NAD+ homeostasis in health and disease

UniProt: a worldwide hub of protein knowledge

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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A subcellular map of the human proteome

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Mammalian Sirtuins: Biological Insights and Disease Relevance

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Sirtuins as regulators of metabolism and healthspan

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Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease

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Effects of extended-release niacin with laropiprant in high-risk patients

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Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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NAD ⁺ /NADH and NADP ⁺ /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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NAD+ and sirtuins in aging and disease

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The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

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SIRT1 regulates circadian clock gene expression through PER2 deacetylation

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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NAD ⁺ in aging, metabolism, and neurodegeneration

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Axonal pathology in traumatic brain injury

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NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Circadian Control of the NAD ⁺ Salvage Pathway by CLOCK-SIRT1

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Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD ⁺ Biosynthesis

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NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

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Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

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Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

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NAD+ metabolism in health and disease

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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

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Hematopoietic stem cell: self‐renewal versus differentiation

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

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Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

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CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

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The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

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Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2

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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

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PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

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Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

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Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

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SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

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Poly(ADP-Ribose) in the Cellular Response to DNA Damage

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Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

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PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

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The power to reduce: pyridine nucleotides—small molecules with a multitude of functions

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Potential roles of gut microbiome and metabolites in modulating ALS in mice

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Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

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Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart

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Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice

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Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

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The NAD metabolome — a key determinant of cancer cell biology

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Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

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Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

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The SARM1 toll/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration

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The Exercise Pressor Reflex: Its Cardiovascular Effects, Afferent Mechanisms, and Central Pathways

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Vitamin B ₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice

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SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

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Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene

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SARM1 activation triggers axon degeneration locally via NAD ⁺ destruction

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Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

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Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.

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Tissue-specific regulation of SIRT1 by calorie restriction

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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

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Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

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NAD(+) in aging: molecular mechanisms and translational implications

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Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

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Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging

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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

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Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

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Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

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Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

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Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

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SIRT3 Reverses Aging-Associated Degeneration

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De novo NAD+ synthesis enhances mitochondrial function and improves health

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Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

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Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

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