CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation in multiple sclerosis

Beliën, Jarne; Swinnen, Stijn; D’hondt, Robbe; Verdú de Juan, Laia; Dedoncker, Nina; Matthys, Patrick; Bauer, Jan; Vens, Celine; Moylett, Sinéad; Dubois, Bénédicte

doi:10.1038/s41467-024-49312-y

CHIT1 at diagnosis predicts faster disability progression and reflects early microglial activation in multiple sclerosis

Multiple sclerosis (MS) is characterized by heterogeneity in disease course and prediction of long-term outcome remains a major challenge. Here, we investigate five myeloid markers – CHIT1, CHI3L1, sTREM2, GPNMB and CCL18 – in the cerebrospinal fluid (CSF) at diagnostic lumbar puncture in a longi…