The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD(+) levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
Open accessAbstract
NRPT is a combination of nicotinamide riboside (NR), a nicotinamide adenine dinucleotide (NAD+) precursor vitamin found in milk, and pterostilbene (PT), a polyphenol found in blueberries. Here, we report this first-in-humans clinical trial designed to assess the safety and efficacy of a repeat dose of NRPT (commercially known as Basis). NRPT was evaluated in a randomized, double-blind, and placebo-controlled study in a population of 120 healthy adults between the ages of 60 and 80 years. The study consisted of three treatment arms: placebo, recommended dose of NRPT (NRPT 1X), and double dose of NRPT (NRPT 2X). All subjects took their blinded supplement daily for eight weeks. Analysis of NAD+ in whole blood demonstrated that NRPT significantly increases the concentration of NAD+ in a dose-dependent manner. NAD+ levels increased by approximately 40% in the NRPT 1X group and approximately 90% in the NRPT 2X group after 4 weeks as compared to placebo and baseline. Furthermore, this significant increase in NAD+ levels was sustained throughout the entire 8-week trial. NAD+ levels did not increase for the placebo group during the trial. No serious adverse events were reported in this study. This study shows that a repeat dose of NRPT is a safe and effective way to increase NAD+ levels sustainably.
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“NRPT treatment increased whole blood NAD+ levels by 90% with no serious adverse events”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Dellinger et al., 2017
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NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice
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“In another study, NR was shown to reverse the decline in the number and function of adult stem cells in old wild-type mice.(14) NR was also shown to significantly increase the lifespan of these animals.”
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Self-citationSlowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
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NAD+ in Brain Aging and Neurodegenerative Disorders
Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790
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Forbes, J. M., & Thorburn, D. R. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2018.9 · Cited by 650
NAD+ homeostasis in health and disease
Katsyuba, E., Romani, M., Hofer, D., & Auwerx, J. (2020) · Nature Metabolism · doi:10.1038/s42255-019-0161-5 · Cited by 627
Hou, Y., Wei, Y. Q., Lautrup, S., Yang, B., Wang, Y., Cordonnier, S. A., Mattson, M. P., Croteau, D. L., & Bohr, V. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011226118 · Cited by 556
Metadata
- Authors
- Dellinger, R. W., Santos, S. R., Morris, M., Evans, M., Alminana, D., Guarente, L., & Marcotulli, E.
- Affiliations
- Elysium Health, Inc. (United States) (US)
- Corresponding author
- Guarente, Leonard
- Venue
- npj Aging and Mechanisms of Disease
- Published
- 2017-11-24
- Volume
- 3
- Issue
- 1
- Pages
- 17-17
- ISSN
- 2056-3973 (ISSN-L)
- PMC
- PMC5701244
- OpenAlex
- W2769536025
- Cited by
- 181
- References
- 35
- Citations by year
- 2026: 7 · 2025: 21 · 2024: 16 · 2023: 21 · 2022: 29 · 2021: 25 · 2020: 22 · 2019: 23 · 2018: 16
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-08-20)
- Open access
- gold
- doi.org
- Locations
- npj Aging and Mechanisms of Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Nature
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- nicotinamide riboside, pterostilbene, NAD+ precursors, NAD levels, dietary supplementation, dose-dependent effects, healthy older adults
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