The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery
Open accessAbstract
Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore, eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and superoxide dismutase may effectively curb inflammatory bowel disease (IBD). Here, Escherichia coli Nissle 1917 (ECN), a kind of oral probiotic, was genetically engineered to overexpress catalase and superoxide dismutase (ECN-pE) for the treatment of intestinal inflammation. To improve the bioavailability of ECN-pE in the gastrointestinal tract, chitosan and sodium alginate, effective biofilms, were used to coat ECN-pE via a layer-by-layer electrostatic self-assembly strategy. In a mouse IBD model induced by different chemical drugs, chitosan/sodium alginate coating ECN-pE (ECN-pE(C/A) 2 ) effectively relieved inflammation and repaired epithelial barriers in the colon. Unexpectedly, such engineered EcN-pE(C/A) 2 could also regulate the intestinal microbial communities and improve the abundance of Lachnospiraceae _NK4A136 and Odoribacter in the intestinal flora, which are important microbes to maintain intestinal homeostasis. Thus, this study lays a foundation for the development of living therapeutic proteins using probiotics to treat intestinal-related diseases.
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Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
Sanna, S., van Zuydam, N. R., Mahajan, A., Kurilshikov, A., Vich Vila, A., Võsa, U., Mujagic, Z., Masclee, A. A. M., Jonkers, D. M. A. E., Oosting, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0350-x · Cited by 1,539
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Inflammatory Bowel Disease in Children and Adolescents
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Cited by
Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health
Mazziotta, C., Tognon, M., Martini, F., Torreggiani, E., & Rotondo, J. C. (2023) · Cells · doi:10.3390/cells12010184 · Cited by 889
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381
Roy, S., & Dhaneshwar, S. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i14.2078 · Cited by 334
Estevinho, M. M., Yuan, Y., Rodríguez‐Lago, I., Sousa‐Pimenta, M., Dias, C. C., Barreiro‐de Acosta, M., Jairath, V., & Magro, F. (2024) · United European gastroenterology journal · doi:10.1002/ueg2.12636 · Cited by 74
“2,3 Over the last decades, several pharmacological treatments have been developed for IBD, covering a wide variety of molecular targets.”
Wang, X., Yang, Y., Wang, P., Li, Q., Gao, W., Sun, Y., Tian, G., Zhang, G., & Xiao, J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.049 · Cited by 26
Self-citation
Metadata
- Authors
- Zhou, J., Li, M., Chen, Q., Li, X., Chen, L., Dong, Z., Zhu, W., Yang, Y., Liu, Z., & Chen, Q.
- Venue
- Nature Communications
- Published
- 2022-06-14
- Volume
- 13
- Issue
- 1
- Pages
- 3432-3432
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W4282937730
- Cited by
- 695
- References
- 51
- FWCI
- 62.31
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhou, J., Li, M., Chen, Q., Li, X., Chen, L., Dong, Z., Zhu, W., Yang, Y., Liu, Z., & Chen, Q. (2022). Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery. Nature Communications. https://doi.org/10.1038/s41467-022-31171-0
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