, X., & Wu, W. (2024) · Aggregate · doi:10.1002/agt2.458 · Cited by 90
Metadata
- Authors
- Liu, M., Chen, Y., Guo, Y., Yuan, H., Cui, T., Yao, S., Jin, S., Fan, H., Wang, C., Xie, R., He, W., & Guo, Z.
- Venue
- Nature Communications
- Published
- 2022-04-21
- Volume
- 13
- Issue
- 1
- Pages
- 2179-2179
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W4224215946
- Cited by
- 218
- References
- 6
- FWCI
- 27.34
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, M., Chen, Y., Guo, Y., Yuan, H., Cui, T., Yao, S., Jin, S., Fan, H., Wang, C., Xie, R., He, W., & Guo, Z. (2022). Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy. Nature Communications. https://doi.org/10.1038/s41467-022-29872-7
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