An NIR‐II Excitable AIE Small Molecule with Multimodal Phototheranostic Features for Orthotopic Breast Cancer Treatment
Abstract
One‐for‐all phototheranostics, referring to a single component simultaneously exhibiting multiple optical imaging and therapeutic modalities, has attracted significant attention due to its excellent performance in cancer treatment. Benefitting from the superiority in balancing the diverse competing energy dissipation pathways, aggregation‐induced emission luminogens (AIEgens) are proven to be ideal templates for constructing one‐for‐all multimodal phototheranostic agents. However, to this knowledge, the all‐round AIEgens that can be triggered by a second near‐infrared (NIR‐II, 1000–1700 nm) light have not been reported. Given the deep tissue penetration and high maximum permissible exposure of the NIR‐II excitation light, herein, this work reports for the first time an NIR‐II laser excitable AIE small molecule (named BETT‐2) with multimodal phototheranostic features by taking full use of the advantage of AIEgens in single molecule‐facilitated versatility as well as synchronously maximizing the molecular donor‐acceptor strength and conformational distortion. As formulated into nanoparticles (NPs), the high performance of BETT‐2 NPs in NIR‐II light‐driven fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photodynamic‐photothermal synergistic therapy of orthotopic mouse breast tumors is fully demonstrated by the systematic in vitro and in vivo evaluations. This work offers valuable insights for developing NIR‐II laser activatable one‐for‐all phototheranostic systems.
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Wang et al. pioneered the development of BETT-2, a NIR-II-excitable AIEgen with multimodal phototheranostic properties.
“Wang et al. pioneered the development of BETT-2, a NIR-II-excitable AIEgen with multimodal phototheranostic properties (Fig. 22c)139.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [139]
BETT-2 NPs prepared by encapsulation with DSPE-mPEG2000 exhibited a high molar absorptivity (1813.56 M−1 cm−1) at 1064 nm, coupled with excellent ROS generation capacity and PCE (56.6%).
“BETT-2 NPs prepared by encapsulation with DSPE-mPEG2000 exhibited a high molar absorptivity (1813.56 M−1 cm−1) at 1064 nm, coupled with excellent ROS generation capacity and PCE (56.6%).”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [139]
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Self-citation
- Authors
- Song, S., Zhao, Y., Kang, M., Zhang, F., Wu, Q., Niu, N., Yang, H., Wen, H., Fu, S., Li, X., Zhang, Z., Tang, B. Z., & Wang, D.
- Affiliations
- National University of Singapore (SG)
- Shenzhen University (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Corresponding author
- Zhang, Zhijun
- Tang, Ben Zhong
- Wang, Dong
- ORCID
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2024-01-08
- Volume
- 36
- Issue
- 14
- Pages
- e2309748-e2309748
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W4390492713
- Cited by
- 147
- References
- 32
- Citations by year
- 2026: 44 · 2025: 70 · 2024: 33
- FWCI
- 14.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (52122317, 22175120, 22275124, 22105130)
- Science and Technology Foundation of Shenzhen City (JCYJ20190808153415062, RCYX20200714114525101, 20220809130438001, JSGG20220606141800001, JCYJ20200109110608167)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Keywords
- aggregation-induced emission, phototheranostics, multimodal imaging, photothermal therapy, photodynamic therapy, synergistic cancer therapy, nanoparticles, breast cancer, orthotopic tumor model, donor-acceptor systems
- MeSH terms
- Theranostic Nanomedicine, Animals, Light, Neoplasms, Phototherapy, Cell Line, Tumor, Mice, Nanoparticles
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