The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation
Open accessAbstract
The immunologically “cold” microenvironment of triple negative breast cancer results in resistance to current immunotherapy. Here, we reveal the immunoadjuvant property of gas therapy with cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway activation to augment aggregation-induced emission (AIE)-active luminogen (AIEgen)-based photoimmunotherapy. A virus-mimicking hollow mesoporous tetrasulfide-doped organosilica is developed for co-encapsulation of AIEgen and manganese carbonyl to fabricate gas nanoadjuvant. As tetra-sulfide bonds are responsive to intratumoral glutathione, the gas nanoadjuvant achieves tumor-specific drug release, promotes photodynamic therapy, and produces hydrogen sulfide (H 2 S). Upon near-infrared laser irradiation, the AIEgen-mediated phototherapy triggers the burst of carbon monoxide (CO)/Mn 2+. Both H 2 S and CO can destroy mitochondrial integrity to induce leakage of mitochondrial DNA into the cytoplasm, serving as gas immunoadjuvants to activate cGAS-STING pathway. Meanwhile, Mn 2+ can sensitize cGAS to augment STING-mediated type I interferon production. Consequently, the gas nanoadjuvant potentiates photoimmunotherapy of poorly immunogenic breast tumors in female mice.
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Self-citationTDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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Cited by
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Self-citationXu, Q., Zhang, M., Huang, Q., Gao, S., Chu, S., Li, Q., Chen, W., Zhang, X., Zhang, T., Tang, B. Z., et al. (2025) · Advanced Materials · doi:10.1002/adma.202502898 · Cited by 69
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Metadata
- Authors
- Wang, K., Li, Y., Wang, X., Zhang, Z., Cao, L., Fan, X., Wan, B., Liu, F., Zhang, X., He, Z., Zhou, Y., Wang, D., Sun, J., & Chen, X.
- Venue
- Nature Communications
- Published
- 2023-05-23
- Volume
- 14
- Issue
- 1
- Pages
- 2950-2950
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W4377821379
- Cited by
- 253
- References
- 65
- FWCI
- 18.56
- Type
- journal article
- Language
- en
- Open access
- gold
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