The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment
Open accessAbstract
Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics across different cancer types. Here, we perform pan-cancer analysis on 226 samples across 10 solid cancer types to profile the TME at single-cell resolution, illustrating the commonalities/plasticity of heterogenous CAFs. Activation trajectory of the major CAF types is divided into three states, exhibiting distinct interactions with other cell components, and relating to prognosis of immunotherapy. Moreover, minor CAF components represent the alternative origin from other TME components (e.g., endothelia and macrophages). Particularly, the ubiquitous presentation of endothelial-to-mesenchymal transition CAF, which may interact with proximal SPP 1 + tumor-associated macrophages, is implicated in endothelial-to-mesenchymal transition and survival stratifications. Our study comprehensively profiles the shared characteristics and dynamics of CAFs, and highlight their heterogeneity and plasticity across different cancer types. Browser of integrated pan-cancer single-cell information is available at https://gist-fgl.github.io/sc-caf-atlas/ .
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Cited by
Fibroblasts in cancer: Unity in heterogeneity
Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 474
Xiong, J., Xiao, R., Zhao, J., Zhao, Q., Luo, M., Li, F., Zhang, W., & Wu, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04810-3 · Cited by 79
Self-citationLi, Y., Jiang, M., Aye, L., Luo, L., Zhang, Y., Xu, F., Wei, Y., Peng, D., He, X., Gu, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45340-w · Cited by 71
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Self-citationProteotoxic stress response drives T cell exhaustion and immune evasion
Wang, Y., Ma, A., Song, N.-J., Shannon, A. E., Amankwah, Y. S., Chen, X., Wu, W., Wang, Z., Saadey, A. A., Yousif, A., et al. (2025) · Nature · doi:10.1038/s41586-025-09539-1 · Cited by 68
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Metadata
- Authors
- Luo, H., Xia, X., Huang, L.-B., An, H., Cao, M., Kim, G. D., Chen, H.-N., Zhang, W.-H., Shu, Y., Kong, X., Ren, Z., Li, P.-H., Liu, Y., Tang, H., Sun, R., Li, C., Bai, B., Jia, W., Liu, Y., Zhang, W., Yang, L., Peng, Y., Dai, L., Hu, H., Jiang, Y., Hu, Y., Zhu, J., Jiang, H., Li, Z., Caulin, C., Park, J., & Xu, H.
- Venue
- Nature Communications
- Published
- 2022-11-04
- Volume
- 13
- Issue
- 1
- Pages
- 6619-6619
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W4308451002
- Cited by
- 567
- References
- 91
- FWCI
- 31.28
- Type
- journal article
- Language
- en
- Open access
- gold
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- Luo, H., Xia, X., Huang, L.-B., An, H., Cao, M., Kim, G. D., Chen, H.-N., Zhang, W.-H., Shu, Y., Kong, X., Ren, Z., Li, P.-H., Liu, Y., Tang, H., Sun, R., Li, C., Bai, B., Jia, W., Liu, Y., . . . Xu, H. (2022). Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment. Nature Communications. https://doi.org/10.1038/s41467-022-34395-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
